New Acquisitions Shelf

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

23 hits in 0.023 seconds
Select All   Deselect All   Toggle Selection   Add To Mindlist   Mail Export   File Export
feed icon
Immunotherapy of Hepatocellular Carcinoma (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Biomedicine ; Biomedicine general ; Springer eBooks
Description / Table of Contents: Preface -- Introduction -- Vaccine approaches -- Spontaneous Immune responses to ablative therapies -- Antigen-specific T cell responses. Immune checkpoint inhibitors -- NASH and HCC -- Cytokine activated killer cells -- Sorafenib combination therapy -- Glypican 3 -- Suppressor cells -- Cytokines in HCC pathogenesis and treatment -- Index
Abstract: In this book we provide insights into liver ́€“ cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical €œínflammation-induced́€ cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. ℗
Pages: X, 167 p. 19 illus., 15 illus. in color. : online resource.
ISBN: 9783319649580
on loan
Inside graduate admissions : merit, diversity, and faculty gatekeeping (2016)
Cambridge, Massachusetts : Harvard University Press
Call number: ALLG-BERUF-LB2371:8
Keywords: Universities and colleges / Graduate work / United States ; Discrimination in higher education / United States ; Minorities / Education (Higher) / United States ; Universities and colleges / Faculty / United States ; Teacher participation in administration / United States
Pages: 250 p.
ISBN: 9780674088696
Drug and Gene Delivery to the Central Nervous System for Neuroprotection : Nanotechnological Advances (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedical Engineering ; Biomedicine ; Neurosciences ; Biomedical Engineering ; Neurobiology ; Springer eBooks
Description / Table of Contents: Chapter 1 Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery -- Chapter 2 Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection -- Chapter 3 Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment -- Chapter 4 Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases -- Chapter 5 Sleep Deprivation Induced Blood-Brain Barrier Breakdown and Brain Pathology. Neuroprotective Effects of Tio2-Nanowired Delivery of Cerebrolysin and Ondansetron -- Chapter 6 Glyco-Functionalised Biomaterials in Neuroregeneration -- Chapter 7 Targeting Nanoparticles to Brain: Impact of N-Methyl D-Aspartate Receptors
Abstract: This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease
Pages: XIII, 228 p. 47 illus., 38 illus. in color. : online resource.
ISBN: 9783319576961
GeNeDis 2016 : Genetics and Neurodegeneration (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Bioinformatics ; Biomedicine ; Neurosciences ; Bioinformatics ; Springer eBooks
Description / Table of Contents: Preclinical Validation of the Located Hyperthermia Using Gold℗ ℗ Macro-Rods℗ ℗ and℗ ℗ Ultrasound℗ ℗ as℗ ℗ an℗ ℗ Effective TreatmentforSolid Tumors.-℗ Cerebral thrombosis: A neurogenetic approach.-℗ Correlations between nutrition habits, anxiety and metabolic parameters in Greek healthy adults.-℗ Neuronal Correlation Parameter the Idea of Thermodynamic Entropy of an N-Body Gravitationally Bounded System.-℗ Determination of Soft Tissue Breakpoint Based on its Temperature Enhancement Pattern: In vivo and in vitro experiments -- Huntington disease:Genetics, prevention, and therapy approaches.-℗ A Paris system-based implant approach to hyperthermia cancer tumor with gold seeds and ultrasound.-℗ Clinical, Social And Demographics Factors Associated With Spiritual Wellbeing In End Stage Renal Disease.-℗ Cognition enhancement for elderly facing dementia with the use of cognitive rehabilitation therapy techniques and psychological treatment. A case study.-℗ Biobibliometrics & Gene Connections: The case of the BRAC1 and BRAC2 Genes.-℗ Diagnostic Evaluation of Huntingtons Disease Within the Frame of Bioinformatics.-℗ Gold rods irradiated with ultrasound for combination of hyperthermia and cancer chemotherapy.-℗ Assessment of depression in elderly. Is perceived social support related? A nursing home study.-℗ Neurofibromatosis-Noonan Syndrome: A possible paradigm of the combination of genetic and epigenetic factors.-℗ Clinical simulation training in geriatric medicine: A review of the evidence and lessons for training in psychiatry of old age.-℗ Integrating Omic Technologies in Alzheimeŕ€™s Disease.-℗ Anxiety and Depression in Staff of Mental Units: The Role of Burnout.-℗ Scheduling and Modeling a Cognitive Assessment Guide for Screening AD by Primary Care Physicians.-℗ Sarcopenia and its impact on Quality of life.-℗ Molecular Chaperones in Neurodegenerative Diseases: a Short Review.-℗ Interactome of obesity ́€“ Obesidome.-℗ Fatigue in arthritis: a multidimensional phenomenon with impact on quality of life.-℗ Association of nutrients with biomarkers of Alzheimeŕ€™s disease.-℗ Searching for correlations between the development of neurodegenerative hallmarks: targeting huntingtin as a contributing factor.-℗ The effects of anodal transcranial direct current stimulation on working memory.-℗ Bioimpendance measurements in adolescents with polycystic ovary syndrome : a pilot study -- Post-Operative Delirum in elderly people diagnostic and management issues of post- operative delirum in elderly people
Abstract: The 2nd World Congress on Genetics, Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international focum for the latest scientific discoveries, medical practices, and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation, and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2016 takes place in Sparta, Greece, 20-23 October, 2016. This volume focuses on the sessions that address neurodegenerative diseases
Pages: VII, 312 p. 50 illus., 25 illus. in color. : online resource.
