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  • Cancer Research  (13)
  • Microbiology  (3)
  • DKFZ-publications
  • 1
    Keywords: Medicine ; Cardiology ; Oncology ; Cytology ; Molecular Medicine ; Cardiology ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Advancements in Managing Intracerebral Hemorrhage: Transition from Nihilism to Optimism -- Mandibular Advancement Devices in Patients with Symptoms of Obstructive Sleep Apnea: A Review -- Online Health Technologies and Mobile Devices: Attitudes, Needs and Future -- Radiological Response and Neutrophil-to-Lymphocyte Ratio as Predictive Factors for Progression-Free and Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib -- Plasminogen Activator Inhibitor Type 1 in Blood at Onset of Chemotherapy Unfavorably Affects Survival in Primary Ovarian Cancer -- Sialidase Attenuates Epidermal Growth Factor Response and Abolishes Antiproliferative Effects of Erlotinib in A549Alveolar Epithelial Cells -- Systemic Sclerosis and Serum Content of Transforming Growth Factor -- Protein-Bound Solute Clearance during Hemodialysis -- Mold Sensitization in Asthmatic and Non-Asthmatic Subjects Diagnosed with Extract-Based versus Component-Based Allergens -- Fructose Consumption and Lipid Metabolism in Obese Children and Adolescents -- Vaccination against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement -- Variability of Dry-Eye Disease Following Removal of Lacrimal Glands in Rats
    Abstract: This book shares the latest research and practice-oriented findings in medical sciences with a wide audience. It addresses a range of contemporary issues, often unresolved or contentious, across various medical fields, including advances in the management of hemorrhagic brain stroke. It also discusses metastatic renal cell carcinoma – a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor. Further, it examines the molecular targeting of proliferative signaling of the epidermal growth factor receptor in the first-line treatment of patients with metastatic non-small-cell lung cancer. Other articles cover clearance of toxins in hemodialyzed patients; the search for diagnostic and therapeutic markers in the connective tissue disease scleroderma; obesity linked to inappropriate dietary habit; clinical problems related to the diagnosis of sensitization to fungi and its role in asthma; and reasons for the perilous trend of avoiding basic vaccinations in children. Lastly, the book explores the rapid developments in e-health technologies that increase access to health services, particularly for the elderly. The book is intended for clinical specialists, researchers, and all allied health professionals from various fields
    Pages: VI, 115 p. 17 illus., 10 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030190590
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  • 2
    Call number: W160:26(2)
    Keywords: DKFZ-publications ; Signal Transduction / physiology ; Intracellular Signaling Peptides and Proteins / physiology
    Pages: xiii, 639 p. : ill.
    Edition: 2nd edition.
    ISBN: 9780815342151
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  • 3
    Keywords: Biochemistry ; Microbiology ; Biochemistry, general ; Microbiology ; Biological and Medical Physics, Biophysics ; Springer Nature Living Reference
    Abstract: Handbook of Molecular Life Sciences will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. Volumes 1 to 3 will focus on genes and genomes, volumes 4 to 6 on protein structure and function, volumes 7 & 8 will explore systems biology, using genomics and proteomics as the focus and volumes 9 and 10 on molecular aspects of cell structure and function. Volume 11 will explore unifying concepts and theory from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences and will also include sections on teaching perspectives and assessment tools. Volume 12 will cover basic aspects of the various experimental approaches that are used in the Molecular Life Sciences
    Pages: 10000 p. 1000 illus. in color. : online resource.
    ISBN: 9781461464365
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  • 4
    Keywords: Oncology ; Oncology   ; Toxicology ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Abstract: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on.℗ The chapters are written by national or international experts and specialists.℗
    Pages: Approx. 800 p. 50 illus. : online resource.
    ISBN: 9789400777408
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  • 5
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    Berlin : Springer
    Keywords: Oncology ; Medicine ; Oncology   ; Cancer Research ; Molecular Medicine ; Oncology ; Springer Nature Living Reference
    Abstract: The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in℗ 7 Volumes with an A-Z format of℗ approx. 7000℗ entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative℗ Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public
    Pages: LXXXVI, 3984 p. 1071 illus., 710 illus. in color. : online resource.
    ISBN: 9783642278419
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  • 6
    Keywords: Oncology ; Oncology   ; Toxicology ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Abstract: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists
    Pages: 800 p. 50 illus. : online resource.
