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  • 11
    Keywords: CANCER ; COHORT ; RISK ; ASSOCIATION ; SUSCEPTIBILITY ; HEALTH ; DESIGN ; WOMEN ; MEN ; cancer risk ; NETHERLANDS ; UNITED-STATES ; TOBACCO ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; pancreatic cancer ; NESTED CASE-CONTROL ; LIFE-STYLE FACTORS ; ONCOLOGY ; case-control study ; REGRESSION ; ASSOCIATIONS ; PANCREATIC-CANCER ; pooled analysis ; CANCER-RISK ; BASE-LINE CHARACTERISTICS ; nested case-control study ; GENOME-WIDE ASSOCIATION ; WOMENS HEALTH ; COFFEE CONSUMPTION ; Type ; nested case control study
    Abstract: The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. 〉 0 to 〈 5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out
    Type of Publication: Journal article published
    PubMed ID: 20373013
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  • 12
    Keywords: CANCER ; MODEL ; LUNG-CANCER ; COHORT ; EXPOSURE ; RISK ; RISK-FACTORS ; CARCINOGENESIS ; ASSOCIATION ; TRIAL ; prevention ; PATTERNS ; HEALTH ; CIGARETTE-SMOKING ; MEN ; smoking ; RISK FACTOR ; case-control studies ; pancreatic cancer ; NESTED CASE-CONTROL ; case-control study ; REGRESSION ; pancreas ; PANCREATIC-CANCER ; intensity ; METAANALYSIS ; pooled analysis ; USA ; smoking cessation ; RISK-FACTOR ; pancreatic neoplasms ; LOGISTIC-REGRESSION ; CONSORTIUM ; CONFIDENCE ; MODELING TOTAL EXPOSURE ; SHANGHAI ; tobacco use cessation
    Abstract: Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR) = 1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (〉= 30 cigarettes/day: OR = 1.75, 95% CI: 1.27, 2.42), duration (〉= 50 years: OR = 2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (〉= 40 pack-years: OR = 1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis
    Type of Publication: Journal article published
    PubMed ID: 19561064
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