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  • 1
    Keywords: Oncology ; Neurosciences ; Cancer Research ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Introduction to Brain Tumor Stem Cells -- Isolation and Culture of Glioblastoma Brain Tumor Stem Cells -- Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines -- Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors -- Detecting Stem Cell Marker Expression Using the NanoString nCounter System -- Flow Cytometric Analysis of Brain Tumor Stem Cells -- In Vitro Self-Renewal Assays for Brain Tumor Stem Cells -- Differentiation of Brain Tumor Initiating Cells -- The Study of Brain Tumor Stem Cell Migration -- The Study of Brain Tumor Stem Cell Invasion -- Cell Cycle Dynamics in Glioma Cancer Stem Cells -- Embryonic Stem Cell Models of Human Brain Tumors -- Chromatin Immunoprecipitation (ChIP) Protocols for the Cancer and Developmental Biology Laboratory -- EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF -- Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells -- In Vitro Assays for Screening Small Molecules -- Drug Delivery in an Orthotopic Tumor Stem Cell-Based Model of Human Glioblastoma -- Engineering Inducible Knock-In Mice to Model Oncogenic Brain Tumor Mutations from Endogenous Loci -- In Vivo Murine Models of Brain Metastasis -- Cellular Magnetic Resonance Imaging for Tracking Metastatic Cancer Cells in the Brain
    Abstract: This detailed volume compiles the best methodologies and experimental techniques to profile and extract maximal data from brain tumor stem cells (BTSCs), the experimental paradigm for brain cancer research that offers insights into cancer stem cell populations that may drive not only tumor initiation but tumor recurrence and patient relapse. The BTSC model recapitulates scientific observations made in brain cancer patients, and these chapters provide the reader with a comprehensive understanding of the skills and techniques that will unlock data from this most informative subset of cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Brain Tumor Stem Cells: Methods and Protocols serves as an ideal guide for researchers seeking to better understand the complexities of brain cancer
    Pages: XII, 254 p. 40 illus., 34 illus. in color. : online resource.
    ISBN: 9781493988051
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  • 2
    Singapore : Springer
    Keywords: Oncology ; Human Genetics ; Medicine ; Biomedical Engineering ; Medical laboratories ; Cancer Research ; Human Genetics ; Molecular Medicine ; Biomedical Engineering/Biotechnology ; Laboratory Medicine ; Springer eBooks
    Description / Table of Contents: 1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance
    Abstract: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians
    Pages: XII, 313 p. 51 illus., 50 illus. in color. : online resource.
    ISBN: 9789811315688
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  • 3
    New York, NY : Springer
    Keywords: Oncology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: An Access Primer to Repositories of Cancer-related Genomic Big Data -- Building Portable and Reproducible Cancer Informatics Workflows: An RNA Sequencing Case Study -- Computational Analysis of Structural Variation in Cancer Genomes -- CORE: A Software Tool for Delineating Regions of Recurrent DNA Copy Number Alteration in Cancer -- Identification of Mutated Cancer Driver Genes on Unpaired RNA-Seq Samples -- A Computational Protocol for Detecting Somatic Mutations by Integrating DNA and RNA Sequencing -- Allele-specific Expression Analysis in Cancer Using Next Generation Sequencing Data -- Computational Analysis of lncRNA Function in Cancer -- Computational Methods for Identification of T Cell Neoepitopes in Tumors -- Computational and Statistical Analysis of Array-based DNA Methylation Data -- Computational Methods for Subtyping Of Tumors and their Applications for Deciphering Tumor Heterogeneity -- Statistically Supported Identification of Tumor Subtypes -- Computational Methods for Analysis of Tumor Clonality and Evolutionary History -- Predictive Modeling of Anti-cancer Drug Sensitivity from Genetic Characterizations -- In silico Oncology Drug Repositioning and Polypharmacology -- Modelling Growth of Tumours and their Spreading Behaviour using Mathematical Functions
    Abstract: This volume covers a wide variety of state of the art cancer-related methods and tools for data analysis and interpretation. Chapters were designed to attract a broad readership, ranging from active researchers in computational biology and bioinformatics developers, clinical oncologists, and anti-cancer drug developers wishing to rationalize their search for new compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, installation instructions for computational tools discussed, explanations of the input and output formats, and illustrative examples of applications. Authoritative and cutting-edge, Cancer Bioinformatics: Methods and Protocols aims to support researchers performing computational analysis of cancer-related data
    Pages: X, 280 p. 89 illus., 64 illus. in color. : online resource.