    ISBN: 9789400777446
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  • 7
    Keywords: Oncology ; Human Genetics ; Medicine ; Cytology ; Cancer Research ; Human Genetics ; Molecular Medicine ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Preface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index
    Abstract: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease
    Pages: VIII, 160 p. 17 illus., 16 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030127343
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  • 8
    Keywords: Oncology ; Toxicology ; Bioorganic chemistry ; Nanotechnology ; Cancer Research ; Pharmacology/Toxicology ; Bioorganic chemistry ; Nanotechnology ; Springer eBooks
    Description / Table of Contents: Chapter 1. General introduction and sources of flavonoids -- Chapter 2. Analytical techniques for the identification and quantification of Flavonoids -- Chapter 3. Chemistry and Synthetic overview of flavonoids -- Chapter 4. Metal complexation and chemopreventive patent studies of flavonoid -- Chapter 5. Molecular targets of flavonoids in cancer: recent advances -- Chapter 6. Absorption and Metabolism of flavonoids -- Chapter 7. Recent trend in flavonoids studies in term of health prospective -- Chapter 8. Role of nanotechnology in flavonoid mediated anti-cancer therapy -- Chapter 9. Clinical trial of Flavonoids in cancer
    Abstract: The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters
    Pages: XVIII, 181 p. 92 illus., 26 illus. in color. : online resource.
    ISBN: 9789811358746
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  • 9
    Keywords: Oncology ; Human Genetics ; Medicine ; Cytology ; Metabolism ; Cancer Research ; Human Genetics ; Molecular Medicine ; Cell Biology ; Metabolomics ; Springer eBooks
    Description / Table of Contents: Preface -- Molecular and Cell Biology of Cancer when cells break the rules and hijack their own planet -- Cancer as an Evolutionary Process -- Cell signaling in cancer -- The cell cycle, cytoskeleton and cancer -- Genomic Instability: DNA Repair and Cancer -- Cell metabolism in cancer – an energetic switch -- Cancer immunoediting and hijacking of the immune system -- Angiogenesis - vessels recruitment by tumor cells -- Tumor niche disruption and metastasis: the role of epithelial-mesenchymal transition (EMT) -- Case studies - Molecular Pathology perspective and impact on oncologic patients’ management -- Index
    Abstract: This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
    Pages: IX, 216 p. 71 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030118129
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  • 10
    Keywords: Oncology ; Human Genetics ; Database management ; Data mining ; Cancer Research ; Human Genetics ; Database management ; Data Mining and Knowledge Discovery ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Resources -- Data Retrieval -- Text Processing -- Semantic processing -- Index
    Abstract: This open access book is a step-by-step introduction on how shell scripting can help solve many of the data processing tasks that Health and Life specialists face everyday with minimal software dependencies. The examples presented in the book show how simple command line tools can be used and combined to retrieve data and text from web resources, to filter and mine literature, and to explore the semantics encoded in biomedical ontologies. To store data this book relies on open standard text file formats, such as TSV, CSV, XML, and OWL, that can be open by any text editor or spreadsheet application. The first two chapters, Introduction and Resources, provide a brief introduction to the shell scripting and describe popular data resources in Health and Life Sciences. The third chapter, Data Retrieval, starts by introducing a common data processing task that involves multiple data resources. Then, this chapter explains how to automate each step of that task by introducing the required commands line tools one by one. The fourth chapter, Text Processing, shows how to filter and analyze text by using simple string matching techniques and regular expressions. The last chapter, Semantic Processing, shows how XPath queries and shell scripting is able to process complex data, such as the graphs used to specify ontologies. Besides being almost immutable for more than four decades and being available in most of our personal computers, shell scripting is relatively easy to learn by Health and Life specialists as a sequence of independent commands. Comprehending them is like conducting a new laboratory protocol by testing and understanding its procedural steps and variables, and combining their intermediate results. Thus, this book is particularly relevant to Health and Life specialists or students that want to easily learn how to process data and text, and which in return may facilitate and inspire them to acquire deeper bioinformatics skills in the future
    Pages: XV, 98 p. 483 illus., 74 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030138455
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  • 11
    Keywords: Stem Cells ; Oncology ; Cell Cycle ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Cell Cycle Analysis ; Springer eBooks
    Description / Table of Contents: Multilayered heterogeneity of glioblastoma stem cells: biological and clinical significance -- Heterogeneity of head and neck squamous cell carcinoma stem cells -- Heterogeneity of small cell lung cancer stem cells -- Heterogeneity of hepatic cancer stem cells -- Heterogeneity and plasticity of breast cancer stem cells -- Heterogeneity of melanoma with stem cell properties -- Heterogeneity of colon cancer stem cells -- Urothelial cancer stem cell heterogeneity -- Acute myeloid leukemia stem cell heterogeneity and its clinical relevance -- Contribution of chronic myeloid leukaemia (CML) as a disease model to define and study clonal heterogeneity -- The heterogeneity of osteosarcoma: the role played by cancer stem cells -- Ovarian cancer stem cell heterogeneity -- Index
    Abstract: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians
    Pages: XII, 228 p. 24 illus., 18 illus. in color. : online resource.