ISBN: 9783319573793
GeNeDis 2016 : Computational Biology and Bioinformatics (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Bioinformatics ; Systems Biology ; Life sciences ; Systems Biology ; Computational Biology/Bioinformatics ; Springer eBooks
Description / Table of Contents: Biological Relevance of Network Architecture -- Design of a Compensator Network To Stabilize Chaotic Tumor Growth -- Evaluation of Anti-Epileptic Effect of New Indole Derivatives by Estimation of Biogenic Amines Concentrations in Rat Brain -- Does health perception, dietary habits and lifestyle effect optimism? A quantitative and qualitative study -- Moderating nutritious habits in psychiatric patients using Transtheoretical Model of Change and Counseling -- Approaches on generating optimized sequences of items used in assessment -- Evaluation of pulse oximetry knowledge of greek registered nurses -- Psychodynamic Leadership Approach and Leader-Member Exchange (LMX): A psychiatric perspective on two leadership theories and implications for training future psychiatrist leaders -- An Approach of Non-Linear Systems through Fuzzy Control based on Takagi-Sugeno Method -- Chronic Lymphocytic Leukemia patient clustering based on somatic hypermutation (SHM) analysis -- Development of Novel Indole Molecules for the Screening Of Anti-inflammatory Activity -- Short Review on Quantum Key Distribution Protocols -- Objective Structured Clinical Examination (OSCE) in Psychiatry Education: A Review of its Role in Competency-based Assessment -- Effectiveness of Neurofeedback Training in Algorithmic Thinking Skills Enhancement -- QM automata - A new class of restricted quantum membrane automata -- On the Detection of Overlapped Network Communities Via Weight Redistributions -- PerSubs: A graph-based algorithm for the identification of perturbed subpathways caused by complex diseases -- MiR-140-3p downregulation in association with PDL-1 overexpression in many cancers. A review from the literature using predictive bioinformatics tools -- Spontaneous persistent neuronal network activity of the neocortex: a(n) (endo)phenotype of brain (patho)physiology -- Evaluating the Homeostasis assessment model insulin resistance and the Cardiac Autonomic System in bariatric surgery patients: a meta-analysis -- Association of Type 1 Diabetes, Social Support, Illness and Treatment Perception with Health Related Quality of Life -- Network Load Balancing Using Modular Arithmetic Computations -- A Quantum Inspired GVNS: Some preliminary results -- Self-optimized computational method calculating robust b values for earthquake catalogs containing small number of events -- The use of translational research platforms in clinical and biomedical data exploration -- EEG Analysis of the Neurofeedback Training Effect in Algorithmic Thinking -- Formal models of Biological Systems
Abstract: The 2nd World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), focuses on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and provides an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies are discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. This volume focuses on the sessions from the conference on computational biology and bioinformatics
Pages: VII, 338 p. 71 illus., 48 illus. in color. : online resource.
ISBN: 9783319562469
Clinical trials : a methodologic perspective (2017)
Hoboken, N.J. : John Wiley & Sons
Call number: W26.5:138(3)
Keywords: Clinical trials / Statistical methods ; Biomedical Research / methods ; Research / methods ; Clinical Trials / methods ; Statistics / methods
Pages: xxviii, 886 p. : ill.
