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on loan
Patenting in biotechnology : a laboratory manual (2015)
Lyngby : Polyteknisk Forlag
Call number: QR53:39(3)
Pages: 138 p. : ill.
Edition: 3rd rev. ed.
ISBN: 9788750211006
Gastrointestinale Tumoren (2018)
München : Elsevier
Call number: QZ365WI320:139
Keywords: Gastrointestinal system / Cancer ; Digestive System Neoplasms / therapy
Pages: xv, 569 p. : ill.
Edition: 1. Aufl.
ISBN: 9783437211522
Making sense of genes (2017)
New York, NY : Cambridge University Press
Call number: QH447:218 ; B110:172
Keywords: Genes
Description / Table of Contents: Prolegomena : genes, science, and science fiction -- Mendel and the origins of the gene concept -- The genes of classical genetics -- The molecularization of genes -- So, what are genes? -- Genes for (almost) everything -- Are there genes for characters? -- Are there genes for diseases? -- So, what do genes do? -- Genes are implicated in the development of characters -- Genes account for variation in characters -- Genomes are more than the sum of genes -- Limitations in the study of genomes -- Concluding remarks : how to think and talk about genes?
Pages: x, 307 p.
ISBN: 9781107128132
on loan
Clinical trials : a methodologic perspective (2017)
Hoboken, N.J. : John Wiley & Sons
Call number: W26.5:138(3)
Keywords: Clinical trials / Statistical methods ; Biomedical Research / methods ; Research / methods ; Clinical Trials / methods ; Statistics / methods
Pages: xxviii, 886 p. : ill.
Edition: 3rd ed.
ISBN: 9781118959206
Healthcare and Big Data Management (2017)
Singapore : Springer Singapore
Keywords: Life sciences ; Molecular Biology ; Bioinformatics ; Life sciences ; Bioinformatics ; Molecular Medicine ; Computational Biology/Bioinformatics ; Springer eBooks
Description / Table of Contents: Chapter 1 How to become a smart patient in the era of precision medicine? -- Chapter 2 Physiological Informatics: Collection and Analyses of Data from Wearable Sensors and Smartphone for Healthcare -- Chapter 3 Entropy for the Complexity of Physiological Signal Dynamics -- Chapter 4 Data Platform for the Research and Prevention of Alzheimer’s disease -- Chapter 5 Data analysis for gut microbiota and health -- Chapter 6 Ontology-based Vaccine Adverse Event Representation and Analysis -- Chapter 7 LEMRG – decision rule generation algorithm for mining microRNA expression data -- Chapter 8 Privacy Challenges of Genomic Big Data -- Chapter 9 Systems health, a transition from disease management towards health promotion
Abstract: The book addresses the interplay of healthcare and big data management. Thanks to major advances in big data technologies and precision medicine, healthcare is now becoming the new frontier for both scientific research and economic development.℗ This volume covers a range of aspects, including: big data management for healthcare; physiological and gut microbiota ́€“ data collection and analysis; big data standardization and ontology; and personal data privacy and systems level modeling in the healthcare context. The book offers a valuable resource for biomedical informaticians, clinicians, health practitioners and researchers alike
Pages: V, 164 p. 30 illus., 23 illus. in color. : online resource.
ISBN: 9789811060410
Technical communication (2018)
Boston : Bedford/St. Martin's
Call number: ALLG-BERUF-Q179:53(12) ; G230:7
Keywords: Technical writing ; Communication of technical information ; Communication of technical information ; Technical writing
Pages: xxxviii, 729 p. : illustrations (chiefly color)
Edition: 12th edition.
ISBN: 9781319058616
Biology : a global approach (2018)
Hoboken : Pearson Higher Education
Call number: QH308:14(11)
Keywords: Biology
Notes: Previous edition: Campbell biology / Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, , Robert B. Jackson. Tenth edition. 2014.
Pages: 1342, various pagings : ill.
Edition: 11th edition.
ISBN: 9781292170435
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Immunology ; Cell Biology ; Biomedicine ; Immunology ; Cancer Research ; Cell Biology ; Springer eBooks
Description / Table of Contents: Regulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation
Abstract: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike
Pages: VIII, 267 p. : online resource.
