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  • 1
    Signatur: QH431:146
    Schlagwort(e): Genetic Phenomena
    Beschreibung / Inhaltsverzeichnis: Introduction to genetics -- Mitosis and meiosis -- Mendelian genetics -- Modification of mendelian ratios -- Sex determination and sex chromosomes -- Chromosome mutations : variation in number and arrangement -- Linkage and chromosome mapping in eukaryotes -- Genetic analysis and mapping in bacteria and bacteriophages -- DNA structure and analysis -- DNA replication -- Chromosome structure and DNA sequence organization -- The genetic code and transcription -- Translation and proteins -- Gene mutation, DNA repair, and transposition -- Regulation of gene expression in bacteria -- Regulation of gene expression in eukariotes -- Recombinant DNA technology -- Genomics, bioinformatics, and proteomics -- The genetics of cancer -- Quantitative genetics and multifactorial traits -- Population and evolutionary genetics
    Ausgabe: Tenth edition.
    ISBN: 9780134898414
    Signatur Verfügbarkeit
    QH431:146 verfügbar
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  • 2
    Unbekannt
    Cham : Springer
    Schlagwort(e): Human Genetics ; Biochemistry ; Biological models ; Human Genetics ; Protein Science ; Systems Biology ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: Preface -- Chromatin regulation by long non-coding RNAs -- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs -- Roles of long non-coding RNAs in X-chromosome inactivation -- Roles of Long Non-Coding RNAs in Genomic Imprinting -- Dysregulation of long noncoding RNAs in human disease -- Functions of long non-coding RNAs in non-mammalian systems -- Emerging technologies to study long non-coding RNAs -- Long non coding RNAs and nuclear body formation and function -- The role of long non-coding RNAs in immunity -- Novel methods to study long non-coding RNAs -- OMICs of long non-coding RNAs -- Cancer epigenetics and long non-coding RNAs -- Roles of long non-coding RNAs in human development -- Index
    Kurzfassung: This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them
    Seiten: VII, 187 p. 10 illus., 9 illus. in color. : online resource.
    Ausgabe: 2nd ed. 2019.
    ISBN: 9783030170868
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  • 3
    Unbekannt
    München : Springer Spektrum
    Signatur: QH581:72
    Schlagwort(e): Cell Biology
    Seiten: xii, 199 p. : ill.
    ISBN: 9783662561102
    Signatur Verfügbarkeit
    QH581:72 verfügbar
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  • 4
    Signatur: QH324:052 ; C020:157
    Schlagwort(e): Computational Biology
    Seiten: xi, 225 pages : illustrations
    ISBN: 9780124104716
    Signatur Verfügbarkeit
    QH324:052 ausgeliehen
    C020:157 departmental collection or stack – please contact the library
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  • 5
    Schlagwort(e): Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Kurzfassung: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Seiten: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 6
    Schlagwort(e): Stem Cells ; Oncology ; Cell Cycle ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Cell Cycle Analysis ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: Multilayered heterogeneity of glioblastoma stem cells: biological and clinical significance -- Heterogeneity of head and neck squamous cell carcinoma stem cells -- Heterogeneity of small cell lung cancer stem cells -- Heterogeneity of hepatic cancer stem cells -- Heterogeneity and plasticity of breast cancer stem cells -- Heterogeneity of melanoma with stem cell properties -- Heterogeneity of colon cancer stem cells -- Urothelial cancer stem cell heterogeneity -- Acute myeloid leukemia stem cell heterogeneity and its clinical relevance -- Contribution of chronic myeloid leukaemia (CML) as a disease model to define and study clonal heterogeneity -- The heterogeneity of osteosarcoma: the role played by cancer stem cells -- Ovarian cancer stem cell heterogeneity -- Index
    Kurzfassung: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians
    Seiten: XII, 228 p. 24 illus., 18 illus. in color. : online resource.
    ISBN: 9783030143664
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  • 7
    Unbekannt
    New York : Springer
    Signatur: QZ200:589
    Seiten: xiv, 203 p.
    ISBN: 9783030203146
    Signatur Verfügbarkeit
    QZ200:589 verfügbar
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  • 8
    Schlagwort(e): Immunology ; Proteins  ; Molecular Biology ; Immunology ; Protein Structure ; Molecular Medicine ; Receptors ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: Structural basis for signalling through shared common g chain cytokines -- MHC Molecules, T Cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins–Key Elements of Adaptive and Innate Immunity -- Structures of Immune Checkpoints: An Overview on the CD28-B7 Family -- Interleukin-10 family cytokines immunobiology and structure -- Structural insights into the interleukin-17 family cytokines and their receptors -- Structural biology of NOD-like receptors -- AIM2 Inflammasome Assembly and Signaling -- Structures of RIG-I-like receptors and insights into viral RNA sensing -- Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death -- NF-κB, IκB, and IKK: Integral Components of Immune System Signaling
    Kurzfassung: This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function
    Seiten: XIII, 226 p. 86 illus., 84 illus. in color. : online resource.
