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  • 1
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    London : Professional Engineering
    Keywords: Engineering, Safety measures. ; Reliability (Engineering)
    Pages: 244 p.
    ISBN: 0-585-48974-2
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurology ; Animal models in research ; Biomedicine ; Neurosciences ; Neurology ; Animal Models ; Springer eBooks
    Description / Table of Contents: Part 1 Introduction -- 1 Introduction -- Part 2 Basic biology of dendrites -- 2 Cytoskeletal organization – actin -- 3 Cytoskeletal organization – microtubules -- 4 Membrane trafficking mechanisms: -endo/exocytosis -- 5 Synapse to nucleus signaling -- 6 Ultrastructural methods -- 7 Bioimaging of dendritic signaling -- Part 3 Patterning dendritic architecture of neurons and their populations -- 8 Self-avoidance -- 9 Dendritic tiling -- 10 Mosaics and lamination -- 11 Modifying dendritic structure after function -- Part 4 Cellular and molecular control of dendrite development and maintenance -- 12 Molecular control of dendrite development -- 13 Sensory-dependent regulation of dendritic morphology -- 14 Dendrite maintenance -- Part 5 Synapse formation onto dendrites -- 15 Molecular assembly of excitatory synapses -- 16 Localizing receptors and channels across the dendritic arbor -- 17 Synaptic adhesion molecules -- 18 Balancing excitatory and inhibitory inputs -- 19 Assembly and reassembly of synapses -- Part 6 Dendrites in disease -- 20 Dendrite development in autism and autism-related disorders -- 21 Dendrite degeneration in Frontotemporal dementia -- 22 Dendrite degeneration and Glaucoma
    Abstract: Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians
    Pages: VII, 608 p. 104 illus., 86 illus. in color. : online resource.
    ISBN: 9784431560500
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  • 3
    Call number: ALLG-BERUF-PN4121:10 ; W110:9
    Keywords: Business presentations
    Notes: Transl. of: Guide to information graphics.
    Pages: 156 p. : ill.
    ISBN: 9783868812770
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    ALLG-BERUF-PN4121:10 available
    W110:9 departmental collection or stack – please contact the library
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  • 4
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    Boca Raton : CRC Press, Taylor & Francis Group
    Call number: QP620:150
    Keywords: Sequence Analysis, RNA / methods ; Transcriptome ; Statistics as Topic
    Abstract: "RNA-seq offers unprecedented information about transcriptome, but harnessing this information with bioinformatics tools is typically a bottleneck. This self-contained guide enables researchers to examine differential expression at gene, exon, and transcript level and to discover novel genes, transcripts, and whole transcriptomes. Each chapter starts with theoretical background, followed by descriptions of relevant analysis tools. The book also provides examples using command line tools and the R statistical environment. For non-programming scientists, the same examples are covered using open source software with a graphical user interface"--
    Notes: "A Chapman & Hall book."
    Pages: xxiv, 298 pages : illustrations
    ISBN: 9781466595002
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    QP620:150 on loan
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  • 5
    Call number: QZ200:504
    Pages: xix, 180 p. : ill.
    ISBN: 9780387693200
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    QZ200:504 available
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  • 6
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    Hoboken, NJ : Wiley
    Call number: C060:42
    Keywords: Optimal designs (Statistics) ; Experimental design
    Pages: xxv, 285 p. : ill.
    ISBN: 0470856971
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    C060:42 departmental collection or stack – please contact the library
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  • 7
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Lipids ; Stem Cells ; Cell Physiology ; Cell Membranes ; Life sciences ; Stem Cells ; Lipidology ; Cell Physiology ; Membrane Biology ; Springer eBooks
    Description / Table of Contents: Preface -- 1. Lysophosphatidic Acid and Sphingosine-1-Phosphate in Pluripotent Stem Cells -- 2. Morphogenetic Sphingolipids in Stem Cell Differentiation and Embryo Development -- 3. Autotaxin in Stem Cell Biology and Neurodevelopment -- 4. Lysophosphatidic Acid (LPA) Signaling in Neurogenesis -- 5. Fate Through Fat: Neutral Lipids as Regulators of Neural Stem Cells -- 6. Cannabinoids as Regulators of Neuronal Development and Adult Neurogenesis -- 7. Ceramide-1 Phosphate and Its Role in Trafficking of Normal Stem Cells and Cancer Metastasis -- 8. The Emerging Role of Sphingolipids in Cancer Stem Cell Biology -- 9. Lysophosphatidic Acid Signalling Enhances Glioma Stem Cell Properties -- 10. New Developments in Free Fatty Acids and Lysophospholipids: Decoding the Role of Phospholipases in Exocytosis -- Index
    Abstract: This book combines the current knowledge on the role of lipids in stem cell pluripotency and differentiation. It showcases various approaches to the study of lipids and focuses on various types of stem cells and specific lipids driving maintenance or differentiation. The volume includes chapters reviewing roles of specific lipids in pluripotency, neurogenesis and exocytosis as well as in cancer stem cells. Examples of different classes of lipidś€”such as sphingolipids, lysophospholipids, cannabinoids and neutral lipids€”áre described and illustrate the vast biological effects of this class of molecules. The international contributors are all recognized experts in their respective fields. Covering the various aspects of the topic, Lipidomics of Stem Cells provides an up-to-date snapshot€”únique among the literature€”óf where the lipid world is in terms of understanding the roles of lipids in stem cell biology. It provides an essential reference for stem cell biologists, lipid biologists, development biologists, students, academics and clinicians in related areas
    Pages: XIII, 212 p. 24 illus., 22 illus. in color. : online resource.
