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  • Medicine  (15)
  • Molecular Biology
  • Biomedical Research
  • Microbiology
  • DKFZ-publications
  • 1
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 2
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    Singapore : Springer
    Call number: QH324:49
    Keywords: Bioinformatics ; Medicine ; Statistics ; Biomedicine general ; Statistics for Life Sciences, Medicine, Health Sciences
    Description / Table of Contents: Part 1. BIOINFORMATICS FOR LIFE AND PERSONAL GENOME INTERPRETATION -- Chapter 1. Bioinformatics For Life -- Chapter 2. Next Generation Sequencing and Personal Genome Data Analysis -- Chapter 3. Personal Genome Data Analysis -- Chapter 4. Personal Genome Interpretation and Disease Risk Prediction -- Part 2. ADVANCED MICROARRAY DATA ANALYSIS -- Chapter 5. Advanced Microarray Data Analysis -- Chapter 6. Gene Expression Data Analysis -- Chapter 7. Gene Ontology and Biological Pathway-based Analysis -- Chapter 8. Gene-set Approaches and Prognostic Subgroup Prediction -- Chapter 9. MicroRNA Data Analysis -- Part 3. NETWORK BIOLOGY, SEQUENCE, PATHWAY AND ONTOLOGY INFORMATICS -- Chapter 10. Network Biology, Sequence, Pathway and Ontology Informatics -- Chapter 11. Motif and Regulatory Sequence Analysis -- Chapter 12. Molecular Pathways and Gene Ontology -- Chapter 13. Biological Network Analysis -- Part 4. SNPS, GWAS AND CNVS, INFORMATICS FOR GENOME VARIANTS -- Chapter 14. SNPs, GWAS, CNVs: Informatics for Human Genome Variations -- Chapter 15. SNP Data Analysis -- Chapter 16. GWAS Data Analysis -- Chapter 17. CNV Data Analysis -- Part 5. METAGENOME AND EPIGENOME, BASIC DATA ANALYSIS -- Chapter 18. Metagenome and Epigenome Data Analysis -- Chapter 19. Metagenome Data Analysis -- Chapter 20. Epigenome Databases and Tools -- Chapter 21. Epigenome Data Analysis -- Appendix A. BASIC PRACTICE USING R FOR DATA ANALYSIS -- Appendix B. APPLICATION PROGRAM FOR GENOME DATA ANALYSIS INSTALL GUIDE
    Abstract: This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. This textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics
    Pages: xvi, 367 p. : ill.
    ISBN: 9789811319419
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  • 3
    Keywords: Medicine ; Cardiology ; Oncology ; Cytology ; Molecular Medicine ; Cardiology ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Advancements in Managing Intracerebral Hemorrhage: Transition from Nihilism to Optimism -- Mandibular Advancement Devices in Patients with Symptoms of Obstructive Sleep Apnea: A Review -- Online Health Technologies and Mobile Devices: Attitudes, Needs and Future -- Radiological Response and Neutrophil-to-Lymphocyte Ratio as Predictive Factors for Progression-Free and Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib -- Plasminogen Activator Inhibitor Type 1 in Blood at Onset of Chemotherapy Unfavorably Affects Survival in Primary Ovarian Cancer -- Sialidase Attenuates Epidermal Growth Factor Response and Abolishes Antiproliferative Effects of Erlotinib in A549Alveolar Epithelial Cells -- Systemic Sclerosis and Serum Content of Transforming Growth Factor -- Protein-Bound Solute Clearance during Hemodialysis -- Mold Sensitization in Asthmatic and Non-Asthmatic Subjects Diagnosed with Extract-Based versus Component-Based Allergens -- Fructose Consumption and Lipid Metabolism in Obese Children and Adolescents -- Vaccination against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement -- Variability of Dry-Eye Disease Following Removal of Lacrimal Glands in Rats
    Abstract: This book shares the latest research and practice-oriented findings in medical sciences with a wide audience. It addresses a range of contemporary issues, often unresolved or contentious, across various medical fields, including advances in the management of hemorrhagic brain stroke. It also discusses metastatic renal cell carcinoma – a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor. Further, it examines the molecular targeting of proliferative signaling of the epidermal growth factor receptor in the first-line treatment of patients with metastatic non-small-cell lung cancer. Other articles cover clearance of toxins in hemodialyzed patients; the search for diagnostic and therapeutic markers in the connective tissue disease scleroderma; obesity linked to inappropriate dietary habit; clinical problems related to the diagnosis of sensitization to fungi and its role in asthma; and reasons for the perilous trend of avoiding basic vaccinations in children. Lastly, the book explores the rapid developments in e-health technologies that increase access to health services, particularly for the elderly. The book is intended for clinical specialists, researchers, and all allied health professionals from various fields
