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  • 1
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The biological behavior of Technetium-99m-L,L-Ethylenedicysteine (Tc-99m-EC)was compared with that of Technetium-99m-Mercaftoacetyltriglycine (Tc-99m-MAG3) and Iodine-131-hippuran (1131-OIH) in mice and rabbits. Tc-99m-EC showed a more rapid urinary excretion and less retention in kidney, liver, intestines and blood in comparison to Tc-99m-MAG3 and I-131-OIH. Urinary excretion decreased after probenecid treatment, indicating active tubular transport. In human bodies, the renal scintigraphy with Tc-99m-EC, Tc-99m-MAG3 and Tc-99m-DTPA were comparable. The promising results of the animal and human studies suggest that Tc-99m-EC may be a useful alternative to Tc-99m-MAG3 and I-131-OIH for renal functional studies.
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  • 2
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope, Bios Inc., Valhalla, New York) and 113mIn in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects 99mTC-RBCs were compared with 113mIn which binds to transferrin after IV injection. With 99mTc-RBCs, average LVEF was 57±7% (1 SD); with 113mIn, average LVEF was 55±8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEFs obtained using 99mTc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and 113mIn increased in 28 normals from 57±9% to 64±13% (P〈0.001) during handgrip exercise, while the LVEF decreased from 45±9% to 41±10% (P〈0.01) in patients with acute myocardial infarction 4–7 weeks after episode, from 48±11 to 40±12% (P〈0.001) in patients with old myocardial infarction, and from 52±9 to 42±9% (P〈0.001) in patients with angina pectoris. The cardiac probe and 113mIn provide a useful alternate means of determining left ventricular dysfunction in facilities where 99mTc and a gamma camera computer system are not readily available.
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  • 3
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the Chinese herbal medicine higenamine on left ventricular function were studied by means of an external radiation detector in 15 patients with heart disease. Higenamine, administered intravenously, markedly increased the ejection fraction of LV, as well as the ejection rate. The LVEF increased from 46%±9% to 60%±15% and 61%±12% (P〈0.005) after a 30- and 60-min infusion of higenamine, respectively. The percentage increase in LVEF paralleled the increase in the heart rate. The effects of higenamine on LV function were similar to the response obtained with isoproterenol. These results document the pharmacologic effect of the Chinese herbal medicine, higenamine, on heart function.
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  • 4
    ISSN: 1573-0743
    Keywords: antimyosin ; infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To establish whether quantitative111In antimyosin uptake can be used to predict infarct age, we studied the heart-lung ratio in 107 images from 90 patients at various intervals following a Q-wave infarction. Imaging was performed 24 hours following111In antimyosin injection. The HLR was measured as the ratio of the maximum counts in the infarcted myocardium to the adjacent lung background. The ratio ranged from 1.26 to 3.87, and declined with increasing infarct age. Infarcts were classified on the basis of age as type I (〈 3 days old), type II (〈14 days), and type III (〈90 days). True positive and false positive rates (TPR and FPR), and test-likelihood ratio calculations were performed for HLR thresholds ranging from 1 to 4, for the three infarct types. A FPR of 0% and likelihood ratio of infinity was obtained at a HLR threshold of 2.3 for type I infarcts (TPR 40.8%); at a HLR threshold of 2 for type II infarcts (TPR 50.6%), and a threshold of 1.8 for type III infarcts (TPR 52.6%). The likelihood of each infarct type can be estimated directly from the HLR for values below the above thresholds. These results show that quantitative111In-antimyosin imaging may be used to predict infarct age.
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  • 5
    ISSN: 1619-7089
    Keywords: Key words: Myocardial perfusion imaging ; Single-photon emission tomography ; Technetium-99m methoxyisobutylisonitrile ; Coronary artery disease ; Electron beam computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We compared technetium-99m methoxyisobutylisonitrile (MIBI) myocardial perfusion single-photon emission tomography (SPET) (MPS) and electron beam computed tomography (EBCT) in order to assess their respective value in the detection of coronary artery disease (CAD). 99mTc-MIBI SPET (stress-resting) and EBCT studies were performed in 51 patients with suspected CAD who underwent coronary angiography (CAG). CAG showed that of the 51 patients, 36 had coronary stenosis ≥50% while 15 had normal results. A moderate positive rank correlation was found between coronary calcification detected by EBCT and MPS score (r s=0.5283, P〈0.01). The concordance between EBCT and MPS for the evaluation of CAD was 72.5% (37/51). The sensitivity of EBCT in detecting CAD in 51 patients was comparable to that of MPS (81% vs 94%, NS). However, the accuracy of EBCT was lower than that of MPS (78% vs 94%, P〈0.025). As regards the detection of individual coronary artery disease, there was no significant difference in sensitivity between EBCT and MPS (65% vs 75%, NS); however, the specificity and accuracy of EBCT were lower than those of MPS (specificity: 77% vs 95%, P〈0.005; accuracy 71% vs 85%, P〈0.005). The sensitivity, specificity and accuracy of MPS in detecting single-vessel disease were higher than those of EBCT (sensitivity: 86% vs 42%, P〈0.025; specificity: 96% vs 70%, P〈0.025; accuracy: 93% vs 61%, P〈0.005). However, no significant differences in the sensitivity, specificity and accuracy of MPS and EBCT were found in respect of multivessel disease. In conclusion: 99mTc-MIBI myocardial perfusion SPET and EBCT provide different information in the assessment of CAD. The sensitivity of EBCT for the detection of CAD is comparable with that of MPS; however, the specificity and accuracy of EBCT are lower than those of MPS. More reliable results will be obtained if both myocardial perfusion SPET and EBCT are performed.
