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Genetics, Evolution and Radiation : Crossing Borders, The Interdisciplinary Legacy of Nikolay W. Timofeeff-Ressovsky (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Human Genetics ; Evolutionary Biology ; Microbial genetics ; Microbial genomics ; Plant genetics ; Animal genetics ; Radiation Protection ; Radiation / Safety measures ; Life sciences ; Animal Genetics and Genomics ; Evolutionary Biology ; Effects of Radiation/Radiation Protection ; Human Genetics ; Plant Genetics & Genomics ; Microbial Genetics and Genomics ; Springer eBooks
Description / Table of Contents: Foreword -- Preface from editors -- Contents -- 1. N.W. Timofeeff-Ressovsky: science without borders -- 2. Genetic processes -- 3. Radiobiology effects and mechanisms -- 4. Radiation in ecological systems -- 4A. Radiation and Man -- 5. Laws of evolution -- Name index -- Subject index
Abstract: This book is dedicated to the great scientist and outstanding individual Nikolay Wladimirovich Timofeeff-Ressovsky. The book brings together a number of brief stories/essays about Timofeeff-Ressovsky including “Stories told by himself”, and scientific chapters addressing his major research areas: genetics, radiobiology, radiation ecology and epidemiology, and evolution. Timofeeff-Ressovsky contributed to several fields of biology and established new directions of scientific research. He often repeated the phrase, which would later become famous: “Science should not be approached with the ferocity of wild animals”. In keeping with that philosophy, the issues discussed here are still open. Each scientific part starts with a current review; the chapters present leading scientific schools and views. The main theme discussed in the genetics part is mutation variability in the context of linear (replication, transcription, translation) and conformational template processes, and its dependence on phylogenetic group. In turn, the radiobiology chapters focus on the reorganization of DNA, cell, and population variability under low-dose irradiation, sparking indirect processes and adaptive response. The radiation ecology and epidemiology parts present data on the consequences of nuclear plants and related accidents for ecological systems and human beings. Here some approaches to estimating radiation risks are also offered. Evolution laws are demonstrated in the genomic universe, plant-microbe symbiosis, stabilizing and destabilizing (directional) selection. The last essay demonstrates the principles of organization operating in local animal populations, which are approached as social organisms of complex systemic nature. The chapter 'Radiation-Induced Aging and Genetic Instability of Mesenchymal Stem Cells: An Issue for Late Health Effects?' is available open access under a CC BY 4.0 license
Pages: XX, 558 p. 138 illus., 78 illus. in color. : online resource.
ISBN: 9783319488387
Drug Resistance in Bacteria, Fungi, Malaria, and Cancer (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Drug Resistance ; Cell Biology ; Bacteriology ; Biomedicine ; Drug Resistance ; Cell Biology ; Cancer Research ; Bacteriology ; Springer eBooks
Abstract: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way
Pages: XIV, 630 p. 64 illus., 49 illus. in color. : online resource.
ISBN: 9783319486833
Immunopathology in Toxicology and Drug Development : Volume 2 / Organ Systems (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Immunology ; Pharmaceutical technology ; Medical Biochemistry ; Pathology ; Medicine & Public Health ; Pathology ; Immunology ; Pharmaceutical Sciences/Technology ; Medical Biochemistry ; Springer eBooks
Description / Table of Contents: Thymus -- Spleen -- Lymph node -- Mucosa-associated lymphoid tissues -- Immunopathology of the nervous system -- Immunopathology of the urinary system -- Immunopathology of the hepatobiliary system -- Immunopathology of the respiratory system -- Immunopathology of the cardiovascular system -- Immunopathology of the male reproductive tract -- Immunopathology of the female reproductive tract and mammary gland -- Immunopathology of the musculoskeletal system -- Immunopathology of the endocrine system -- Ocular Immunopathology -- Immunopathology of Drug and Toxin-related Skin Reactions
Abstract: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system
Pages: XXII, 826 p. 194 illus., 167 illus. in color. : online resource.