    Pages: VI, 115 p. 17 illus., 10 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030190590
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  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Chapter 1. Improvement of HDL -- 1-1.Clinical application of HDL: Overview -- 1-2.Regression effect of V156K-apoA-I -- 1-3.Anti-diabetic effect of V156K-apoA-I -- 1-4.Vitamin C and HDL -- 1-5.Growth hormone-1 in HDL -- 1-6.Growth hormone-2 in HDL -- 1-7.Omega-3 and HDL -- Chapter 2. HDL as therapeutic tools -- 2-1.Delivery vehicle for therapeutics : Overview -- 2-2.Gene delivery: adenovirus and V156K-apoA-I -- 2-3.Solubilization of rapamycin and delivery -- 2-4.Solubilization of minoxidil and delivery -- Chapter 3. Enhancement of HDL by policosanol: anti-aging and longevity -- 3-1.Policosanol and HDL functionality -- 3-2.Policosanol and raising HDL in zebrafish -- 3-3.Policosanol and CETP inhibition: human trial 8 weeks -- 3-4.Policosanol and blood pressure lowering: human trial 8 weeks -- 3-5.Policosanol blood pressure lowering human trial for 24 weeks -- 3-6.Policosanol and improvement of aortic stiffness -- 3-7.Policosanol and blood pressure lowering in rat model -- 3-8.Twelve week consumption of policosanol and lowering blood pressure -- 3-9.Publication analysis of policosanol-related studies -- 3-10.Athero-protective effects of policosanol and sugar cane wax acid -- 3-11.Cuban sugarcane wax acids and policosanol improved serum lipid profiles -- Summary and perspectives -- Epilogue
    Abstract: This book is the second of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. In this volume, the focus is on the improvement of HDL, enhancement of its functionality, and the use of HDL for therapeutic purposes. In the first section, up-to-date information is provided on such topics as the tumor regression-promoting and antidiabetic activities of reconstituted HDL containing V156K apolipoprotein A-I, the enhancement of HDL effects by high doses of vitamin C, the benefits derived from incorporation of growth hormones 1 and 2 into rHDL, and the biological functions of omega-3 linolenic acid in rHDL. The enhancement of HDL functionality by policosanol and the resultant benefits are thoroughly examined in a separate section. Readers will also find the latest information on clinical applications of HDL. Here, specific topics include the enhancement of adenoviral gene delivery and the delivery of rapamycin. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XVI, 268 p. 174 illus. : online resource.
    ISBN: 9789811373831
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  • 5
    Keywords: Oncology ; Medicine ; Immunology ; Human Genetics ; Cancer Research ; Molecular Medicine ; Immunology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Mhc/Hla Class I Loss In Cancer Cells -- Hla Class-I Expression And Cancer Immunotherapy -- Hla Class-Ii Expression In Human Tumors -- Index
    Abstract: This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the €œÁntigen Presenting Moleculeś€ and the ́€œT Lymphocyteś€. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between ́€œself and non self́€. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast́€Œect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in ́€œTumor Immunologý€&#x9d
    Pages: X, 101 p. 41 illus., 38 illus. in color. : online resource.
    ISBN: 9783030178642
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  • 6
    Keywords: Biochemistry ; Microbiology ; Biochemistry, general ; Microbiology ; Biological and Medical Physics, Biophysics ; Springer Nature Living Reference
    Abstract: Handbook of Molecular Life Sciences will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. Volumes 1 to 3 will focus on genes and genomes, volumes 4 to 6 on protein structure and function, volumes 7 & 8 will explore systems biology, using genomics and proteomics as the focus and volumes 9 and 10 on molecular aspects of cell structure and function. Volume 11 will explore unifying concepts and theory from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences and will also include sections on teaching perspectives and assessment tools. Volume 12 will cover basic aspects of the various experimental approaches that are used in the Molecular Life Sciences
    Pages: 10000 p. 1000 illus. in color. : online resource.
