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Translational Research in Breast Cancer : Biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Cancer Research ; Cell Biology ; Biomedicine ; Cancer Research ; Cell Biology ; Springer eBooks
Description / Table of Contents: Chap. 1 The Dawning of Translational Breast Cancer: from Bench to Bedside -- Chap. 2 Biomarker Studies in Early Detection and Prognosis of Breast Cancer -- Chap. 3 The Preventive Intervention of Hereditary Breast Cancer -- Chap. 4 Predicting and Overcoming Chemotherapeutic Resistance for Breast Cancer -- Chap. 5 Studies on DNA Damage Repair and Precision Radiotherapy for Breast Cancer -- Chap. 6 Targeted Therapies against Growth Factor Signaling in Breast Cancer -- Chap. 7 Targeting Stemness: Implications for Precision Medicine in Breast Cancer -- Chap. 8 Disrupting Tumor Angiogenesis and “the Hunger Games” for Breast Cancer -- Chap. 9 Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives -- Chap. 10 Perspectives of Reprogramming Breast Cancer Metabolism -- Chap. 11 Metabolic Changes during Cancer Cachexia Pathogenesis -- Chap. 12 Cell Cycle Regulation in Treatment of Breast Cancer -- Chap. 13 BRCA Gene Mutations and Poly (ADP-ribose) Polymerase Inhibitors in Triple-negative Breast Cancer -- Chap. 14 Targeting the Epigenome as a Novel Therapeutic Approach for Breast Cancer -- Chap. 15 Progress in Vaccine Therapies for Breast Cancer -- Chap. 16 Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer -- Chap 17 New Approaches in CAR-T Cell Immunotherapy for Breast Cancer -- Chap 18 Immune Checkpoint Blockade in Breast Cancer Therapy
Abstract: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. ℗ With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. ℗ ℗ As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research. ℗
Pages: VIII, 418 p. 15 illus. in color. : online resource.
ISBN: 9789811060205
Epidemiologie für Dummies (2017)
Weinheim : Wiley-VCH
Call number: WA100:53(3) ; M110:21
Pages: 412 p. : ill.
Edition: 3., aktual. u. überarb. Aufl.
ISBN: 9783527712694
Update Hämatologie / Onkologie 2017 (2017)
München : LUKON-Verl.-Ges.
Call number: QZ200:472/2017,24
Keywords: Oncology ; Neoplasms / diagnosis ; Neoplasms / therapy ; Hematologic Neoplasms
Pages: vii, 686 p. : ill.
ISBN: 9783933012388
on loan
Qualitative methods for health economics (2017)
London : Rowman & Littlefield International Ltd.
Call number: W20.5:12
Keywords: Qualitative Research ; Economics, Medical ; Research Design ; Evaluation Studies as Topic
Description / Table of Contents: Theoretical and methodological positions and the choice to use qualitative methods / Joanna Coast and Louise Jackson -- Designing qualitative research studies in health economics / Joanna Coast, Amanda Owen-Smith, and Philip Kinghorn -- Understanding sampling and recruitment / Amanda Owen-Smith and Joanna Coast -- Understanding data collection : interviews, focus groups and observation / Amanda Owen-Smith and Joanna Coast -- Understanding primary data analysis / Joanna Coast and Louise Jackson -- Understanding secondary data analysis / Hareth Al-Janabi and Amanda Owen-Smith -- Presenting and publishing qualitative research in health economics / Joanna Coast -- Introduction to the case studies / Joanna Coast -- Constructing statement sets for use in Q methodology studies / Rachel Baker, Neil McHugh, and Helen Mason -- Qualitative methods in discrete choice experiments : two case studies / Jane Vosper, Joanna Coast, and Terry Flynn -- Using qualitative methods to develop a preference based health related quality of life measure for use in economic evaluation : the development of the Child Health Utility 9D / Katherine Stevens -- Incorporating novel qualitative methods within health economics : the use of pictorial tools / Alastair Canaway, Hareth Al-Janabi, Philip Kinghorn, Cara Bailey, and Joanna Coast -- Using non-participant observation and think-aloud to understand and improve modelling processes / Samantha Husband, Sue Jowett, Pelham Barton, and Joanna Coast -- Using think-aloud and interview data to explore patient and proxy completion of health and capability measures at the end of life / Cara Bailey, Philip Kinghorn, and Joanna Coast -- Getting beyond the numbers : using qualitative methods to explore the validity of health state valuation techniques / Suzanne Robinson -- Use of deliberative methods to facilitate and enhance understanding of the weighting of survey attributes / Philip Kinghorn, Alastair Canaway, Cara Bailey, and Joanna Coast -- Using qualitative methods in impact evaluation : the case of the results-based financing for maternal and neonatal care impact evaluation in Malawi / Manuela De Allegri -- An assessment of an international declaration on aid effectiveness through qualitative methods at the country level / Melisa Martinez-Álvarez -- Using cost-effectiveness evidence in making priority gradings : the case of the Swedish national guidelines for heart diseases / Nathalie Eckard and Ann-Charlotte Nedlund -- Contributions of qualitative methods to the study of priority setting and resource allocation in health care / Neale Smith -- Afterword : walking the disciplinary tightrope / Joanna Coast, Hareth Al-Janabi, Louise Jackson, Philip Kinghorn, Amanda Owen-Smith
Pages: xviii, 386 p.
