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  • 1
    London : Professional Engineering
    Keywords: Engineering, Safety measures. ; Reliability (Engineering)
    Pages: 244 p.
    ISBN: 0-585-48974-2
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  • 2
    Call number: QZ200:504
    Pages: xix, 180 p. : ill.
    ISBN: 9780387693200
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    QZ200:504 available
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  • 3
    Boston, MA : Springer Science+Business Media, LLC
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Radiology, Medical ; Biochemistry ; Biomedicine ; Neurosciences ; Biophysics and Biological Physics ; Medical Biochemistry ; Human Physiology ; Neuroradiology ; Imaging / Radiology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441974099
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  • 4
    Keywords: Life sciences ; Human Genetics ; Biostatistics ; Microbial genetics ; Microbial genomics ; Life sciences ; Microbial Genetics and Genomics ; Human Genetics ; Biostatistics ; Springer eBooks
    Description / Table of Contents: Part I: overview -- 1. NGS, The new gold standard of identification of defective genes -- 2. Principles of target gene enrichments, pros and cons -- 3. Criteria for clinical application: Full validation and performance characteristics -- 4. Clinical requirements: variant interpretation, confirmation, and turnaround time -- Part II: Experiences in various applications -- 5. The metabolic pathways: GSD, CDG, cobalamin metabolism, and others -- 6. The eye gene panels -- 7. The otogenes -- 8. The immunodeficiency disorders -- 9. The bone density and skeletal related disorders -- 10.The hereditary cancer genes -- 11.The molecular diagnosis of cancers and implications in treatment: Marilyn Li -- 12. Neuromuscular disorders -- 13. The cardiac panel: YuXin Fan, GeneDx or Harvard Partner -- 14. The mitochondrial genome -- 15. The Nuclear Mitomes
    Abstract: Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application
    Pages: VIII, 364 p. 23 illus., 17 illus. in color. : online resource.
    ISBN: 9783319564180
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  • 5
    Hoboken, New Jersey : Wiley
    Call number: E020:84
    Keywords: Molecular Imaging ; Chemical Phenomena ; Diagnostic Imaging
    Description / Table of Contents: 1. An Introduction to Molecular Imaging -- 2. Chemical Methodology for Labelling and Bioconjugation -- 3. Recent Developments in the Chemistry of [ 18F]Fluoride for PET -- 3. Recent Developments in the Chemistry of [ 18F]Fluoride for PET -- 4. Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-Lived Radioisotopes -- 5. The Chemistry of Inorganic Nuclides (86Y, 68Ga, 64Cu, 89Zr, 124I) -- 6. The Radiopharmaceutical Chemistry of Technetium and Rhenium -- 7. The Radiopharmaceutical Chemistry of Gallium(Ill) and Indium(III) for SPECT Imaging -- 8. The Chemistry of Lanthanide MRI Contrast Agents -- 9. Nanoparticulate MRI Contrast Agents -- 10. CEST and PARACEST Agents for Molecular Imaging -- 11. Organic Molecules for Optical Imaging -- 12. Application of d- and f-Block Fluorescent Cell Imaging Agents -- 13. Lanthanide-Based Upconversion Nanophosphors for Bioimaging -- 14. Microbubbles: Contrast Agents for Ultrasound and MRI -- 15. Non-Nanoparticle-Based Dual-Modality Imaging Agents -- 16. Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles
    Abstract: "Covering all the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry, The Chemistry of Molecular Imaging focuses primarily on the chemistry of probes and imaging agents, as well as chemical methodology for labelling and bioconjugation. Written by an interdisciplinary team of experts, this book investigates the chemistry of molecular imaging and helps to educate non-chemists already involved in the area of molecular imaging. It addresses all the major modalities and techniques, such as MRI, positron emission tomography, single photon emission computed tomography, ultrasound, and fluorescence/optical imaging"--
    Pages: xii, 395 pages, [24] pages of plates : illustrations (some color)
    ISBN: 9781118093276
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    E020:84 departmental collection or stack – please contact the library
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  • 6
    Weinheim : Wiley-VCH
    Call number: E080:220 ; E080:221 ; W160:20 ; W160:21
    Keywords: Carbohydrates / pharmacology ; Carbohydrates / chemistry ; Carbohydrate metabolism ; Glycoconjugates / physiology ; Drug Design
    Pages: 2 v. (xxxii, 947 p.) : ill. (some col.)
