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  • 1
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    Freiburg im Breisgau : Aurum Verl.
    Call number: 0420:84
    Keywords: Moerman, Cornelis ; Cancer / Diet therapy
    Notes: Translation of: De Moerman therapie
    Pages: 84 p.
    Edition: 3. Aufl.
    ISBN: 3591081132
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    0420:84 departmental collection or stack – please contact the library
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  • 2
    Abstract: PURPOSE: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple primary melanoma (SMP) and compare the data with those for patients from Spain to establish bases for melanoma genetic counseling in Latin America. METHODS: CDKN2A and MC1R were sequenced in 186 Latin American patients from Argentina, Brazil, Chile, Mexico, and Uruguay, and in 904 Spanish patients. Clinical and phenotypic data were obtained. RESULTS: Overall, 24 and 14% of melanoma-prone families in Latin America and Spain, respectively, had mutations in CDKN2A. Latin American families had CDKN2A mutations more frequently (P = 0.014) than Spanish ones. Of patients with SMP, 10% of those from Latin America and 8.5% of those from Spain had mutations in CDKN2A (P = 0.623). The most recurrent CDKN2A mutations were c.-34G〉T and p.G101W. Latin American patients had fairer hair (P = 0.016) and skin (P 〈 0.001) and a higher prevalence of MC1R variants (P = 0.003) compared with Spanish patients. CONCLUSION: The inclusion criteria for genetic counseling of melanoma in Latin America may be the same criteria used in Spain, as suggested in areas with low to medium incidence, SMP with at least two melanomas, or families with at least two cases among first- or second-degree relatives.Genet Med 18 7, 727-736.
    Type of Publication: Journal article published
    PubMed ID: 26681309
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  • 3
    Keywords: MORTALITY ; RISK ; HEART ; ASSOCIATION ; ARTERY-DISEASE ; CREATININE ; CKD ; CHRONIC KIDNEY-DISEASE ; EQUATION ; CYSTATIN C
    Abstract: Background The usefulness of estimated glomerular filtration rate (eGFR) and albuminuria for prediction of cardiovascular outcomes is controversial. We aimed to assess the addition of creatinine-based eGFR and albuminuria to traditional risk factors for prediction of cardiovascular risk with a meta-analytic approach. Methods We meta-analysed individual-level data for 637 315 individuals without a history of cardiovascular disease from 24 cohorts (median follow-up 4.2-19.0 years) included in the Chronic Kidney Disease Prognosis Consortium. We assessed C statistic difference and reclassification improvement for cardiovascular mortality and fatal and non-fatal cases of coronary heart disease, stroke, and heart failure in a 5 year timeframe, contrasting prediction models for traditional risk factors with and without creatinine-based eGFR, albuminuria (either albumin-to-creatinine ratio [ACR] or semi-quantitative dipstick proteinuria), or both. Findings The addition of eGFR and ACR significantly improved the discrimination of cardiovascular outcomes beyond traditional risk factors in general populations, but the improvement was greater with ACR than with eGFR, and more evident for cardiovascular mortality (C statistic difference 0.0139 [95% CI 0.0105- 0.0174] for ACR and 0.0065 [0.0042-0.0088] for eGFR) and heart failure (0.0196 [0.0108-0.0284] and 0.0109 [0.0059-0.0159]) than for coronary disease (0.0048 [0.0029-0.0067] and 0.0036 [0.0019-0.0054]) and stroke (0.0105 [0.0058-0.0151]and 0.0036 [0.0004-0.0069]). Dipstick proteinuria showed smaller improvement than ACR. The discrimination improvement with eGFR or ACR was especially evident in individuals with diabetes or hypertension, but remained significant with ACR for cardiovascular mortality and heart failure in those without either of these disorders. In individuals with chronic kidney disease, the combination of eGFR and ACR for risk discrimination outperformed most single traditional predictors; the C statistic for cardiovascular mortality fell by 0.0227 (0.0158-0.0296) after omission of eGFR and ACR compared with less than 0.007 for any single modifiable traditional predictor. Interpretation Creatinine-based eGFR and albuminuria should be taken into account for cardiovascular prediction, especially when these measures are already assessed for clinical purpose or if cardiovascular mortality and heart failure are outcomes of interest. ACR could have particularly broad implications for cardiovascular prediction. In populations with chronic kidney disease, the simultaneous assessment of eGFR and ACR could facilitate improved classification of cardiovascular risk, supporting current guidelines for chronic kidney disease. Our results lend some support to also incorporating eGFR and ACR into assessments of cardiovascular risk in the general population.