ISBN: 9783319689296
Human vaccines : emerging technologies in design and development
Call number: QR189:1
Keywords: Vaccines / Biotechnology ; Vaccines / Design ; Vaccination ; Vaccines ; Drug Discovery / trends ; Technology, Pharmaceutical / trends ; Vaccination ; Vaccines / Biotechnology ; Vaccines / Design
Description / Table of Contents: Part I. Designing vaccines from a new starting point : Broadly neutralizing antibodies / L. Morris and T.A. Moody -- part II. Pathogen free vaccines : Replication-competent viral vectors for vaccines delivery / C.L. Parks ; Reverse vaccinology: exploiting genomes for vaccines design / E. Del Tordello, R. Rappuoli and I. Delany ; Virus-like particle and nanoparticle vaccines / M. Kanekiyo and C.B. Buck -- part III. Immune monitoring : Systems vaccinology / M. Rolland and M.A. Eller ; Immunogenetics and vaccination / M. John, S. Gaudieri and S. Mallal -- part IV. Advanced vaccine development : Methodical considerations / P.B. Gilbert and R. Gottardo ; Vaccine development in special populations / K.M. Edwards and C.B. Creech
Abstract: "Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics-among other disciplines-that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology."--
Pages: xvii, 191 pages : illustrations (some color)
ISBN: 9780128023020
RNA Detection : Methods and Protocols (2018)
New York, NY : Springer New York
Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
Description / Table of Contents: The Secret Life of RNA: Lessons from Emerging Methodologies -- Quantification of 2'-O-Me Residues in RNA using Next-Generation Sequencing (Illumina RiboMethSeq Protocol) -- Identifying the m6A Methylome by Affinity Purification and Sequencing -- PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution -- Axon-TRAP-RiboTag: Affinity-Purification of Translated mRNAs from Neuronal Axons in Mouse In Vivo -- LCM-Seq: A Method for Spatial Transcriptomic Profiling using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing -- Spatial Transcriptomics: Constructing a Single-Cell Resolution Transcriptome-Wide Expression Atlas -- Single mRNA Molecule Detection in Drosophila -- Detection and Automated Analysis of Single Transcripts at Subcellular Resolution in Zebrafish Embryos -- Super-Resolution Single Molecule FISH at the Drosophila Neuromuscular Junction -- Detection of mRNA and Associated Molecules by ISH-IEM on Frozen Sections -- Hybridization Chain Reaction for Direct mRNA Detection without Nucleic Acid Purification -- In Situ Detection of MicroRNA Expression with RNAscope Probes -- Padlock Probes to Detect Single Nucleotide Polymorphisms -- Quantifying Gene Expression in Living Cells with Ratiometric Bimolecular Beacons -- Optimizing Molecular Beacons for Intracellular Analysis of RNA -- Live Imaging of Nuclear RNPs in Mammalian Complex Tissue with ECHO-liveFISH -- In Vivo Visualization and Function Probing of Transport mRNPs using Injected FIT Probes -- Visualizing RNA in Live Bacterial Cells using Fluorophore- and Quencher-Binding Aptamers -- Method for Imaging Live-Cell RNA using an RNA Aptamer and a Fluorescent Probe -- RNA Live Imaging in the Model Microorganism Ustilago maydis -- Real-Time Fluorescence Imaging of Single-Molecule Endogenous Non-Coding RNA in Living Cells -- Live Imaging of mRNA Synthesis in Drosophila -- Imaging Newly Transcribed RNA in Cells by Using a Clickable Azide-Modified UTP Analog -- Detection of the First Round of Translation: The TRICK Assay -- Imaging Translation Dynamics of Single mRNA Molecules in Live Cells -- Systematic Detection of Poly(A)+ RNA-Interacting Proteins and Their Differential Binding -- Isolation and Characterization of Endogenous RNPs from Brain Tissues -- Individual Nucleotide Resolution UV Cross-Linking and Immunoprecipitation (iCLIP) to Determine Protein-RNA Interactions -- RNA Tagging: Preparation of High-Throughput Sequencing Libraries -- RAP-MS: A Method to Identify Proteins that Interact Directly with a Specific RNA Molecule in Cells
Abstract: This volume introduces different concepts and methods of detecting RNA in biological material in a variety of model systems. The chapters in this book discuss methods that will answer numerous biological questions that arise in the study of RNAs. Some of the topics covered in this book are single mRNA molecule detection in embryos and neurons; detection of mRNA and associated molecules by ISH-IEM on frozen sections; optimizing molecular beacons for intracellular analysis of RNA; imaging translation dynamics of single mRNA molecules in live cells; preparation of high-throughput sequencing libraries; and capturing RNA binding proteins in embryos and in cell-culture. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNA Detection: Methods and Protocols is a valuable resource for novel and experiences scientist in the expanding field of RNAs
Pages: XIV, 492 p. 94 illus., 78 illus. in color. : online resource.
