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  • Action potentials  (1)
  • Carcinogen / Liste  (1)
  • Cell & Developmental Biology  (1)
  • Hazardous substances / Handbooks, manuals, etc  (1)
  • 1
    New York : Van Nostrand Reinhold
    Call number: 01-SichIng:179
    Keywords: Hazardous substances / Handbooks, manuals, etc ; Chemie / Substanzliste ; Chemikalie / Toxikologie ; Carcinogen / Liste
    Notes: Rev. ed. of: Dangerous properties of industrial materials / N. Irving Sax and Richard J. Lewis, Sr. 7th ed. c1989.
    Pages: 3 v.
    Edition: 8th ed.
    ISBN: 0442012764
    Signatur Availability
    01-SichIng:179 departmental collection or stack – please contact the library
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 661-671 
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X-ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
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  • 3
    ISSN: 1432-1912
    Keywords: Ciguatoxin ; Myocardium ; Na+ channel activator toxin ; Tetrodotoxin ; Action potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mode of action of ciguatoxin (CTX) on the isolated atrial and papillary muscle of the guinea-pig heart was investigated using conventional methods for the measurement of mechanical and electrophysiological parameters. CTX induced positive inotropic and positive klinotropic responses in atrial and papillary muscles. Each response consisted of two phases. The initial positive inotropic response developed rapidly and resulted from the previously reported indirect action of CTX. The second phase of positive inotropy developed more slowly and was well maintained at doses of CTX up to 0.15 mouse units/ml in atria and up to 0.8 M.U./ml in papillary muscles. This phase was found to result from a direct action of CTX on the myocardium which was not reversed by washing. Tetrodotoxin (TTX) reversed the positive inotropic effects stemming from the direct action of CTX. The (-) and (+) enantiomers of propranolol were equally effective in inhibiting the direct effect of CTX. These antagonists did not displace CTX from the myocardium. CTX induced a TTX-sensitive depolarization of stimulated or quiescent atrial cells. All the effects of CTX on the atrial action potential were reversed by TTX. It was therefore concluded that CTX opens voltage dependent Na+ channels. CTX bound equally to resting and K+-depolarized Na+ channels but there were indications that electrical stimulation enhanced the rate of CTX binding. CTX overrides the positive staircase effect of increasing stimulation frequency. Na+ channels found in the atria which were particularly sensitive to TTX did not play a prominent role in mediating the CTX effect. CTX appeared to have little effect on the normal Na+ channel inactivation process. CTX did not restore contractions in the K+-depolarized cardiac muscles examined. The sensitivity of CTX action to TTX distinguished it from cardiac glycoside activity. Established mechanisms of Na+/Ca2+ exchange and Ca2+-induced release of Ca2+ can explain the link between CTX-induced increase of intracellular [Na+] and the positive inotropic response.
    Type of Medium: Electronic Resource
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