Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles  (145)
  • Articles: DFG German National Licenses  (145)
  • Medicine  (143)
  • Geography  (2)
Collection
  • Articles  (145)
Source
  • 1
    ISSN: 1573-7217
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radappertized chicken drumsticks were experimentally contaminated with suspensions ofCampylobacter jejuni in two trials. Qualitative analysis on drumsticks with an initial level of contamination of 4.8×103 CFU/cm2 showed that viability was retained for at least 10 days of storage at either 9° or −12°C. In a second quantitative trial, the level of contamination declined from 9.9×102 CFU/cm2 to 4.5×101 CFU/cm2 after 7 days at −20°C. Thereafter,C. jejuni persisted at levels ranging from 1.8×101 to 0.2×101 CFU/cm2 through the 26th week of storage. Drumsticks held at 4°C showed a significant decline in count from 9.9×102 CFU/cm2 to 1.8×102 CFU/cm2 on day 7. It is concluded that the viability ofC. jejuni on chicken parts is maintained under both refrigerated and freezing conditions which approximate commercial storage. This is of significance to the meat industry and consumers.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 19 (1992), S. 68-68 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1619-7089
    Keywords: Key words Mercaptoacetyltriglycine ; Diuretic renography ; Output efficiency ; Kidney transplantation ; Ureteric obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Suspected urinary tract obstruction following renal transplantation presents a diagnostic dilemma. The purposes of this study were: (1) to establish a normal range of measurement of output efficiency (OE) in the renal transplant population, and (2) to assess prospectively the usefulness of OE in the setting of allograft obstruction. Twenty-two renal transplant patients with stable renal function and no evidence of hydronephrosis on serial ultrasound examination had a diuretic mercaptoacetyltriglycine scan with calculation of OE. Three renal transplant patients with confirmed graft obstruction were also studied. Standard qualitative and quantitative parameters as well as OE were calculated. The mean OE for the 22 normal renal transplant patients was 86.3%±3.7% (range: 77%–91%). OE values in the three obstructed patients were 59%, 68% and 75% respectively. It is concluded that OE should normally exceed 77% in renal graft recipients. OE is a promising means of diagnosing functional obstruction in these patients.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1615-5742
    Keywords: Key words: cystic nephroma, renal tumors, Wilms' tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT We report a case of juxtaposed Wilms' tumor (WT) and cystic nephroma (CN) in a 21-month-old girl which gave rise to radiological diagnostic difficulty. Preoperative chemotherapy was given, resulting in marked tumor necrosis but the cystic nephroma remained untouched. Histological examination showed characteristic features of a triphasic WT and a CN; the two lesions were separated by a thick fibrous capsule. While everybody agrees that WT and cystic partially differentiated nephroblastoma (CPDN) are closely related, there are two opposite views about their relationship to CN. One is that CN may represent the final step in maturation of WT and CPDN. Other authors argue that there is no evidence to support this theory but believe CN might have something in common with nephrogenic rests. We suggest that the two lesions in the present case may have originated from two intralobar nephrogenic rests, which would strengthen the latter view.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1573-2592
    Keywords: Phycomycosis ; Rhizopus ; blast transformation ; T lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 64-year-old diabetic man had phycomycotic infection withRhizopus and expired following surgical debridement. Extensive immunological evaluation revealed normal cellular and humoral immune responses including anin vivo response toRhizopus antigen following delayed hypersensitivity skin testing. Evidence for increasedin vivo lymphocyte activation consisted of increased spontaneous morphological blast transformation and increased T non-mu non-gamma cells. This work extends the previous findings of normal immunological responsiveness includingin vitro reactivity toRhizopus antigen in such patients.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1573-2568
    Keywords: iron ; iron overload ; hemochromatosis ; baboon ; fibrosis ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two baboons receiving intramuscular injections of ferric nitrilotriacetate over a two-year period were compared with two control baboons. The results indicate that in ironoverloaded animals: (1) liver iron excess was major (maximal liver iron concentration values of 42 μmol/100 mg dry weight for both animals vs 1.3±0.2 (mean±sd) in controls) and chronic (for 15 months liver iron concentrations were higher than 15); (2) iron deposition, although less abundant than in sinusoidal cells, was pronounced within parenchymal cells; (3) serum transaminase activities were markedly increased; (4) rare foci of perisinusoidal fibrosis were observed in areas of massive iron overload; and (5) a dramatic decrease in hepatic 4-prolyl-hydroxylase activity was found, in contrast with unchanged glucosyltransferase and galactosyltransferase activities. In conclusion these findings suggest that, in our model, chronic liver iron overload: (1) exerts a marked biochemical cytolytic effect; and (2) does not produce significant hepatic fibrosis, possibly related to an inhibiting effect of ferric nitrilotriacetate complex on 4-prolyl-hydroxylase activity.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1573-3688
    Keywords: memory ; recall accuracy ; LBP ; pain ratings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Physiological and psychological stressors, disease state, and psychosocial factors may influence recall accuracy in low back pain (LBP) reporting. The literature indicates that duration or frequency of the painful episode(s) may exert a greater influence on recall accuracy than pain intensity. The focus of this study is the recall accuracy in self-report of pain by a chronic, nonspecific LBP population. This retrospective study examined recall accuracy of LBP at 1-week, 1-month, and 6-month intervals as compared to self-report using daily pain diaries. Significant differences in recall accuracy were found at the 6-month recall period, but not at the 1-week or 1-month periods. Significant differences in accuracy were found between men and women at the 6-month recall period. Subjects with recurrent LBP were more accurate than subjects with more chronic pain. Pain level or intensity was not shown to effect recall.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Infection 14 (1986), S. 177-180 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Verfasser beschreiben einen typischen Fall von kongenitalem Varizella-Syndrom. Die mütterliche Varizella-Infektion trat in der 17. Schwangerschaftswoche auf. Bei Geburt waren auf der Haut des Neugeborenen nekrotische Blasen zu sehen, die später mit charakteristischen Narben heilten. Andere typische Anomalien, wie hypoplastische Extremitäten mit muskulärer Atrophie und Klumpfüßen, intrauteriner Atrophie, Dysphagie und Anisokorie wurden ebenfalls beobachtet. Wegen des Risikos schwerer Mißbildungen durch intrauterine Varizella-Infektion ist die Prävention der Varizella-Zoster-Virus-Infektion während der Schwangerschaft anzustreben.