ISBN: 9781493972135
DJ-1/PARK7 Protein : Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Cancer Research ; Neurosciences ; Biochemistry ; Cell Biology ; Biomedicine ; Cancer Research ; Biochemistry, general ; Neurosciences ; Cell Biology ; Springer eBooks
Description / Table of Contents: Preface.-̂€€Chapter 1 Introduction/Overview -- Chapter 2 Structural Biology of the DJ-1 Superfamily -- Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases -- Chapter 4 DJ-1 as an oncogene and its clinical significance -- Chapter 5 Role of DJ-1 in fertilization -- Chapter 6 Anti-oxidative stress function of DJ-1 -- Chapter 7 Ttranscriptional regulation of DJ-1 -- Chapter 8 Regulation of Signal Transduction by DJ-1 -- Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal -- Chapter 10 DJ-1 as a biomarker of Parkinson's disease -- Chapter 11 Roles of DJ-1 in diabetes mellitus -- Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases -- Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy.℗
Abstract: This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The℗ DJ-1℗ gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinsoń€™s disease (PD), park7. The℗ DJ-1℗ gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of℗ DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of℗ DJ-1℗ in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.℗
Pages: VIII, 222 p. 78 illus., 46 illus. in color. : online resource.
ISBN: 9789811065835
on loan
Inside graduate admissions : merit, diversity, and faculty gatekeeping (2016)
Cambridge, Massachusetts : Harvard University Press
Call number: ALLG-BERUF-LB2371:8
Keywords: Universities and colleges / Graduate work / United States ; Discrimination in higher education / United States ; Minorities / Education (Higher) / United States ; Universities and colleges / Faculty / United States ; Teacher participation in administration / United States
Pages: 250 p.
ISBN: 9780674088696
Cell Division Machinery and Disease (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Cell Cycle ; Cell Physiology ; Life sciences ; Cell Cycle Analysis ; Cell Physiology ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization
Abstract: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases
Pages: XIV, 235 p. 33 illus., 32 illus. in color. : online resource.
ISBN: 9783319571270
Drug and Gene Delivery to the Central Nervous System for Neuroprotection : Nanotechnological Advances (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedical Engineering ; Biomedicine ; Neurosciences ; Biomedical Engineering ; Neurobiology ; Springer eBooks
Description / Table of Contents: Chapter 1 Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery -- Chapter 2 Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection -- Chapter 3 Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment -- Chapter 4 Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases -- Chapter 5 Sleep Deprivation Induced Blood-Brain Barrier Breakdown and Brain Pathology. Neuroprotective Effects of Tio2-Nanowired Delivery of Cerebrolysin and Ondansetron -- Chapter 6 Glyco-Functionalised Biomaterials in Neuroregeneration -- Chapter 7 Targeting Nanoparticles to Brain: Impact of N-Methyl D-Aspartate Receptors
Abstract: This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease
Pages: XIII, 228 p. 47 illus., 38 illus. in color. : online resource.
ISBN: 9783319576961
EU-Datenschutz-Grundverordnung im Unternehmen : Praxisleitfaden (2016)
Frankfurt : Fachmedien Recht u. Wirtschaft im Dt. Fachverl.
Call number: JN3954:1 ; M080:15
Pages: xvi, 264 p.
ISBN: 9783800516346
Uroonkologie kompakt : Diagnostik und Therapie (2017)
Stuttgart : Schattauer
Call number: QZ365WJ358:140
Pages: xiii, 229 p. : ill.
ISBN: 9783794530724
Pschyrembel : Klinisches Wörterbuch 2017 (2017)
Berlin : de Gruyter
Call number: W13:23(267)
Keywords: Medicine / Bibliography
Pages: xxii, 1998 p. : ill.
Edition: 267., neu bearb. Aufl.
ISBN: 9783110494976
on loan
Lehninger principles of biochemistry (2017)
New York : W.H. Freeman
Call number: QP514:75(7) ; D090:50
Keywords: Biochemistry ; Biochemical Phenomena / physiology ; Biochemical Phenomena / genetics ; Energy Metabolism
Notes: Previous edition 2013.
Pages: xxxiv, 1172, AS34, G20, I45 pages : illustrations, portraits
Edition: 7th ed.
ISBN: 9781319108243
Call number: WM270:9 ; WM270:9a
Keywords: Alcohol Drinking / health aspects ; Alcoholism ; Alcoholism / prevention & control ; Alcoholic Beverages / adverse effects ; Alcoholics / Germany ; DKFZ-publications ; Germany
Pages: 140 p. : ill.