    ISBN: 9781461464365
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  • 7
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    New York, NY : Springer
    Keywords: Human Genetics ; Medicine ; Human Genetics ; Cytogenetics ; Molecular Medicine ; Springer Nature Living Reference
    Description / Table of Contents: Acardia -- Achondrogenesis -- Achondroplasia -- Adams-Oliver syndrome -- Agnathia -- Aicardi syndrome -- Alagille syndrome -- Albinism -- Alpha thalassemia-mental retardation (ATR-X) syndrome -- Ambiguous genitalia -- Amniotic deformity, adhesions, mutilations (ADAM) syndrome -- Androgen insensitivity syndrome -- Angelman syndrome -- Apert syndrome -- Aplasia cutis congenita -- Arthrogryposis multiplex congenita -- Asphyxiating thoracic dystrophy -- Ataxia telangiectasia -- Atelosteogenesis -- Autism -- Bannayan-Riley-Ruvalcaba syndrome -- Beckwith-Wiedemann syndrome -- Behcet disease -- Biotinidase deficiency -- Bladder exstrophy -- Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) -- Body stalk anomaly -- Brachydactyly -- Branchial cleft cyst -- Calcinosis cutis -- Campomelic dysplasia -- Carpenter syndrome -- Cat-eye syndrome -- Celiac disease -- Cerebral palsy -- Cerebro-costo-mandibular syndrome -- Charcot-Marie-Tooth disease -- CHARGE association -- Cherubism -- Chiari malformation -- Chondrodysplasia punctata -- Chromosome abnormalities in pediatric solid tumors -- Cleft lip/palate -- Cleidocranial dysplasia -- Cloacal exstrophy -- Clubfoot (talipes equinovarus) -- Collodion baby -- Congenital adrenal hyperplasia -- Congenital cutis laxa -- Congenital cytomegalovirus infection -- Congenital generalized lipodystrophy -- Congenital hemihyperplasia (congenital hemihypertrophy) -- Congenital hydrocephalus -- Congenital hypothyroidism -- Congenital muscular dystrophy -- Congenital toxoplasmosis -- Conjoined twins -- Corpus-callosum agenesis/dysgenesis -- Craniometaphyseal dysplasia -- Cri-du-chat syndrome -- Crouzon syndrome -- Cutis marmorata telangiectatica congenita -- Cystic fibrosis -- Dandy-Walker malformation -- De Lange syndrome -- Del(18p) syndrome -- Del(22q11.2) syndrome -- Del(Yq) syndrome -- Diabetic embryopathy -- Down syndrome -- Duncan syndrome (X-linked lymphoproliferative disease) -- Dyschondrosteosis/Langer mesomelic dysplasia -- Dysmelia (limb deficiency/reduction) -- Dysplasia epiphysealis hemimelica -- Dystonia -- Dystrophinopathies -- EEC syndrome -- Ehlers-Danlos syndrome -- Ellis-van Creveld syndrome -- Enchondromatosis -- Epidermolysis bullosa -- Epidermolytic palmoplantar keratoderma -- Faciogenital (Aarskog) syndrome -- Facioscapulohumeral muscular dystrophy (FSH) -- Familial adenomatous polyposis syndrome -- Familial hyperlysinemia -- Familial Mediterranean fever -- Fanconi anemia -- Femoral hypoplasia-unusual facies syndrome -- Fetal akinesia syndrome -- Fetal alcohol syndrome -- Fetal hydantoin syndrome -- Fibrodysplasia ossificans progressiva -- Finlay-Marks syndrome -- Floppy infant -- Fragile X syndrome -- Fraser syndrome -- Freeman-Sheldon (whistling face) syndrome -- Friedreich ataxia -- Frontonasal dysplasia -- Galactosemia -- Gastroschisis -- Gaucher disease -- Generalized arterial calcification -- Genitopatellar syndrome -- Giant congenital melanocytic nevi (giant congenital nevi) -- Glucose-6-phosphate dehydrogenase deficiency -- Glycogen storage disease, type II (Pompe) -- Goldenhar syndrome -- Gorlin (nevoid basal cell carcinoma) syndrome -- Greig cephalopolysyndactyly syndrome -- Hallermann-Streiff syndrome -- Harlequin fetus -- Hemophilia A -- Hereditary hearing loss -- Hereditary hemochromatosis -- Hereditary multiple exostosis -- Herlyn-Werner-Wunderlich syndrome -- Holoprosencephaly -- Holt-Oram syndrome -- Huntington disease -- Hydrolethalus syndrome -- Hydrops fetalis -- Hyper-IgE syndrome -- Hypochondroplasia -- Hypoglossia-hypodactyly (oromandibular limb hypogenesis) syndrome -- Hypohidrotic ectodermal dysplasia -- Hypomelanosis of Ito -- Hypophosphatasia -- Hypopituitarism -- I(1p),I(1q) syndrome -- Isodic(Yq) syndrome -- Incontinentia pigmenti -- Infantile myofibromatosis -- Ivemark syndrome -- Jarcho-Levin syndrome -- Joubert syndrome -- Kabuki syndrome -- Kassback-Merritt syndrome -- KID syndrome -- Klinefelter syndrome -- Klippel-Feil syndrome -- Klippel-Trenaunay syndrome -- Kniest dysplasia -- Larsen syndrome -- LEOPARD syndrome -- Lesch-Nyhan syndrome -- Lethal multiple pterygium syndrome -- Loeys-Dietz syndrome -- Lowe syndrome -- Marfan syndrome -- McCune-Albright syndrome -- Meckel-Gruber syndrome -- Megalencephalic leukoencephalopathy with subcortical cysts (van der Knaap disease) -- Menkes disease -- Metachromatic leukodystrophy -- Miller-Dieker syndrome -- Mitochondrial Leber hereditary optic neuropathy -- Mobius syndrome -- Mowat-Wilson Disease -- Mucolipidosis II (I-cell disease) -- Mucolipidosis III (pseudo-Hurler Polydystrophy) -- MPS I (Hurler syndrome) -- MPS II (Hunter syndrome) -- MPS III (Sanfilippo syndrome) -- MPS IV (Morquio syndrome) -- MPS VI (Maroteaux-Lamy syndrome) -- Multiple endocrine neoplasia Syndrome -- Multiple epiphyseal dysplasia -- Multiple pterygium syndrome -- Myotonic dystrophy -- Nail-Patella Syndrome (hereditary Osteo-onychodysplasia) -- Neonatal Herpes simplex infection -- Nephrogenic diabetes insipidus -- Netherton syndrome -- Neu-Laxova syndrome -- Neural tube defects -- Neurofibromatosis 1 -- Neurofibromatosis 2 -- Noonan syndrome -- Oblique facial cleft syndrome -- Oligohydramnios sequence -- Omphalocele -- Oro-Facial-Digital Syndrome -- Osteogenesis imperfecta -- Osteopetrosis -- Osteopoikilosis -- Otopalatodigital spectrum disorders -- Pachyonychia congenita -- Pallister-Killian syndrome -- Phenylketonuria (PKU) -- Pierre Robin sequence -- Polycystic kidney disease, AD form -- Polycystic kidney disease, AR form -- Popliteal pterygium syndrome -- Prader-Willi syndrome -- Progeria -- Prune belly syndrome -- Pseudoachondroplasia -- R(18) syndrome -- Retinoid embryopathy -- Rett syndrome -- Rickets -- Rigid spine syndrome -- Roberts syndrome -- Robinow syndrome -- Rubinstein-Taybi syndrome -- Saethre-Chotzen syndrome -- Sagittal synostosis associated with chromosome abnormalities -- Schizencephaly -- Schmid metaphyseal chondrodystrophy -- Seckel syndrome -- Severe combined immune deficiency -- Short rib polydactyly syndromes (SRPS) -- Sickle cell disease -- Silver-Russell syndrome -- Sirenomelia -- Smith-Lemli-Optiz syndrome -- Smith-Magenis syndrome -- Sotos syndrome -- Spinal muscular atrophy -- Spondyloepiphyseal dysplasia -- Stickler syndrome -- Sturge-Weber syndrome -- Tay-Sachs disease -- Tetrasomy 9p syndrome -- Thalassemia -- Thanatophoric dysplasia -- Thrombocytopenia-absent radius (TAR) syndrome -- Treacher-Collins syndrome -- Trimethylaminuria -- Triploidy -- Trismus pseudocamptodactyly (Hecht syndrome) -- Trisomy 8 mosaicism (Warkany) syndrome -- Trisomy 13 syndrome -- Trisomy 18 syndrome -- Tuberous sclerosis -- Turner syndrome -- Twin-twin transfusion syndrome -- Ulnar-mammary syndrome -- Urofacial (Ochoa) Syndrome -- VATER (VACTERL) association -- Von Hippel-Lindau disease -- Waardenburg syndrome -- Weill-Marchesani syndrome -- Williams syndrome -- Wolf-Hirschhorn syndrome -- X-linked agammaglobulinemia (Bruton type) -- X-linked ichthyosis -- XX Male -- XXX syndrome -- XXXXX syndrome -- XXXXY syndrome -- XY female.-XYY syndrome
