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  • 1
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    New York : Garland Press
    Call number: B060:135
    Keywords: Human molecular genetics ; Molecular Biology
    Pages: xxv, 674 p. : ill.
    Edition: 3rd ed.
    ISBN: 0815341849
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  • 2
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    Heidelberg : Spektrum Akad. Verl.
    Call number: H0600:53 ; H0600:65
    Keywords: Human molecular genetics ; Molecular genetics ; Molecular Biology
    Notes: Translation of: Human molecular genetics.
    Pages: xxxix, 743 p. : ill.
    ISBN: 3-8274-0039-2
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    H0600:53 departmental collection or stack – please contact the library
    H0600:65 departmental collection or stack – please contact the library
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  • 3
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    Oxford : BIOS Scientific Publ.
    Call number: H0600:109 ; H0700:50 ; C050:2 ; H0900:60
    Keywords: Human molecular genetics ; Molecular Biology
    Notes: Includes index.
    Pages: xxiii, 576 p. : ill.
    Edition: 2nd ed.
    ISBN: 1-85996-202-5
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    H0600:109 departmental collection or stack – please contact the library
    H0700:50 departmental collection or stack – please contact the library
    C050:2 departmental collection or stack – please contact the library
    H0900:60 departmental collection or stack – please contact the library
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  • 4
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    New York : Garland Press
    Call number: QH447:199(5)
    Keywords: Human molecular genetics ; Molecular Biology
    Pages: xiii, 770 p. : ill.
    Edition: 4th ed.
    ISBN: 9780815345893
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    QH447:199(5) available
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  • 5
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    New York : Garland Press
    Call number: C050:55
    Keywords: Human molecular genetics ; Molecular Biology
    Pages: xxv, 781 p. : ill.
    Edition: 4th rev. ed.
    ISBN: 978-0-8153-4149-9
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    C050:55 available
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  • 6
    ISSN: 0167-0115
    Keywords: Gastric acid secretion ; Omeprazole ; Sheep
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Measurements of protein and amino acid metabolism in man using stable isotopes and selected ion monitoring gas chromatographic/mass spectrometric techniques are limited by the requirement of relatively high levels of labelling for adequate precision ( 〉 0.05 at % excess). We describe here a means of extending the scope of such studies by measurement of lower levels of enrichment achieved in gaseous CO2 derived from whole blood or protein-bound amino acids following the administration of tracer amounts of appropriately labelled substrates. Construction and operation of a novel glass vacuum line required for this work are described in detail and specific applications relevant to clinical investigations are outlined. Measurements of both the total amount of CO2 and its 13C enrichment are performed in an isotope-ratio mass spectrometer which provides acceptable levels of accuracy and reproducibility for both measurements ( ±0.1% and ±0.0001 at% excess respectively).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this paper is to report five patients with chronic secretory diarrhea (maximum stool volume greater than 1 liter per day, duration 6 weeks to 8 years) in whom we could find no evidence of an endocrine tumor or of surreptitious laxative ingestion. All except one had severe hypokalemia. There was apparent improvement after treatment with prednisone in two patients and loperamide in one. The diarrhea resolved spontaneously in three patients and has undergone several temporary remissions in one patient. The last patient died after a severe unremitting illness. Extensive investigations failed to establish the etiology, but intestinal perfusion (carried out in four of the five patients) revealed secretion or abnormally low absorption of water and electrolytes in the jejunum and abnormally low absorption in the colon. The management of patients with chronic watery diarrhea is discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the effect of loperamide (4 mg tds) on the continence to a standard volume of rectally infused saline and anorectal manometry in 26 patients complaing of chronic diarrhea complicated by fecal incontinence and severe urgency. Each patient was treated for one week with loperamide (4 mg tds) and for one week with an identical placebo in a double-blind cross-over trial. Our results showed that as well as its established effects of improving stool consistency and reducing stool weight, frequency and episodes of incontinence and severe urgency, loperamide also significantly improved continence to a standard volume of rectally infused saline. This action was associated with an increase in the maximum basal sphincter pressure, an increase in the rectal volume required to abolish recovery of the rectoanal inhibitory reflex, and a reduction in rectal compliance. These results suggest that loperamide may have a specific action on the anal sphincter, which may aid continence in patients who complain of diarrhea and fecal incontinence.
    Type of Medium: Electronic Resource
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  • 10
    Keywords: brain ; RECEPTOR ; ANGIOGENESIS ; APOPTOSIS ; CELLS ; EXPRESSION ; GROWTH ; IN-VITRO ; INVASION ; proliferation ; SURVIVAL ; tumor ; TUMOR-CELLS ; Germany ; human ; IN-VIVO ; INHIBITION ; KINASE ; THERAPY ; VITRO ; DISTINCT ; TUMORS ; validation ; LINES ; MICE ; TIME ; IDENTIFICATION ; METASTASIS ; CELL-LINE ; leukemia ; LINE ; MIGRATION ; OVEREXPRESSION ; CANCER-THERAPY ; GLIOMAS ; INVITRO ; CELL-GROWTH ; signaling ; BRAIN-TUMORS ; GLIOMA ; PROTOONCOGENE ; LEVEL ; cell migration ; in vivo ; GLIOBLASTOMA ; receptor tyrosine kinase ; GAS6
    Abstract: Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular events underlying gliomagenesis are poorly understood. In this study, we have identified the receptor tyrosine kinase Axl as a mediator of glioma growth and invasion. We demonstrate that Axl and its ligand Gas6 are overexpressed in human glioma cell lines and that Axl is activated under baseline conditions. Furthermore, AxI is expressed at high levels in human malignant glioma. Inhibition of Axl signaling by overexpression of a dominant-negative receptor mutant (AXL-DN) suppressed experimental gliomagenesis (growth inhibition 〉 85%, P 〈 0.05) and resulted in long-term survival of mice after intracerebral glioma cell implantation when compared with Axl wild-type (AXL-WT) transfected tumor cells (survival times: AXL-WT, 10 days; AXL-DN, 〉 72 days). A detailed analysis of the distinct hallmarks of glioma pathology, such as cell proliferation, migration, and invasion and tumor angiogenesis, revealed that inhibition of Axl signaling interfered with cell proliferation (inhibition 30% versus AXL-WT), glioma cell migration (inhibition 90% versus mock and AXL-WT, P 〈 0.05), and invasion (inhibition 62% and 79% versus mock and AXL-WT, respectively; P 〈 0.05). This study describes the identification, functional manipulation, in vitro and in vivo validation, and preclinical therapeutic inhibition of a target receptor tyrosine kinase mediating glioma growth and invasion. Our findings implicate Axl in gliomagenesis and validate it as a promising target for the development of approaches toward a therapy of these highly aggressive but, as yet, therapy-refractory, tumors
    Type of Publication: Journal article published
    PubMed ID: 16585512
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