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  • 11
    ISSN: 1432-0843
    Keywords: Key words Adenocarcinoma ; Chemotherapy ; Surgery ; Oesophagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2; MIC) were given followed by evaluation of response by barium swallow and computed tomography scan. Of 20 patients, 17 completed both courses and 4 (20%) showed a partial response. Toxicity was generally mild and consisted principally of nausea and vomiting. Altogether, 15 patients were surgically explored; resection was completed in 12 patients, 3 of whom died in hospital (25%). Neoadjuvant therapy with MIC offers no advantage over surgery alone.
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  • 12
    ISSN: 1432-0851
    Keywords: Key words Mucin ; Tumor Immunotherapy ; Vaccines ; Tumor antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The action of various purified phospholipases on intact cells is reviewed, with special emphasis on platelets. Their effects are strongly dependent on the substrate specificity of the enzymes. Moreover, phospholipases can be divided into two groups according to their ability to hydrolyse phospholipids in an intact cell. Comparative studies of their behaviour towards phospholipid monolayers maintained at different surface pressures have allowed to estimate the surface pressure of erythrocyte and platelet membrane as 31–34 dynes/cm. Non-lytic degradation of platelet phospholipids has been used to identify the phospholipids directly accessible on the platelet surface. An asymmetric distribution of phospholipids has been described for the membrane whose outer leaflet contains essentially choline-phospholipids, whereas the anionic procoagulant phospholipids (phosphatidylserine and phosphatidylinositol) are confined to the inner leaflet. Furthermore, as a consequence of phospholipid asymmetry, arachidonic acid is concentrated towards the inside of the platelets, since only 6% of the total cell content is present in the exterior half of the platelet membrane. The platelet aggregation induced by exogenous phospholipase C is accompanied by phospholipid modifications such as phosphatidic and lysophosphatidic acid production. Since these changes occur also with physiological aggregating agents, some evidence is given for the involvement of endogenous platelet phospholipase C and diglyceride lipase, whose exact roles remain to be determined.
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  • 14
    ISSN: 1420-9136
    Keywords: Key Words: Variscan basement, 3-D wide-angle data, DEKORP, deep seismic sounding, crustal structure, prestack-migration.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —In addition to the near normal-incidence observations within the German DEKORP 2 project in 1984, wide-angle observations have been carried out on a parallel profile across the boundary between the Saxothuringian and Moldanubian crust, approximately 50 km NE of the main transect to control three-dimensional variations. Explosion sources have been used for the entire survey, providing excellent conditions for wide-angle registrations. A velocity model has been derived on the basis of in- and off-line refraction measurements using a kinematic raytracer which was extended to three dimensions by interpolation of 2-D velocity fields between parallel sections. Although prestack-migration of the data led to aliasing effects due to large shot and geophone spacing, stable results were obtained by forming envelopes after single-shot migration. The migrated sections reveal a strongly reflective Moho at about 31 km depth and a steeply (50°) dipping intracrustal reflector, which seems to be related to the border between the two Variscan units.
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  • 15
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. A bovine large-insert DNA library has been constructed in a Bacterial Artificial Chromosome (BAC) vector. The source DNA was derived from lymphocytes of a Jersey male. High-molecular-weight DNA fragments were produced by treatment with EcoRI/EcoRI methylase and cloned into the EcoRI site of pBACe3.6. In total, 157,240 individual BACs have been picked into 384-well plates. Approximately 190 randomly chosen clones have been characterized by Pulsed Field Gel Electrophoresis (PFGE) and have an average insert size of 105 kb, suggesting library coverage representing 5–6 genome equivalents. The frequency of clones without inserts is 4%. The chromosomal location of 51 BACs was studied by FISH; 3 showed more than one signal, indicating a chimerism frequency of roughly 6%. Approximately 50% of the clones in the library contain Simple Repeat Sequences (microsatellites), and 4% of the clones contain centromeric repeats. Insert stability was assessed by restriction digestion of DNA prepared from 20 clones after serial culture for one and three nights. Only one clone showed any evidence of an altered restriction pattern. Clones from 360 × 384-well plates (138,240 colonies) were gridded onto high-density membranes, and PCR superpools were produced from the same set of clones. Both membranes and superpools are available from the RZPD, Berlin (http://www.rzpd.de). PCR 4-D superpools have been prepared from an additional 23,000 clones. The library has been screened for a total of 24 single-copy sequences; positive clones have been obtained in all cases.
