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  • 1
    Abstract: INTRODUCTION: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density. METHODS: The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies included in the Breast Cancer Association Consortium. We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (P int) in a meta-analysis of genome-wide gene-environment interaction studies with MHT use on risk of breast cancer, 2541 SNPs in candidate genes (AKR1C4, CYP1A1-CYP1A2, CYP1B1, ESR2, PPARG, PRL, SULT1A1-SULT1A2 and TNF) and ten SNPs (AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, ZNF365-rs10995190, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, 12q24-rs1265507, TMEM184B-rs7289126, and SGSM3-rs17001868) associated with mammographic density in genome-wide studies. We used multiple linear regression models adjusted for potential confounders to evaluate interactions between SNPs and current use of MHT on mammographic density. RESULTS: No significant interactions were identified after adjustment for multiple testing. The strongest SNP-MHT interaction (unadjusted P int 〈0.0004) was observed with rs9358531 6.5kb 5' of PRL. Furthermore, three SNPs in PLCG2 that had previously been shown to modify the association of MHT use with breast cancer risk were found to modify also the association of MHT use with mammographic density (unadjusted P int 〈0.002), but solely among cases (unadjusted P int SNPxMHTxcase-status 〈0.02). CONCLUSIONS: The study identified potential interactions on mammographic density between current use of MHT and SNPs near PRL and in PLCG2, which require confirmation. Given the moderate size of the interactions observed, larger studies are needed to identify genetic modifiers of the association of MHT use with mammographic density.
    Type of Publication: Journal article published
    PubMed ID: 26275715
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  • 2
    Electronic Resource
    Electronic Resource
    Langenbeck's archives of surgery 364 (1984), S. 229-232 
    ISSN: 1435-2451
    Keywords: Third-degree burn injuries ; Necrectomy ; Temporary defect cover ; Skin transplantation ; Drittgradige Brandverletzung ; Nekrektomie ; Temporäre Defektdeckung ; Hauttransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drittgradige Brandverletzungen erfordern aus vitaler, funktioneller oder ästhetischer Indikation eine plastisch-chirurgische Therapie. Um das Infektionsrisiko möglichst gering zu halten, sollte mit der Nekrektomie so früh als möglich begonnen werden. Ausdehnung und Tiefe der Gewebsschädigung, der Infektionsgrad der Wunde sowie der Allgemeinzustand des Verletzten entscheiden darüber, ob eine temporäre Defektdeckung notwendig ist oder die autologe Spalthauttransplantation sofort angeschlossen werden kann. Hierzu haben sich neben den Streifentransplantaten Mesh-graft-Transplantate in unterschiedlicher Vergrößerung sehr bewährt.
    Notes: Summary In third-degree bum injuries vital, functional or esthetic indications require surgical therapy. In order to keep the risk of infection as low as possible it is necessary to begin with the necrectomy as soon as possible. Extent and depth of the damaged tissue, the degree of the wound infection as well as the patient's physical condition decide whether the defect should be covered temporarily or whether an autologous splitskin transplantation should be performed. In addition to stripe transplants meshgraft-transplants of different sizes have proved to be very successful in surgery of burn injuries.
    Type of Medium: Electronic Resource
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