    Notes: Summary The authors are reporting a typical case of congenital varicella syndrome following maternal varicella during the 17th week of pregnancy. At birth, the newborn showed necrotic bullae on the skin that healed later with characteristic scars. Other typical anomalies, i.e. hypoplastic limbs with muscular atrophy and clubfoot, intrauterine atrophy, dysphagia and anisocoria were also found. In view of the risk of serious malformations following intrauterine varicella infection attempts should be made to prevent varicella zoster virus infection during pregnancy.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Untersuchungen zur Impfstoffentwicklung gegen dieBorrelia burgdorferi-Infektion haben wir grundlegende Prinzipien der protektiven Immunantwort in einem murinen Modell erarbeitet. Wir fanden, daß das Oberflächenlipoprotein „outer surface protein A (lipOspA)“ in nativer und rekombinanter lipidierter Form monospezifische Immunseren induziert, die in passiven Transferexperimenten immuninkompetente (SCID) Mäuse gegen experimentelle und zeckenvermittelte Infektion und Erkrankung schützen. Diese Befunde zusammen mit ähnlichen Befunden anderer Arbeitsgruppen führten zur Entwicklung eines Impfstoffs auf der Basis des lipOspA. In klinischen Phase I/II Prüfungen erwies sich der rekombinante lipOspA-Impfstoff als verträglich und immunogen und fähig zur Induktion bakterizider anti-Borrelien-Antikörper. Zum gegenwärtigen Zeitpunkt werden klinische Phase III-Prüfungen zur Untersuchung der protektiven Effizienz durchgeführt. Ausgehend von der Stelle des Zeckenbisses kommt es bei derB. burgdorferi-Infektion zur Verbreitung der Spirochäten in entfernte Organe und zur Induktion einer chronischen Entzündung. Kürzlich durchgeführte Untersuchungen zeigen, daß die Borrelien möglicherweise wirtseigene humorale Enzymsysteme rekrutieren, die ihnen die Ausbreitung erleichtern. In diesem Zusammenhang fanden wir, daß das lipOspA als ein Oberflächenrezeptor für das wirtseigene proteolytische Enzym Plasmin(ogen) fungiert. Darüber hinaus konnten wir zeigen, daß Borrelien in der Lage sind, vaskuläre Endothelzellen und Leukozyten, wie Monozyten/Makrophagen, B Zellen und T Zellen, zu aktivieren. Die aktivierten Zellen exprimieren Funktionen und sezernieren Moleküle mit proinflammatorischer Wirkung. Ein Teil der stimulierenden Aktivitäten konnte auf das gereinigte lipOspA zurückgeführt werden. Unsere Studien weisen demnach darauf hin, daß lipOspA als Zielstruktur protektiver Antikörper nicht nur eine wichtige Rolle bei der Induktion einer protektiven Immunantwort, sondern auch bei den pathogenen Reaktionen im Rahmen derB. burgdorferi-Infektion spielt.
    Notes: Summary In the search for a suitable vaccine candidate for Lyme borreliosis the principles of protective immunity were studied in a murine model ofBorrelia burgdorferi infection. It was found that the spirochetal outer surface protein A (lipOspA) in its native and recombinant lipidated form induces monospecific immune sera, which in passive transfer experiments protect SCID mice against experimental and tick-borne infection and disease. These and similar findings of independent groups led to the development of a vaccine formulation containing lipOspA. When tested in clinical phase I/II safety trials the recombinant lipOspA vaccine was shown to be safe, immunogenic and able to elicit borreliacidal antibodies. At present, clinical phase III efficacy trials are being conducted.B. burgdorferi infection involves the dissemination of the spirochetes from the site of the tick bite, infection of distant organs, and induction of a chronic inflammatory process. Recent studies indicate that the spirochetes may utilize host-derived enzyme systems to increase their virulence/pathogenicity. It was found that lipOspA serves as a surface receptor for the host-derived proteolytic enzyme plasmin(ogen), the central component of the so-called plasminogen activator system. Moreover, it was found that spirochetes are able to activate endothelial cells and blood-derived leukocytes, such as monocytes/macrophages, B cells and T cells, to express functions and/or secrete molecules, which are known to promote inflammatory responses. Part of these activities were exerted by the isolated lipOspA. The studies indicate an important role of lipOspA, both for the induction of a protective immune response by the host, as well as for the pathogenic processes elicited duringB. burgdorferi infection.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...