ISBN: 9783958533349
Infectious Agents Associated Cancers : Epidemiology and Molecular Biology (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Cancer Research ; Medical Microbiology ; Parasitology ; Virology ; Biomedicine ; Cancer Research ; Medical Microbiology ; Virology ; Parasitology ; Springer eBooks
Abstract: This book offers a state-of-the-art report on recent discoveries concerning viral, bacterial, and parasite infectious cancers. Cancer is one of the most common causes of death and diseases in human populations, and 15%-25% of human cancers in worldwide are considered to result from chronic infection by pathogens. Most oncology textbooks address genetic mutation, but not infectious agents such as viruses, bacteria and parasites. As such this book stimulates further research in the new area between cancers and chronic infection, and discusses the epidemiology and molecular biology of infectious causes of cancers. It also explores the prevention and treatment of infection-related cancers, and brings pathogenic research to the forefront in the never-ending endeavor to understand how pathogens maneuver and negotiate in a complex environment, including the micro/macro- environment of the human host. Further, it highlights the urgent need for a concerted program to develop vaccines and other diagnosis and interventions that will eventually help prevent and treat infectious cancers, and decrease their burden on human populations. It offers graduate students and researchers a comprehensive overview of the infectious causes of cancers
Pages: XII, 271 p. 18 illus. in color. : online resource.
ISBN: 9789811057656
Perioperative Inflammation as Triggering Origin of Metastasis Development (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: The Natural History of Breast Cancer -- Perioperative Inflammation as Triggering Origin of Metastasis Development -- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients -- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation -- Circulating tumor cells as predictive marker in metastatic disease -- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints -- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs -- The impact of wound inflammation on cancer progression; Studies in fish and patients -- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives -- Cancer: Nurture and Nature -- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer
Abstract: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities
Pages: XXIII, 236 p. 49 illus., 39 illus. in color. : online resource.
ISBN: 9783319579436
Immunotherapy of Hepatocellular Carcinoma (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Biomedicine ; Biomedicine general ; Springer eBooks
Description / Table of Contents: Preface -- Introduction -- Vaccine approaches -- Spontaneous Immune responses to ablative therapies -- Antigen-specific T cell responses. Immune checkpoint inhibitors -- NASH and HCC -- Cytokine activated killer cells -- Sorafenib combination therapy -- Glypican 3 -- Suppressor cells -- Cytokines in HCC pathogenesis and treatment -- Index
Abstract: In this book we provide insights into liver ́€“ cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical €œínflammation-induced́€ cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. ℗
Pages: X, 167 p. 19 illus., 15 illus. in color. : online resource.
ISBN: 9783319649580
Inflammation and Angiogenesis (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Abstract: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.℗
Pages: VIII, 111 p. 36 illus., 24 illus. in color. : online resource.
ISBN: 9783319684482
Epidemiologie für Dummies (2017)
Weinheim : Wiley-VCH
Call number: WA100:53(3) ; M110:21
Pages: 412 p. : ill.
Edition: 3., aktual. u. überarb. Aufl.
ISBN: 9783527712694
Update Hämatologie / Onkologie 2017 (2017)
München : LUKON-Verl.-Ges.
Call number: QZ200:472/2017,24
Keywords: Oncology ; Neoplasms / diagnosis ; Neoplasms / therapy ; Hematologic Neoplasms
Pages: vii, 686 p. : ill.
ISBN: 9783933012388
TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Proteins ; Stem Cells ; Cell Cycle ; Apoptosis ; Biomedicine ; Cancer Research ; Protein Structure ; Stem Cells ; Cell Cycle Analysis ; Apoptosis ; Springer eBooks
Description / Table of Contents: 1 Introduction: How we encountered TCTP and our purpose in studying it -- 2 Structural insights into TCTP and its interactions with ligands and proteins -- 3 Structure-Function relationship of TCTP -- 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation -- 5 Current understanding of the TCTP interactome -- 6 Role and fate of TCTP in protein degradative pathways -- 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development -- 8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies -- 9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms -- 10 Tctp in Neuronal Circuitry Assembly -- 11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation -- 12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage -- 13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression -- 14 Role of TCTP for cellular differentiation and cancer therapy -- 15 Targeting TCTP with sertraline and thioridazine in cancer treatment -- 16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy
Abstract: This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike
Pages: X, 309 p. 51 illus., 36 illus. in color. : online resource.
ISBN: 9783319675916
Lung cancer : treatment and research (2016)
Cham : Springer
Call number: QZ365WF658:173
Keywords: Lung Neoplasms
Pages: vi, 322 p. : ill.
ISBN: 9783319403878