Springer Online Journal Archives 1860-2000
Abstract This report provides the first direct measurements of the stroke volume and total cardiac output of crustacean hearts, as recorded from a semi-isolated in vitro preparation. The responses to mechanical perturbations, changes in preload and afterload, show that these hearts do not possess automatic compensatory Frank-Starling-like mechanisms. Heart rate, reflecting the burst rate of the cardiac ganglion, is minimally affected by stretch. On the other hand, these hearts are exquisitely responsive to the neurohormones of the pericardial organs. Serotonin, CCAP and proctolin all produce positive chronotropic and inotropic effects, but the responses to each are unique. Two FMRFamide peptides were positively chronotropic, but negatively inotropic.
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