ISBN: 9781783485611
Pulmonary Disorders and Therapy (2018)
Cham : Springer International Publishing
Keywords: Medicine ; Respiratory organs / Diseases ; Environmental Health ; Medicine & Public Health ; Pneumology/Respiratory System ; Biomedicine general ; Environmental Health ; Springer eBooks
Description / Table of Contents: Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity, L. Pappov©Ł, I. Kazimierov©Ł, M. Jo¿Łkov©Ł, M. ¿ utovsk©Ł, and S. Fra¿˜ov©Ł -- Inhalation Exposure to PM-Bound Polycyclic Aromatic Hydrocarbons Released from Barbecue Grills Powered by Gas, Lump Charcoal, and Charcoal Briquettes, A.J. Badyda, K. Widziewicz, W. Rogula-Koz¿‚owska, G. Majewski, and I. Jureczko -- Intensity of Anxiety and Depression in Patients with Lung Cancer in Relation to Quality of Life, J. Pola¿„ski, M. Chabowski, A. Chudiak, B. Uchmanowicz, D. Janczak, J. Rosi¿„czuk, and G. Mazur -- Oleic Derivatives of Dopamine and Respiration, D. Zajac, A. Stasinska, and M. Pokorski.-℗ Intermittent Hypoxia and Unsaturated Aldehydes: Effects on Oral Epithelial Wound Healing, K. Avezov, L. Lavie, and D. Aizenbud -- Body Mass Disorders in Healthy Short Children and in Children with Growth Hormone Deficiency, P. Tomaszewski, K. Milde, A. Majcher, B. Pyr¿ơak, G. Tiryaki-Sonmez, and B.J. Schoenfeld -- Survival of Patients with Cystic Fibrosis Depending on Mutation Type and Nutritional Status , A. Szwed, A. John, J. Go¿ðdzik-Spychalska, W. Czai¿„ski, W. Czerniak, J. Ratajczak, and H. Batura-Gabryel -- Lung Function in Pregnancy in Langerhans Cell Histiocytosis, E. Radzikowska, E. Wiatr, M. Franczuk, I. Bestry, and K. Roszkowski-¿šli¿ơ -- Psychobehavioral Effects of Mindfulness Meditation and Moving Meditation, M. Pokorski, A. Suchorzynska -- Vaccine Effectiveness against Influenza in 2015/16 in Hospital and Ambulatory Medical Care Facilities: Polish Results of the European I-MOVE+ Multicenter Study, I. Paradowska-Stankiewicz, M.R. Korczy¿„ska, K. Cie¿›lak, D. Kowalczyk, K. Szyma¿„ski, and L.B. Brydak
Abstract: The aim of this book is to present articles that are stimulating to read and inform readers with the most up-to-date clinical research. The articles incorporate the latest developments on a variety of topics in pulmonary medicine, therapy, and related mutlisystem disorders with varied manifestations. Emphasis is given to air quality and lung health, therapeutic management of airway reactivity and cough sensitivity linked to mucous clearance ability, ventilatory and cellular effects of hypoxia, influenza epidemics and persistently dismal vaccination coverage rate, disorders of mixed provenance and genetic background affecting lung parenchyma such as cystic fibrosis or Langerhans cell histiocytosis, and others. New diagnostic strategies and therapeutic management will hopefully serve to enhance the way patient care is delivered and thus clinical outcomes. Being a blend of medical research and practice the book addresses the needs of respiratory scientists and physicians, and allied health professionals
Pages: VIII, 102 p. 15 illus., 6 illus. in color. : online resource.
ISBN: 9783319737034
Mammasonographie : Befundkategorisierung maligner und benigner Mammaläsionen - Fallbeispiele (2018)
Berlin : De Gruyter
Call number: QZ365WP870:446(2)
Keywords: Breast Diseases / radiography ; Diagnosis, Differential / Case Reports ; Mammography / Case Reports
Pages: xiii, 183 p. : ill.
Edition: 2., vollst. überarb. Aufl.
ISBN: 9783110330151
Resistance to Targeted Therapies in Breast Cancer (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: Invasive Breast Cancer Therapy 2017: How Well Are We Hitting The Target? -- Resistance to HER2-targeted therapy -- Endocrine Resistance and Breast Cancer Stem Cells – The Inflammatory Connection That Could Lead to New and Improved Therapy Outcomes -- EGFR Resistance -- Targeting FGFR for the treatment of breast cancer -- Targeted Therapies in Breast Cancer -- Future paradigm of breast cancer resistance and treatment
Abstract: We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy. ℗
Pages: XV, 184 p. 12 illus. in color. : online resource.
ISBN: 9783319701424
Stem Cell Microenvironments and Beyond (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Stem Cells ; Regenerative Medicine ; Tissue Engineering ; Life sciences ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1. Stem Cell Microenvironments and Beyond -- 2. The bone marrow microenvironment for hematopoietic stem cells -- 3. Leukemia stem cells microenvironment -- 4. Developmental HSC Microenvironments: Lessons from Zebrafish -- 5. Spinal cord stem cells microenvironment: the ependyme as a stem cell niche -- 6. Being a Neural Stem Cell: a matter of character but defined by the microenvironment -- 7. Glioblastoma Stem Cells and their Microenvironment -- 8. Plasticity of the Muscle Stem Cell Microenvironment -- 9. The Macula Flava of the Human Vocal Fold as a Stem Cell Microenvironment -- 10. Oesophageal stem cells microenvironment -- 11. ℗ Oral cancer stem cells microenvironment -- 12 Fetal membranes-derived stem cells microenvironment -- 13. Current technologies based on the knowledge of the stem cells microenvironments. ℗ ℗ ℗ ℗ ℗
Abstract: This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces.℗ Stem Cell Microenvironments and Beyond℗ is part of the highly successful℗ Advances in Experimental Medicine and Biology℗ series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians
Pages: XI, 270 p. 445 illus., 432 illus. in color. : online resource.