    ISBN: 9781493988686
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  • 4
    Keywords: Oncology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Ex-Vivo signal Transduction Studies in Chronic Lymphocytic Leukemia -- Ex vivo Pharmacological Profiling in Chronic Lymphocytic Leukemia Cells -- Culture and Harvest of CpG-stimulated Blood and Bone Marrow in Chronic Lymphocytic Leukemia -- Analysis of Common Abnormalities seen in Chronic Lymphocytic Leukemia using Fluorescence in situ Hybridization -- Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia -- Detection and Functional Analysis of TP53 Mutations in CLL -- The Development and Use of Scalable Systems for Studying Aberrant Splicing in SF3B1-mutant CLL -- Methods for Investigating VLA-4 (CD49d/CD29) Expression and Activation in Chronic Lymphocytic Leukemia and its Clinical Applications -- In vitro Assay to Study CLL and Monocyte Interactions -- Extracellular Flux Assays to Determine Oxidative Phosphorylation and Glycolysis in Chronic Lymphocytic Leukemia Cells -- Measurement of Leukemic B-cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia -- Assays on DNA Damage and Repair in CLL -- Method for Generating a Patient-Derived Xenograft Model of CLL -- Immunological Methods to Study Monoclonal Antibody Activity in Chronic Lymphocytic Leukemia -- CRISPR/Cas9-based Gene Dropout Screens -- Gene Disruption using CRISPR-Cas9 Technology -- Minimal Residual Disease Quantification in Chronic Lymphocytic Leukemia: Clinical Significance and Flow Cytometric Methods -- Rare Variant Quantitation Using Droplet Digital PCR -- Methods for Measuring ctDNA in Lymphomas -- Measurement of miRNAs in Chronic Lymphocytic Leukemia Patient Samples by Quantitative Reverse Transcription PCR -- Bioinformatics Analysis of Whole Exome Sequencing Data -- Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia -- Characterization of Somatically-acquired Copy Number Alterations in Chronic Lymphocytic Leukaemia using Shallow Whole Genome Sequencing -- High-throughput Sequencing of the T Cell Receptor Beta Chain Gene Repertoire in Chronic Lymphocytic Leukemia
    Abstract: This book aims to provide scientists with tools and well-researched protocols to enable their research and to facilitate further progress in this common leukemia. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chronic Lymphocytic Leukemia: Methods and Protocols aims to accelerate research on chronic lymphocytic leukemia and further improvements in patient outcomes
    Pages: XII, 373 p. 44 illus., 37 illus. in color. : online resource.
    ISBN: 9781493988761
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  • 5
    Keywords: Biological models ; Metabolism ; Proteomics ; Animal genetics ; Oncology ; Systems Biology ; Metabolomics ; Proteomics ; Animal Genetics and Genomics ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Recent Development in Omics Studies -- Functional Genomics -- Proteomics in Systems Biology -- Metabolomics in Systems Biology -- Integrative Multi-Omics Through Bioinformatics -- Index
    Abstract: This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics’ platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers’ understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run
    Pages: XIX, 99 p. 31 illus., 18 illus. in color. : online resource.
    ISBN: 9783319987583
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  • 6
    Keywords: Oncology ; Stem Cells ; Cancer Research ; Stem Cells ; Springer eBooks
    Description / Table of Contents: Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut -- Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens -- Glutathione and Transsulfuration in Alcohol-associated Tissue Injury and Carcinogenesis -- Fatty liver disease and hepatocellular carcinoma: The pathologist’s view -- Alcoholic liver disease accelerates early hepatocellular cancer in a mouse model -- Chronic ethanol consumption and generation of etheno-DNA adducts in cancer-prone tissues -- Role of TGF-β in Alcohol-Induced Liver Disease -- NANOG-dependent metabolic reprogramming and symmetric division in tumor-initiating stem-like cells -- Diet supplementation with soy protein isolate, but not the isoflavone genistein, protects against alcohol-induced tumor progression in DEN-treated male mice -- ALDH1L1 and ALDH1L2 folate regulatory enzymes in cancer -- Developmental Morphogens & Recovery from Alcoholic Liver Disease -- Suppressed fat mobilization due to PNPLA3 rs738409 -associated liver damage in heavy drinkers: The liver damage feedback hypothesis -- Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease -- Engineered animal models designed for investigating ethanol metabolism, toxicity and cancer -- Index
    Abstract: Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption
    Pages: XII, 271 p. 36 illus., 23 illus. in color. : online resource.
