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  • 11
    Keywords: INHIBITOR ; MODEL ; NF-KAPPA-B ; T-CELLS ; CASPASE-8 ACTIVATION ; CD95-induced apoptosis ; LONG FORM ; RECEPTOR-INDUCED APOPTOSIS ; FADD ; C-FLIPL
    Abstract: This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell death and in others leads to the activation of NF-kappaB. We established an integrated kinetic mathematical model for CD95-mediated apoptotic and NF-kappaB signaling. Systematic model reduction resulted in a surprisingly simple model well approximating experimentally observed dynamics. The model postulates a new link between c-FLIP(L) cleavage in the death-inducing signaling complex (DISC) and the NF-kappaB pathway. We validated experimentally that CD95 stimulation resulted in an interaction of p43-FLIP with the IKK complex followed by its activation. Furthermore, we showed that the apoptotic and NF-kappaB pathways diverge already at the DISC. Model and experimental analysis of DISC formation showed that a subtle balance of c-FLIP(L) and procaspase-8 determines life/death decisions in a nonlinear manner. We present an integrated model describing the complex dynamics of CD95-mediated apoptosis and NF-kappaB signaling.
    Type of Publication: Journal article published
    PubMed ID: 20212524
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  • 12
    Keywords: MODEL ; NF-KAPPA-B ; MODULATION ; FLICE ; SIGNALING COMPLEX ; CD95-induced apoptosis ; CASPASE ACTIVATION ; RECEPTOR-INDUCED APOPTOSIS ; BISTABILITY ; PROCASPASE-8 ACTIVATION
    Type of Publication: Journal article published
    PubMed ID: 21153319
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  • 13
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Social Science & Medicine 36 (1993), S. 419-427 
    ISSN: 0277-9536
    Keywords: gender ; gender related risks ; health perceptions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-1041
    Keywords: Stress ; Atenolol ; Bopindolol ; catecholamines ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a study in mild hypertensives, the impact of mental and physical stress on plasma epinephrine (E), norepinephrine (NE), and on their ratio (NE/E) was evaluated. The effect of twoβ-adrenoceptor blocking drugs, atenolol and bopindolol, on plasma catecholamine levels was also examined. Each stressful stimulus significantly increased the NE and E levels compared to rest. The increase was progressive from mental stress, through the handgrip test to the treadmill test. A slight decrease in the NE/E ratio was observed following mental stress and the handgrip test, while this ratio increased during the treadmill test. No significant impact of beta blocking treatment on catecholamine levels was observed under any test condition.
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Mud ; Balneotherapy ; Dead Sea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight patients with classical or definite rheumatoid arthritis were randomly divided into two groups of fourteen patients each. All patients were treated once a day with mud packs derived from the Dead Sea heated to 40°C and applied over the four extremities, neck and back for 20 minutes. Group 1 was treated with the true mud packs and Group 2 with washed out and less concentrated mud packs. The study was double blind and of two weeks duration. All patients were evaluated by one rheumatologist both before treatment and two weeks later at the end of the treatment period. Follow-up evaluations were made one and three months after conclusion of the treatment. The clinical indices evaluated included duration of morning stiffness, hand-grip strength, activities of daily living, patient's own assessment of disease activity, number of active joints and the Ritchie index. A statistically significant improvement (p〈0.01 or p〈0.05) was observed in Group 1 only in most of the clinical indices, lasting between 1 to 3 months.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1434-9949
    Keywords: Key words:Osteoarthritic knee – WOMAC validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of the study was to validate a translated version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in Hebrew speaking populations. The WOMAC was translated into Hebrew from its English version and its reliability and validity were studied. Before its use in patients, the Hebrew version was translated back into English by an independent translator and minor amendments were made to satisfy the original English versions designed by Bellamy et al. The Hebrew version of the WOMAC questionnaire was administered to 114 patients with osteoarthritis of the knee. All the subjects were asked about the presence and severity of pain during movement and handicap, using a visual analogue scale (VAS) of pain and handicap. Test–retest reliability was assessed using Pearson’s and intraclass correlation coefficients. Internal consistency was evaluated by Cronbach’s alpha coefficient of reliability. Construct validity was tested by correlating the WOMAC items with VAS of pain and handicap. The test–retest reliability Pearson’s correlation coefficients for the WOMAC items ranged from 0.55 to 0.78 (p〈0.01), and the Cronbach’s alpha was 0.97 at time 1 and 0.98 at time 2. Significant correlations (p〈0.01) were obtained between the WOMAC items and VAS of pain and handicap. The Hebrew version of WOMAC is a reliable and valid instrument for evaluating the severity of osteoarthritis of the knee in Israeli patients.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The structure of an isolated vortex line, and the lower critical fieldH c 1, is calculated by means of the generalized Ginzburg-Landau (GL) theory for arbitrary values of the GL-parameterk(≧1/√2) and the mean free pathl at temperaturesT in the vicinity ofT c . The free energy functional including the corrections of order [1−(T/T c )] to the GL-functional is derived exactly. The corresponding Euler-Lagrange equations determining the zero-order (GL) contributions and the corrections of order [1−(T/T c )] to the order parameter,f(r), and the superfluid velocity,v(r), have been solved numerically. The shapes of the first-order corrections off(r), v(r), and the magnetic field,h(r) are found to depend markedly, for a given value ofκ, on a second parameter,α=0.882(ξ 0 /l) (whereξ 0 is theBCS-coherence-distance). The deviations from the GL-solutions become largest forh(r) at parameter valuesk≈ 1 andα ≈ 0(the deviation ofh(0) is about 6% atT=0.9T c forκ=1 andα=0). The ratioH c1/H c (where the thermodynamic criticalH c has the BCS-temperature-dependence) is found to increase slightly in the “clean” limit (α=0), and to decrease slightly in the “dirty” limit (α=∞) asT decreases (the variation ofH c 1/H c is always less than 3% for arbitrary values ofκ andα asT decreases fromT c to 0.9T c ).
