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  • MicroRNAs/genetics  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • 1
    Publication Date: 2011-12-17
    Description: Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. By using high-throughput sequencing, we demonstrate the absence of all HoxC transcripts from embryos of the shark Scyliorhinus canicula and the skate Leucoraja erinacea and the absence of all HoxC genes and two HoxC-associated microRNAs from the genome of L. erinacea. These data suggest a loss of the entire HoxC cluster in elasmobranch fishes and represent evidence for the natural deletion of an entire Hox cluster in vertebrates.〈br /〉〈br /〉〈a href="" target="_blank"〉〈img src="" border="0"〉〈/a〉   〈a href="" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, Benjamin L -- Gillis, J Andrew -- Carlisle, Heather R -- Dahn, Randall D -- P20 RR016463/RR/NCRR NIH HHS/ -- P20 RR016463-12/RR/NCRR NIH HHS/ -- P20RR016463/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1517. doi: 10.1126/science.1210912.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kathryn W. Davis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Gene Deletion ; Gene Silencing ; Homeodomain Proteins/*genetics ; MicroRNAs/genetics ; Multigene Family ; Sharks/*genetics ; Skates (Fish)/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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