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  • 1
    Keywords: Human Genetics ; Human Physiology ; Epidemiology ; Genetics ; Genetics / Mathematics ; Human Genetics ; Human Physiology ; Epidemiology ; Genetics and Genomics ; Genetics and Population Dynamics ; Springer eBooks
    Description / Table of Contents: Preface -- Life-cycle approach for prevention of non-communicable diseases (NCDs) -- Early origins of health and disease in development of NCDs -- Epigenetic and NCDs -- The role of environmental disruptor chemicals in development of NCDs -- Early life nutrition and NCDs -- Prevention and control of childhood obesity: the backbone in prevention of NCDs -- Index
    Abstract: This book is about primordial prevention of non-communicable diseases (NCDs). It is a comprehensive overview on developmental origins of health and disease regarding various factors related to the origins of NCDs from early life. It provides a summary of the impacts of various factors including epigenetics; gene-environment interaction; ethnic predisposition to NCDs and their risk factors; prenatal factors; fetal programming; maternal weight status; type of feeding during infancy; growth pattern during childhood; obesity; socioeconomic status; dietary and physical activity habits; as well as environmental factors for attenuating the development and progress of NCDs and their risk factors. We discuss about comprehensive interventions including modification for healthy lifestyle, regular physical activity, decrease screen time and behavioral interventions for management of childhood obesity. The present book is especially suitable for students, faculty members, researchers, and the entire health care system
    Pages: VII, 67 p. 3 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030106164
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  • 2
    Keywords: Human Genetics ; Lipids ; Human Physiology ; Cytology ; Oncology ; Medicine ; Human Genetics ; Lipidology ; Human Physiology ; Cell Biology ; Cancer Research ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Prelims -- Introduction -- Understanding the role of pro-resolving lipid mediators in infectious keratitis -- Immunoresolvent resolvin D1 maintains the health of the ocular surface -- The evolving role of specialized pro-resolving mediators in modulating neuroinflammation in perioperative neurocognitive disorders -- Relationship between specialized pro-resolving mediators and inflammatory markers in chronic cardiac disorders -- Specialized pro-resolving mediators directs cardiac healing and repair with activation of inflammation and resolution program in heart failure -- Novel n-3 docosapentaneoic acid-derived pro-resolving mediators are vasculoprotective and mediate the actions of statins in controlling inflammation -- Aspects of prostaglandin glycerol ester biology -- Targeting the COX/mPGES-1/PGE2 pathway in neuroblastoma -- Metabolomics biomarkers for precision psychiatry -- Cytochrome P450 eicosanoid signaling pathway in colorectal tumorigenesis -- Contributions of 12/15-Lipoxygenase to bleeding in the brain following ischemic stroke -- Systematic understanding of bioactive lipids in neuro-immune interactions: Lessons from an animal model of multiple sclerosis -- Role of bioactive sphingolipids in inflammation and eye diseases -- Roles of ceramides and other sphingolipids in immune cell function and inflammation -- Acute and chronic mild traumatic brain injury differentially changes levels of bioactive lipids in the CNS associated with headache -- Novel anti-inflammatory and vasodilatory ω-3 endocannabinoid epoxide regioisomers -- Overview of lipid biomarkers in Amyotrophic Lateral Sclerosis (ALS) -- Flavonoids ability to disrupt inflammation mediated by lipid and cholesterol oxidation -- Index
    Abstract: This book examines the role of bioactive lipids as pro- and anti-inflammatory mediators in the diagnosis of and as novel therapies for cardiovascular disease, cancer, ocular and neurologic diseases, and inflammatory conditions. The major pathways of arachidonic acid and omega-3 fatty acid metabolism are represented, including cyclooxygenases, lipoxygenases, cytochrome P450 monooxygenases, specialized pro-resolving mediators, endocannabinoids, and ceramide and other sphingolipids. This book would be of great interest to basic and translational researchers, as well as physician-scientists working on selected topics (e.g., cancer, cardiovascular disease, stroke, diabetes, inflammation, etc.) in which the underlying role of lipid mediators in the pathophysiology is known or suspected. This compilation of peer-reviewed manuscripts represents reviews of timely topics presented at the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases. Authors selected are outstanding junior investigators representative of future leaders in the field of bioactive lipids
    Pages: IX, 257 p. 43 illus., 39 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030217358
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  • 3
    Keywords: Aging ; Developmental Biology ; Medicine ; Human Physiology ; Immunology ; Biogerontology ; Molecular Medicine ; Human Physiology ; Immunology ; Springer eBooks
    Description / Table of Contents: Introduction -- Section-1 BIOMARKERS OF AGING AND HEALTH -- Practical Detection of Biological Age: Why it is not a trivial task -- Biological age is a universal marker of aging, stress, and frailty -- Biomarkers of health and healthy ageing from the outside-in -- Biomarkers of aging -- Review of molecular and cellular biomarkers of aging -- Section-2 PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING -- IgG glycans as a biomarker of biological age -- Oxidatively modified proteins and maintenance systems as biomarkers of aging -- Is impaired proteodynamics a key to understand the biomarkers of cellular aging -- Section-3 GENETICS AND EPIGENETICS AGING MARKERS -- Genetic markers of extreme human longevity -- Epigenetic biomarkers of aging -- DNA methylation biomarkers to assess biological age -- Epigenetics of brain aging: lessons from chemo brain and tumor brain -- Approaches and methods for variant analysis in a cell -- Section 4 IMMUNOSENESCENCE AND INFLAMMAGING MARKERS -- Is there any reliable biomarker for immunosenescence and inflammaging? -- Immune parameters associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar populations -- Gut microbiota and aging -- Section-5 SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS -- Deep integrated biomarkers of aging -- Quantification of the biological age of the brain using -- Arterial aging: the role of hormonal and metabolic status and telomere biology -- Circulating Biomarkers of Aging -- Molecular signature of aging driven by Wnt signaling pathway: Lessons from nematodes -- The problem of integrating of biological and clinical markers of aging -- Index
    Abstract: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the €œépigenetic clock,́€ as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers
    Pages: VII, 421 p. 39 illus., 34 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030249700
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