ISBN: 9783319691947
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Immunology ; Molecular Biology ; Oncology ; Biomedicine ; Cancer Research ; Oncology ; Immunology ; Molecular Medicine ; Springer eBooks
Description / Table of Contents: Part 1. Interplay Between Tumor Cells, Stroma and Inflammatory Infiltrate in Regulating Tumor Micro-Environment -- Tumor Immuno-Environment in Cancer Progression and Therapy -- Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment -- Regulation of CTL Infiltration Within the Tumor Microenvironment -- The Role of Tumor Microenvironment in Cancer Immunotherapy -- Part 2. Mediators of Tumor Microenvironment -- Immunogenic and Non-Immunogenic Cell Death in the Tumor Microenvironment -- Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression -- Chemo-immunotherapy: Impact of Indoleamine 2,3-dioxygenase in Defining Immunogenic versus Tolerogenic Cell Death in the Tumor Microenvironment -- Targeting Myeloid-Derived Suppressor Cells in Cancer -- Tryptophan catabolism and cancer immunotherapy targeting IDO mediated immune Suppression -- Part 3. Emerging Targets and Technologies of Modulation of Tumor Microenvironment -- Tumor Microenvironment in Cancer Progression and Therapy -- The Role of the Immune System and Immunoregulatory Mechanisms Relevant to Melanoma -- Oncolytic Virotherapy and the Tumor Microenvironment -- The Impact of Housing Temperature Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous Role for the Nervous System -- (Immuno)therapeutic Targeting of Tumor-Associated Blood Vessels -- Adaptive Resistance to Cancer Immunotherapy -- Imaging the Tumor Microenvironment
Abstract: The tumor microenvironment℗ has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to℗ moving the field forward, since there are many players in a tumoŕ€™s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy℗ aims to shed light on the mechanisms, factors, and mediators that are involved in the℗ cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the℗ dual℗ role℗ of the tumor microenvironment is the℗ integral focus of the volume.℗ The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It℗ also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups℗ are℗ discussed under the lens of℗ their℗ role℗ in promoting tumor growth,℗ shielding the tumor from℗ rejection and from standard forms of cancer therapies.℗ They are emerging℗ as targets and mediators of standard and new forms of potential therapy
Pages: XIV, 264 p. 47 illus., 43 illus. in color. : online resource.
ISBN: 9783319675770
Physiology and Genetics : Selected Basic and Applied Aspects (2018)
Cham : Springer International Publishing
Keywords: Life sciences ; Microbiology ; Microbial genetics ; Microbial genomics ; Mycology ; Life sciences ; Mycology ; Microbial Genetics and Genomics ; Applied Microbiology ; Springer eBooks
Description / Table of Contents: Fruiting Body Development in Ascomycetes -- Fungal inteins ́€“ Distribution, Evolution and Applications -- Yeast killer toxins: fundamentals and applications -- The fungal MCC/eisosome complex ́€“ an unfolding story -- The Genus Periglandula and its Symbiotum with Morning Glory Plants (Convolvulaceae) -- Volatiles in communication of Agaricomycetes -- ℗ Endophytic Fungi, Occurrence and Metabolites -- Secondary Metabolites of Basidiomycetes -- Identification of fungicide targets in pathogenic fungi -- Helminth Electron Transport Inhibitors Produced by Fungi -- Cyclic peptides and depsipeptides from fungi -- Polyketide Synthas逓Nonribosomal Peptide Synthetase Hybrid Enzymes of Fungi -- Biosynthesis of Fungal Polyketides -- Aspects of the occurrence, genetics and regulation of biosynthesis of the three food relevant Penicillium mycotoxins: ochratoxin A, citrinin and patulin
Abstract: In the last few decades, DNA-based tools for the investigation of fungal taxonomy, signal transduction and regulation, differentiation processes and biosynthetic potential have accelerated advances in our understanding of the Mycota. This completely updated and revised second edition presents a selection of exciting issues involving basic and applied aspects of fungal physiology and genetics. In 14 chapters, respected experts provide an overview of traditional, topical and future aspects of basic fungal principles and potential applications in biotechnology. The contributions will bring scientists up-to-date on the latest developments, and help students familiarize themselves with the different topics
Pages: XVIII, 464 p. 128 illus., 33 illus. in color. : online resource.
Edition: 2nd ed. 2018.
ISBN: 9783319717401
Advances in Personalized Nanotherapeutics (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Biomedical Engineering ; Nanoscale science ; Nanoscience ; Nanostructures ; Biomedicine ; Biomedical Engineering/Biotechnology ; Nanoscale Science and Technology ; Springer eBooks
Abstract: Health agencies have declared personalized nanomedicine as an important area to investigate novel therapies to combat against targeted diseases with no-side effects. The disease profile varies from patient-to-patient and standard therapies sometime are unsuitable for complete cure. This raises the demand of nanomedicine development. The tunable therapeutic salient features of nanomedicine including site-specific delivery and controlled release of a specific drug according to patient requirement make nanomedicine very special. Such of human compatible personalization is very useful in diseases management required to optimize a therapy for health care. Knowing the potentials of the nanomedicines, significant efforts are being to design and develop nano-enabled therapeutic strategies to cure and monitor diseases contributing to personalized health care. As per state-of-the-art, various approaches have been optimized resulting in development of pharmacologically relevant personalized nanomedicine to combat against diseases with improved efficacy and no adverse effects. In this book, we described the fundamentals nanomedicine, nanotechnology for nanomedicine development, approach of personalized nanomedicine, potential novel nano-carriers for site-specific drug delivery, role of nano-bio-technology for efficient therapeutics, nano-pharmacology, targeted CNS drug delivery, stimuli- responsive drug release, aspects of bioinformatics for diseases management, miniaturized bio-sensing systems for diseases detection with monitoring, and nano-bio-technology for diseases management. The challenges in personalized nano-therapeutics development, possible vision to overcome challenges, and future prospects to promote therapies for clinical application are also discussed in this book. We believe that present book would serve as a platform for new scholars of academia and industries to understand state-of-the-art of nano-bio-technology for therapeutics to plan future research to develop effective personalized nanomedicine against targeted diseases. Our book is a call for experts to explore multidisciplinary research towards developing novel personalized nanomedicines to combat against targeted diseases to personalized health care
Pages: XIII, 240 p. 56 illus., 53 illus. in color. : online resource.
ISBN: 9783319636337
TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Proteins ; Stem Cells ; Cell Cycle ; Apoptosis ; Biomedicine ; Cancer Research ; Protein Structure ; Stem Cells ; Cell Cycle Analysis ; Apoptosis ; Springer eBooks
Description / Table of Contents: 1 Introduction: How we encountered TCTP and our purpose in studying it -- 2 Structural insights into TCTP and its interactions with ligands and proteins -- 3 Structure-Function relationship of TCTP -- 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation -- 5 Current understanding of the TCTP interactome -- 6 Role and fate of TCTP in protein degradative pathways -- 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development -- 8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies -- 9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms -- 10 Tctp in Neuronal Circuitry Assembly -- 11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation -- 12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage -- 13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression -- 14 Role of TCTP for cellular differentiation and cancer therapy -- 15 Targeting TCTP with sertraline and thioridazine in cancer treatment -- 16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy
Abstract: This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike
Pages: X, 309 p. 51 illus., 36 illus. in color. : online resource.