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  • 16
    ISSN: 1617-4623
    Keywords: Key words Transcription ; TFIIH ; MAT1 ; RING finger protein ; Saccharomyces cerevisiae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Kin28/Ccl1, a cyclin-dependent kinase, is essential for the in vivo phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II in Saccharomyces cerevisiae. In a search for mutations co-lethal with a thermosensitive kin28 mutation, we have identified genes whose products interact functionally with Kin28. In the present work, we have studied a new complementation group of synthetic lethal mutations. The corresponding gene, RIG2, encodes a predicted RING finger protein. Rig2 is likely to be a homolog of MAT1 of higher eukaryotes which forms a ternary complex with MO15(cdk7) and cyclin H. Our genetic data suggest that Rig2 is a component of transcription factor TFIIH. Transcription activity in a rig2-ts mutant is impeded at restrictive temperature. However, none of the rig2-ts mutants obtained was UV sensitive, suggesting that Rig2 is dispensable for nucleotide excision repair.
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  • 17
    ISSN: 1619-7089
    Keywords: Key words Mercaptoacetyltriglycine ; Diuretic renography ; Output efficiency ; Kidney transplantation ; Ureteric obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Suspected urinary tract obstruction following renal transplantation presents a diagnostic dilemma. The purposes of this study were: (1) to establish a normal range of measurement of output efficiency (OE) in the renal transplant population, and (2) to assess prospectively the usefulness of OE in the setting of allograft obstruction. Twenty-two renal transplant patients with stable renal function and no evidence of hydronephrosis on serial ultrasound examination had a diuretic mercaptoacetyltriglycine scan with calculation of OE. Three renal transplant patients with confirmed graft obstruction were also studied. Standard qualitative and quantitative parameters as well as OE were calculated. The mean OE for the 22 normal renal transplant patients was 86.3%±3.7% (range: 77%–91%). OE values in the three obstructed patients were 59%, 68% and 75% respectively. It is concluded that OE should normally exceed 77% in renal graft recipients. OE is a promising means of diagnosing functional obstruction in these patients.
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  • 18
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 3728-3737 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: In this article we describe the design and the operation of an original, high transmission, electrostatic "double toroidal" electron energy analyzer. The double toroidal analyzer allows the high resolution and high luminosity simultaneous measurement of the kinetic energy, and angular distribution of electrons, using a two-dimensional position sensitive detector. The exact shape of the electrodes is deduced from both analytical and numerical electron trajectory calculations. The electron detector is based on a charge analysis and optimized to attain a 100 kHz counting rate. The actual performances of the analyzer are illustrated with spectra obtained after resonant Auger decay of N2O excited around the nitrogen K shell (hν=401 eV), and of Kr after 3d5/2→5p excitation at hν=91.2 eV. A "étendue" of 15% of the pass energy, as well as a resolving power (Ep/δE) of 100were measured. © 1997 American Institute of Physics.
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  • 19
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 400 (1999), S. 323-324 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The stable levitation of magnets is forbidden by Earnshaw's theorem, which states that no stationary object made of magnets in a fixed configuration can be held in stable equilibrium by any combination of static magnetic or gravitational forces. Earnshaw's theorem can be viewed as a consequence ...
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  • 20
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America, Inc.
    Nature genetics 23 (1999), S. 82-82 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Facioscapulohumeral muscular dystrophy (FSHD) is the third most common form of inherited muscle disease following Duchenne and myotonic dystrophy. FSHD is initially characterized by an asymmetric, progressive weakness of the facial and pectoral girdle muscles. The disorder is inherited in an ...
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