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  • DKFZ Publication Database  (5)
  • 1
    Keywords: CANCER ; PROSTATE ; SAMPLE ; ASSOCIATION ; HEALTH ; CIGARETTE-SMOKING ; MEN ; smoking ; prostate cancer ; PROSTATE-CANCER ; US ; NETHERLANDS ; ALCOHOL ; CONSUMPTION ; nutrition ; physical activity ; SERUM ; REGRESSION ; BODY-MASS INDEX ; USA ; HORMONES ; TESTOSTERONE ; older men ; FREE ESTRADIOL ; 3RD NATIONAL-HEALTH ; NUTRITION EXAMINATION SURVEY ; BONE-MINERAL DENSITY ; URINARY-TRACT SYMPTOMS ; HORMONE-BINDING GLOBULIN ; FREE TESTOSTERONE ; sex hormone-binding globulin ; COGNITIVE FUNCTION ; REPRESENTATIVE SAMPLE ; SURVEY NHANES-III
    Abstract: We evaluated the associations of smoking, alcohol consumption, and physical activity with sex steroid hormone concentrations among 1,275 men a parts per thousand yen20 years old who participated in the Third National Health and Nutrition Examination Survey (NHANES III). Serum concentrations of testosterone, estradiol, and sex hormone-binding globulin (SHBG) were measured. We compared geometric mean concentrations across levels of smoking, alcohol, and physical activity using multiple linear regression. Current smokers had higher total testosterone (5.42, 5.10, and 5.26 ng/ml in current, former, and never smokers), free testosterone (0.110, 0.102, and 0.104 ng/ml), total estradiol (40.0, 34.5, and 33.5 pg/ml), and free estradiol (1.05, 0.88, and 0.84 pg/ml) compared with former and never smokers (all p a parts per thousand currency sign 0.05). Men who consumed a parts per thousand yen1 drink/day had lower SHBG than men who drank less frequently (31.5 vs. 34.8 nmol/l, p = 0.01); total (p-trend = 0.08) and free testosterone (p-trend = 0.06) increased with number of drinks per day. Physical activity was positively associated with total (p-trend = 0.01) and free testosterone (p-trend = 0.05). In this nationally representative sample of men, smoking, alcohol, and physical activity were associated with hormones and SHBG, thus these factors should be considered as possible confounders or upstream variables in studies of hormones and men's health, including prostate cancer
    Type of Publication: Journal article published
    PubMed ID: 19277882
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  • 2
    Keywords: MODEL ; MODELS ; PHASE-I ; DISEASE ; POPULATION ; SAMPLE ; METABOLISM ; PATIENT ; kidney ; CONTRAST ; ASSOCIATION ; hormone ; PROGRESSION ; HEALTH ; DESIGN ; MEN ; PATHOGENESIS ; DAMAGE ; US ; DIET ; BLOOD-PRESSURE ; nutrition ; albumin ; SERUM ; ADULT ; CARDIOVASCULAR-DISEASE ; EGFR ; RENAL-DISEASE ; PHASE ; USA ; HORMONES ; TESTOSTERONE ; Phase I ; NUTRITION EXAMINATION SURVEY ; androgens ; SERUM CREATININE ; FREE TESTOSTERONE ; SERUM TESTOSTERONE ; GLOMERULAR-FILTRATION-RATE ; SERUM CYSTATIN-C ; 3 ; SEX-STEROID-HORMONES ; CREATININE ; REPRESENTATIVE SAMPLE ; Chronic kidney disease ; CKD ; CYSTATIN-C ; Kidney function ; Urinary albumin
    Abstract: P〉Context Sex steroid hormones may play a role in the pathogenesis of chronic kidney disease (CKD). Objective To determine whether sex steroid hormone concentrations are associated with kidney function or kidney damage in men in the general US population. We hypothesized that lower serum testosterone and E-2 concentrations are associated with CKD. Design patients and measurements Serum sex steroid hormones were measured by electrochemiluminescence immunoassays for 1470 men who attended the morning session of Phase I of the Third National Health and Nutrition Examination Survey (NHANES III). We used two measures of CKD, estimated glomerular filtration rate (eGFR) 〈 60 ml/min/1 center dot 73 m(2) calculated using serum creatinine or cystatin C levels and the abbreviated Modification of Diet in Renal Disease Study formulae and urinary albumin : creatinine ratio (UACR) 〉= 17 mg/g. Results Mean free testosterone concentration was higher in men with an eGFR 〈 60 ml/min/1 center dot 73 m(2) than in men with a higher eGFR. In multivariable adjusted models, the odds of an eGFR 〈 60 ml/min/1 center dot 73 m(2) or UACR 〉= 17 mg/g did not differ across tertiles of hormones with the exception of free E-2; those in the highest vs. lowest tertile had an elevated odds of decreased eGFR (OR: 3 center dot 04, 95% CI (1 center dot 22, 7 center dot 57); P-trend = 0 center dot 02). Conclusions In a nationally representative sample of US adult men, higher free E-2 concentration was significantly associated with an eGFR 〈 60 ml/min/1 center dot 73 m(2) as assessed by serum creatinine or cystatin C even after multivariable adjustment. These findings are in contrast to the hypothesis that oestrogens may protect against CKD, though reverse causation cannot be ruled out. Longitudinal investigation of the role of oestrogens in kidney haemodynamics, function, and pathophysiology is warranted
    Type of Publication: Journal article published
    PubMed ID: 19178534
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  • 3
    Keywords: CANCER ; neoplasms ; FOLLOW-UP ; COHORT ; cohort study ; DEATH ; DISEASE ; MORTALITY ; RISK ; MECHANISM ; ASSOCIATION ; HEALTH ; MEN ; PROSPECTIVE COHORT ; nutrition ; HEART-DISEASE ; ESTRADIOL ; CARDIOVASCULAR-DISEASE ; ELDERLY-MEN ; PHASE ; HORMONES ; HORMONE LEVELS ; TESTOSTERONE ; prospective ; older men ; cardiovascular diseases ; androgens ; sex hormone-binding globulin ; journals ; ADULT MEN ; ALL-CAUSE ; CRITICAL ILLNESS ; LOW SERUM TESTOSTERONE ; NHANES-III