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  • 6
    ISSN: 1619-7089
    Keywords: Cardiac probe ; Atriopeptin ; Left ventricular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of α-hANP on left ventricular function were studied with a cardiac probe in ten patients with essential hypertension. Our data showed that intravenous administration of α-hANP significantly elevated left ventricular function. At 5 min, the elevation of EF, RCO, ER, RSV, PFR were 13.23% (P〈0.02), 12.7 (P〈0.02), 0.618 (P〈0.02), 0.133 (P〈0.05), 0.283 (P〈0.01), respectively. At 10 min, the increase of EF, ER, were 11.07% (P〈0.02) and 0.233 (P〈0.01), respectively. Atriopeptin significantly reduced systolic and diastolic blood pressure from 2 min to 20 min (P〈0.001–0.05).
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  • 7
    ISSN: 1619-7089
    Keywords: 99mTc-labeled t-butylisonitrile (99mTc-TBI) ; Myocardial perfusion imaging ; Coronary artery disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc-TBI myocardial perfusion imaging has been studied in 7 normal subjects and 24 patients with coronary artery disease. Scintigraphic data revealed that 99mTc-TBI myocardial perfusion imaging is more sensitive than ECG in detecting myocardial infarction. In comparing 99mTc-TBI imaging with contrast angiography, its' sensitivity for the diagnosis of coronary artery disease was 91.7%.
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  • 8
    ISSN: 1619-7089
    Keywords: Myocardial perfusion imaging ; Single-photon emission tomography ; Technetium-99m methoxyisobutylisonitrile ; Coronary artery disease ; Electron beam computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared technetium-99m methoxyisobutylisonitrile (MIBI) myocardial perfusion single-photon emission tomography (SPET) (MPS) and electron beam computed tomography (EBCT) in order to assess their respective value in the detection of coronary artery disease (CAD).99mTc-MIBI SPET (stress-resting) and EBCT studies were performed in 51 patients with suspected CAD who underwent coronary angiography (CAG). CAG showed that of the 51 patients, 36 had coronary stenosis ≥50% while 15 had normal results. A moderate positive rank correlation was found between coronary calcification detected by EBCT and MPS score (r s=0.5283,P〈0.01). The concordance between EBCT and MPS for the evaluation of CAD was 72.5% (37/51). The sensitivity of EBCT in detecting CAD in 51 patients was comparable to that of MPS (81% vs 94%, NS). However, the accuracy of EBCT was lower than that of MPS (78% vs 94%,P〈0.025). As regards the detection of individual coronary artery disease, there was no significant difference in sensitivity between EBCT and MPS (65% vs 75%, NS); however, the specificity and accuracy of EBCT were lower than those of MPS (specificity: 77% vs 95%,P〈0.005; accuracy 71% vs 85%,P〈0.005). The sensitivity, specificity and accuracy of MPS in detecting single-vessel disease were higher than those of EBCT (sensitivity: 86% vs 42%,P〈0.025; specificity: 96% vs 70%,P〈0.025; accuracy: 93% vs 61%,P〈0.005). However, no significant differences in the sensitivity, specificity and accuracy of MPS and EBCT were found in respect of multivessel disease. In conclusion:99mTc-MIBI myocardial perfusion SPET and EBCT provide different information in the assessment of CAD. The sensitivity of EBCT for the detection of CAD is comparable with that of MPS; however, the specificity and accuracy of EBCT are lower than those of MPS. More reliable results will be obtained if both myocardial perfusion SPET and EBCT are performed.
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  • 9
    ISSN: 1619-7089
    Keywords: 99mTc-labeled carbomethoxy-isopropyl isonitrile (99mTc-CPI) ; Myocardial perfusion planar imaging ; Myocardial perfusion SPECT ; Coronary artery disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc-CPI myocardial perfusion scintigraphy including planar images in 35 patients and SPECT images in 16 patients has been studied. Scintigraphic data revealed that high quality 99mTc-CPI myocardial perfusion images were obtained. The sensitivity and specificity of 99mTc-CPI planar images in detecting CAD was 92% and 80% respectively. There was no significant difference in sensitivity for detecting CAD between planar and SPECT. However, the specificity of SPECT was much better than that of planar imaging.
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