    ISBN: 9783319493435
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  • 8
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    Weinheim : Wiley-VCH
    Call number: E080:220 ; E080:221 ; W160:20 ; W160:21
    Keywords: Carbohydrates / pharmacology ; Carbohydrates / chemistry ; Carbohydrate metabolism ; Glycoconjugates / physiology ; Drug Design
    Pages: 2 v. (xxxii, 947 p.) : ill. (some col.)
    ISBN: 3527306323
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    E080:220 departmental collection or stack – please contact the library
    E080:221 departmental collection or stack – please contact the library
    W160:20 departmental collection or stack – please contact the library
    W160:21 departmental collection or stack – please contact the library
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  • 9
    Keywords: Biochemistry ; Cytology ; Oncology ; Biochemistry, general ; Cell Biology ; Cancer Research ; Springer Nature Living Reference
    Description / Table of Contents: A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- GlycomeDB -- GlycoEpitope -- SugarBindDB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells
    Abstract: The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience
    Pages: Approx. 1200 p. 540 illus., 240 illus. in color. : online resource.
    ISBN: 9784431548362
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  • 10
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    Cham : Springer International Publishing
    Keywords: Medicine ; Human Genetics ; Food / Biotechnology ; Plant physiology ; Zoology ; Biomedicine ; Human Genetics ; Food science ; Plant physiology ; Zoology ; Springer eBooks
    Description / Table of Contents: Fundamentals of Genetic Processes -- Introductory Concepts -- Structures of Nucleic Acids -- Structures of Proteins -- The Genetic Process -- Organization of Genes -- Reading The Nucleotide Sequence of a Gene -- Techniques and Strategies of Gene Cloning -- Enzymes Used in Cloning -- Techniques Used in Cloning -- Cloning Vectors for Introducing Genes into Host Cells -- Transformation -- Isolating Genes for Cloning -- Impact of Gene Cloning -- Improving Tomato Quality by Antisense Rna -- Transgenic Crops Engineered with Insecticidal Activity -- Transgenic Crops Conferred with Herbicide Resistance -- Growth Enhancement in Transgenic Fish -- Impact of Gene Cloning -- Microbial Production of Recombinant Human Insulin -- Finding Disease-Causing Genes -- Human Gene Therapy -- Gene Targeting -- DNA Typing -- Transpharmers - Bioreactors for Pharmaceutical Products -- Animal Cloning -- Human Genome Sequencing -- Manipulating Gene Vector Constructs
    Abstract: Clear and concise, this easy-to-use book offers an introductory course on the language of gene cloning, covering microbial, plant, and mammalian systems. It presents the nuts and bolts of gene cloning in a well-organized and accessible manner. Part I of this book outlines the essentials of biology and genetics relevant to the concept of gene cloning. Part II describes common techniques and approaches of gene cloning, ranging from the basic mechanics of DNA manipulation, vector systems, process transformation, to gene analysis. Part III & IV present application technologies of major impact in agriculture, biomedicine, and related areas. The ABCs of Gene Cloning, Third Edition contains updates including a tutorial chapter on gene-vector construction, methodologies on exome sequencing in finding disease genes, revised topics on gene therapy and whole genome sequencing, new developments for gene targeting and genome editing, as well as the current state of next generation sequencing. With more than 140 illustrations, this new edition provides an invaluable text for students and anyone who have interest in gaining proficiency in reading and speaking the language of gene cloning
    Pages: XIX, 257 p. 172 illus., 1 illus. in color. : online resource.
    Edition: 3rd ed. 2018.
    ISBN: 9783319779829
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