    Type of Publication: Journal article published
    PubMed ID: 26028594
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  • 4
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mutants of Aspergillus nidulans blocked in the main pathway of cysteine synthesis show an elevated level of the enzymes involved in the synthesis of cysteine from homocysteine i.e. cystathionine β-synthase and γ-cystathionase and a depressed level of homocysteine methyltransferase. This results in a considerable change in the sulfur amino acids pool as compared to the wild type. Upon addition of cysteine to the growth medium the first two enzymes are repressed while the level of the third one increases. These data indicate that the two diverging pathways of homocysteine metabolism are anti-coordinately regulated.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Aequationes mathematicae 27 (1984), S. 150-156 
    ISSN: 1420-8903
    Keywords: Primary 10A50, 39A10, 10L20 ; Secondary 39A99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The local behavior of the iterates of a real polynomial is investigated. The fundamental result may be stated as follows: THEOREM. Let xi, for i=1, 2, ..., n+2, be defined recursively by xi+1=f(xi), where x1 is an arbitrary real number and f is a polynomial of degree n. Let xi+1−xi≧1 for i=1, ..., n + 1. Then for all i, 1 ≦i≦n, and all k, 1≦k≦n+1−i, $$ - \frac{{2^{k - 1} }}{{k!}}〈 f\left[ {x_1 ,... + x_{i + k} } \right]〈 \frac{{x_{i + k + 1} - x_{i + k} + 2^{k - 1} }}{{k!}},$$ where f[xi, ..., xi+k] denotes the Newton difference quotient. As a consequence of this theorem, the authors obtain information on the local behavior of the solutions of certain nonlinear difference equations. There are several cases, of which the following is typical: THEOREM. Let {xi}, i = 1, 2, 3, ..., be the solution of the nonlinear first order difference equation xi+1=f(xi) where x1 is an arbitrarily assigned real number and f is the polynomial $$f(x) = \sum\limits_{j = 0}^n {a_j x^j } ,n \geqq 2$$ . Let δ be positive with δn−1=|2n−1/n!an|. Then, if n is even and an〈0, there do not exist n + 1 consecutive increments Δxi=xi+1−xi in the solution {xi} with Δxi≧δ. The special case in which the iterated polynomial has integer coefficients leads to a “nice” upper bound on a generalization of the van der Waerden numbers. Ap k -sequence of length n is defined to be a strictly increasing sequence of positive integers {x 1, ...,x n } for which there exists a polynomial of degree at mostk with integer coefficients and satisfyingf(x j )=x j+1 forj=1, 2, ...,n−1. Definep k (n) to be the least positive integer such that if {1, 2, ...,p k (n)} is partitioned into two sets, then one of the two sets must contain ap k -sequence of lengthn. THEOREM. pn−2(n)≦(n!)(n−2)!/2.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-6079
    Keywords: 36.40 ; 64.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The evolution of thermodynamic, dynamic and quantum size effects in clusters is expected to contribute towards the merging between microscopic and macroscopic points of view in molecular, surface and bulk phenomena.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-5914
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract A family ℬ of sequences has the Ramsey property if for every positive integerk, there exists a least positive integerf ℬ(k) such that for every 2-coloring of {1,2, ...,f ℬ(k)} there is a monochromatick-term member of ℬ. For fixed integersm 〉 1 and 0 ≤q 〈 m, let ℬq(m) be the collection of those increasing sequences of positive integers {x 1,..., xk} such thatx i+1 − xi ≡ q(modm) for 1 ≤i ≤ k − 1. Fort a fixed positive integer, denote byA t the collection of those arithmetic progressions having constant differencet. Landman and Long showed that for allm ≥ 2 and 1 ≤q 〈 m, ℬ q(m) does not have the Ramsey property, while ℬ q(m) ∪A m does. We extend these results to various finite unions of ℬ q(m) 's andA t 's. We show that for allm ≥ 2, $$ \cup $$ q=1 m−1 ℬq(m) does not have the Ramsey property. We give necessary and sufficient conditions for collections of the form ℬ q(m) ∪ ( $$ \cup $$ t ∈ T A t) to have the Ramsey property. We determine when collections of the form ℬa(m1) ∪ ℬb(m2) have the Ramsey property. We extend this to the study of arbitrary finite unions of ℬq(m)'s. In all cases considered for whichℬ has the Ramsey property, upper bounds are given forf ℬ.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Graphs and combinatorics 14 (1998), S. 131-142 