ISBN: 9783319675916
RNA Detection : Methods and Protocols (2018)
New York, NY : Springer New York
Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
Description / Table of Contents: The Secret Life of RNA: Lessons from Emerging Methodologies -- Quantification of 2'-O-Me Residues in RNA using Next-Generation Sequencing (Illumina RiboMethSeq Protocol) -- Identifying the m6A Methylome by Affinity Purification and Sequencing -- PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution -- Axon-TRAP-RiboTag: Affinity-Purification of Translated mRNAs from Neuronal Axons in Mouse In Vivo -- LCM-Seq: A Method for Spatial Transcriptomic Profiling using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing -- Spatial Transcriptomics: Constructing a Single-Cell Resolution Transcriptome-Wide Expression Atlas -- Single mRNA Molecule Detection in Drosophila -- Detection and Automated Analysis of Single Transcripts at Subcellular Resolution in Zebrafish Embryos -- Super-Resolution Single Molecule FISH at the Drosophila Neuromuscular Junction -- Detection of mRNA and Associated Molecules by ISH-IEM on Frozen Sections -- Hybridization Chain Reaction for Direct mRNA Detection without Nucleic Acid Purification -- In Situ Detection of MicroRNA Expression with RNAscope Probes -- Padlock Probes to Detect Single Nucleotide Polymorphisms -- Quantifying Gene Expression in Living Cells with Ratiometric Bimolecular Beacons -- Optimizing Molecular Beacons for Intracellular Analysis of RNA -- Live Imaging of Nuclear RNPs in Mammalian Complex Tissue with ECHO-liveFISH -- In Vivo Visualization and Function Probing of Transport mRNPs using Injected FIT Probes -- Visualizing RNA in Live Bacterial Cells using Fluorophore- and Quencher-Binding Aptamers -- Method for Imaging Live-Cell RNA using an RNA Aptamer and a Fluorescent Probe -- RNA Live Imaging in the Model Microorganism Ustilago maydis -- Real-Time Fluorescence Imaging of Single-Molecule Endogenous Non-Coding RNA in Living Cells -- Live Imaging of mRNA Synthesis in Drosophila -- Imaging Newly Transcribed RNA in Cells by Using a Clickable Azide-Modified UTP Analog -- Detection of the First Round of Translation: The TRICK Assay -- Imaging Translation Dynamics of Single mRNA Molecules in Live Cells -- Systematic Detection of Poly(A)+ RNA-Interacting Proteins and Their Differential Binding -- Isolation and Characterization of Endogenous RNPs from Brain Tissues -- Individual Nucleotide Resolution UV Cross-Linking and Immunoprecipitation (iCLIP) to Determine Protein-RNA Interactions -- RNA Tagging: Preparation of High-Throughput Sequencing Libraries -- RAP-MS: A Method to Identify Proteins that Interact Directly with a Specific RNA Molecule in Cells
Abstract: This volume introduces different concepts and methods of detecting RNA in biological material in a variety of model systems. The chapters in this book discuss methods that will answer numerous biological questions that arise in the study of RNAs. Some of the topics covered in this book are single mRNA molecule detection in embryos and neurons; detection of mRNA and associated molecules by ISH-IEM on frozen sections; optimizing molecular beacons for intracellular analysis of RNA; imaging translation dynamics of single mRNA molecules in live cells; preparation of high-throughput sequencing libraries; and capturing RNA binding proteins in embryos and in cell-culture. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNA Detection: Methods and Protocols is a valuable resource for novel and experiences scientist in the expanding field of RNAs
Pages: XIV, 492 p. 94 illus., 78 illus. in color. : online resource.
ISBN: 9781493972135
DJ-1/PARK7 Protein : Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases (2017)
Singapore : Springer Singapore
Keywords: Medicine ; Cancer Research ; Neurosciences ; Biochemistry ; Cell Biology ; Biomedicine ; Cancer Research ; Biochemistry, general ; Neurosciences ; Cell Biology ; Springer eBooks
Description / Table of Contents: Preface.-̂€€Chapter 1 Introduction/Overview -- Chapter 2 Structural Biology of the DJ-1 Superfamily -- Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases -- Chapter 4 DJ-1 as an oncogene and its clinical significance -- Chapter 5 Role of DJ-1 in fertilization -- Chapter 6 Anti-oxidative stress function of DJ-1 -- Chapter 7 Ttranscriptional regulation of DJ-1 -- Chapter 8 Regulation of Signal Transduction by DJ-1 -- Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal -- Chapter 10 DJ-1 as a biomarker of Parkinson's disease -- Chapter 11 Roles of DJ-1 in diabetes mellitus -- Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases -- Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy.℗
Abstract: This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The℗ DJ-1℗ gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinsoń€™s disease (PD), park7. The℗ DJ-1℗ gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of℗ DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of℗ DJ-1℗ in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.℗
Pages: VIII, 222 p. 78 illus., 46 illus. in color. : online resource.
ISBN: 9789811065835
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Immunology ; Cell Biology ; Biomedicine ; Immunology ; Cancer Research ; Cell Biology ; Springer eBooks
Description / Table of Contents: Regulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation
Abstract: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike
Pages: VIII, 267 p. : online resource.
