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  • 1
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 2
    Keywords: Medical Microbiology ; Molecular Biology ; Medical Microbiology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Part I: Bacteriophages as antibacterialagents -- Chapter 1:Production of PhageTherapeutics and Formulations – InnovativeApproaches -- Chapter 2:Phagepharmacokinetics: relationship with administrationroute -- Chapter 3:BacterialResistance to Phage and itsImpact on Clinical Therapy -- Part II: Bacteriophages and the immune system -- Chapter 4:Phageinteraction with the mammalianimmune system -- Chapter 5:Humoralimmuneresponse to phage-basedtherapeutics -- Part III:Use of bacteriophages to combat bacterial infections -- Chapter 6:How to achieve a goodphage therapy clinical trial? -- Chapter 7: Perspectives on the RenewedInterest in the United States -- Chapter 8:Phage Therapy in Orthopaedic Implant-associated Infections -- Chapter 9:The use of bacteriophages in animalhealth and food protection -- Chapter 10:Combiningbacteriophages with otherantibacterialagents to combatbacteria -- Chapter 11: Phage therapy of infectious biofilms: Challenges and strategies -- Part IV:Phage therapy – regulatory and ethical aspects -- Chapter 12:Regulatory Considerations for Bacteriophage Therapy Products -- Chapter 13:Developing phagesintomedicines for Europe -- Chapter 14: Phagetherapy in Europe: Regulatory and intellectualpropertyprotectionissues -- Chapter 15:Ethics of phagetherapy -- Part V: Bacteriophage-derived antibacterial agents -- Chapter 16: NovelAlternative to Antibiotics
    Abstract: This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies
    Pages: XIII, 385 p. 26 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030267360
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