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  • Germany  (17)
  • ANGIOGRAPHY  (7)
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  • 21
    Keywords: Germany ; imaging ; segmentation ; SYSTEM ; VOLUME ; DISEASE ; PATIENT ; MARKER ; MRI ; STAGE ; PROGRESSION ; TRANSFORMATION ; DEMENTIA ; ATROPHY ; MILD COGNITIVE IMPAIRMENT ; CLINICAL-DIAGNOSIS ; MEMORY IMPAIRMENT ; IMPAIRMENT ; HIPPOCAMPAL VOLUMETRY ; SIZE ; CRITERIA ; ADRDA WORK GROUP ; PROBABLE ALZHEIMERS-DISEASE
    Abstract: Background and purpose: Quantitative markers of alzheimer disease (Ad), Particularly in the early stages, are needed for clinical assessment and monitoring. We have evaluated a novel method to segment and visualize the ventricular system and obtain volumetric measures thereof. The temporal horn volume (Thv) And index in patients with mild cognitive impairment (Mci) And in those with ad were evaluated. Methods: High-resolution t1-weighted volume imaging was performed in 52 subjects (21 Patients with mci, 10 with ad, and 21 healthy control subjects). An interactive watershed transformation and semiautomated histogram analysis were implemented to produce segmented thv and temporal horn indices (Thi) (Ratio of thv to lateral ventricular volume). Results: Cerebral ventricular and temporal horn size could be semiautomatically quantified from all 52 datasets. The method was fast and rater-independent. Qualitative ventricular inspections using surface rendering shading could uncover atrophic process with enlargement of the whole and especially temporal horn volume. Both thv and thi of patients with ad were significantly larger than those of patients with mci or control subjects (P 〈.005). There was no significant difference in thv and thi between patients with mci or control subjects (P 〉.05). There was a significant correlation between the neuropsychologic performance and both thi and thv across groups (P 〈.01). Conclusion: Thv and thi could be used as markers of ad in the clinical environment and are expected to be helpful in monitoring therapeutic intervention
    Type of Publication: Journal article published
    PubMed ID: 16908557
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  • 22
    Keywords: Germany ; LUNG ; FOLLOW-UP ; SYSTEM ; VENTILATION ; MORTALITY ; PATIENT ; COMPLEX ; INJURIES ; COMPLEXES ; INFECTION ; LESIONS ; EXPERIENCE ; REPAIR ; arteries ; HIGH-RISK ; pathology ; FAILURE ; RECONSTRUCTION ; COMPLICATIONS ; CARDIOPULMONARY BYPASS ; STROKE ; EVENTS ; technique ; CAROTID-ARTERY ; aneurysm ; endograft ; endovascular ; ENDOVASCULAR TREATMENT ; DISSECTIONS ; REPLACEMENT ; CLINICAL-EXPERIENCE ; EXCLUSION ; aorta,thoracic ; BRANCHED STENT-GRAFT ; endovascular surgical procedures ; hybrid aortic procedure ; SUPRAAORTIC BRANCHES ; TRANSPOSITION
    Abstract: The aim of this study was to report our clinical experience with and review current literature on endoluminal aortic hybrid techniques and to evaluate outcome in high-risk patients treated for complex aortic arch lesions combining conventional supra-aortic debranching bypasses with subsequent or staged thoracic endovascular grafting. Of 172 patients treated with thoracic endografts for different thoracic aortic pathologies within the last 8 years, the mid-aortic arch was involved in 25, i.e. at least the left common carotid artery had to be overstented and revascularized to provide a proper proximal landing zone. These debranching bypasses were performed as a simultaneous or a staged procedure. All patients were at high-risk and were excluded by cardiac surgeons as ineligible for conventional arch repair. After partial (n=16) or complete (n=9) supra-aortic transposition, 4 different commercially available endografts (80% TAG, WL Gore) were implanted transfemorally or via iliac conduit. Deployment success was 100% in 25 patients after simultaneous or staged supra-aortic transposition; in 32% an emergency procedure was performed due to contained rupture; in 36% more than 1 endograft system was implanted (2 in 20%, 3 in 8% and 4 in 8%). The overall perioperative thirty-day mortality was 5 of 25 (20%) due to interoperative proximal bare stent perforation (n=1), transfusion related acute lung injury (TRALI n=1), cardiac failure (n=1), embolic stroke (n=1) and pneumonia (n=1). The mean follow-up was 21 months. All endoleaks type I (n=3) were corrected with another endograft; the 2 endoleaks type II sealed spontaneously. The major adverse events were: prolonged ventilation in 5 (20%), temporary renal insufficiency with hemodialysis (n=2), bypass infection (n=1), without any complications (n=9). No cases of paraplegia were recorded. Hybrid aortic arch repair is technically challenging but feasible. This novel approach may be an alternative to standard open procedures in high-risk patients and emergency cases. However, the promising early results need to be confirmed by longer follow-up and larger series
    Type of Publication: Journal article published
    PubMed ID: 17033600
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