    Abstract: Dr. Chen shares his almost 40 years of clinical genetics practice in a comprehensive pictorial atlas of almost 250 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clinical features, diagnostic tests, and counseling issues, including recurrence risk, prenatal diagnosis, and management. Numerous color photographs of prenatal ultrasounds, imagings, cytogenetics, and postmortem findings illustrate the clinical features of patients at different ages, patients with varying degrees of severity, and the optimal diagnostic strategies. The disorders cited are supplemented by case histories and diagnostic confirmation by cytogenetics, biochemical, and molecular techniques, when available. The Atlas of Genetic Diagnosis and Counseling will help all physicians to understand and recognize genetic diseases and malformation syndromes and better evaluate, counsel, and manage affected patients. In this new edition, 47 additional genetic disorders are added, as well as extensive updates made to the previous disorders. New illustrations, as previous edition, will be supplemented by case and family history, clinical features, and laboratory data, especially molecular confirmation
    Pages: LX, 2224 p. 2472 illus., 2018 illus. in color. : online resource.
    ISBN: 9781461464303
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  • 8
    Keywords: Medicine ; Cardiology ; Oncology ; Cytology ; Molecular Medicine ; Cardiology ; Cancer Research ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review -- Acceptance of Illness Associates with Better Quality of Life in Patients with Non-malignant Pulmonary Diseases -- Heart Rate Variability in the Diagnostics and CPAP Treatment of Obstructive Sleep Apnea -- Subterranean Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease -- Epidemiological Aspects of Low Back Pain -- Sex Hormones Response to Physical Hyperoxic and Hyperbaric Stress in Male Scuba Divers: a Pilot Study -- Cigarette Smoke-induced Oxidative Stress and Autophagy in Human Alveolar Epithelial Cell Line (A549 Cells) -- Relative Cerebral Blood Transit Time Decline and Neurological Improvement in Patients after Internal Carotid Artery Stenting -- Influence of Glycemic Control and Coagulation and Lipid Metabolism in Pregnancies Complicated by Pregestational and Gestational Diabetes Mellitus -- Maternal Nutritional and Water Homeostasis as a Presage of Fetal Birth Weight -- Cytotoxicity, Oxidative Stress and Autophagy in Human Alveolar Epithelial Cell Line (A549 Cells) Exposed to Standardized Urban Dust -- Autologous Platelet-Rich Plasma Reduces Healing Time of Chronic Venous Leg Ulcers: A Prospective Observational Study
    Abstract: This book gathers multidisciplinary articles that present advances of our understanding of diseases and the effective treatment of patients. The authors share recent clinical and experimental research findings, highlighting poorly understood areas with uncertain treatment outcomes, such as giant-cell bone tumors and their propensity to metastasize to the lungs; subterranean rehabilitation in pulmonary disorders; male reproductive hormone regulation during physical exercise in hyperbaric, hyperoxic environments, like underwater diving; and amelioration of cognitive decline owing to increased cerebral blood transit time after internal carotid artery stenting. Other topics include new concepts and innovations in the treatment of diabetes in pregnancy, and leg ulcers in chronic venous insufficiency, as well as molecular research on the toxic effects of oxidative stress, impaired cell autophagy, and experimental conditions resembling air pollution. Featuring the latest interdisciplinary advances in biomedicine, this book is a valuable resource for medical professionals, both academics and practitioners, and all allied health-care workers
    Pages: VI, 118 p. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030253738
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  • 9
