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  • 1
    Keywords: Bioinformatics ; Genetics ; Human Genetics ; Agriculture ; Bioinformatics ; Genetics and Genomics ; Human Genetics ; Agriculture ; Springer eBooks
    Description / Table of Contents: Introduction to biological data -- Computers and bioinformatics -- Sequence biological databases -- Biological databases -- Other biological databases -- Nucleic acid sequencing -- Tools and methods in analysis of simple sequences -- Tools and methods in analysis of complex sequences -- Structural bioinformatics -- Protein structure annotations -- Introduction to functional bioinformatics -- Biological networks – tools, methods and analysis -- Metabolomics -- Drug discovery: concepts and approaches -- Drug designing methods and analysis -- Molecular molecular docking -- Insilico pcr -- Modeling and optimization of molecular bio-systems to generate predictive models -- Index
    Abstract: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it mostly focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Unlike other bioinformatics books which are mostly theoretical, this book provides practical examples for the readers on state-of-the-art open source tools to solve biological problems. Flow charts of experiments, graphical illustrations, and mock data are included for quick reference. Volume I is therefore an ideal companion for students and early stage professionals wishing to master this blooming field
    Pages: XIV, 405 p. 193 illus., 186 illus. in color. : online resource.
    ISBN: 9783030026349
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  • 2
    Call number: YY Diss Noor/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 123 p.
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    YY Diss Noor/Mag departmental collection or stack – please contact the library
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  • 3
    ISSN: 1573-6784
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Hydrolytic and esterifying activities of lipase from Candida cylindracea adsorbed on rice husks were lost by dehydration using molecular sieve pellets and P2O5which removed 90-97% of the water after 9 days. However, only the esterifying activity of the enzyme was restored by gradual water transfer via the organic phase to the dried enzyme either by direct water addition or by using salt hydrates as water donors.
    Type of Medium: Electronic Resource
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  31. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII); 20170216-20170218; Dortmund; DOC17dgii007 /20170215/
    Publication Date: 2017-02-15
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  176. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte; 20140131-20140201; Krefeld; DOC14rwa01 /20140129/
    Publication Date: 2014-01-30
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    Keywords: POPULATION ; ASSOCIATION ; SCHIZOPHRENIA ; PERVASIVE DEVELOPMENTAL DISORDERS ; INDIVIDUALS ; SPECTRUM DISORDERS ; Copy number variation ; GENETIC ARCHITECTURE ; NEUROPSYCHIATRIC CONDITIONS ; PTEN MUTATIONS
    Abstract: Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P 〈 5 x 10(-8). When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P 〈 5 x 10(-8) threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C
    Type of Publication: Journal article published
    PubMed ID: 20663923
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  • 7
    Abstract: Autism is a common neurodevelopmental disorder with a complex mode of inheritance. It is one of the most highly heritable of the complex disorders, although the underlying genetic factors remain largely unknown. Here, we report mutations in the X-chromosome PTCHD1 (patched-related) gene in seven families with autism spectrum disorder (ASD) and in three families with intellectual disability. A 167-kilobase microdeletion spanning exon 1 was found in two brothers, one with ASD and the other with a learning disability and ASD features; a 90-kilobase microdeletion spanning the entire gene was found in three males with intellectual disability in a second family. In 900 probands with ASD and 208 male probands with intellectual disability, we identified seven different missense changes (in eight male probands) that were inherited from unaffected mothers and not found in controls. Two of the ASD individuals with missense changes also carried a de novo deletion at another ASD susceptibility locus (DPYD and DPP6), suggesting complex genetic contributions. In additional males with ASD, we identified deletions in the 5 flanking region of PTCHD1 that disrupted a complex noncoding RNA and potential regulatory elements; equivalent changes were not found in male control individuals. Thus, our systematic screen of PTCHD1 and its 5 flanking regions suggests that this locus is involved in 1% of individuals with ASD and intellectual disability.
    Type of Publication: Journal article published
    PubMed ID: 20844286
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  • 8
    Abstract: Biomarkers are strongly needed for diagnostic surveillance of metastatic melanoma patients. Based on its known association with tumor metastasis and its ability to induce cancer cachexia we investigated serum levels of growth and differentiation factor 15 (sGDF-15) as marker for overall survival (OS). sGDF-15 was retrospectively measured by ELISA in 761 samples obtained at distinct time points during routine clinical care of stage III/IV melanoma patients. In the entire cohort sGDF-15 〉/=1.5ng/mL was strongly associated with reduced OS after assessment. Subsequent analyses were performed separately for tumor-free stage III, tumor-free stage IV and unresectable stage IV patients. For patients with unresectable distant metastasis (n=206), sGDF-15 was independently associated with OS when considered together with the M-category and superior to sLDH. Analysis in tumor-free stage III patients during routine surveillance (n=468) revealed sGDF-15 to be associated with OS and an independent factor when considered together with S100B and the pattern of loco-regional metastasis. Only in tumor-free stage IV patients (n=87) sGDF-15 was not associated with OS. sGDF-15 should thus be further validated as marker for early detection of recurrence in stage III patients and as prognostic or predictive marker particularly in the context newly available treatments in unresectable stage IV patients.
    Type of Publication: Journal article published
    PubMed ID: 27705749
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  • 9
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  179. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte; 20170203-20170204; Essen; DOC17rwa117 /20170202/
    Publication Date: 2017-02-02
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 10
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  177. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte; 20150130-20150131; Dortmund; DOC15rwa080 /20150129/
    Publication Date: 2015-01-30
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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