Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The ratio of the fragment ions at m/z 122 and m/z 123 in the positive ion fast atom bombardment or secondary ion mass spectra of thiamine hydrochloride varies with sample preparation and experimental conditions. For all mass spectra that contained significant abundances of matrix (S) ions [S + H]+, the fragment at m/z 123 is the more abundant of the two ions. If [S + H]+ ions are not observed in the mass spectrum under the conditions selected, the ion at m/z 122 is more abundant. This correlation suggests that hydrogen transfer to the fragment ion occurs in the gas phase, with the composition of the ion-solvent cluster ions in the selvedge region being the key factor. The ratio of the fragment ions at m/z 123 and m/z 122 is thus an indicator of the extent of protonation in the selvedge, the region immediately above the solvent surface created by primary particle bombardment.
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