ISBN: 9783319473857
Dictionary of Pharmaceutical Medicine (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Pharmacy ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Pharmacy ; Springer eBooks
Description / Table of Contents: Dictionary of pharmaceutical medicine -- Abbreviations/acronyms -- Selected bibliography -- Useful websites
Abstract: This dictionary defines various terms typically used in pharmaceutical medicine. A new, 4th edition includes adaptations of the text to the steadily increasing regulatory requirements, particularly in the area of genetics/gene therapy, product quality (e.g., protection against falsified medicines) and of product safety (pharmacovigilance). Further evolving areas that are covered by the 4th edition are typical “grey zones” (health effects often borderline to medicinal products) such as cosmetics and dietary supplements where misleading information is prohibited on one hand but where any health claims need formal authorisation on the other. These but also other areas are reviewed and presented in an updated and – if justified – in an enlarged form
Pages: X, 396 p. : online resource.
Edition: 4th ed. 2017.
ISBN: 9783319506692
IgG4-Related Disease (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Immunology ; Rheumatology ; Biomedicine ; Immunology ; Rheumatology ; Springer eBooks
Description / Table of Contents: Current concept of IgG4-related disease -- Diagnosis and treatment of IgG4-related disease -- Immunogenetics of IgG4-related disease -- The histopathology of IgG4-related disease -- The immunobiology of immunoglobulin G-4 and Complement activation pathways in IgG4-related disease -- Th1/Th2 immune balance in IgG4-related disease -- ℗ Roles of plasmablasts and B cells in IgG4-related disease -- Roles of regulatory T and B cells in IgG4-related disease -- Roles of innate immunity in IgG4-related disease.℗
Abstract: This volume focuses on IgG4-related disease (IgG4-RD), a novel clinical entity involving multiple organs and of unknown origin, associated with the abundant infiltration of IgG4-positive cells. It consists of nine chapters written by prominent experts in the field and discusses the disease concept, diagnosis and treatment, as well as recent findings on its pathogenesis and pathophysiology. As such, it offers an invaluable source of information for researchers and clinicians alike
Pages: VII, 128 p. : online resource.
ISBN: 9783319525426
Non-coding RNAs in the Vasculature (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Human Genetics ; Human Physiology ; Molecular Biology ; Internal Medicine ; Biomedicine ; Human Physiology ; Human Genetics ; Internal Medicine ; Molecular Medicine ; Springer eBooks
Description / Table of Contents: 1. Non-coding RNAs in the vasculature -- Introduction (Thomas Thum, Stefanie Dimmeler) -- Non-coding RNAs in vascular Development and Angiogenesis (Nathan Lawson or ℗ Didier Steinier) -- 2. Diagnostics of Vascular Diseases using circulating miRNAs -- 2.1 Basic and Technical Principles (Manuel Mayr) -- 2.2 Diagnostics use of circulating miRNAs in cardiovascular diseases (Andreas Zeiher , Stephan Fichtlscherer) -- 2.3 Non-coding RNAs in Ischemic cardiovascular disease and repair mechanisms (incl. AMI,℗ cell therapy) (Ulf Landmesser) -- 3. Non-coding RNas in Diabetes and Metabolic Diseases -- 3.1 Non-coding RNAs in vascular complications of Diabetes (Costanza Emanueli) -- 3.2 Non-coding RNAs in Metabolic Diseases, Cholesterol Metabolism (Carlos Fernandez-Hernando) -- 3.3 Non-coding RNAs in Atherosclerosis and Vascular Inflammation (incl. aging processes and aneurysms, platelelets)(Christian Weber, Feinberg) -- 4. Outlook and Perspectives (long non coding RNAs, microvesicles, new therapies, ect) (Thomas Thum, Stefanie Dimmeler)
Abstract: This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology
Pages: VII, 101 p. 11 illus. : online resource.
ISBN: 9783319529455
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1. Overview of Basic Immunology for Clinical Investigators -- 2. Interleukin-2. Old and New Approaches to Enhance Immune-Therapeutic Efficacy -- 3. Optimizing Radiotherapy with Immunotherapeutic Approaches -- 4. Harnessing the Immune System against Leukemia: Monoclonal antibodies and Checkpoint Strategies for AML -- 5. Immunotherapy in NSCLC: A Promising and Revolutionary Weapon -- 6. Immune Therapy for Sarcomas -- 7. Cancer Imaging in Immunotherapy -- 8. Adverse Events in Cancer Immunotherapy -- 9. Skin Reactions to Immune Checkpoint Inhibitors
Abstract: In the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response. Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer
Pages: V, 184 p. 17 illus. in color. : online resource.