    Keywords: Oncology ; Human Genetics ; Medicine ; Cytology ; Metabolism ; Cancer Research ; Human Genetics ; Molecular Medicine ; Cell Biology ; Metabolomics ; Springer eBooks
    Description / Table of Contents: Preface -- Molecular and Cell Biology of Cancer when cells break the rules and hijack their own planet -- Cancer as an Evolutionary Process -- Cell signaling in cancer -- The cell cycle, cytoskeleton and cancer -- Genomic Instability: DNA Repair and Cancer -- Cell metabolism in cancer – an energetic switch -- Cancer immunoediting and hijacking of the immune system -- Angiogenesis - vessels recruitment by tumor cells -- Tumor niche disruption and metastasis: the role of epithelial-mesenchymal transition (EMT) -- Case studies - Molecular Pathology perspective and impact on oncologic patients’ management -- Index
    Abstract: This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
    Pages: IX, 216 p. 71 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030118129
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  • 10
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Preface -- Chapter 1. Understanding HDL: overview -- 1-1.HDL and disease -- 1-2.HDL functions and clinical applications -- 1-3.HDL composition : apolipoproteins and enzymes -- 1-4.Maturation of HDL -- 1-5.HDL and blood pressure -- Chapter 2. Change of HDL by life style -- 2-1.Exercise and HDL -- 2-2.Smoking and HDL -- 2-3.Elderly’s HDL -- 2-4.HDL depends on body weight -- 2-5.HDL from obese but healthy subject -- 2-6.HDL and apoA-I in smokers’ breast milk -- 2-7.Breast milk from frequent trans fatty acid consumers -- 2-8.HDL in cord blood from small neonates -- Chapter 3. Change of HDL in various diseases -- 3-1.HDL from patients with myocardial infarction -- 3-2.HDL from patients with female angina pectoris -- 3-3.HDL and metabolic syndrome -- 3-4.HDL from male patients with atrial fibrillation -- 3-5.HDL from female patients with atrial fibrillation -- 3-6.HDL from patients with hemorrhagic fever with renal syndrome -- 3-7.HDL from patients with rheumatoid arthritis -- 3-8.HDL and prehypertension -- Chapter 4. Detriment of HDL by pollutant and its evaluation -- 4-1.Particulate matter and HDL -- 4-2.Phthalate and HDL -- 4-3.Cadmium and HDL -- 4-4.Humidifier Sterilizer and HDL -- 4-5.Detection of dysfunctional HDL by microfluidics -- 4-6.Evaluation of dysfunctional HDL using zebrafish embryo -- Chapter 5. Change of HDL by food ingredient -- 5-1.Fructose and apoA-I -- 5-2.Fructose and impairment of HDL functionality -- 5-3.Artificial sweeteners and apoA-I -- 5-4.Artificial sweeteners (aspartame, saccharin) and HDL -- 5-5.Aldoketohexoses and HDL -- 5-6.Iron and HDL -- 5-7.Trans fat and HDL -- 5-8.Salt and HDL 576 p -- Summary and perspectives
    Abstract: This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XXIV, 383 p. 244 illus. : online resource.
    ISBN: 9789811373879
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  • 11
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    Berlin : Springer
    Keywords: Oncology ; Medicine ; Oncology   ; Cancer Research ; Molecular Medicine ; Oncology ; Springer Nature Living Reference
    Abstract: The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in℗ 7 Volumes with an A-Z format of℗ approx. 7000℗ entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative℗ Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public
    Pages: LXXXVI, 3984 p. 1071 illus., 710 illus. in color. : online resource.
    ISBN: 9783642278419
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  • 12
    Keywords: Oncology ; Immunology ; Medicine ; Cancer Research ; Immunology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index
    Abstract: This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients
    Pages: XIX, 256 p. 21 illus. in color. : online resource.
