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  • 1
    Keywords: Oncology ; Human Genetics ; Medicine ; Biomedical Engineering ; Medical laboratories ; Cancer Research ; Human Genetics ; Molecular Medicine ; Biomedical Engineering/Biotechnology ; Laboratory Medicine ; Springer eBooks
    Description / Table of Contents: 1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance
    Abstract: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians
    Pages: XII, 313 p. 51 illus., 50 illus. in color. : online resource.
    ISBN: 9789811315688
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  • 2
    Keywords: Cell Cycle ; Medicine ; Oncology ; Urology ; Radiology, Medical ; Cell Cycle Analysis ; Molecular Medicine ; Cancer Research ; Urology ; Diagnostic Radiology ; Springer eBooks
    Description / Table of Contents: 1. The role of imaging in clinical prostate cancer – Overview of Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Dynamic Contrast-Enhanced MRI (DCE-MRI), MR spectroscopic Imaging (MRSI), Photoacoustic Imaging (PAI) -- 2. Automated quantitative cell and tissue imaging technologies -- 3. Diagnostic and early prostate cancer imaging; imaging of advanced prostate cancer -- 4. Emerging radiation techniques -- 5. Radiation therapy and partial prostate irradiation -- 6. Prostate cancer screening: radiology perspectives -- 7. Preclinical imaging of metastasis and dormancy: clinical implications -- 8. Utility of CT in the management of prostate cancer -- 9. Nanotechnology, cancer diagnosis and treatments -- 10. Imaging approaches to distinguish lethal from non-lethal disease -- 11. Photoacoustic imaging -- 12. Molecular and anatomical imaging in drug development -- 13. Molecular imaging modalities including CT, PET, SPECT, MRI, MRS, Hyperpolarized MRI, Ultrasound, X-ray computed tomography, Fusion Imaging (Molecular/Anatomic) -- 14. Functional imaging (PET vs. SPECT) -- 15. Optical bioluminescence molecular imaging -- 16. Therapeutic radiopharmaceutical translational research imaging -- 17. Accuracy of magnetic resonance imaging for local staging of prostate cancer: diagnostic meta-analysis -- 18. Adjuvant radiotherapy for pathologically advanced prostate cancer: randomized clinical trial -- 19. High-intensity focused ultrasound (HIFU) with histopathological analysis -- 20. Image-directed, tissue-preserving focal therapy of prostate cancer with a novel deformable magnetic resonance-ultrasound (MR-US) registration system -- 21. Focal therapy for localized unifocal and multifocal prostate cancer -- 22. Focal cryotherapy for clinically unilateral, low to intermediate risk prostate cancer -- 23. Impact of obesity on clinico-pathologic outcomes after robot-assisted laparoscopic prostatectomy -- 24. Body mass index, prostate weight and transrectal ultrasound prostate volume accuracy
    Abstract: The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature
    Pages: XI, 194 p. 23 illus., 19 illus. in color. : online resource.
    ISBN: 9783319992860
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