ISBN: 9783319531564
Molecular Oncology: Underlying Mechanisms and Translational Advancements (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Oncology ; Biomedicine ; Cancer Research ; Oncology ; Springer eBooks
Description / Table of Contents: - Microtubule targeting agents in cancer therapy: Elucidating the underlying molecular mechanisms -- Adenosine signaling pathways as potential therapeutic targets in cancer disease -- Anticancer activities of Hippophae rhamnoides: Journey from Benchtop to the Bedside -- Emerging role of ncRNAs in cancer biology: techniques for diagnostic monitoring and potential ncRNA-based therapies -- Clinical and translational research on the pathophysiology of several ocular tumors types -- Exosomes and cancer: from diagnosis to therapy -- Blood-based Cancer Detection: Towards Solving Diagnostic Puzzle -- Non-coding RNAs, Critical Therapy Targets against Cancer - Detection of Virus-caused Cancer in Publicly Available Next Generation Sequencing Data -- TRAIL mediated signaling in prostate cancer -- Index
Abstract: Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer
Pages: X, 302 p. 27 illus., 24 illus. in color. : online resource.
ISBN: 9783319530826
Zellbiologie (2017)
Stuttgart : Georg Thieme Verlag
Call number: QH581:60(5)
Keywords: Cells / anatomy & histology
Notes: carlo märz 2017
Pages: 586 p. : ill.
Edition: 5. überarb. Auflage
ISBN: 9783132402270
Lung cancer : treatment and research (2016)
Cham : Springer
Call number: QZ365WF658:173
Keywords: Lung Neoplasms
Pages: vi, 322 p. : ill.
ISBN: 9783319403878
on loan
Inside graduate admissions : merit, diversity, and faculty gatekeeping (2016)
Cambridge, Massachusetts : Harvard University Press
Call number: ALLG-BERUF-LB2371:8
Keywords: Universities and colleges / Graduate work / United States ; Discrimination in higher education / United States ; Minorities / Education (Higher) / United States ; Universities and colleges / Faculty / United States ; Teacher participation in administration / United States
Pages: 250 p.
ISBN: 9780674088696
Immunopathology in Toxicology and Drug Development : Volume 1 / Immunobiology, Investigative Techniques, and Special Studies (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Immunology ; Pharmaceutical technology ; Medical Biochemistry ; Pathology ; Medicine & Public Health ; Pathology ; Immunology ; Pharmaceutical Sciences/Technology ; Medical Biochemistry ; Springer eBooks
Description / Table of Contents: Basic Immunobiology -- Cells of the Immune System -- Signaling and effector molecules in immunity -- Development of immune system organs -- Aging of immune system organs -- Flow cytometry and immunophenotyping in drug development -- Pathology evaluation for detection of immunomodulation -- Enhanced immunohistopathology -- Clinical Pathology Assays in Immunopathology -- Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system -- Morphometry and stereology in immunopathology -- Molecular techniques in immunopathology -- Current issues in developmental immunotoxicity -- The Murine local lymph node assay -- Host Resistance assays for efficacy and immunotoxicology safety evaluations
Abstract: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system
Pages: XXII, 670 p. 255 illus., 250 illus. in color. : online resource.
ISBN: 9783319473772
on loan
Tumors and tumor-like lesions of the hepatobiliary tract : general and surgical pathology (2017)
Cham : Springer
Call number: QZ365WI735:79/1 ; QZ365WI735:79/2 ; QZ365WI735:79/3 ; QZ365WI735:79/4
Pages: 4 v. (xxxii, 3559 p.) : ill.
ISBN: 9783319269542
Molekularbiologie der Zelle (2017)
Weinheim : Wiley-VCH
Call number: QH581:70(6)
Keywords: Cells ; Molecular Biology
Notes: Translation of: Molecular biology of the cell, 6th edition.
Pages: lxiii, 1612 p. : ill. +
Edition: 6. Aufl.
ISBN: 9783527340729
Tietz textbook of clinical chemistry and molecular diagnostics (2018)
St. Louis, Missouri : Elsevier
Call number: QY25:23(6)
Keywords: Molecular Diagnostic Techniques ; Chemistry, Clinical / methods ; Clinical chemistry ; Molecular diagnosis
Notes: Previous ed.: 2012.
