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  • 1
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 2
    Keywords: Immunology ; Evolution (Biology) ; Developmental Biology ; Immunology ; Evolutionary Biology ; Developmental Biology ; Springer eBooks
    Description / Table of Contents: Chapter 1: What makes evolution tick? -- Chapter 2: Immunity - the unicellular to metazoan transition -- Chapter 3: Innate immunity -- Chapter 4: The triumph of individualism: evolution of somatically generated adaptive immune systems -- Chapter 5: The other side of the arms race -- Chapter 6: Postface
    Abstract: Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge
    Pages: XVI, 145 p. 26 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030186678
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  • 3
    New York : Springer
    Call number: QZ200:578
    Pages: xiv, 203 p.
    ISBN: 9783030203146
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    QZ200:578 available
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  • 4
    Keywords: Immunology ; Proteins  ; Molecular Biology ; Immunology ; Protein Structure ; Molecular Medicine ; Receptors ; Springer eBooks
    Description / Table of Contents: Structural basis for signalling through shared common g chain cytokines -- MHC Molecules, T Cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins–Key Elements of Adaptive and Innate Immunity -- Structures of Immune Checkpoints: An Overview on the CD28-B7 Family -- Interleukin-10 family cytokines immunobiology and structure -- Structural insights into the interleukin-17 family cytokines and their receptors -- Structural biology of NOD-like receptors -- AIM2 Inflammasome Assembly and Signaling -- Structures of RIG-I-like receptors and insights into viral RNA sensing -- Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death -- NF-κB, IκB, and IKK: Integral Components of Immune System Signaling
    Abstract: This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function
    Pages: XIII, 226 p. 86 illus., 84 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811393679
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  • 5
    New York : Oxford University Press
    Associated volumes
    Call number: QH405:062
    Keywords: Medicine / Research ; Biometry ; Mathematical Statistics
    Pages: xv, 192 : illustrations
    ISBN: 9780199365067
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    QH405:062 available
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  • 6
    Call number: QZ208:158
    Keywords: Neoplasms / genetics ; Genomics ; Precision Medicine ; Biomarkers, Tumor
    Pages: xxii, 698 pages : illustrations
    ISBN: 9780128117859
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    QZ208:158 available
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  • 7
    San Diego : Elsevier Science & Technology
    Call number: W26.5:143
    Pages: xii, 219 p.
    ISBN: 9780128125120
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    W26.5:143 available
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  • 8
    München : Springer Spektrum
    Call number: QH581:72
    Keywords: Cell Biology
    Pages: xii, 199 p. : ill.
    ISBN: 9783662561102
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    QH581:72 available
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  • 9
    Keywords: Human Genetics ; Biochemistry ; Biological models ; Human Genetics ; Protein Science ; Systems Biology ; Springer eBooks
    Description / Table of Contents: Preface -- Chromatin regulation by long non-coding RNAs -- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs -- Roles of long non-coding RNAs in X-chromosome inactivation -- Roles of Long Non-Coding RNAs in Genomic Imprinting -- Dysregulation of long noncoding RNAs in human disease -- Functions of long non-coding RNAs in non-mammalian systems -- Emerging technologies to study long non-coding RNAs -- Long non coding RNAs and nuclear body formation and function -- The role of long non-coding RNAs in immunity -- Novel methods to study long non-coding RNAs -- OMICs of long non-coding RNAs -- Cancer epigenetics and long non-coding RNAs -- Roles of long non-coding RNAs in human development -- Index
    Abstract: This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them
    Pages: VII, 187 p. 10 illus., 9 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9783030170868
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  • 10
    Keywords: Stem Cells ; Oncology ; Cell Cycle ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Cell Cycle Analysis ; Springer eBooks
    Description / Table of Contents: Multilayered heterogeneity of glioblastoma stem cells: biological and clinical significance -- Heterogeneity of head and neck squamous cell carcinoma stem cells -- Heterogeneity of small cell lung cancer stem cells -- Heterogeneity of hepatic cancer stem cells -- Heterogeneity and plasticity of breast cancer stem cells -- Heterogeneity of melanoma with stem cell properties -- Heterogeneity of colon cancer stem cells -- Urothelial cancer stem cell heterogeneity -- Acute myeloid leukemia stem cell heterogeneity and its clinical relevance -- Contribution of chronic myeloid leukaemia (CML) as a disease model to define and study clonal heterogeneity -- The heterogeneity of osteosarcoma: the role played by cancer stem cells -- Ovarian cancer stem cell heterogeneity -- Index
    Abstract: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians
    Pages: XII, 228 p. 24 illus., 18 illus. in color. : online resource.
    ISBN: 9783030143664
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  • 11
    Keywords: Biomedical Engineering ; Signal processing ; Image processing ; Speech processing systems ; Radiology ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Signal, Image and Speech Processing ; Imaging / Radiology ; Springer eBooks
    Description / Table of Contents: What is Medical Imaging? -- Part I: From Signals… -- Basic Concepts -- Transmission: X-Rays -- Reflection : Ultrasound -- Emission: SPECT/PET -- Resonance: NMR -- Part II: …To Images -- A Revision of Frequency Analysis -- Basic Concepts -- Timing-Based Reconstruction -- Back-Projection Reconstruction: X-Ray and PET/SPECT -- Fourier Reconstruction: MRI -- Part III: Functional and Physiological Imaging -- Contrast Agents -- Tracer Kinetics -- Examples of Tracer Kinetic Methods -- Other Physiological and Functional MRI Methods
    Abstract: This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of ‘contrast’ in the context of medical imaging. This introductory text separates the principles by which ‘signals’ are generated and the subsequent ‘reconstruction’ processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of ‘reconstruction’ are shared by some imaging methods despite relying on different physics to generate the ‘signals’. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers
    Pages: XIV, 169 p. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030305116
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