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Zika Virus Infection : Risk of Spreading in Europe (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Immunology ; Medical Microbiology ; Virology ; Health Promotion ; Infectious Diseases ; Medicine & Public Health ; Infectious Diseases ; Virology ; Immunology ; Medical Microbiology ; Health Promotion and Disease Prevention ; Springer eBooks
Abstract: This book describes the demographic and clinical patterns of Zika infection and evaluates the risk of it spreading to Europe. It reflects the hands-on experience of the author, who as a physician, was faced with the first-ever cases reported in Europe. Providing essential background information on the viral vector, it addresses the various symptoms after infection, and places them in the epidemiological context of past outbreaks. The book addresses the needs of physicians attending patients with infectious diseases, including infectious-disease specialists, pediatricians, internal medicine specialists, general practitioners, obstetricians, tropical medicine and travel medicine specialists, preventive medicine and public health specialists, microbiologists, biologists and vectorial control specialists. It raises clinicians’ and travel health clinics’ awareness of the evolution of Zika virus outbreaks and the affected areas so that they can include this infection in their differential diagnoses for travelers from those areas
Pages: XI, 93 p. 9 illus., 2 illus. in color. : online resource.
ISBN: 9783319594064
Transient Receptor Potential Canonical Channels and Brain Diseases (2017)
Dordrecht : Springer Netherlands
Keywords: Medicine ; Cancer Research ; Neurosciences ; Pharmacology ; Biochemistry ; Biomedicine ; Neurosciences ; Biochemistry, general ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
Description / Table of Contents: TRP channel classification -- TRPC channel structure and properties -- TRPC channel downstream signaling cascades -- TRPC Channels in Health and Disease -- TRPC channels and programmed cell death -- TRPC channels and stroke -- TRPC channels and Alzheimer’s disease -- TRPC channels and Parkinson’s disease -- TRPC channels and neuron development, plasticity and activities -- TRPC channels and brain inflammation -- TRPC channels and Epilepsy -- TRPC channels and mental disorders -- TRPC channels and cell proliferation -- TRPC channels and glioma
Abstract: This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field
Pages: VIII, 165 p. 16 illus., 15 illus. in color. : online resource.
ISBN: 9789402410884
Drittmittel für die Forschung : Grundlagen, Erfolgsfaktoren und Praxistipps für das Schreiben von Förderanträgen (2017)
Wiesbaden : Springer Gabler
Call number: ALLG-BERUF-LB2376:4 ; M250:8
Keywords: Proposal writing for grants
Pages: x, 206 p.
ISBN: 9783658164515
on loan
Cellular and molecular immunology (2017)
Philadelphia : Saunders Elsevier
Call number: QR181:95(9) ; L401:7
Keywords: Immunity, Cellular ; Antibody Formation / immunology ; Antigens / immunology ; Immune System Diseases / immunology ; Lymphocytes / immunology
Description / Table of Contents: Properties and overview of immune responses -- Innate immunity -- Cells and tissues of the adaptive immune system -- Antibodies and antigens -- The major histocompatibility complex -- Antigen processing and presentation to T lymphocytes -- Antigen receptors and accessory molecules of T lymphocytes -- Lymphocyte development and the rearrangement and expression of antigen receptor genes -- Activation of T lymphocytes -- B cell activation and antibody production -- Immunologic tolerance -- Cytokines -- Effector mechanisms of cell-mediated immunity -- Effector mechanisms of humoral immunity -- Immunity to microbes -- Transplantation immunology -- Immunity to tumors -- Diseases caused by immune responses: hypersensitivity and autoimmunity -- Immediate hypersensitivity -- Congenital and acquired immunodeficiencies
Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail:
Pages: x, 565 p. : ill.
Edition: 9th ed.
ISBN: 9780323479783
Fluorescence microscopy : from principles to biological applications (2017)
Weinheim : Wiley-VCH
Call number: QH207:18(2)
Keywords: Microscopy, Fluorescence / methods ; Fluorescence microscopy
Pages: xxii, 482 p. : ill.
Edition: 2nd ed.
ISBN: 9783527338375
Applied mathematics for the analysis of biomedical data : models, methods, and MATLAB (2017)
Hoboken, New Jersey : Wiley
Call number: QH405:57
Keywords: Biomathematics ; Bioinformatics / Mathematical models
Description / Table of Contents: Data -- Some examples -- Seir models -- Statistical pattern recognition and classification -- Biostatistics and hypothesis testing -- Clustered data and analysis of variance
Pages: xxxv, 409 pages : illustrations
ISBN: 9781119269496
Nuklearmedizin : Basiswissen und klinische Anwendung (2017)
Stuttgart : Schattauer
Call number: WN440:29(8)
Keywords: Nuclear Medicine
Pages: xv, 464 p. : ill.