Pages: xx, 1867 p. : col. ill.
Edition: 6th ed.
Squamous cell Carcinoma : Molecular Therapeutic Targets (2017)
Dordrecht : Springer Netherlands
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: Preface -- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck -- Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers -- Hypoxia in head and neck cancer -- Genetic aberrations and molecular pathways in head and neck cancer -- p53 in Head and Neck Squamous Cell Carcinoma -- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck -- Targeting the mTOR signaling circuitry in head and neck cancer -- Survivin as a Therapeutic Target in Squamous Cell Carcinoma -- MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma -- Envoi – An appraisal of Targeted Therapies for Head and Neck Cancer -- Index
Abstract: This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer
Pages: XII, 281 p. 30 illus. in color. : online resource.
ISBN: 9789402410846
Translational Bioinformatics and Its Application (2017)
Dordrecht : Springer Netherlands
Keywords: Life sciences ; Human Genetics ; Health Informatics ; Bioinformatics ; Biostatistics ; Life sciences ; Bioinformatics ; Human Genetics ; Biostatistics ; Health Informatics ; Springer eBooks
Description / Table of Contents: Drug Discovery -- Translational Bioinformatics and Drug Discovery -- Translational Research in Drug Discovery and Development -- Exploring the Potential of Herbal Ligands towards Multidrug Resistant Bacterial Pathogens by Computational Drug Discovery -- The Progress of New Targets of Anti-HIV and Its Inhibitors -- Exploration of Drug Candidates Interacting on Amyloid-β Protofibrils for Alzheimer’s Disease -- Homology Modeling, Structure Based Pharmacophore Modeling, High Throughput Virtual Screening and Docking Studies of L-Type Calcium Channel for Cadmium Toxicity -- Natural Compounds Are Smart Player in Context to Anticancer Potential: An In Silico and In Vitro Advancement -- Genome Wide Association Studies -- A Survey of Bioinformatics Based Tools in RNA-Sequencing (RNA-Seq) Data Analysis -- Epigenetics and Its Role in Human Cancer -- Methods for Microbiome Analysis -- Pharmacogenomics: Clinical Perspective, Strategies and Challenges -- Computational Network Approaches and Their Applications for Complex Diseases -- Bioinformatics Applications in Clinical Microbiology -- Artificial Intelligence and Automatic Image Interpretation in Modern Medicine -- Computation in Medicine: Medical Image Analysis and Visualization
Abstract: This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics
Pages: VIII, 437 p. 85 illus., 59 illus. in color. : online resource.
ISBN: 9789402410457
Keywords: Medicine ; Medical genetics ; Oncology ; Proteins ; Biomedicine ; Gene Function ; Oncology ; Protein Science ; Springer eBooks
Description / Table of Contents: RUNX in invertebrates -- Structure and biophysics of CBFb/RUNX and its transcription products -- Covalent modification of RUNX proteins: structure affects function -- The role of Runx1 in embryonic blood cell formation -- RUNX1 structure and function in blood cell development -- Roles of Runx2 in skeletal development -- Roles of Runx genes in nervous system development -- Runx family genes in tissue stem cell dynamics -- Roles of RUNX1 enhancer in normal hematopoiesis and leukemogenesis -- RUNX1-ETO leukemia -- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders -- Mechanism of ETV6-RUNX1 leukemia -- ETV6-RUNX1+ acute lymphoblastic leukemia in identical twins -- Molecular basis and targeted inhibition of CBFb-SMMHC acute myeloid leukemia -- The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models -- RUNX1 and CBFb mutations and activities of their wild-type alleles in AML -- Roles of RUNX in B cell immortalization -- Roles of RUNX in solid tumors -- RUNX3 and p53: How two tumor suppressors cooperate against oncogenic Ras -- Runx3 and cell fate decisions in pancreas cancer -- RUNX genes in breast cancer and the mammary lineage -- Runx3 in immunity, inflammation and cancer -- Roles of RUNX complexes in immune cell development -- CBFb and HIV infection -- Roles of RUNX in Hippo pathway signaling -- Roles of RUNX in hypoxia-induced responses and angiogenesis -- The emerging roles of RUNX transcription factors in Epithelial-Mesenchymal Transition -- Regulatory role of RUNX1 and RUNX3 in the maintenance of genomic integrity
Abstract: This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists
Pages: XX, 515 p. 98 illus., 92 illus. in color. : online resource.