    Abstract: The association of sex hormone levels with mortality over a median of 16 years of follow-up was evaluated in a prospective cohort study. The study included 1,114 US men who participated in phase 1 (1988-1991) of the Third National Health and Nutrition Examination Survey Mortality Study and had no history of cardiovascular disease or cancer at baseline. Multivariable adjusted hazard ratios for all-cause mortality associated with a decrease in hormone concentration equal to the difference between the 90th and 10th percentiles of the sex hormone distributions were estimated by using proportional hazards regression. The hazard ratios associated with low free testosterone and low bioavailable testosterone levels were 1.43 (95% confidence interval (CI): 1.09, 1.87) and 1.52 (95% CI: 1.15, 2.02), respectively, for follow-up between baseline and year 9; they were 0.94 (95% CI: 0.51, 1.72) and 0.98 (95% CI: 0.56, 1.72), respectively, for follow-up between year 9 and year 18. Men with low free and bioavailable testosterone levels may have a higher risk of mortality within 9 years of hormone measurement. Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association
    Type of Publication: Journal article published
    PubMed ID: 20083549
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  • 4
    Keywords: MORTALITY ; RISK ; HEART ; ASSOCIATION ; ARTERY-DISEASE ; CREATININE ; CKD ; CHRONIC KIDNEY-DISEASE ; EQUATION ; CYSTATIN C
    Abstract: Background The usefulness of estimated glomerular filtration rate (eGFR) and albuminuria for prediction of cardiovascular outcomes is controversial. We aimed to assess the addition of creatinine-based eGFR and albuminuria to traditional risk factors for prediction of cardiovascular risk with a meta-analytic approach. Methods We meta-analysed individual-level data for 637 315 individuals without a history of cardiovascular disease from 24 cohorts (median follow-up 4.2-19.0 years) included in the Chronic Kidney Disease Prognosis Consortium. We assessed C statistic difference and reclassification improvement for cardiovascular mortality and fatal and non-fatal cases of coronary heart disease, stroke, and heart failure in a 5 year timeframe, contrasting prediction models for traditional risk factors with and without creatinine-based eGFR, albuminuria (either albumin-to-creatinine ratio [ACR] or semi-quantitative dipstick proteinuria), or both. Findings The addition of eGFR and ACR significantly improved the discrimination of cardiovascular outcomes beyond traditional risk factors in general populations, but the improvement was greater with ACR than with eGFR, and more evident for cardiovascular mortality (C statistic difference 0.0139 [95% CI 0.0105- 0.0174] for ACR and 0.0065 [0.0042-0.0088] for eGFR) and heart failure (0.0196 [0.0108-0.0284] and 0.0109 [0.0059-0.0159]) than for coronary disease (0.0048 [0.0029-0.0067] and 0.0036 [0.0019-0.0054]) and stroke (0.0105 [0.0058-0.0151]and 0.0036 [0.0004-0.0069]). Dipstick proteinuria showed smaller improvement than ACR. The discrimination improvement with eGFR or ACR was especially evident in individuals with diabetes or hypertension, but remained significant with ACR for cardiovascular mortality and heart failure in those without either of these disorders. In individuals with chronic kidney disease, the combination of eGFR and ACR for risk discrimination outperformed most single traditional predictors; the C statistic for cardiovascular mortality fell by 0.0227 (0.0158-0.0296) after omission of eGFR and ACR compared with less than 0.007 for any single modifiable traditional predictor. Interpretation Creatinine-based eGFR and albuminuria should be taken into account for cardiovascular prediction, especially when these measures are already assessed for clinical purpose or if cardiovascular mortality and heart failure are outcomes of interest. ACR could have particularly broad implications for cardiovascular prediction. In populations with chronic kidney disease, the simultaneous assessment of eGFR and ACR could facilitate improved classification of cardiovascular risk, supporting current guidelines for chronic kidney disease. Our results lend some support to also incorporating eGFR and ACR into assessments of cardiovascular risk in the general population.
    Type of Publication: Journal article published
    PubMed ID: 26028594
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  • 5
    Keywords: EXPRESSION ; EXPOSURE ; POPULATION ; SAMPLE ; ASSOCIATION ; HEALTH ; PLASMA ; AGE ; MEN ; smoking ; MASS-SPECTROMETRY ; nutrition ; ESTRADIOL ; NATIONAL-HEALTH ; SERUM ; ADULT ; LEVEL ; methods ; PHASE ; USA ; ENGLAND ; FREE TESTOSTERONE ; REPRODUCTIVE ENDOCRINE FUNCTION ; SEMEN QUALITY ; ZEEMAN BACKGROUND CORRECTION
    Abstract: Background: Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods: In a nationally representative sample of 1,262 men participating in the morning examination session of phase 1 (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results: After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol ( each p-trend 〈 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium ( each p-trend 〉 0.05). Conclusion: Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men
    Type of Publication: Journal article published
    PubMed ID: 18294394
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