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  • 1
    ISSN: 1573-7284
    Keywords: Hepatitis B ; Vaccination ; Immunity ; HBsAg Carriers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We assessed in a western population the efficacy of a plasma-derived hepatitis B vaccine in relatives of highly infectious hepatitis B virus (HBV) carriers. A consecutive group of 103 HbsAg, anti-HBs and anti-HBc negative household relatives of 45 HBV-DNA positive chronic carriers received a 5 pg dose of plasma-derived vaccine at 0, 1, 2 and 12 months. Protective levels of immunity developed in 101 subjects (97.8%) 3 months after boosting. Low responders to the vaccine were mostly found among parents and spouses of carriers, whilst offspring and siblings were usually high responders. The main discriminant in predicting a good response was age below 12 years. Hyporesponsiveness did not occur in family clusters. No major HBV events occurred among immunized relatives patients. Hepatitis B vaccine is safe and effective in immunizing relatives of HBV carriers while no genetic conditioning of the immune response is evident among them.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Blends of three polyethylene (PE) samples (two HDPE grades and LLDPE) with an experimental sample of a semiflexible liquid crystalline polymer (SBH 1:1:2 by Eniricerche) have been prepared in a Brabender compounder. The processing-aid effect of the LCP has been demonstrated by the decreased energy required for extruding the blends, as compared to that needed for neat PE. The thermal properties, as studied by differential scanning calorimetry (DSC), have shown that the two components of the blends are immiscible. However, the dispersed SBH phase has been found to act as a nucleating agent for the crystallization of LLDPE, whereas no such effect was observed for HDPE. This has been taken as an indication that the phase interactions of SBH with LLDPE are more pronounced than with HDPE. The morphological study of the blends, done by scanning electron microscopy (SEM), has confirmed this conclusion. In fact, the SBH particles show a much better dispersion and a narrower size distribution in the LLDPE/SBH blends. The mechanical properties of the blends have been studied on compression-molded specimens. The results indicate that the reinforcing effect of SBH is practically none for both HDPE grades. In fact, the elongation at break decreases to very low values, and the tensile strength is also reduced, when the LCP concentration increases beyond 5-10%, whereas the tensile modulus does not vary appreciably, over the whole (0-20%) LCP range investigated. On the contrary, the tensile modulus of the LLDPE/SBH blends increases up to ca. 50%, and the elongation at break decreases more smoothly, on increasing the SBH content up to 20%. © 1995 John Wiley & Sons, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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