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  • Biomedical Engineering/Biotechnology  (6)
  • Molecular Biology
  • Biomedical Research
  • Microbiology
  • DKFZ-publications
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  • 1
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Chapter 1. Improvement of HDL -- 1-1.Clinical application of HDL: Overview -- 1-2.Regression effect of V156K-apoA-I -- 1-3.Anti-diabetic effect of V156K-apoA-I -- 1-4.Vitamin C and HDL -- 1-5.Growth hormone-1 in HDL -- 1-6.Growth hormone-2 in HDL -- 1-7.Omega-3 and HDL -- Chapter 2. HDL as therapeutic tools -- 2-1.Delivery vehicle for therapeutics : Overview -- 2-2.Gene delivery: adenovirus and V156K-apoA-I -- 2-3.Solubilization of rapamycin and delivery -- 2-4.Solubilization of minoxidil and delivery -- Chapter 3. Enhancement of HDL by policosanol: anti-aging and longevity -- 3-1.Policosanol and HDL functionality -- 3-2.Policosanol and raising HDL in zebrafish -- 3-3.Policosanol and CETP inhibition: human trial 8 weeks -- 3-4.Policosanol and blood pressure lowering: human trial 8 weeks -- 3-5.Policosanol blood pressure lowering human trial for 24 weeks -- 3-6.Policosanol and improvement of aortic stiffness -- 3-7.Policosanol and blood pressure lowering in rat model -- 3-8.Twelve week consumption of policosanol and lowering blood pressure -- 3-9.Publication analysis of policosanol-related studies -- 3-10.Athero-protective effects of policosanol and sugar cane wax acid -- 3-11.Cuban sugarcane wax acids and policosanol improved serum lipid profiles -- Summary and perspectives -- Epilogue
    Abstract: This book is the second of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. In this volume, the focus is on the improvement of HDL, enhancement of its functionality, and the use of HDL for therapeutic purposes. In the first section, up-to-date information is provided on such topics as the tumor regression-promoting and antidiabetic activities of reconstituted HDL containing V156K apolipoprotein A-I, the enhancement of HDL effects by high doses of vitamin C, the benefits derived from incorporation of growth hormones 1 and 2 into rHDL, and the biological functions of omega-3 linolenic acid in rHDL. The enhancement of HDL functionality by policosanol and the resultant benefits are thoroughly examined in a separate section. Readers will also find the latest information on clinical applications of HDL. Here, specific topics include the enhancement of adenoviral gene delivery and the delivery of rapamycin. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XVI, 268 p. 174 illus. : online resource.
    ISBN: 9789811373831
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  • 2
    Keywords: Biochemistry ; Microbiology ; Biochemistry, general ; Microbiology ; Biological and Medical Physics, Biophysics ; Springer Nature Living Reference
    Abstract: Handbook of Molecular Life Sciences will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. Volumes 1 to 3 will focus on genes and genomes, volumes 4 to 6 on protein structure and function, volumes 7 & 8 will explore systems biology, using genomics and proteomics as the focus and volumes 9 and 10 on molecular aspects of cell structure and function. Volume 11 will explore unifying concepts and theory from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences and will also include sections on teaching perspectives and assessment tools. Volume 12 will cover basic aspects of the various experimental approaches that are used in the Molecular Life Sciences
    Pages: 10000 p. 1000 illus. in color. : online resource.
    ISBN: 9781461464365
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  • 3
    Keywords: Biomedical Engineering ; Biology / Data processing ; Biotechnology ; Biomedical Engineering/Biotechnology ; Computer Appl. in Life Sciences ; Biotechnology ; Springer eBooks
    Description / Table of Contents: The Use of Ultrasound in Educational Settings: What Should We Consider When Implementing this Technique for Visualisation of Anatomical Structures? -- Interactive 3D Visualisation of the Mammalian Circadian System -- Utilising anatomical and physiological visualisations to enhance the face-to-face student learning experience in biomedical sciences and medicine -- Anatomy Visualizations Using Stereopsis: Current Methodologies in Developing Stereoscopic Virtual Models in Anatomical Education -- Statistical Shape Models - Understanding and Mastering Variation in Anatomy -- Towards Advanced Interactive Visualization for Virtual Atlases -- An Experiential Learning-Based Approach to Neurofeedback Visualisation in Serious Games -- Visual Analysis for Understanding Irritable Bowel Syndrome -- A Showcase of Medical, Therapeutic and Pastime Uses of Virtual Reality (VR) and How (VR) Is Impacting the Dementia Sector -- Immersive Technology and Medical Visualisation: A Users Guide