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1434-9949
    Keywords: Key words:CLINHAQ – Fibromyalgia – Health status – Physical functioning – Validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Assessment of health status in patients with rheumatic disease, including fibromyalgia (FM), using structured questionnaires has become an important approach to evaluate treatment and outcome. The objectives of this study were to validate a translated version of the Clinical Health Assessment Questionnaire (CLINHAQ) to be used by Hebrew-speaking populations, and specifically to evaluate its usefulness in fibromyalgia syndrome (FM). The CLINHAQ was translated into Hebrew and administered to 90 women with FM along with the Hebrew versions of the Fibromyalgia Impact Questionnaire (FIQ) and the Quality of Life (QOL) Scale. The CLINHAQ includes scales of functional disability, helplessness, anxiety and depression, as well as assessment of current health status and satisfaction with this. All subjects were asked about the presence and severity (assessed by visual analogue scale) of current FM symptoms (pain, fatigue, anxiety etc.); a count of 18 tender points was conducted by thumb palpation, and tenderness thresholds were measured by dolorimetry. Test–retest reliability was assessed by Pearson correlation coefficients, and internal consistency was evaluated with Cronbach’s α coefficient of reliability. Construct validity was tested by correlating the CLINHAQ items with measures of symptom severity, count of tender point, tenderness thresholds, physical functioning measured by FIQ, and with a score of QOL. Test–retest reliability coefficients ranged from 0.82 to 0.99, and Cronbach’s α coefficients from 0.725 to 0.929. Significant moderate to high correlations were obtained between most subscales of CLINHAQ and measures of physical functioning, quality of life and severity of FM symptoms. In conclusion, the CLINHAQ is a reliable and valid instrument for measuring health status and physical functioning in Israeli women with FM.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The theory of Abrikosov of the immediate subcritical region in the mixed state is extended by means of the generalized Ginzburg-Landau theory to temperatures belowT c and arbitrary mean free pathl of the electrons. The results for the magnetization and the free energy can still be presented in the form derived by Abrikosov apart from the fact thatκ is replaced by a new parameterκ 2(T). The slope of the curveκ 2/κ versust=T/T c att=1 is found to decrease monotonically from −0.105 to — (1.367-0.136κ −2) asl increases from zero to infinity. The results for short mean free paths are consistent with experiment, in particular,κ 2 is always larger thanκ in the vicinity ofT c . But the experimental temperature dependence ofκ 2/κ in pure Nb is much higher than the theoretical one.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In the first part of the paper we derive expressions of the Ginzburg-Landau (GL) type for the local tunneling density of states of superconducting alloys. These expressions are quite generally applicable at high excitation energies. One can see immediately that the density of states,N(r, ω), at any positionr and high energiesω is always larger than the local BCS density of states if the space dependence of the order parameter is governed by the GL-equation. This effect is largest for long mean free pathsl. In the second part of the paper we calculate the spatial average of the density of states,¯N, at all energiesω for a lattice of vortex lines in a magnetic field slightly below the upper critical field. The resulting curve of [¯N− N(0)]/N(0) versus co shows no gap and has a zero at about the gap value in zero field. Its value at ω=0 depends onl like ln(ξ0/l) for l≫ξ0 [N(0) denotes the normal density of states, and ξ0 is the BCS coherence length].
    Type of Medium: Electronic Resource
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