    ISBN: 9783030143664
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  • 12
    Keywords: Oncology ; Oncology   ; Endocrinology ; Cancer Research ; Oncology ; Endocrinology ; Springer Nature Living Reference
    Description / Table of Contents: Epidemiology: world overview, risk factors, prospects for prevention -- Development and structure of pancreas -- Pathologic classification and biological behaviour of pancreatic neoplasia -- Developmental molecular biology of the pancreas -- Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN) -- Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer -- Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis -- Sporadic neuroendocrine pancreatic tumours -- Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer -- Miscellaneous non-pancreatic non-endocrine tumours -- Novel molecular relationships between chronic pancreatitis and cancer -- Pancreatic cancer stem cells -- Cell cycle control: signalling pathways in pancreatic pathogenesis -- Apoptosis: signalling pathways in pancreatic pathogenesis -- EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK -- Hedgehog: signalling pathways in pancreatic pathogenesis -- Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis -- Notch signalling in pancreatic morphogenesis and pancreatic cancer -- Molecular characterization of pancreatic cell lines -- Mouse models of exocrine pancreatic cancer -- Principles and applications of microarray gene expression in pancreatic cancer -- Principles and applications of proteomics in pancreatic cancer -- Tumour-stromal interaction: invasion and metastases -- Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes -- Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1 -- Clinical decision making in pancreatic cancer -- Paraneoplastic syndromes -- Diagnostic and therapeutic response markers -- CT and fusion PET-CT Diagnosis, staging, and follow-up -- MRI and MRCP: diagnosis and staging of pancreatic cancer -- EUS Diagnosis and staging -- Laparoscopy and laparoscopic ultrasound: diagnosis and staging -- Overview of palliative management for pancreatic cancer -- Endoscopy -- Interventional radiology -- Role of palliative surgery in advanced pancreatic cancer -- Chemotherapy for advanced pancreatic cancer -- Developments in chemoradiation in advanced pancreatic cancer -- Surgical resection for pancreatic cancer -- Role of venous resection in pancreatic cancer surgery -- Pathological reporting and staging following resection -- Japanese Pancreas Society staging for pancreatic cancer -- Adjuvant chemotherapy in pancreatic cancer -- Case for adjuvant chemoradiation therapy for pancreatic cancer -- Case for neoadjuvant treatment in pancreatic cancer -- Borderline resectable disease -- Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms -- Laparoscopic surgery for pancreatic neoplasm -- Modern Japanese approach to pancreas cancer -- Development of novel biomarkers -- Inherited genetics of pancreatic cancer and secondary screening -- Gene therapy for pancreatic cancer -- Vaccine therapy and immunotherapy -- Emerging targets in pancreatic cancer.-
    Abstract: Worldwide, there are an estimated 232, 000 new cases of pancreatic cancer annually. In the United States, it is the fourth leading cause of cancer death, and approximately 30,000 people die of pancreatic cancer each year. The disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this disease is less than 5%. In organizing this handbook, Dr. Neoptolemos and his co-editors will produce a distinguished Major Reference Work devoted to pancreatic cancer. This handbook will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer (there is currently an unprecedented investment by academia and industry in this field), each researcher’s knowledge of other specialty areas outside his or her own is now often quite limited. The aim of this book is to place these the tangible advances—those that are indispensable to all working on pancreatic cancer—readily at hand. The book will focus on advances that will not become dated, and the editors will choose authors who are the very best in each area
    Pages: 208 illus., 60 illus. in color. : online resource.
    ISBN: 9781493966318
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  • 13
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 14
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    Stuttgart : Thieme
    Call number: QR46:18(7)
    Keywords: Microbiology
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Pages: xx, 718 p.
    Edition: 7., vollst. überarb. u. erw. Aufl.
    ISBN: 9783132423558
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  • 15
    Keywords: Oncology ; Medicine ; Immunology ; Human Genetics ; Cancer Research ; Molecular Medicine ; Immunology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Mhc/Hla Class I Loss In Cancer Cells -- Hla Class-I Expression And Cancer Immunotherapy -- Hla Class-Ii Expression In Human Tumors -- Index
    Abstract: This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the €œÁntigen Presenting Moleculeś€ and the ́€œT Lymphocyteś€. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between ́€œself and non self́€. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast́€Œect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in ́€œTumor Immunologý€&#x9d
    Pages: X, 101 p. 41 illus., 38 illus. in color. : online resource.
    ISBN: 9783030178642
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  • 16
    Keywords: Oncology ; Immunology ; Medicine ; Cancer Research ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index
    Abstract: This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients
    Pages: XIX, 256 p. 21 illus. in color. : online resource.
    ISBN: 9783030166243
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  • 17
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    New York, NY : Springer
    Keywords: Oncology ; Oncology   ; Medical laboratories ; Internal Medicine ; Medicine ; Toxicology ; Cancer Research ; Oncology ; Laboratory Medicine ; Internal Medicine ; Molecular Medicine ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Abstract: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well
    Pages: 800 p. 164 illus., 64 illus. in color. : online resource.
    ISBN: 9781461466130
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