    ISBN: 3527306323
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    E080:220 departmental collection or stack – please contact the library
    E080:221 departmental collection or stack – please contact the library
    W160:20 departmental collection or stack – please contact the library
    W160:21 departmental collection or stack – please contact the library
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  • 7
    Call number: ALLG-BERUF-PN4121:10 ; W110:9
    Keywords: Business presentations
    Notes: Transl. of: Guide to information graphics.
    Pages: 156 p. : ill.
    ISBN: 9783868812770
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    ALLG-BERUF-PN4121:10 available
    W110:9 departmental collection or stack – please contact the library
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  • 8
    Keywords: Medicine ; Human Genetics ; Bioinformatics ; Biomedicine ; Human Genetics ; Bioinformatics ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Part I: Overview.-℗ History of DNA Sequencing Technologies -- Clinical Molecular Diagnostic Techniques: A Brief Review -- Part II: The Technologies and Bioinformatics -- Methods of Gene Enrichment and Massively Parallel Sequencing Technologies -- Sequence Alignment, Analysis, and Bioinformatics Pipelines -- Protein Structural Based Analysis for Variant Interpretation of Missense Variants at the Genomics Era: Using MNGIE Disease as an Example -- Algorithms and Guidelines for Interpretation of DNA Variants -- Part III: Application to Clinical Diagnostics -- NGS-based Clinical Diagnosis of Genetically Heterogeneous Disorders -- Molecular Diagnosis of Congenital Disorders of Glycosylation (CDG) -- NGS Improves the Diagnosis of X-Linked Intellectual Disability (XLID) -- NGS Analysis of Heterogeneous Retinitis Pigmentosa -- Next Generation Sequencing of the Whole Mitochondrial Genome -- Application of Next-Generation Sequencing of Nuclear Genes for Mitochondrial Disorders -- Noninvasive Prenatal Diagnosis Using Next Generation Sequencing -- Part IV: Compliance with CAP/CLIA Regulations -- Guidelines and Approaches to Compliance with Regulatory and Clinical Standards: Quality Control Procedures and Quality Assurance -- Validation of NGS-based Test and Implementation of Quality Control Procedures -- Frequently Asked Questions about the Clinical Utility of Next Generation Sequencing in Molecular Diagnosis of Human Genetic Diseases -- Index
    Abstract: In recent years, owing to the fast development of a variety of sequencing technologies in the post human genome project era, sequencing analysis of a group of target genes, entire protein coding regions of the human genome, and the whole human genome has become a reality.℗ ℗ Next Generation Sequencing (NGS) or Massively Parallel Sequencing (MPS) technologies offers a way to screen for mutations in many different genes in a cost and time efficient manner by deep coverage of the target sequences.℗ This novel technology has now been applied to clinical diagnosis of Mendelian disorders of well characterized or undefined diseases, discovery of new disease genes, noninvasive prenatal diagnosis using maternal blood, and population based carrier testing of severe autosomal recessive disorders.℗ This book covers topics of these applications, including potential limitations and expanded application in the future.℗ ℗ ℗ ℗
    Pages: : digital.
    ISBN: 9781461470014
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  • 9
    Keywords: Life sciences ; Oncology ; Biochemistry ; Cytology ; Life sciences ; Biochemistry, general ; Cell Biology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- Glycome DB -- GlycoEpitope -- Sugar Bind DB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells
    Abstract: The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience
    Pages: LXII, 1568 p. 333 illus., 233 illus. in color. eReference. : online resource.
    ISBN: 9784431548416
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  • 10
    Boca Raton : CRC Press, Taylor & Francis Group
    Call number: QP620:150
    Keywords: Sequence Analysis, RNA / methods ; Transcriptome ; Statistics as Topic
    Abstract: "RNA-seq offers unprecedented information about transcriptome, but harnessing this information with bioinformatics tools is typically a bottleneck. This self-contained guide enables researchers to examine differential expression at gene, exon, and transcript level and to discover novel genes, transcripts, and whole transcriptomes. Each chapter starts with theoretical background, followed by descriptions of relevant analysis tools. The book also provides examples using command line tools and the R statistical environment. For non-programming scientists, the same examples are covered using open source software with a graphical user interface"--
    Notes: "A Chapman & Hall book."
    Pages: xxiv, 298 pages : illustrations
    ISBN: 9781466595002
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    QP620:150 on loan
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