Edition: 3rd ed.
ISBN: 9781118959206
Pschyrembel : Klinisches Wörterbuch 2017 (2017)
Berlin : de Gruyter
Call number: W13:23(267)
Keywords: Medicine / Bibliography
Pages: xxii, 1998 p. : ill.
Edition: 267., neu bearb. Aufl.
ISBN: 9783110494976
on loan
Patenting in biotechnology : a laboratory manual (2015)
Lyngby : Polyteknisk Forlag
Call number: QR53:39(3)
Pages: 138 p. : ill.
Edition: 3rd rev. ed.
ISBN: 9788750211006
Lung cancer : treatment and research (2016)
Cham : Springer
Call number: QZ365WF658:173
Keywords: Lung Neoplasms
Pages: vi, 322 p. : ill.
ISBN: 9783319403878
Viruses, Genes, and Cancer (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Virology ; Biomedicine ; Cancer Research ; Virology ; Springer eBooks
Description / Table of Contents: Exchange of Genetic Sequences Between Viruses and Host -- Virus-Host Gene Interactions that Define HIV Disease Progression -- Sequencing the Biology of Entry: The Retroviral env Gene -- Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases -- MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer -- Oncogenic Roles of the PI3K/AKT/mTOR Axis -- MicroRNAs and Cancer -- The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene
Abstract: This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike
Pages: XIII, 221 p. : online resource.
ISBN: 9783319618043
Personalised Medicine : Lessons from Neurodegeneration to Cancer (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Medical genetics ; Molecular Biology ; Biomedicine ; Cancer Research ; Gene Function ; Molecular Medicine ; Springer eBooks
Description / Table of Contents: Preface - Personalised Medicine: Lessons from Neurodegenration to Cancer, Sherif F. El-Khamisy -- chap. 1 Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair, Dean T. Williams et al -- chap. 2 Nucleotide excision repair: from neurodegeneration to cancer, Liakos et al -- chap. 3 The Role of Protein-Linked DNA Breaks in Personalized Medicine Walaa R. et al -- chap. 4 The Emerging Role of Proteomics in Precision Medicine: Application in Neurodegenerative Diseases and Neurotrauma, Rana Alaaeddine et al -- chap. 5 The Role of Nitric Oxide from Neurological Disease to Cancer, Ahmed Maher et al -- chap. 6 RNA nuclear export: from neurological disorders to cancer, Guillaume M. Hautbergue -- chap. 7. Can astrocytes be a target for precision medicine, Chloe Allen et al -- chap. 8 Mitochondrial Diseases as Model of Neurodegeneration, Laila A. Selim et al -- chap. 9 Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism, Arwa A. Abugable et al -- chap. 10 The Power of Zebrafish in Personalised Medicine, Sarah Baxendale et al -- chap. 11 Alzheimer’s Disease: a Modular Approach Based on GSK-3β Inhibitors Reem k. Arafa et al -- chap. 12. Regenerative medicine: advances from developmental to degenerative diseases, Nicholas F. Blair et al -- chap. 13 Gene therapy in the nervous system: failures and successes, Jayanth S. Chandran et al -- index
Abstract: The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine
Pages: VIII, 260 p. 98 illus., 52 illus. in color. : online resource.