ISBN: 9783319689296
Rare Diseases Epidemiology : Update and Overview (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Human Genetics ; Health Promotion ; Epidemiology ; Medicine & Public Health ; Health Promotion and Disease Prevention ; Human Genetics ; Epidemiology ; Springer eBooks
Description / Table of Contents: Part I Introduction -- Rare Diseases: Joining Mainstream Research and Treatment Based on Reliable Epidemiological Data.-℗ Part II Rare diseases diagnosis.-℗ Undiagnosed diseases: Italy-US collaboration and international efforts to tackle rare and common diseases lacking a diagnosis.-℗ Intellectual disability & rare disorders: A diagnostic challenge.-℗ Improved diagnosis and care for rare diseases through implementation of a precision public health framework -- Part III℗ Registries, Natural History of Rare Diseases and Biobanks.-℗ Natural history, trial readiness and gene discovery: advances in patient registries for neuromuscular disease.-℗ Facilitating Clinical Studies in Rare Diseases.-℗ Rare Diseases Biospecimens and patient registries: Interoperability for research promotion, a European example: EuroBioBank and Spain RDR-BioNER.-℗ Data Quality in Rare Diseases Registries.-℗ Preparing data at the source to foster interoperability across r are disease resources.-℗ Part IV℗ Orphan drugs and therapies.-℗ Incentivizing orphan product development: United States Food and Drug Administration orphan incentive programs.-℗ Post-approval Studies for Rare Disease Treatments and Orphan Drugs.-℗ Evidence-Based Medicine and Rare Diseases.-℗ Health technology assessment and appraisal of therapies for rare diseases.-℗ New Therapeutic Uses for Existing Drugs.-℗ Patient empowerment and involvement in research.-℗ Part V Cost-Effectiveness and Cost-of-illness.-℗ Cost-effectiveness methods and newborn screening assessment.-℗ Cost-of-illness in rare diseases.-℗ Part VI℗ Rare Diseases Prevention.-℗ Primary prevention of congenital anomalies: special focus on environmental chemicals and other toxicants, maternal health and health services and infectious diseases.-℗ Newborn Screening: Beyond the Spot.-℗ Part VII℗ New Research Perspectives in RD.-℗ A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC).-℗ Prospects of Pluripotent and Adult Stem Cells for Rare Diseases.-℗ Personalized Medicine: What́€™s in for Rare Diseases?.-℗ Microphysiological systems (tissue chips) and their utility for rare disease research.-℗ Part VIII℗ Rare Diseases Epidemiology.-℗ Epidemiology of Rare Lung Diseases: The Challenges and Opportunities to Improve Research and Knowledge.-℗ Rare neurodegenerative diseases: clinical and genetic aspects.-℗ Immunological rare diseases.-℗ Indigenous Genetics and Rare Diseases: Harmony, Diversity and Equity.-℗ Mortality Statistics and their Contribution to Improving Rare Diseases Epidemiology: the Example of Hereditary Ataxia in Europe.-℗ Congenital Anomalies: Cluster detection and investigation -- Part℗ IX℗ Rare Diseases policies and society.-℗ The European Union Policy in the Field of Rare Diseases.-℗ The role of solidarity(-ies) in rare diseases research.-℗ Bridging the gap between health and social care for rare diseases: key issues and innovative solutions.-℗ Health systems sustainability and rare diseases.-℗ Preparing for the Future of Rare Diseases.-℗ Index
Abstract: This second edition of the book about Rare Diseases Epidemiology aims to highlight the progress of rare diseases research and related activities since the first volume published. As with the previous book, this update provides a comprehensive list of issues and adds new authors who are leaders in their different areas of expertise related to rare diseases at national and international levels. Rare diseases and orphan drugs are challenges for patients and families but also for physicians, researchers, and policy-makers in both the public and private sectors. This book aims to help all of them to address topics like health care policies, societal issues and clinical and experimental research. Readers will discover methods and procedures to address a variety of questions like cases of undiagnosed rare diseases, patient registries and biobanks, health care and public health approach to rare diseases, orphan drugs and new therapies, cost-effectiveness analyses, prevention, clinical and epidemiology of individual and groups of related rare diseases, novel advances in study design and data analyses, national and international policies and social issues. Within each one of these general issues, ℗ advances, new challenges and opportunities to address significant health care issues are described across thirty-two chapters. Editors and all authors providing chapters include globally recognized experts in different areas of rare diseases, including epidemiology, public health, health economics and pharmacology, statistics, and basic, clinical and translational research. People engaged in policy formulation decisions on rare diseases as well as patient representatives relate their own point of view about social constraints they live under on a daily basis. Renowned research investigators, highly-skilled clinicians, and recognized patient leaders ℗ are included as contributing authors to this new book about rare diseases. In fact, two of the editors are the current President and President Elect of the International Conference on Rare Diseases and Orphan Drugs and the third one is a board member of this society. The book has been written for all stakeholders but mainly for those involved in the many issues related to rare diseases. They can discover new ways for dealing with important matters related to the prevention, diagnosis, natural history, treatments, and research of rare diseases and the development of orphan products.℗
Pages: XXXVI, 667 p. 30 illus. : online resource.
Edition: 2nd ed. 2017.
ISBN: 9783319671444
Encyclopedia of Signaling Molecules (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Medical genetics ; Molecular Biology ; Proteins ; Cytokines ; Growth factors ; Bioinformatics ; Cell Biology ; Biomedicine ; Gene Function ; Molecular Medicine ; Cytokines and Growth Factors ; Cell Biology ; Protein-Ligand Interactions ; Bioinformatics ; Springer eBooks
Description / Table of Contents: From the contents 14-3-3 -- 3-Phosphoinositide-Dependent Kinase 1 (PDK1) -- 5-HTT -- 5-Hydroxytryptamine Receptor 2C -- 5-Hydroxytryptamine Receptor 6 -- A-Kinase Anchoring Protein (AKAP) -- A-RAF -- ABCA Transporters -- ABCA3 -- ACAP1 -- Acetylcholine (Nicotinic) Receptor -- ℗ Acetylcholinesterase -- ACK1 -- ACSL4 -- ACT -- Actinin Family -- ADAMTS13 -- ADAP -- ADAP1 -- ℗ ADAP2 -- ADCY9 (Adenylyl Cyclase 9) -- Adenomatous Polyposis Coli -- Adenylyl Cyclase -- ℗ ADGRB3 -- ADGRG2 -- Adiponectin -- ADP-Ribosylation Factor-6 (ARF6) -- AGAP1 -- AIFM1 -- ℗ AIRE -- AKT -- Alpha-1-Syntrophin -- Alpha-2A Adrenergic Receptor -- ALS2 -- AMP-Activated Protein Kinase (AMPK) -- Androgen Receptor (AR) -- ANT -- AP-4 -- APO2L/TRAIL -- Apoptosis Regulator BAX -- Apoptosis-inducing factor 1, mitochondrial -- App -- Aquaporin -- ARAP3 -- ARF1 -- ℗ Arl8b -- Aryl Hydrocarbon Receptor -- Ataxia Telangiectasia and Rad3-Related (ATR) -- ATF2 -- ℗ ATP-Binding Cassette Subfamily A Member 2 -- Aurora Kinases -- Axin -- AXL -- B Lymphocyte Antigen CD19
Abstract: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research -based teaching and scientific capabilities
Pages: 1893 illus., 1746 illus. in color. eReference. : online resource.