    Ausgabe: 1st ed. 2019.
    ISBN: 9789811393679
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  • 9
    Unbekannt
    Edinburgh : Elsevier
    Signatur: ALLG-BERUF-Q180:084(7)
    Notizen: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php)
    Seiten: vi, 213 p.
    Ausgabe: 7th ed.
    ISBN: 9780702074936
    Signatur Verfügbarkeit
    ALLG-BERUF-Q180:084(7) verfügbar
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  • 10
    Schlagwort(e): Immunology ; Evolution (Biology) ; Developmental Biology ; Immunology ; Evolutionary Biology ; Developmental Biology ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: Chapter 1: What makes evolution tick? -- Chapter 2: Immunity - the unicellular to metazoan transition -- Chapter 3: Innate immunity -- Chapter 4: The triumph of individualism: evolution of somatically generated adaptive immune systems -- Chapter 5: The other side of the arms race -- Chapter 6: Postface
    Kurzfassung: Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge
    Seiten: XVI, 145 p. 26 illus., 24 illus. in color. : online resource.
    Ausgabe: 1st ed. 2019.
    ISBN: 9783030186678
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  • 11
    Unbekannt
    London : Elsevier
    Signatur: QZ208:158
    Schlagwort(e): Neoplasms / genetics ; Genomics ; Precision Medicine ; Biomarkers, Tumor
    Seiten: xxii, 698 pages : illustrations
    ISBN: 9780128117859
    Signatur Verfügbarkeit
    QZ208:158 verfügbar
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  • 12
    Schlagwort(e): Biomedical Engineering ; Signal processing ; Image processing ; Speech processing systems ; Radiology ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Signal, Image and Speech Processing ; Imaging / Radiology ; Springer eBooks
    Beschreibung / Inhaltsverzeichnis: What is Medical Imaging? -- Part I: From Signals… -- Basic Concepts -- Transmission: X-Rays -- Reflection : Ultrasound -- Emission: SPECT/PET -- Resonance: NMR -- Part II: …To Images -- A Revision of Frequency Analysis -- Basic Concepts -- Timing-Based Reconstruction -- Back-Projection Reconstruction: X-Ray and PET/SPECT -- Fourier Reconstruction: MRI -- Part III: Functional and Physiological Imaging -- Contrast Agents -- Tracer Kinetics -- Examples of Tracer Kinetic Methods -- Other Physiological and Functional MRI Methods
    Kurzfassung: This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of ‘contrast’ in the context of medical imaging. This introductory text separates the principles by which ‘signals’ are generated and the subsequent ‘reconstruction’ processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of ‘reconstruction’ are shared by some imaging methods despite relying on different physics to generate the ‘signals’. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers
    Seiten: XIV, 169 p. : online resource.
    Ausgabe: 1st ed. 2019.
    ISBN: 9783030305116
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  • 13
    Signatur: ALLG-BERUF-Q180:82
    Schlagwort(e): Science / Vocational guidance ; Communication in science ; Research ; Technical writing ; Scholarly publishing
    Kurzfassung: "True academic success for a medical professional is multifaceted; one should have a clear and correct definition of success in order to proceed in the right direction. In establishing a successful career, communication skills and networking know-how are as important as having sufficient clinical knowledge and being capable of conducting research and writing scientific papers. Therefore, we are going to emphasize in the book that to be successful, a medical student/resident should have good communication skills, sound clinical judgment, enough knowledge of research methodology and good writing skills. We believe that for achieving this, students/residents need to have comprehensive guidelines to address each of these aspects. We believe this book has the potential to inspire many students/residents and physicians and will be well-received by the academic community"--
    Seiten: xliii, 742 p. : ill.
    Ausgabe: First edition.
    ISBN: 9781118907429
    Signatur Verfügbarkeit
    ALLG-BERUF-Q180:82 verfügbar
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  • 14
    Unbekannt
    Cham : Springer
    Signatur: QZ266:355
    Seiten: xxiv, 326 p. : illl.
    ISBN: 9783030388614
    Signatur Verfügbarkeit
    QZ266:355 verfügbar
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  • 15
    Unbekannt
    San Diego : Elsevier Science & Technology
    Signatur: W26.5:143
    Seiten: xii, 219 p.
    ISBN: 9780128125120
    Signatur Verfügbarkeit
    W26.5:143 verfügbar
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