ISBN: 9783319607337
Clinical Research and Practice (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Respiratory organs / Diseases ; Neurobiology ; Medicine & Public Health ; Pneumology/Respiratory System ; Neurosciences ; Neurobiology ; Springer eBooks
Description / Table of Contents: Regional Diversification of Influenza Activity in Poland during the 2015/16 Epidemic Season, K. Szyma¿„ski, D. Kowalczyk, K. Cie¿›lak, L.B Brydak -- Impact of Internal and External Factors on EBC-pH and FeNO Changes in Humans Following Challenge with Ethyl Acrylate, F. Hoffmeyer, K. Sucker, H. Berresheim, C. Mons©♭, B. Jettkant, A. Beine, M. Raulf, J. B©ơnger, T. Br©ơning -- Influence of Socioeconomic Factors on Self-Reported Prevalence of Allergic Diseases among Female University Students, K. Kli¿›, M. ¿»urawiecka, A. Suder, I. Teul, B. Borowska-Strugi¿„ska, E. Suliga, I. Wronka -- Microbiologic Methods in the Diagnostics of Upper Respiratory Tract Pathogens, J. Kompanikova, A. Zumdick, M. Neuschlova, V. Sadlonova, and E. Novakova -- ℗ Seroprevalence of Bartonella Species in Patients with Ocular Inflammation, J. Brydak-Godowska, D. Kopacz, P.K. Borkowski, B. Fiecek, A. Hevelke, D. Rabczenko, S. Tylewska-Wierzbanowska, D. K♯™cik, and Tomasz Chmielewski -- Body Composition, Anthropometric Indices and Hydration Status of Obstructive Sleep Apnea Patients: Can Cachexia Coexist with Obesity?, B. Ku¿ðnar-Kami¿„ska, M. Grabicki, T. Trafas, M. Szuli¿„ska, S. Cofta, T. Piorunek, B. Brajer-Luftmann, A. Nowicka, B. Bromi¿„ska, H. Batura-Gabryel -- Frailty and Primary Sarcopenia: a Review, E. Carmeli -- Exercise Strategies to Counteract Brain Aging Effects, D. Szalewska, M. Radkowski, U. Demkow, P.J. Winklewski -- Evaluation of Immune Indices and Serum Vitamin D Content in Children with Atopic Dermatitis, A. Lipi¿„ska-Opa¿‚ka, A. Wawrzyniak, S. Lewicki, R Zdanowski, B. Kalicki -- Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells, B.J. Ba¿‚an, A.K.Siwicki, K. Pastewka, U. Demkow, P. Skopi¿„ski, E. Skopi¿„ska-R©đ¿ơewska, S. Lewicki, R. Zdanowski -- Solitary Rectal Ulcer Syndrome in Children: A Case Series Study, K. Kowalska-Duplaga, I. Lazowska-Przeorek, K. Karolewska-Bochenek, M. Woynarowski, G. Czaja-Bulsa, A. Stawarski, S. Pieczarkowski, E. Hapyn, J. Jozefczuk, B. Korczowski, A. Szaflarska-Poplawska, A. Banaszkiewicz -- Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique, B. Sadlik, G. Jaroslawski, D. Gladysz, M. Puszkarz, M. Markowska, K. Pawelec, D. Boruczkowski, T. Oldak -- index
Abstract: This book is a blend of medical research and clinical practice. Advancements in practice are inextricably bound to have research underpinnings. The articles highlight a range of practical topics. The respiratory tract is upfront as the first line of defense of the organism. Virological and bacteriological aspects of the infections that continue to be a scourge worldwide, influenza and tuberculosis, are dealt with. Sleep disordered breathing is another hot topic. Allergy and atopy, and the role of nutraceuticals in providing anticancer benefits due to the inhibitory effects on tumor growth and angiogenesis are referred to. Other chapters describe the use of mesenchymal stem cells for regeneration of the worn away cartilage tissue in the knee. The assessment and management of cognitive decline, sarcopenia and frailty of old age also figure prominently in the texts. The book is an attempt to demonstrate the viability of a bench-to-bedside design in point-of-care patient applications. Hopefully, it will be a source of information on interdisciplinary medical research advancements, addressing the needs of medical professionals, from scientists to clinicians and allied health professionals
Pages: VIII, 124 p. 17 illus., 7 illus. in color. : online resource.