ISBN: 9783319671994
Molecular Life Sciences : An Encyclopedic Reference (2018)
New York, NY : Springer New York
Keywords: Life sciences ; Biochemistry ; Microbiology ; Life sciences ; Biochemistry, general ; Microbiology ; Biological and Medical Physics, Biophysics ; Springer eBooks
Description / Table of Contents: Allostery and Quaternary Structure -- Analysis of Damaged DNA -- Artificial Chromosomes -- Artificial Endonucleases for Genome Editing -- Bacterial DNA Replicases -- Bacteriophage and Viral Cloning Vectors -- Base Intercalation -- Bioactivation of Carcinogens -- Bioinorganic Chemistry -- Blue/White Selection -- Characteristics of Enzymes and Cloning Vectors Used to Create Recombinant DNA -- Chemical Biology of DNA Replication -- Chemical Denaturation -- Chemical Reaction Kinetics: Mathematical Underpinnings -- Chromatin Remodeling during Homologous Recombination Repair in Saccharomyces Cerevisiae -- Cis-Regulation of Eukaryotic Transcription -- Classic Approaches to sequence determination -- Classical and Alternative End Joining -- Cloning Vector Compatibility -- Computational methods in epigenetic research -- Conjugative Transfer Systems and Classifying Plasmid Genomes -- Conservative Site-specific Recombination -- Control of Initiation in E.coli -- Co-Transcriptional mRNA Processing in Eukaryotes -- Crosslinking -- Cycling of the Lagging Strand Replicase During Okazaki Fragment Synthesis -- Depurination -- Differential Equations and Chemical Master Equation Models for Gene Regulatory Networks -- Direct Enzymatic Reversal of DNA Damage -- Division of Labor -- DNA Damage as a Therapeutic Strategy -- DNA Damage by Endogenous Chemicals -- DNA Methylation and Cancer -- DNA Polymerase III Structure -- DNA Repair -- DNA Repair Polymerases -- DNA Replication -- DNA Topology and Topoisomerases -- DnaA, DnaB, DnaC -- DnaX Complex Composition and Assembly Within Cells -- Double-strand Break Repair -- Effects of adducts on Tm -- Equilibria and Bifurcations in the Molecular Biosciences -- Eukaryotic DNA Replicases -- Evolution of Gene Regulatory Networks -- Evolution of Plant Genomes -- Exocyclic Adducts -- Experimental Assessment of Secondary Structure by Circular Dichroism -- Exploring Nuclear Lamin–Chromatin Interactions and Their Signalling Cascades -- Expression Assessment -- Fatty Acid Metabolism -- Forces Maintaining the Stability of Tertiary Structure -- Frequency of DNA Damage -- Gene Regulation -- Genes and Genomes: Structure -- Genomic Imprinting -- Genomic Imprinting in Mammals: Memories of Generations Past -- Genomic Sequence and Structural Diversity in Plants -- Genomic Signature Analysis to Predict Plasmid Host Range -- Golgi Apparatus -- Gyrase and Topoisomerase IV as Targets for Antibacterial Drugs -- HDAC Inhibitors Entinostat and Suberoylanilide Hydroxamic Acid (SAHA): The Ray of Hope for Cancer Therapy -- Helicase and Primase Interactions with Replisome Components and Accessory Factors -- Helicase Mechanism of Action -- Hereditary Breast and Ovarian Cancer and Poly(ADP-ribose) Polymerase Inhibition -- Homologous Recombination in Lesion Bypass -- Hydrolytic, Deamination, and Rearrangement Reactions of DNA Adducts -- Immunology and the Immune Response -- In Silico Approaches Towards Safe Targetting of Class I Histone Deacetylases -- Inflammation and Host Response to Infection -- Innate and Regulatory B cells -- Innate Immunity -- Ion Channels and Transporters -- Kinetics of DNA Damage -- Large, Theta-replicating Plasmids -- Long-Term Genetic Silencing at Centromere and Telomeres -- Mammalian Sugar Transporters -- Many Bacteria Use a Special Mutagenic Pol III in Place of Pol V -- Mass Spectrometry Approaches -- Mathematical Modelling of Plasmid Dynamics -- Mathematical Models in the Sciences -- Mathematics of Fitting Scientific Data -- Mechanism of Initiation Complex Formation -- Mechanism of PCNA loading by RFC -- Mechanisms of DNA Recombination -- Meiotic Recombination -- Metamobilomics – The Plasmid Metagenome of Natural Environments -- Methods for Plant Genome Annotation -- Mismatch Repair -- Mitochondrial Genomes -- Mitochondrial Genomes in Alveolates -- Mitochondrial Genomes in Amoebozoa -- Mitochondrial Genomes in Fungi -- Mitochondrial Genomes in Invertebrate Animals -- Mitochondrial Genomes in Land Plants -- Mitochondrial Genomes in Unicellular Relatives of Animals -- Mitochondrial Genomes in Vertebrate Animals -- Mitochondrial Genomes of Chromists (Stramenopiles, Haptophytes and Cryptophytes) -- Mitochondrial Genomes of Excavata -- Mitochondrial Genomes of Green, Red and Glaucophyte Algae -- Mobile DNA: Mechanisms, Utility, and Consequences -- Modelling Plasmid Regulatory Systems -- Modes of Base Pairing -- mRNA localization and localized translation -- Naming and Annotation of plasmids -- Natural Products that Damage DNA -- NMR Approaches to Determine Protein Structure -- NMR Basis For Biomolecular Structure (Theory) -- Nucleotide Excision Repair -- Obtaining Crystals -- Oxidative Damage -- Pattern Recognition Receptors: Evolution, Redundancy, and Cross Talk -- PCNA Structure and Interactions with Partner Proteins -- Peptide Pheromones and their Protein Receptors: Cellular Signaling in Gram-positive Bacteria -- Phagocytosis -- Plant Genome Sequencing Methods -- Plant Genomes: From Sequence to Function Across Evolutionary Time -- Plant Transposable Elements: Beyond Insertions and Interruptions -- Plasmid Cloning Vectors -- Plasmid Genomes, Introduction to -- Plasmid Incompatibility -- Plasmids as Secondary Chromosomes -- Polyglutamine Folding Diseases -- Polymerase Chain Reaction -- Practical Screening