Edition: 8., vollständig überarb. Aufl.
ISBN: 9783794531097
Advances in Radiation Oncology (2017)
Cham : Springer International Publishing
Call number: QZ269:199
Keywords: Cancer / Radiotherapy
Pages: viii, 271 p. : ill.
ISBN: 9783319532332
Medizininformatik : ein Kompendium für Studium und Praxis (2017)
Berlin : Springer Vieweg
Call number: W26.5:137
Keywords: Bioinformatics
Pages: 259 p. : ill.
Edition: 1. Aufl.
ISBN: 9783662533277
History of Human Genetics : Aspects of Its Development and Global Perspectives (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Human Genetics ; Molecular Biology ; Biomedicine ; Human Genetics ; Molecular Medicine ; Springer eBooks
Description / Table of Contents: Introduction -- Part I: Workshops on the History of Human Genetics -- The International Workshops on Genetics, Medicine and History: An Overview, 2003–2015 -- Part II: Beginning of Human Genetics -- Ancestral Concepts of Human Genetics and Molecular Medicine in Epicurean Philosophy -- Bateson and the Doctors: The Introduction of Mendelian Genetics to the British Medical Community 1900–1910 -- Part III: Genetics and Medicine -- Pedigrees and Prejudices: Pre-WWII Inherited Disease Classification at the US Eugenics Record Office -- Aldred Scott Warthin’s Family ‘G’: The American Plot Against Cancer and Heredity (1895–1940) -- Genetic Discrimination in the Doctoring of Cancer and Alcoholism -- The Genomization of Biology: Counterbalancing Radical Reductionism -- A Brief History of Uncertainty in Medical Genetics and Genomics -- Part IV: Countries -- “Nature’s Laboratories of Human Genetics”: Alpine Isolates, Hereditary Diseases and Medical Genetic Fieldwork, 1920–1970 -- Some Thoughts on Genetics and Politics. The Historical Misrepresentation of Scandinavian Eugenics and Sterilization -- Changing the Point of View: The History of Human Genetics as an Applied Science in the Federal Republic of Germany, 1945–1975 -- Herbert Bach (1926–1996): One of the Pioneers of Human Genetics in East Germany (GDR) -- Concise History of Prenatal Diagnostic Service in Russia -- Foundation of the International Federation of Human Genetic Societies: The Catalyst -- Part V: Gene Mapping -- The First Human Genetic Map 1936 -- Glasgow Contributions to Human Gene Mapping -- Human Gene Mapping: The Mass Media Iconography of the Human Genome Project in the Most Popular Greek Newspapers -- Part VI: Narrated History -- National Human Genome Research Institute History of Genomics Oral History Program: An Example of “Triangulation” -- Narrating Genes: How Patients with Chronic Inflammatory Bowel Diseases Interpret an Emerging Disease Aetiology and How We Can Make Sense Out of It by Developing a Historically and Sociologically Informed Framework -- Part VII: Genetic Counselling -- The Establishment of Genetic Counselling in Sweden: 1940–1980 -- Counselling, Risk and Prevention in Human Genetic Early Diagnosis in the Federal Republic of Germany -- “The Happiness of the Individual Is of Primary Importance”:Genetic Counselling in the GDR -- Remarks on the History of Genetic Counselling in Czechoslovakia, 1945–1990 -- The Establishment of Human Genetic Counselling in Austria in the 1970s in Between the Establishment of Human Genetics and the Eugenic Indication of Abortion -- Genetic Counselling in Belgium: The Centre for Human Genetics at the University of Leuven, 1960–1990 -- Genetic Counselling for Mediterranean Anaemia in Post-war Greece -- Karyotyping and the Emergence of Genetic Counselling in Mexico in the 1960s -- Newborn Screening on the Cusp of Genetic Screening: From Solidarity in Public Health to Personal Counselling -- Feminist Criticism of Genetic Counselling in the Second Half of the Twentieth Century -- The Evolving Concept of Non-directiveness in Genetic Counselling -- A Comparative and Social History of Genetic Counselling?
Abstract: Written by 30 authors from all over the world, this book provides a unique overview of exciting discoveries and surprising developments in human genetics over the last 50 years. The individual contributions, based on seven international workshops on the history of human genetics, cover a diverse range of topics, including the early years of the discipline, gene mapping and diagnostics. Further, they discuss the status quo of human genetics in different countries and highlight the value of genetic counseling as an important subfield of medical genetics
Pages: VIII, 576 p. 36 illus., 29 illus. in color. : online resource.