ISBN: 9783319654454
Multi-Parametric Live Cell Microscopy of 3D Tissue Models (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Microscopy ; Spectroscopy ; Life sciences ; Regenerative Medicine/Tissue Engineering ; Biological Microscopy ; Biomedical Engineering/Biotechnology ; Biomedical Engineering ; Spectroscopy and Microscopy ; Springer eBooks
Description / Table of Contents: Current state-of-the-art 3D tissue models and their compatibility with live cell imaging -- Simultaneous Phosphorescence and Fluorescence Lifetime Imaging by Multi-Dimensional TCSPC and Multi-Pulse Excitation -- Quantitative live cell FLIM imaging in three dimensions -- Three-dimensional tissue models and available probes for multi-parametric live cell microscopy: a brief overview -- Fabrication and handling of 3D scaffolds based on polymers and decellularized tissues -- Multi-parametric imaging of hypoxia and cell cycle in intestinal organoid culture -- Imaging of intracellular pH in tumor spheroids using genetically encoded sensor SypHer2 -- Application of fluorescence lifetime imaging (FLIM) to measure intracellular environments in a single cell -- Quantitative imaging of Ca2+ by 3D-FLIM in live tissues -- Live cell imaging of viscosity in 3D tumour cell models -- Live imaging of cell invasion using a multicellular spheroid model and lightsheet microscopy -- Raman imaging microscopy for quantitative analysis of biological samples
Abstract: This book provides an essential overview of existing state-of-the-art quantitative imaging methodologies and protocols (intensity-based ratiometric and FLIM/ PLIM). A variety of applications are covered, including multi-parametric quantitative imaging in intestinal organoid culture, autofluorescence imaging in cancer and stem cell biology, Ca2+ imaging in neural ex vivo tissue models, as well as multi-parametric imaging of pH and viscosity in cancer biology. The current state-of-the-art of 3D tissue models and their compatibility with live cell imaging is also covered. This is an ideal℗ book for specialists working in tissue engineering and designing novel biomaterial
Pages: XII, 172 p. 53 illus., 39 illus. in color. : online resource.
ISBN: 9783319673585
Biology : a global approach (2018)
Hoboken : Pearson Higher Education
Call number: QH308:14(11)
Keywords: Biology
Notes: Previous edition: Campbell biology / Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, , Robert B. Jackson. Tenth edition. 2014.
Pages: 1342, various pagings : ill.
Edition: 11th edition.
ISBN: 9781292170435
Making sense of genes (2017)
New York, NY : Cambridge University Press
Call number: QH447:218 ; B110:172
Keywords: Genes
Description / Table of Contents: Prolegomena : genes, science, and science fiction -- Mendel and the origins of the gene concept -- The genes of classical genetics -- The molecularization of genes -- So, what are genes? -- Genes for (almost) everything -- Are there genes for characters? -- Are there genes for diseases? -- So, what do genes do? -- Genes are implicated in the development of characters -- Genes account for variation in characters -- Genomes are more than the sum of genes -- Limitations in the study of genomes -- Concluding remarks : how to think and talk about genes?
Pages: x, 307 p.
ISBN: 9781107128132
Perioperative Inflammation as Triggering Origin of Metastasis Development (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: The Natural History of Breast Cancer -- Perioperative Inflammation as Triggering Origin of Metastasis Development -- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients -- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation -- Circulating tumor cells as predictive marker in metastatic disease -- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints -- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs -- The impact of wound inflammation on cancer progression; Studies in fish and patients -- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives -- Cancer: Nurture and Nature -- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer
Abstract: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities
Pages: XXIII, 236 p. 49 illus., 39 illus. in color. : online resource.
ISBN: 9783319579436
Cell Division Machinery and Disease (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Cell Cycle ; Cell Physiology ; Life sciences ; Cell Cycle Analysis ; Cell Physiology ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization
Abstract: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases
Pages: XIV, 235 p. 33 illus., 32 illus. in color. : online resource.
ISBN: 9783319571270
Uroonkologie kompakt : Diagnostik und Therapie (2017)
Stuttgart : Schattauer
Call number: QZ365WJ358:140
Pages: xiii, 229 p. : ill.
ISBN: 9783794530724
on loan
Lehninger principles of biochemistry (2017)
New York : W.H. Freeman
Call number: QP514:75(7) ; D090:50
Keywords: Biochemistry ; Biochemical Phenomena / physiology ; Biochemical Phenomena / genetics ; Energy Metabolism
Notes: Previous edition 2013.
Pages: xxxiv, 1172, AS34, G20, I45 pages : illustrations, portraits
Edition: 7th ed.
ISBN: 9781319108243
Call number: WM270:9 ; WM270:9a
Keywords: Alcohol Drinking / health aspects ; Alcoholism ; Alcoholism / prevention & control ; Alcoholic Beverages / adverse effects ; Alcoholics / Germany ; DKFZ-publications ; Germany
Pages: 140 p. : ill.
