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  • 1
    Publication Date: 2018-07-26
    Description: Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma. Microparticles released from activated platelets in the blood of SSc patients (SSc-microparticles) are abundant and express the damage-associated molecular pattern (DAMP) HMGB1. SSc-microparticles interacted with neutrophils in vitro and in immunocompromised mice and promoted neutrophil autophagy, which was characterized by mobilization of their granule content, enhanced proteolytic activity, prolonged survival, and generation of neutrophil extracellular traps (NETs). Neutrophils migrated within the mouse lung, with collagen accumulation in the interstitial space and the release of soluble E-selectin by the vascular endothelium. Microparticle-neutrophil interaction, neutrophil autophagy and survival, and generation of NETs abated in the presence of BoxA, a competitive inhibitor of HMGB1. Consistent with these results, neutrophils in the blood of SSc patients were autophagic and NET by-products were abundant. Our findings implicate neutrophils in SSc vasculopathy and suggest that platelet-derived, microparticle-associated HMGB1 may be a potential indicator of disease and target for novel therapeutics.
    Print ISSN: 1946-6234
    Electronic ISSN: 1946-6242
    Topics: Medicine
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 94 (1991), S. 5032-5039 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We discuss the calculation of the general three-center nuclear attraction integrals with Slater type orbitals using a one-center expansion method which exploits the algorithms previously developed by us for long-range integrals. From the analysis of the numerical stability, accuracy, and computational cost we conclude that the reported procedure is suitable for the calculation of these integrals with any desired precision. Moreover, we have found that most of these integrals can be obtained with high accuracy at a very low computational cost, but the procedure could be too expensive for a few of them.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 1788-1799 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a recently reported method, the molecular density is partitioned in minimally deformed atomic contributions, which are expanded in spherical harmonics times radial factors. Here we use this representation to express the electrostatic potential of the molecule, the force on its nuclei, and the conformational variations of energy in terms of some simple integrals of the atomic radial factors. As a first application, we analyze the relationship between the density and the binding forces (and the bonding energy) in the diatomic molecules of the first row atoms. Two types of forces act on each nucleus: the self-pulling exerted by its own cloud and the external force due to the remaining atoms. The self-pulling comes only from the dipole type term of the atomic density. The external force comes from the other clouds and nuclei and is dominated by the effective charges which depend on the outermost region of the charge term. Analyzing the progressive deformations of the atoms when they approach each other, the forces associated with these deformations and their contributions to the energy, one has a detailed description of the chemical bond which is complementary, and in many aspects more appealing, than the conventional ones. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 9807-9816 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The numerical and analytical procedures, used for calculating exchange integrals with Slater functions, fail to give high accuracy for large quantum numbers and some values of the parameters. We propose here an algorithmic approach based on recurrence relations which start from some simple functions. An extensive study in which exponents, interatomic distances, and quantum numbers were varied proves that the new procedure is fully reliable. Finally, the cost of the procedure is analyzed, including the effect of the number of terms needed to attain a given accuracy. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 2811-2814 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Amino acid incorporation in vivo was investigated in the cortex and hippocampus of rats raised in enriched and deprived environments for various periods of time following weaning. At early times after weaning (7 days), the incorporation of l-[3H]leucine into all sub-cellular fractions of both cortex and hippocampus was higher in enriched than in deprived rats. At 16 days, incorporation into synaptosomal sub-cellular fractions was higher in enriched than in deprived hippocampus, and lower in enriched than in deprived cortex; incorporation into perikaryal fractions of both brain regions was the same in the two groups of animals. Incorporation into subcortical nuclear protein fractions was higher in enriched rats at this time. At 35 days, the only difference between enriched and deprived rats was a lower incorporation into cortical synaptosomal sub-fractions in the former. Experiments involving double labelling and electrophoresis indicate that there is no stimulation or inhibition of the synthesis of any particular protein in hippocampal nuclear and synaptosomal sub-fractions of enriched rats. Synaptosomal proteins of cortex have a greater half-life in enriched than in deprived rats; proteins of perikaryal fractions of cortex, and of all fractions of hippocampus, are turning over at the same rate in enriched and deprived animals.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histochemical and Morphometric Study of the Fibrilar Population in Diaphragm Muscle. Part II: Ox and PigM-ATPase techniques, at different pH levels prior to incubation, as well as metabolic procedures (α-MGPDH and NADH-TR), were used to determine the fibre-type content of the lumbar and costal portions in the bovine and porcine diaphragm. The fibre samples were exposed to image analysis in order to evaluate both the morphometrical and statistical values.On the basis of tintorial reactions, the fibre types IA, IB and IIC were found in the lumbar portion of the bovine diaphragm; in the costal portion of the same diaphragm, IA, IB, IIA and IIC fibre types were observed. With regard to the porcine diaphragm, the I, IIA, IIB, IIC fibre types were present in both portions of the muscle. Further morphometrical and statistical data concerning all the fibre types are obtained and discussed.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The anatomical and clinical studies of computed tomography (CT) in Camelidae are scarce. The use of CT in large animal medicine is currently limited by the logistic problems of acquiring computed tomographic images. Several CT studies exist on adult llamas, but not in camels. Accurate interpretation of the planimetric CT normal anatomy is necessary for the study and evaluation of pathological tissues. The purpose of our work was to evaluate the thorax of the newborn camel and related structures by means of CT images and macroscopic sections. One newborn camel of one week was used. It was euthanized for medical reasons unrelated to disease of the thorax. CT images were obtained and detailed anatomy of the thorax was acquired. Different CT windows, soft-tissue and pulmonary windows, were applied in order to obtain detailed attenuation shades of the thoracic structures. The camel was frozen and sectioned using an electric saw, and we obtained high quality images of the thorax compared with CT images. Clinically relevant anatomic structures of the thorax cavity were identified and labelled in the corresponding CT and gross-section photographs. The information presented in this paper should serve as an initial reference to evaluate CT images of the newborn camel thorax.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to provide a new reference for interpretation of the normal anatomy of the canine thorax as imaged using computed tomography (CT). Three mature dogs, all mixed breed males, were used for this study. The dogs were sedated, anaesthetized and maintained in sternal recumbency. CT study from the first to the thirteen thoracic vertebra was performed with a TOSHIBA 600HQ scanner (third generation equipment). Dogs were killed and vascular-injection technique was performed: red latex and blue latex filled vascular system. Injected dogs were frozen and sectioned with an electric bandsaw, the cuts matched as closely as possible to the CT images. The CT images from this study are intended as a reference for clinical CT imaging studies of the thoracic cavity of the dog and for interpreting lesions of the thorax and associated structures.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to determine the temperature effect on the axial muscle growth of sea bass, a stock of larvae was subjected to the following incubation and cultivation temperatures, respectively: 15°C/ambient, 15/17°C, 17°C/ambient and 17/17°C. In all groups the cross-sectional area of white and red muscles and the number and average area of the white and red muscle fibres were quantified. Results showed that the embryonic period, pre-larval phase and the end of metamorphosis were accelerated at higher temperatures. During the endogenous feeding period, muscle growth took place by fibrillar hypertrophy, and was not influenced by the temperature. Thereafter (external feeding) muscular hyperplasia began, and growth of all the muscular parameters was favoured by the effect of high incubation and cultivation temperatures, with the latter having higher influence. High incubation temperature had an slight effect on muscle growth and body length, which was only observed from 15 days. Metamorphosis finished at 3 ± 0.4 cm in all the larvae, but this length was earlier reached at higher temperatures. At 120 days, the largest growth was obtained in the larvae maintained at a higher temperature.
    Type of Medium: Electronic Resource
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