ISBN: 9783319517834
Instrumentelles und bioanalytisches Praktikum (2017)
Berlin : Springer Spektrum
Call number: QP519:89
Notes: Basierend auf den Grundlagen der 3. Aufl. von "Instrumentelle Analytik und Bioanalytik", 2015.
Pages: xvii, 307 p. : ill.
ISBN: 9783662541227
Mechanisms of Molecular Carcinogenesis : Volume 2 (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Gene Expression ; Molecular Biology ; Oncology ; Cytokines ; Growth factors ; Biomedicine ; Cancer Research ; Oncology ; Molecular Medicine ; Cytokines and Growth Factors ; Gene Expression ; Springer eBooks
Description / Table of Contents: 1. Breast Carcinogenesis -- 2. Non-melanoma skin cancer, Actinic keratosis and squamous cell cancer -- 3. Molecular Pathogenesis of Soft Tissue Tumours -- 4. Colorectal carcinogenesis -- 5. Pancreatic Carcinogenesis -- 6. Hepatocellular carcinogenesis -- 7. Neuroendocrine tumorigenesis -- 8. Molecular etiopathogenesis of extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue -- 9. Urologic neoplasms including Kidney and Urinary Bladder -- 10. Molecular Carcinogenesis of Urinary Bladder Cancer -- 11. Gynecologic Carcinogenesis -- 12. CTCs and ctDNA -- 13. Computational Pathology -- 14. In vitro three-dimensional cultures as tool for personalized medicine -- 15. Stratifying cancer therapies by molecular interactions and imaging -- 16. Molecular Modelling
Abstract: Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research
Pages: VIII, 374 p. 47 illus., 42 illus. in color. : online resource.
ISBN: 9783319536613
Neuroepigenomics in Aging and Disease (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Gene Expression ; Medical genetics ; Proteomics ; Life sciences ; Proteomics ; Gene Expression ; Gene Function ; Springer eBooks
Description / Table of Contents: Part I: Neurodevelopmental and Childhood Disorders -- MECP2, a modulator of Neuronal Chromatin Organization Involved in Rett Syndrome -- The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome -- Rubinstein-Taybi Syndrome and Epigenetic Alterations -- Epigenetics of Autism Spectrum Disorder -- Part II: Adolescence Brain Diseases -- Eating Disorders and Epignetics -- Drug Addiction and DNA Modifications.-Drug Addiction and Histone Code Alterations -- Anxiety and Epigenetics -- Part III: Brain Disorders During Adulthood -- Histone Modifications in Major Depressive Disorder and Related Rodent Models -- DNA Methylation in Major Depressive Disorder -- Non-Coding RNAs in Depression -- DNA Methtlation in Schizophrenia -- Histone Post-translational Modifications in Schizophrenia -- Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis (ALS) -- Epigenetics of Huntington’s Disease -- Part IV: Elderly Disorders.-DNA Modifications and Alzheimer’s Disease -- Alzheimer’s Disease and Histone Code Alterations -- Alzheimer’s Disease and ncRNAs -- Epigenetics in Parkinson’s Disease -- Part V: New Approaches for Neuroepigenomic Studies -- Single Cell Genomics Unravels Brain Cell Type Complexity -- Epigenome Editing in the Brain -- Techniques for Single Molecule mRNA Imaging in Living Cells -- Stem Cell Technology for (epi)genetic Brain Disorders -- Technologies for Deciphering Epigenomic DNA Patterns -- Bioinformatics Tools for Genome Wide Epigenetic Research
Abstract: Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases
Pages: XIII, 525 p. 41 illus., 39 illus. in color. : online resource.