ISBN: 9783958533349
Infectious Agents Associated Cancers : Epidemiology and Molecular Biology (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Cancer Research ; Medical Microbiology ; Parasitology ; Virology ; Biomedicine ; Cancer Research ; Medical Microbiology ; Virology ; Parasitology ; Springer eBooks
Abstract: This book offers a state-of-the-art report on recent discoveries concerning viral, bacterial, and parasite infectious cancers. Cancer is one of the most common causes of death and diseases in human populations, and 15%-25% of human cancers in worldwide are considered to result from chronic infection by pathogens. Most oncology textbooks address genetic mutation, but not infectious agents such as viruses, bacteria and parasites. As such this book stimulates further research in the new area between cancers and chronic infection, and discusses the epidemiology and molecular biology of infectious causes of cancers. It also explores the prevention and treatment of infection-related cancers, and brings pathogenic research to the forefront in the never-ending endeavor to understand how pathogens maneuver and negotiate in a complex environment, including the micro/macro- environment of the human host. Further, it highlights the urgent need for a concerted program to develop vaccines and other diagnosis and interventions that will eventually help prevent and treat infectious cancers, and decrease their burden on human populations. It offers graduate students and researchers a comprehensive overview of the infectious causes of cancers
Pages: XII, 271 p. 18 illus. in color. : online resource.
ISBN: 9789811057656
Metabolic Engineering for Bioactive Compounds : Strategies and Processes (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Gene Expression ; Biomedical Engineering ; Microbiology ; Bacteriology ; Biomedicine ; Gene Expression ; Biomedical Engineering/Biotechnology ; Eukaryotic Microbiology ; Applied Microbiology ; Bacteriology ; Springer eBooks
Description / Table of Contents: 1. Developments and diversity of proteins and enzymes -- 2. Strategies for Gene Expression in Prokaryotic and Eukaryotic System -- 3. Molecular farming approach towards bioactive compound -- 4. Protein therapeutics: Production, application and future scenario -- 5. Engineering in plant genome using Agrobacterium: progress and future -- 6. Engineering Saccharomyces cerevisiae for C5 fermentation: A step towards second generation biofuel production -- 7. Gaining insight into plant responses to beneficial and pathogenic microorganisms using metabolomic and transcriptomic approaches -- 8. Engineering Yeast as cellular factory -- 9. Yeast as a model system to study human diseases -- 10. Cellulases: Industrial workhorse in bioenergy sector -- 11. Green chemistry approach towards nanoparticles synthesis -- 12. The antiproliferative and anti-bacterial effect of Moringa oleifera mediated gold nanoparticles: A review -- 13. Nanoparticles in diverse biological Application -- 14. Nanomaterials enabled immunotherapeutic applications -- 15. Biosynthesis of Nanoparticles and their application in Pharmaceutical industry
Abstract: This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc
Pages: XVI, 412 p. 54 illus., 31 illus. in color. : online resource.
ISBN: 9789811055119
Healthcare and Big Data Management (2017)
Singapore : Springer Singapore
Keywords: Life sciences ; Molecular Biology ; Bioinformatics ; Life sciences ; Bioinformatics ; Molecular Medicine ; Computational Biology/Bioinformatics ; Springer eBooks
Description / Table of Contents: Chapter 1 How to become a smart patient in the era of precision medicine? -- Chapter 2 Physiological Informatics: Collection and Analyses of Data from Wearable Sensors and Smartphone for Healthcare -- Chapter 3 Entropy for the Complexity of Physiological Signal Dynamics -- Chapter 4 Data Platform for the Research and Prevention of Alzheimer’s disease -- Chapter 5 Data analysis for gut microbiota and health -- Chapter 6 Ontology-based Vaccine Adverse Event Representation and Analysis -- Chapter 7 LEMRG – decision rule generation algorithm for mining microRNA expression data -- Chapter 8 Privacy Challenges of Genomic Big Data -- Chapter 9 Systems health, a transition from disease management towards health promotion
Abstract: The book addresses the interplay of healthcare and big data management. Thanks to major advances in big data technologies and precision medicine, healthcare is now becoming the new frontier for both scientific research and economic development.℗ This volume covers a range of aspects, including: big data management for healthcare; physiological and gut microbiota ́€“ data collection and analysis; big data standardization and ontology; and personal data privacy and systems level modeling in the healthcare context. The book offers a valuable resource for biomedical informaticians, clinicians, health practitioners and researchers alike
Pages: V, 164 p. 30 illus., 23 illus. in color. : online resource.
ISBN: 9789811060410