    ISSN: 1435-5914
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract.  A quasi-progression of diameter n is a finite sequence for which there exists a positive integer L such that for . Let be the least positive integer such that every 2-coloring of will contain a monochromatic k-term quasi-progression of diameter n. We give a lower bound for in terms of k and i that holds for all . Upper bounds are obtained for in all cases for which . In particular, we show that . Exact formulae are found for and . We include a table of computer-generated values of , and make several conjectures.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary Wave-organized convective features in the southwest Indian Ocean are described using Hovmoller composites of satellite imagery, OLR anomalies and ECMWF precipitable water departures during the southern summer. Westward movement of large convective elements is noted in the 10–20°S latitude band in about half of the years between 1970 and 1984. A study of 47 convective systems from satellite imagery establishes the climatological features, including zonal propagation speeds for maritime systems in the range −2 to −4 m s−1, wavelengths of 25–35° longitude (3,000 km), lifespans of 10–20 days and convective areas of 7–10° longitude (800 km). Transient convective waves over the tropical SW Indian Ocean are slower and more diverse than their northern hemisphere counterparts. Interannual tendencies in the frequency and mode are studied. Wet summers over SE Africa correspond with an increased frequency of westward moving convective systems, whereas in dry summers convective systems tend to be quasi-stationary. INSAT data composites provide additional insight into the convective structure and show that tropical waves penetrated into southern Africa in February 1988. A more quantitative assessment of transient convective waves is provided by Hovmoller composites of OLR anomalies and precipitable water departures. Both display westward moving systems in 1976 and 1984 and highlight the wide variety and mixed mode character of convective waves. A case study is analyzed which illustrates the deepening of a moist, unstable layer coincident with the westward passage of a convective wave.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary Differences in the convective potential of troughs passing over the plateau of southern Africa in the early summer are assessed using operational synoptic weather data and radiosonde time-height sections. Wet and dry trough cases are chosen on the basis of the intensity and distribution of rainfall, sharp thermodynamic changes across the plateau and the passage of a geopotential wave. Composite differences are computed and indicate a high-low geopotential anomaly in the east-west direction, and a threefold increase in precipi-table water from 15 mm in dry cases to 28 mm in wet cases. The 500 hPa structure obtained by differencing wet and dry composites is dominated by low geopotentials and cyclonic vorticity over the plateau near 25°S, 25°E, and high geopotentials and anticyclonic vorticity to the south over the oceans near 40°S, 30°E. The dipole anomaly suggests a diffluent tilted baroclinic wave in the subtropical jet stream in convective cases. A double jet streak structure in the wet events enhances upper divergence which contributes to widespread uplift in the mid-troposphere. A case study comparison highlights the importance of pre-frontal moist influx, the kinematic trigger and thermodynamic instability.
    Type of Medium: Electronic Resource
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