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first six chapters have an anatomical focus examining digital technologies and applications to enhance education. The first examines the history and development of ultrasound, applications in an educational setting, and as a point-of-care ultrasound at the bedside. The second chapter presents a transferable workflow methodology in creating an interactive educational and training package to enhance understanding of the circadian rhythm. The third chapter reviews tools and technologies, which can be used to enhance off-campus learning, and the current range of visualisation technologies like virtual, augmented and mixed reality systems. Chapter four discusses how scanning methodologies like CT imagery, can make stereoscopic models. The fifth chapter describes a novel way to reconstruct 3D anatomy from imaging datasets and how to build statistical 3D shape models, described in a clinical context and applied to diagnostic disease scoring. The sixth chapter looks at interactive visualisations of atlases in the creation of a virtual resource, for providing next generation interfaces. The seventh and eight chapters discuss neurofeedback for mental health education and interactive visual data analysis (applied to irritable bowel disease) respectively. The final two chapters examine current immersive technologies –virtual and augmented reality, with the last chapter detailing virtual reality in patients with dementia. This book is accessible to a wide range of users from faculty and students, developers and computing experts, the wider public audience. It is hoped this will aid understanding of the variety of technologies which can be used to enhance understanding of clinical conditions using modern day methodologies
    Pages: XVI, 141 p. 87 illus., 57 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030193850
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  • 4
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 5
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Preface -- Chapter 1. Understanding HDL: overview -- 1-1.HDL and disease -- 1-2.HDL functions and clinical applications -- 1-3.HDL composition : apolipoproteins and enzymes -- 1-4.Maturation of HDL -- 1-5.HDL and blood pressure -- Chapter 2. Change of HDL by life style -- 2-1.Exercise and HDL -- 2-2.Smoking and HDL -- 2-3.Elderly’s HDL -- 2-4.HDL depends on body weight -- 2-5.HDL from obese but healthy subject -- 2-6.HDL and apoA-I in smokers’ breast milk -- 2-7.Breast milk from frequent trans fatty acid consumers -- 2-8.HDL in cord blood from small neonates -- Chapter 3. Change of HDL in various diseases -- 3-1.HDL from patients with myocardial infarction -- 3-2.HDL from patients with female angina pectoris -- 3-3.HDL and metabolic syndrome -- 3-4.HDL from male patients with atrial fibrillation -- 3-5.HDL from female patients with atrial fibrillation -- 3-6.HDL from patients with hemorrhagic fever with renal syndrome -- 3-7.HDL from patients with rheumatoid arthritis -- 3-8.HDL and prehypertension -- Chapter 4. Detriment of HDL by pollutant and its evaluation -- 4-1.Particulate matter and HDL -- 4-2.Phthalate and HDL -- 4-3.Cadmium and HDL -- 4-4.Humidifier Sterilizer and HDL -- 4-5.Detection of dysfunctional HDL by microfluidics -- 4-6.Evaluation of dysfunctional HDL using zebrafish embryo -- Chapter 5. Change of HDL by food ingredient -- 5-1.Fructose and apoA-I -- 5-2.Fructose and impairment of HDL functionality -- 5-3.Artificial sweeteners and apoA-I -- 5-4.Artificial sweeteners (aspartame, saccharin) and HDL -- 5-5.Aldoketohexoses and HDL -- 5-6.Iron and HDL -- 5-7.Trans fat and HDL -- 5-8.Salt and HDL 576 p -- Summary and perspectives
    Abstract: This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XXIV, 383 p. 244 illus. : online resource.
    ISBN: 9789811373879
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  • 6
    Keywords: Mass spectrometry ; Proteomics ; Biomedical Engineering ; Mass spectrometry ; Proteomics ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Springer eBooks
    Description / Table of Contents: Mass Spectrometry for Proteomics-based Investigation -- MALDI profiling and applications in medicine -- Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry -- Proteome imaging: from classic to modern mass spectrometry-based molecular histology -- Mass Spectrometry-Based Tissue Imaging of Small Molecules -- Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase -- Proteomics and non-proteomics approaches to study stable and transient protein-protein interactions -- Contribution of Mass spectrometry-based Proteomics to Discoveries in Developmental Biology -- Profiling optimal conditions for capturing EDEM proteins complexes in melanoma using mass spectrometry -- The Methods employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein–Protein Interactions (PPIs) -- Identification of post-translational modifications (PTMs) of proteins by mass spectrometry -- Sequence Variant and Post-translational Modification Analysis During Cell Line Selection via High-throughput Peptide Mapping -- Selective derivatization of hexahistidine-tagged recombinant proteins -- Investigation of Antibody-Drug Conjugates by Mass Spectrometry -- Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides -- Strategies for Membrane Protein Analysis by Mass Spectrometry -- The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses -- Application of Ion Mobility Mass Spectrometry in Lipidomics -- Mass Spectrometry in Advancement of Redox Precision Medicine -- Applications for mass spectrometry in the study of ion channel structure and function -- Immuno – affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance -- Developing well-annotated species-specific protein databases using comparative proteogenomics -- Stoichiometry of heavy metal binding to peptides involved in Alzheimer’s disease: mass spectrometric evidence -- Role of mass spectrometry in investigating a novel protein: the example of Tumor Differentiation Factor (TDF) -- Mass Spectrometry-Based Biomarkers in Drug Developmen -- Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery -- Proteomic approaches to dissect neuronal signalling pathways -- Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders -- Simplifying the proteome: Analytical strategies for improving peak capacity -- Exploration of nicotine metabolism in Paenarthrobacter nicotinovorans pAO1 by microbial proteomics -- Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics -- Mass spectrometry based comparative proteomics using one dimensional and two dimensional SDS-PAGE of rat atria induced with obstructive sleep apnea -- 2D SDS PAGE in combination with western blotting and mass spectrometry is a robust method for protein analysis with many applications -- Pulse SILAC approaches to the measurement of cellular dynamics -- Protein Biomarkers in Major Depressive Disorder: an Update -- A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy -- Metabolomics and biomarker discovery -- Analytical Methods for Mass Spectrometry-Based Metabolomics Studies -- Trends in analysis of cortisol and its derivatives -- Detection of biomedically relevant stilbenes from wines by mass spectrometry -- Mass spectrometry as a complementary approach for noncovalently bound complexes based on cyclodextrins -- Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry -- Non-targeted Screening in Environmental Monitoring Programs -- Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and its Future Use for the Molecular Epidemiology of Cancer -- Bottlenecks in proteomics: an update -- Recent Applications of Mass Spectrometry at Clarkson University -- Index
    Abstract: This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field
    Pages: XXI, 813 p. 362 illus., 310 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9783030159504
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  • 7
    Keywords: Pharmaceutical technology ; Biomedical Engineering ; Medical laboratories ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Laboratory Medicine ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction & Literature review -- Materials & Methods -- A Simple Method of Microneedle Array Fabrication for Transdermal Drug Delivery -- Protein Encapsulation in Polymeric Microneedles by Photolithography -- Microneedle Patch for Fast Onset and Long-lasting Delivery of Painkillers -- Microneedle Patch to Deliver Collagen through the Skin -- Recent trends in microneedle development & applications in medicine & cosmetics (2013-2018) -- Conclusions & Future Directions -- Index
    Abstract: This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data
    Pages: X, 156 p. 25 illus., 18 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030154448
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  • 8
    Call number: W160:26(2)
    Keywords: DKFZ-publications ; Signal Transduction / physiology ; Intracellular Signaling Peptides and Proteins / physiology
    Pages: xiii, 639 p. : ill.
    Edition: 2nd edition.
    ISBN: 9780815342151
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  • 9
    Keywords: Biomedical Engineering ; Computer vision ; Computer Simulation ; Radiology, Medical ; Computer science ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Computer Imaging, Vision, Pattern Recognition and Graphics ; Simulation and Modeling ; Imaging / Radiology ; Computational Science and Engineering ; Springer eBooks
    Description / Table of Contents: Chapter 1. The impact of patches on blood flow disorders in carotid artery -- Chapter 2. Numerical study of carotid bifurcation angle effect on blood flow disorders -- Chapter 3. Evaluating the effect of tissue anisotropy on brain tumor growth using a mechanically-coupled reaction-diffusion model -- Chapter 4. Prediction of stress and strain patterns from load rearrangement in human osteoarthritic femur head: finite element study with the integration of muscular forces and friction contact -- Chapter 5. Numerical simulation of the deployment process of a new stent produced by ultrasonic-microcasting: the role of the balloon’s constitutive modeling -- Chapter 6. New techniques for combined FEM-multibody anatomical simulation -- Chapter 7. Computational cell-based modelling and visualization of cancer development and progression -- Chapter 8. Estimation of 6 degree of freedom accelerations from head impact telemetry system outputs for computational modeling -- Chapter 9. Physiological Cybernetics: methods and applications -- Chapter 10. New computational solution to compute the uptake index from 99mTc-MDP bone scintigraphy images
    Abstract: This book gathers selected, extended and revised contributions to the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018), and the 3rd Conference on Imaging and Visualization, which took place on 26-29 March, 2018, in Lisbon, Portugal. The respective chapters highlight cutting-edge methods, e.g. new algorithms, image analysis techniques, and multibody modeling methods; and new findings obtained by applying them in biological and/or medical contexts. Original numerical studies, Monte Carlo simulations, FEM analyses and reaction-diffusion models are described in detail, together with intriguing new applications. The book offers a timely source of information for biologists, engineers, applied mathematicians and clinical researchers working on multidisciplinary projects, and is also intended to foster closer collaboration between these groups
    Pages: X, 160 p. 98 illus., 88 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030230739
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