for DNA Damage -- Predictions from Sequence -- Primary Structure -- Prokaryotic Gene Regulation by Sigma Factors and RNA Polymerase -- Prokaryotic Gene Regulation by Small RNAs -- Protein Domain Structure Evolution -- Rad51 and Dmc1 Recombinases -- Reactive Oxygen Species -- Recombination: Mechanisms, Pathways, and Applications -- Recombineering -- Regulation of cytoplasmic mRNA -- Regulation of DSB Repair by Cell-cycle Signaling and the DNA Damage Response -- Regulation of Genetic Element Mobility -- Relevance of DNA Damage to Cancer -- Repeating Sequences in Proteins: Their Identification and Structural/Functional Implications -- Replication Origin of E. coli and the Mechanism of Initiation -- Replicative DNA Helicases and Primases -- Resolution of Inflammation -- Restriction Endonucleases -- RNA Interference -- RNA Quality Control -- RNA-induced chromatin remodeling -- Role of Chromatin Remodeling and DNA Modification in Transcriptional Regulation -- Roles of Post-translational Modifications in DNA Double Strand Break Repair -- Rolling-circle Replicating Plasmids -- Secondary Structure -- Selection with Antibiotics -- Selectivity of Chemicals for DNA Damage -- Sequence Selectivity of DNA Damage -- Signal Recognition in Lower Organisms: Light-Induced Control of Cell Movement in the Ciliates Blepharisma and Stentor -- SIKE: Discovery, Structure, and Function -- Single Strand Annealing -- Site-specific Mutagenesis -- Some Key Enzymes Used in Cloning -- Spectroscopy of Damaged DNA -- Synthesis of Modified Oligonucleotides -- Synthetic Plasmid Biology -- TANK-Binding Kinase 1 (TBK1): Structure, Function, and Regulation -- Target-primed Mobilization Mechanisms -- Target-site Selection -- Tertiary Structure Domains, Folds and Motifs -- The Complement System -- Theoretical Aspects of Secondary Structure -- Toll-Like Receptor 3: Structure and Function -- Toll-Like Receptors: Evolution and Structure -- Toll-Like Receptors: Pathogen Recognition and Signaling -- Topoisomerases and Cancer -- Transcription Factor Classes -- Transduction of Environmental Signals by Prokaryotic Two Component Regulatory Systems -- Transposable elements and plasmid genomes -- Transposons -- Types of DNA damage -- Types of Electrophiles -- Ultraviolet Light Damage -- uORFs: an unusual cis element that regulates translation -- Using Sequence Information to Assess Evolutionary Relationships -- Using Sequence Information to Identify Motifs -- V(D)J Recombination -- Why Do Proteins Have Quaternary Structure: Non-allosteric Proteins
Abstract: Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes.℗ The work℗ will℗ include articles℗ on genes and genomes, protein structure and function, systems biology using genomics and proteomics as the focus, molecular aspects of cell structure and function, unifying concepts and theories from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences (including teaching perspectives and assessment tools), and basic aspects of the various experimental approaches that are used in the Molecular Life Sciences
Pages: 456 illus., 307 illus. in color. eReference. : online resource.
ISBN: 9781461415312
Perioperative Inflammation as Triggering Origin of Metastasis Development (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: The Natural History of Breast Cancer -- Perioperative Inflammation as Triggering Origin of Metastasis Development -- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients -- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation -- Circulating tumor cells as predictive marker in metastatic disease -- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints -- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs -- The impact of wound inflammation on cancer progression; Studies in fish and patients -- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives -- Cancer: Nurture and Nature -- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer
Abstract: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities
Pages: XXIII, 236 p. 49 illus., 39 illus. in color. : online resource.
ISBN: 9783319579436
Lymph node FNC : lymph node cytopathology and extranodal lymphoproliferative processes (2018)
Basel : Karger
Call number: QZ350:409
Keywords: Lymphoproliferative Disorders / diagnosis ; Lymph Nodes / cytology ; Lymph Nodes / pathology ; Biopsy, Fine-Needle / methods
Description / Table of Contents: Fine-needle cytology : technical procedures and ancillary techniques -- Lymph nodal structure and cytological patterns -- Lymphadenitis and lymphadenopathy -- Non-Hodgkin lymphoma -- Hodgkin lymphoma -- Paediatric lymphadenopathies -- Immunodeficiency-associated lymphoproliferative disorders -- Extranodal and deeply located lymphoproliferative processes -- Metastases -- Lymph node haematopoietic and histiocytic proliferatons and other lymphoid organs
ISBN: 9783318061147
Optimizing Breast Cancer Management (2018)
Cham : Springer International Publishing
Call number: QZ365WP870:447
Keywords: Breast Neoplasms
Pages: v, 189 p. : ill.
ISBN: 9783319701950
Technical communication (2018)
Boston : Bedford/St. Martin's
Call number: ALLG-BERUF-Q179:53(12) ; G230:7
Keywords: Technical writing ; Communication of technical information ; Communication of technical information ; Technical writing
Pages: xxxviii, 729 p. : illustrations (chiefly color)
Edition: 12th edition.
ISBN: 9781319058616
Anticancer therapeutics : from drug discovery to clinical applications (2018)
Hoboken, NJ : Wiley
Call number: QZ267:521
Keywords: Neoplasms / drug therapy ; Neoplasms / physiopathology ; Antineoplastic Agents ; Drug Discovery
Pages: 434 p. : ill.
