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  • 1
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 2
    Keywords: Immunology ; Evolution (Biology) ; Developmental Biology ; Immunology ; Evolutionary Biology ; Developmental Biology ; Springer eBooks
    Description / Table of Contents: Chapter 1: What makes evolution tick? -- Chapter 2: Immunity - the unicellular to metazoan transition -- Chapter 3: Innate immunity -- Chapter 4: The triumph of individualism: evolution of somatically generated adaptive immune systems -- Chapter 5: The other side of the arms race -- Chapter 6: Postface
    Abstract: Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge
    Pages: XVI, 145 p. 26 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030186678
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  • 3
    Keywords: Immunology ; Proteins  ; Molecular Biology ; Immunology ; Protein Structure ; Molecular Medicine ; Receptors ; Springer eBooks
    Description / Table of Contents: Structural basis for signalling through shared common g chain cytokines -- MHC Molecules, T Cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins–Key Elements of Adaptive and Innate Immunity -- Structures of Immune Checkpoints: An Overview on the CD28-B7 Family -- Interleukin-10 family cytokines immunobiology and structure -- Structural insights into the interleukin-17 family cytokines and their receptors -- Structural biology of NOD-like receptors -- AIM2 Inflammasome Assembly and Signaling -- Structures of RIG-I-like receptors and insights into viral RNA sensing -- Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death -- NF-κB, IκB, and IKK: Integral Components of Immune System Signaling
    Abstract: This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function
    Pages: XIII, 226 p. 86 illus., 84 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811393679
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