ISBN: 9789811032332
Human Chromosome Variation: Heteromorphism, Polymorphism and Pathogenesis (2017)
Singapore : Springer
Keywords: Medicine ; Medical genetics ; General practice (Medicine) ; Biomedicine ; Gene Function ; General Practice / Family Medicine ; Springer eBooks
Description / Table of Contents: Introduction -- Chromosome Heteromorphism -- Frequencies of Heteromorphisms -- Clinical Populations -- Euchromatic Variants -- Chromosome Heteromorphism (Summaries)- Fragile Sites -- Chromosome Variation Detected by Fluorescent In Situ Hybridization (FISH) -- Array-Comparative Genomic Hybridization/Microarray Analysis: Interpretation of Copy Number variants -- A CNV Catalog -- Gene and Genome Sequencing: Interpreting Genetic Variation at the Nucleotide Level
Abstract: This new edition now titled ́€œHuman Chromosome Variation: Heteromorphism, Polymorphism and Pathogenesiś€ provides the reader with an up-to-date overview of microarrays, fragile sites, copy number variations and whole genome sequencing. Greatly expanding the discussion of microarray analysis in the previous edition of the book, are new chapters on microarray and genomic analysis, plus comprehensive tables on the subtle microdeletions and microduplications that are found on each chromosome, including 235 recurring copy number variants that are associated with well-established or emerging chromosomal syndromes. The current edition features concise information on cytogenetic methods and applications, extending these discussions to DNA analysis and genome sequencing. Sections on euchromatin, heterochromatin, FISH pattern, fragile site, copy number, and DNA sequence variation are integrated with actual clinical examples from cytogenetic laboratories and from clinical practice. The principles that allow for the distinction between benign chromosome / DNA variation and pathogenic heteromorphisms / polymorphisms are discussed and include references to the latest organizational guidelines and genomic or population databases. The two previous incarnations of this book: the €˜Átlas of Human Chromosome Heteromorphisḿ€™, and ́€˜Human Chromosome Variation: Heteromorphism and Polymorphisḿ€™ have been standard reference works in most cytogenetic laboratories, used by laboratory directors and clinicians all around the world. While widely used sections from the previous edition on cytogenetic technologies and heteromorphisms are retained intact the present volume adds extensive material on copy number variations (polymorphisms detected by microarray analysis), fragile sites in disease and cancer, and practical views on interpreting emerging technologies, including whole exome sequencing. This book should be of interest to clinicians, technicians and students who are or will be exposed to DNA and/or chromosome analysis and the data derived from these continuously developing techniques. This fully updated book volume will bring the reader up to speed on the latest technologies, their applications, benefits and drawbacks and as such, is a must read for anyone with an interest in DNA and chromosome analysis and the distinction between benign variation and pathogenic mistakes
Pages: XX, 490 p. 87 illus., 29 illus. in color. : online resource.
Edition: 2nd ed. 2017.
ISBN: 9789811030352
on loan
Image-based computer-assisted radiation therapy (2017)
Singapore : Springer Nature
Call number: QZ269:198
Keywords: Radiation Oncology / methods ; Radiotherapy, Computer-Assisted / methods
Pages: x, 381 p. : ill.
ISBN: 9789811029431
Diagnostic imaging : [2] / Head and neck (2017)
Salt Lake City, UT : Elsevier
Call number: WN200:54/2(3)
Keywords: Head / Imaging ; Neck / Imaging ; Head / pathology ; Head / pathology ; Neck / pathology ; Neck / pathology ; Diagnostic Imaging ; Diagnostic Imaging ; Head / radiography ; Head / radiography ; Neck / radiography ; Neck / radiography
Pages: various pagings
Edition: 3rd ed.
ISBN: 9780323443012
Medizinische Statistik : angewandte Biometrie für Ärzte und Gesundheitsberufe (2017)
Stuttgart : Schattauer
Call number: W26.5:136(2)
Keywords: Clinical Medicine ; Medical statistics
Pages: 640 p. : ill.
ISBN: 9783794532414
Call number: QH581:71(3)
Keywords: Cell Physiological Phenomena ; Cells
Pages: xi, 882 pages : illustrations, portraits
Edition: 3rd edition.