ISBN: 9781118622124
Human Epigenomics (2018)
Singapore : Springer Singapore
Keywords: Medicine ; Human Genetics ; Molecular Biology ; Biomedicine ; Human Genetics ; Molecular Medicine ; Springer eBooks
Description / Table of Contents: What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics
Abstract: The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule €œá picture tells more than thousand wordś€. The content of the book is based on the lecture course ́€œMolecular Medicine and Geneticś€ that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks ́€œMechanisms of Gene Regulatioń€ (ISBN 978-94-017-7741-4) and ́€œNutrigenomicś€ (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine
Pages: XIX, 223 p. 120 illus. in color. : online resource.
ISBN: 9789811076145
Current Concepts in Medical Research and Practice (2018)
Cham : Springer International Publishing
Keywords: Medicine ; Neurochemistry ; Respiratory organs / Diseases ; Neurobiology ; Medicine & Public Health ; Pneumology/Respiratory System ; Neurobiology ; Neurochemistry ; Springer eBooks
Description / Table of Contents: Electronic Cigarettes and Awareness of Their Health Effects ,A. Daniluk, A. Gawlikowska-Sroka, M. St♯™pien-S¿‚odkowska, E. Dzi♯™cio¿‚owska-Baran, and K. Michnik.-℗ Metachronous Lung Cancer: Clinical Characteristics and Effects of Surgical Treatment, A. Rzechonek, P. B¿‚asiak, B. Muszczy¿„ska-Bernhard, K. Pawe¿‚czyk, G. Pniewski, M. Ornat, J. Grzegrz©đ¿‚ka, and A. Brzecka -- Healthcare Professionalś€™ Knowledge of Influenza and Influenza Vaccination: Results of a National Survey in Poland, E. Kuchar, K. Ludwikowska, A. Antczak, and A. Nitch-Osuch -- Benign Acute Childhood Myositis during Influenza, B Outbreak, L. Szenborn, K. Toczek-Kubicka, J. Zarycza¿„ski, M. Marchewka-Kowalik, K. Mi¿›kiewicz, and E. Kuchar -- Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population, J. Kacik, B. Wr©đblewska, S. Lewicki, R. Zdanowski, and B. Kalicki -- Spontaneous Elimination of HCV Infection,℗ M. Janiak, K. Caraballo Cortes, U. Demkow, and M. Radkowski -- Clinical Manifestations of Huge Diaphragmatic Hernias, J. Lesi¿„ski, T.M. Zielonka, A. Kaszy¿„ska, O. Wajtryt, K. Pepli¿„ska, K. ¿»yci¿„ska, and K.A. Wardyn -- The Diagnostics of Human Steroid Hormone Disturbances, M. Dobosz, A. Manda-Handzlik, B. Pyr¿ơak, and U. Demkow -- Discriminant Analysis of Intracranial Volumetric Variables in Patients with Normal Pressure Hydrocephalus and Brain Atrophy, L. Czerwosz, E. Szczepek, K. Nowi¿„ski, B. Soko¿‚owska, Z. Czernicki, J. Jurkiewicz, and W. Koszewski.-℗ Hoffမs Fat Pad Abnormality in the Development of Knee Osteoarthritis, W. Paduszy¿„ski, M. Je¿›kiewicz, P. Ucha¿„ski, S. Gackowski, M. Radkowski, and U. Demkow
Abstract: Change is an inherent feature of all aspects of clinical practice and patient management. This book seeks to contribute to presenting novel knowledge in various fields of clinical work. The articles tackle transdisciplinary topics and focus on the underlying mechanisms of clinical disorders, their prevention and management. The themes addressed include allergy and pseudoallergy in the pediatric population, influenza-related infections and their sequelae, which continues to be a scourge in the developing world, the risk of lung cancer repeats and their management, viral hepatitis that may lead to hepatocarcinoma, respiratory consequences of diaphragmatic hernias, disorders of steroid hormone metabolism, and others. The articles bring the updated strategies, research, and best practices to improve outcomes and to deliver state-of-the-art clinical care to patients. The book will be of interest to physicians, academic scientists, and researchers who are keen in sharing the latest medical practice developments
Pages: VIII, 104 p. 15 illus., 7 illus. in color. : online resource.
ISBN: 9783319741505
Inflammation and Angiogenesis (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Abstract: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.℗
Pages: VIII, 111 p. 36 illus., 24 illus. in color. : online resource.
ISBN: 9783319684482
Handbook of epigenetics : the new molecular and medical genetics (2017)
London : Elsevier/Academic Press
Call number: QH447:219(2)
Keywords: Epigenesis, Genetic ; Epigenomics / methods
Pages: xiii, 668 pages : illustrations
Edition: 2nd edition.
ISBN: 9780128053881
Cell Division Machinery and Disease (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Cell Cycle ; Cell Physiology ; Life sciences ; Cell Cycle Analysis ; Cell Physiology ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization
Abstract: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases
Pages: XIV, 235 p. 33 illus., 32 illus. in color. : online resource.
ISBN: 9783319571270
Drug and Gene Delivery to the Central Nervous System for Neuroprotection : Nanotechnological Advances (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedical Engineering ; Biomedicine ; Neurosciences ; Biomedical Engineering ; Neurobiology ; Springer eBooks
Description / Table of Contents: Chapter 1 Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery -- Chapter 2 Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection -- Chapter 3 Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment -- Chapter 4 Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases -- Chapter 5 Sleep Deprivation Induced Blood-Brain Barrier Breakdown and Brain Pathology. Neuroprotective Effects of Tio2-Nanowired Delivery of Cerebrolysin and Ondansetron -- Chapter 6 Glyco-Functionalised Biomaterials in Neuroregeneration -- Chapter 7 Targeting Nanoparticles to Brain: Impact of N-Methyl D-Aspartate Receptors
Abstract: This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease
Pages: XIII, 228 p. 47 illus., 38 illus. in color. : online resource.
ISBN: 9783319576961