ISBN: 9783319538891
Cancer Therapeutic Targets (2017)
New York, NY : Springer New York
Keywords: Medicine ; Cancer Research ; Laboratory Medicine ; Molecular Biology ; Pharmacology ; Internal Medicine ; Oncology ; Biomedicine ; Cancer Research ; Oncology ; Laboratory Medicine ; Internal Medicine ; Molecular Medicine ; Pharmacology/Toxicology ; Springer eBooks
Description / Table of Contents: AKT -- Anti-4-1BB/4-1BBL -- Anti-B7-H4 -- Anti-CD40/Anti CD40L -- Anti-Idiotype antibodies -- Anti-Programmed Death 1 (PD1) -- B7.1 -- Bacterial Vaccines -- Brachyury -- CCL21 -- CD4+ T Cells -- CD8 T Cells -- CEA -- CTLA-4 -- Dendritic cells -- DNA Vaccines -- EGFR, Immunology -- Fc Gamma R -- Gangliosides -- Glucocorticoid-Induced TNF Receptor (GITR) -- GM-CSF and Whole Cells -- gp100 -- HER2/neu -- indoleamine 2,3-dioxygenase -- Integrins, Immunology -- Interferon alpha -- Interleukin 2 -- Interleukin 7 -- Interleukin 12 -- Interleukin 15 -- Interleukin 21 -- Lymphocyte Activation Gene 3 (LAG-3) -- MART-1 -- MUC1 -- NK Cells -- P53, Immunology -- PAP -- Peptide Vaccine: Overview -- Proteins (Mesothelin) -- PSA -- Survivin -- Telomerase-related proteins -- TGF Beta Receptors -- TLR7 and TLR8, Resiquimod, and 852A -- TLR9 -- Transforming Growth Factor β -- Tregs -- Tyrosinase: Overview -- VEGF -- Viral-Like Proteins -- Whole-Cell Vaccines -- FGF-FGFR Signaling in Cancer -- MMPs -- PDGF -- TIE -- VEGF A -- VEGF Ligands -- AXL -- B-Raf -- CKIT -- DNA Repair, Overview -- EGFR, Growth factors -- HER3 -- IGF 1 and IGF 2 -- Jak2/Stat5a/b Pathway in Prostate Cancer -- JNK Signaling in Diseases -- K-Ras -- MET -- NEDD9 -- N-Ras -- P38 -- Rac 1 -- Type I Insulin-Like Growth Factor Receptor -- Anti-apoptotic Bcl-2 -- BH3-Only Mimetics -- Caspase -- DR4 and DR5 -- FLIP -- MLH1 -- NF-κB -- PARP -- ROS -- X-Linked IAP -- APC -- AR, Overview -- BRCA 1 and 2 -- Cell Cycle Related Kinases -- ER -- Histone Deacetylases (HDAC) -- Methylation -- PR -- Retinoids -- Topoisomerase 1 -- Topoisomerase 2 -- VDR
Abstract: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well
Pages: 51 illus., 42 illus. in color. eReference. : online resource.
ISBN: 9781441907172
Zellbiologie (2017)
Stuttgart : Georg Thieme Verlag
Call number: QH581:60(5)
Keywords: Cells / anatomy & histology
Notes: carlo märz 2017
Pages: 586 p. : ill.
Edition: 5. überarb. Auflage
ISBN: 9783132402270
Call number: QR41:28(15)
Keywords: Microbiology
Notes: Includes index.
Pages: xxvii, 1022 pages : illustrations (some color)
Edition: 15th edition.
ISBN: 9780134261928
Lung cancer : treatment and research (2016)
Cham : Springer
Call number: QZ365WF658:173
Keywords: Lung Neoplasms
Pages: vi, 322 p. : ill.
ISBN: 9783319403878
Call number: QZ200:530/9(4) ; QZ365WI200:95(4) ; G033:99
Keywords: Head and Neck Neoplasms ; Head and Neck Neoplasms / genetics ; Head and Neck Neoplasms / pathology
Notes: The WHO Classification of head and neck tumours presented in this book reflects the views of a Working Group that convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer, Lyon 14-16 June 2016.
Pages: 347p. : ill.
Edition: 4th. ed.
ISBN: 9789283224389
The molecular basis of human cancer (2017)
New York, N.Y. : Springer
Call number: QZ208:157(2)
Keywords: Carcinogenesis / Molecular aspects ; Cancer / Genetic aspects ; Mutation (Biology)
Pages: xviii, 873 p. : ill.