    ISBN: 9783030166243
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  • 13
    Keywords: Oncology ; Medicine ; Cancer Research ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Introduction to the Acquisition of Resistance to Targeted Therapy -- Targeting the Tumor Microenvironment to Overcome Resistance to Targeted Therapy -- Current Challenges and Applications of Oncolytic Viruses in Overcoming Resistance to Therapies in Cancer -- Novel Methods to Overcome Acquired Resistance to Immunotherapy -- Therapies to Overcome Multidrug-Resistant Receptors -- Overcoming Resistance to PARP Inhibition -- Novel Methods of Overcoming HER2 Therapy Resistance in Breast Cancer -- Emerging Novel Therapies for Overcoming Resistance to Targeted Therapies -- Targeting Epigenetic Regulators in Cancer to Overcome Resistance to Targeted Therapy -- Nanomedicine and Drug Delivery Systems in Overcoming Resistance to Targeted Therapy -- Index
    Abstract: Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome
    Pages: XVIII, 320 p. 31 illus., 29 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030214777
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  • 14
    Call number: W160:26(2)
    Keywords: DKFZ-publications ; Signal Transduction / physiology ; Intracellular Signaling Peptides and Proteins / physiology
    Pages: xiii, 639 p. : ill.
    Edition: 2nd edition.
    ISBN: 9780815342151
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    W160:26(2) available
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  • 15
    Keywords: Oncology ; Human Genetics ; Medicine ; Cytology ; Cancer Research ; Human Genetics ; Molecular Medicine ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Preface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index
    Abstract: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease
    Pages: VIII, 160 p. 17 illus., 16 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030127343
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  • 16
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    New York, NY : Springer
    Keywords: Oncology ; Oncology   ; Medical laboratories ; Internal Medicine ; Medicine ; Toxicology ; Cancer Research ; Oncology ; Laboratory Medicine ; Internal Medicine ; Molecular Medicine ; Pharmacology/Toxicology ; Springer Nature Living Reference
    Abstract: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well
    Pages: 800 p. 164 illus., 64 illus. in color. : online resource.
    ISBN: 9781461466130
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  • 17
    Keywords: Human Genetics ; Oncology ; Medicine ; Nucleic Acids ; Human Genetics ; Cancer Research ; Molecular Medicine ; Nucleic Acid Chemistry ; Springer eBooks
    Description / Table of Contents: Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
    Abstract: The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community
    Pages: IX, 180 p. 18 illus., 17 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030199661
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  • 18
    Keywords: Oncology ; Immunology ; Human Genetics ; Medicine ; Cytology ; Cancer Research ; Immunology ; Human Genetics ; Molecular Medicine ; Cell Biology ; Medicine/Public Health, general ; Springer eBooks
    Description / Table of Contents: Foreword -- Mast cell ontogeny -- Staining of mast cells -- Mast cells heterogeneity -- Mast cell biology and functions -- Mast cells in arteriogenesis -- Mast cells in primary systemic vasculitides -- Mast cells in blood-brain barrier alterations and neurodegenerative diseases -- Mast cells and basophils: a link between angiogenesis and inflammation in allergic diseases -- Mast cells in tumor fate -- Mast cells in tumor angiogenesis and lymphoangiogenesis -- Mast cells as therapeutic target in cancer -- Index
    Abstract: This book covers the most important aspects of Mast Cell Biology. It enables the reader to immerse in the new aspects of Mast Cells biology, which are no longer seen as an immunological effector cell, but a multi-functional efector cell. One which have roles that expands beyond the immunological realm and shows deep implications in the pathophysiology of several human disorders as well as transforming into a very important and promising target for therapy development in cancer, neurodegerative disorders, angiogenesis, inflammation and allergy. Across twelve chapter on Mast Cells Research, starting from the discovery and characterization of Mast Cells until the lastest findings and translational perspectives, the reader will get a complete view and a profound insight on the fundamental and applied aspects of Mast Cells Biology. The chapters are written in a clear and concise way in order to help navigating through complex biological scenarios. The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications
    Pages: VII, 112 p. 12 illus., 8 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030241902
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