ISBN: 9780323341264
Cancer medicine 9 (2017)
Hoboken, N.J. : John Wiley & Sons Inc.
Call number: QZ200:569(9)
Keywords: Neoplasms
Notes: Rev. ed. of: Holland Frei cancer medicine 8 / editors, Waun Ki Hong ... [et al.]. 8th ed. 2010.
Pages: xxv, 1971 p.
Edition: 9th ed.
ISBN: 9781118934692
Molecular Therapies of Cancer (2015)
Cham : Springer
Keywords: Medicine ; Oncology ; Medical laboratories ; Biomedicine ; Cancer Research ; Laboratory Medicine ; Oncology ; Springer eBooks
Description / Table of Contents: DNA Damaging Drugs -- Drugs that Suppress Proliferation -- Molecular Inhibitors of Growth Signals -- Anti-Metastasis Therapy -- Induction of Senesence -- Combination Chemotherapy -- Gene Therapy -- Drugs with Diverse Modes of Action -- Hormone Therapy -- Immunotherapy -- Anti-Angiogenesis -- Drug Delivery and Drug Transport -- Drug Metabolism -- Prodrug Activation -- Drug Resistance -- Protection from Adverse Effects -- Pain Management -- Preventative Treatment
Abstract: Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies
Pages: XV, 453 p. 120 illus., 86 illus. in color. : online resource.
ISBN: 9783319132785
TNM Klassifikation maligner Tumoren (2017)
Weinheim : Wiley-VCH
Call number: QZ200:12(8) ; C020:162 ; E050:25 ; G033:91 ; G033:92 ; G033:93 ; G033:94 ; G033:95 ; G033:96 ; G033:97 ; G033:98 ; M100:605 ; M100:606 ; M100:607 ; M110:14 ; M110:15 ; M110:16 ; M110:17 ; M110:18
Keywords: Tumors / Classification ; Neoplasms / classification
Notes: Translation of: TNM classification of malignant tumours, 8th ed., 2017.
Pages: xxi, 313 p.
Edition: 8. Auflage.
ISBN: 9783527342808
Roitt's essential immunology (2017)
Chichester, West Sussex : John Wiley & Sons
Call number: QR181:101(13)
Keywords: Immune System ; Immunity
Description / Table of Contents: Innate immunity -- Specific acquired immunity -- Antibodies -- Membrane receptors for antigen -- Antigen-specific recognition -- Immunological methods and applications [JS2] -- The anatomy of the immune response -- Lymphocyte activation -- The production of effectors -- The regulation of the immune response -- Development and evolution of the immune response -- Adversarial strategies during infection -- Vaccines -- Immunodeficiency -- Allergy and other hypersensitivities -- Transplantation -- Tumor immunology -- Autoimmune diseases
Notes: Preceded by Roitt's essential immunology / Peter J. Delves ... [et al.]. 12th ed. 2011.
Edition: 13th edition.
ISBN: 9781118415771
Stem cells in toxicology and medicine (2017)
Chichester, UK : John Wiley & Sons
Call number: QH587:34
Keywords: Stem cells / Research ; Toxicology / Research
Pages: xxv, 532 p. : ill.
ISBN: 9781119135418
Introduction to Bayesian statistics (2017)
Hoboken, N.J. : John Wiley & Sons
Call number: QA276:87(3)
Keywords: Bayes Theorem
Pages: xvi, 601p. : ill.
Edition: 3rd ed.
ISBN: 9781118091562
Harrison's hematology and oncology (2017)
New York : McGraw-Hill Education Medical
Call number: QZ200:567(3)
Keywords: Hematologic Diseases ; Neoplasms
Notes: "This third edition is derived from the 19th edition of Harrison's Principles of Internal Medicine."
Pages: xv, 832 p. :
Edition: 3rd ed.
ISBN: 9781259835834
Call number: QZ200:530/9(4) ; QZ365WI200:95(4) ; G033:99
Keywords: Head and Neck Neoplasms ; Head and Neck Neoplasms / genetics ; Head and Neck Neoplasms / pathology
Notes: The WHO Classification of head and neck tumours presented in this book reflects the views of a Working Group that convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer, Lyon 14-16 June 2016.
Pages: 347p. : ill.
Edition: 4th. ed.
ISBN: 9789283224389