    ISBN: 9783319987880
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  • 7
    Keywords: Cell Cycle ; Medicine ; Oncology ; Urology ; Radiology, Medical ; Cell Cycle Analysis ; Molecular Medicine ; Cancer Research ; Urology ; Diagnostic Radiology ; Springer eBooks
    Description / Table of Contents: 1. The role of imaging in clinical prostate cancer – Overview of Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Dynamic Contrast-Enhanced MRI (DCE-MRI), MR spectroscopic Imaging (MRSI), Photoacoustic Imaging (PAI) -- 2. Automated quantitative cell and tissue imaging technologies -- 3. Diagnostic and early prostate cancer imaging; imaging of advanced prostate cancer -- 4. Emerging radiation techniques -- 5. Radiation therapy and partial prostate irradiation -- 6. Prostate cancer screening: radiology perspectives -- 7. Preclinical imaging of metastasis and dormancy: clinical implications -- 8. Utility of CT in the management of prostate cancer -- 9. Nanotechnology, cancer diagnosis and treatments -- 10. Imaging approaches to distinguish lethal from non-lethal disease -- 11. Photoacoustic imaging -- 12. Molecular and anatomical imaging in drug development -- 13. Molecular imaging modalities including CT, PET, SPECT, MRI, MRS, Hyperpolarized MRI, Ultrasound, X-ray computed tomography, Fusion Imaging (Molecular/Anatomic) -- 14. Functional imaging (PET vs. SPECT) -- 15. Optical bioluminescence molecular imaging -- 16. Therapeutic radiopharmaceutical translational research imaging -- 17. Accuracy of magnetic resonance imaging for local staging of prostate cancer: diagnostic meta-analysis -- 18. Adjuvant radiotherapy for pathologically advanced prostate cancer: randomized clinical trial -- 19. High-intensity focused ultrasound (HIFU) with histopathological analysis -- 20. Image-directed, tissue-preserving focal therapy of prostate cancer with a novel deformable magnetic resonance-ultrasound (MR-US) registration system -- 21. Focal therapy for localized unifocal and multifocal prostate cancer -- 22. Focal cryotherapy for clinically unilateral, low to intermediate risk prostate cancer -- 23. Impact of obesity on clinico-pathologic outcomes after robot-assisted laparoscopic prostatectomy -- 24. Body mass index, prostate weight and transrectal ultrasound prostate volume accuracy
    Abstract: The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature
    Pages: XI, 194 p. 23 illus., 19 illus. in color. : online resource.
    ISBN: 9783319992860
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  • 8
    Keywords: Oncology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Subtyping of IPMN -- Clinical Management and Surgical Decision-Making of IPMN of the Pancreas -- Develop Nomogram to Predict Malignancy of Intraductal Papillary Mucinous Neoplasm -- Generation of Induced Pluripotent Stem Cell-Like Lines from Human Pancreatic Ductal Adenocarcinoma -- Lineage Tracing of Primary Human Pancreatic Acinar and Ductal Cells for Studying Acinar to Ductal Metaplasia -- Spheroid Culture of Human Pancreatic Ductal Cells to Reconstitute Development of Pancreatic Intraepithelial Neoplasia -- Pancreatic Microtumors: A Novel D Ex Vivo Testing Platform -- 3D Models of Pancreatic Ductal Adenocarcinoma via Tissue Engineering -- Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens -- Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma -- An In Vitro Three-Dimensional Organotypic Model to Analyze Peripancreatic Fat Invasion in Pancreatic Cancer: A Culture System Based on Collagen Gel Embedding -- Osteoclasts Differentiation Assay -- Primary Cultures for Pancreatic Stellate Cells (PSCs) -- Cytokine Profiling and Orthotopic Xenografing of Pancreatic Stellate Cells -- Quantitative Method to Track Proteolytic Invasion in 3D Collagen -- Detection and Quantification of Macropinosomes in Pancreatic Tumors -- Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo -- Methods for Monitoring Macroautophagy in Pancreatic Cancer Cells -- Measurement of Reactive Oxygen Species by Fluorescent Probes in Pancreatic Cancer Cells -- Evaluating the Metabolic Alterations in Pancreatic Cancer -- Isolation of Extracellular Vesicles for Cancer Diagnosis and Functional Studies -- Evaluation of Post-Transcriptional Gene Regulation in Pancreatic Cancer Cells: Studying RNA Binding Proteins and their mRNA Targets -- Laser Capture Microdissection on Frozen Sections for Extraction of High-Quality Nucleic Acids -- Statistical Methods for Identifying Biomarkers from miRNA Profiles of Cancers -- Induction of Pancreatic Inflammation Accelerates Pancreatic Tumorigenesis in Mice -- Pancreatic Acinar to Ductal Metaplasia and Pancreatic Cancer -- Orthotopic Pancreatic Tumor Mouse Models of Liver Metastasis -- Molecular and Physiological Evaluation of Pancreatic Cancer-Induced Cachexia
    Abstract: This third edition volume expands on the previous editions with discussions on the latest developments in 2D- and 3D-organoid cultures that allow for the execution of precision medicine, and in vitro studies of tumor cell growth and invasion. The chapters in this book explore protocols for evaluating macropinocytosis, stress granules, autophagy, metabolic alterations, and reactive oxygen species, which have showed to be possible therapeutic opportunities. The protocols described in this book look at both human and animal models, ranging from in vitro and in vivo, and will aid in future research of pancreatic cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Pancreatic Cancer: Methods and Protocols, Third Edition is a valuable resource for scientists and researchers who are interested in learning more about ways to improving patient care for pancreatic cancer
    Pages: XII, 337 p. 51 illus., 40 illus. in color. : online resource.
    Edition: 3rd ed. 2019.
    ISBN: 9781493988792
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