ISBN: 9781934115183
Biobanking of Human Biospecimens : Principles and Practice (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Laboratory Medicine ; Biomedicine ; Laboratory Medicine ; Springer eBooks
Description / Table of Contents: -- 1. 20 years of biobanking: dawning or a new era (Volume Editors) -- SECTION 1: BIOBANKS IN PRACTICE -- 2. Principles of cryo-preservation-Allison Hubel (University of Minnesota) -- 3. Biobank design and infrastructure-A. Zaayenga (SmarterLab Inc) -- 4. Minimal standards for biobank annotations-H.M. Moore (National Cancer Institute) -- 5. Biobank governance and sustainability- M. Pasterk (IPRI, France) -- 6. Biobanking in low resource contexts-R. Lawlor (University of Verona) -- 7. Biosafety and biosecurity -G. D€™Ágnolo (Italian National Committee on Biosafety, Biotechnology and Life Sciences) -- 8. Quality assurance and quality control in Biobanking- Di Donato (INSERM, France) -- 9. Biocomputing for biobanks-P. Fearn (University of Washington) -- 10. Ethical and societal challenges for biobanks-Jane Kay (INSERM, France) -- SECTION 2: TYPES OF BIOBANKS -- 11. Disease-oriented biobanks: from pathology archives to personalized medicine-Peter Riegman (Erasmus University) -- 12. Biobanking for molecular epidemiology- J.Dillner (Helmoltz, Munich). -- 13. Biobanking for biomarker discovery- Jim Vaught (National Cancer Institute) -- 14. Biobanking in clinical trials- G. Golfinopoulos (EORTC, Belgium) -- 15. Industrial Biobanks-(To Be Defined). -- SECTION 3: NETWORKING BIOBANKS -- 16. International biobank networks: the P3G experience-I. Fortier (McGill University) -- 17. Networking Biobanks throughout Europe- KurtEero Vuorio (INSERM, France) -- 18. Biobanking networks through 5 continents -R. Hewitt, N. Zeps -- 19. Driving international convergence through evidence-based standards (Volume Editors). -- 20. National Networking ́€“ the case of Spain- Morente Manuel (CNIO, Madrid) -- SECTION 4: The Future of Biobanking -- 21. Training biobankers for the 21st century-E. Gormally (Fac Catholique, France) -- 22. The Science of Biobanking and biospecimen research- Jim Vaught (National Cancer Institute) -- 23. Economics of Biobanking-Jim Vaught (National Cancer Institute) -- 24. Meeting Tomorroẃ€™s Challenges: Biobanking for All (Volume Editors)
Abstract: This volume is the first comprehensive text on human biobanking, authored by scientists and regulatory officers who have led the field over the past 10 years. It covers biobanking issues and its importance in advancing the field of research in cancer, cardiovascular, metabolic, and other diseases. Biobanks of human specimens have become the cornerstone for research on human health that harnesses the power of €œómicś€ technologies to identify biomarkers for disease susceptibility. Biobanks are an essential component of the development of personalized medicine, which relies on the molecular analysis of biospecimens that are truly representative of individuals and of diseases. Over the past decade, biobanking has been the focus of major investments and developments aimed at developing appropriate infrastructure, methods, networking practice and evidence-based pre-analytical procedures. This volume explores topics including specimen storage, protocol design, specimen collection, pre-analytical processing and preservation, long-term storage, retrieval and separation, and distribution to analytical laboratory platforms. These activities are extremely complex and are essential for biomedical and biotechnological developments and this text provides critical information about biobanking for the development of future forms of medicine
Pages: XII, 240 p. 20 illus., 16 illus. in color. : online resource.
ISBN: 9783319551203
Pancreas, Kidney and Skin Regeneration (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Nephrology ; Stem Cells ; Regenerative Medicine ; Tissue Engineering ; Biomedical Engineering ; Life sciences ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering ; Nephrology ; Springer eBooks
Description / Table of Contents: Part 1. Pancreas Regeneration -- Chapter 1. Stem cell transplantation in type I and type II diabetes mellitus -- Chapter 2. Stem cell therapy for type I diabetes mellitus -- Chapter 3. New trends in stem cell transplantation in diabetes mellitus type I and type II -- Chapter 4. New advances in stem cell therapy for diabetes mellitus -- Chapter 5. Therapeutic Potential of Mesenchymal Stem Cells and miRNAs in Diabetes -- Chapter 6. Novel biomarkers at risk stratification of diabetes mellitus patients -- Part 2. Kidney Regeneration -- Chapter 7. Role of endothelial progenitor cells in kidney repair -- Chapter 8. Stem cell transplantation for kidney diseases -- Part 3. Skin Regeneration -- Chapter 9. Use of Stem Cells in Acute and Complex Wounds -- Chapter 10. Wound treatment by stem cells -- Chapter 11. Stem cell therapy for ischemic heart disease -- Chapter 11. Adipose derived stem cells for wound healing: an update -- Chapter 12. Adipose tissue derived stem cells in regenerative medicine and plastic surgery: perspective from personal practice -- Chapter 13. Stem cell applications in rejuvenation
Abstract: This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering
Pages: XI, 326 p. 29 illus., 23 illus. in color. : online resource.
ISBN: 9783319556871
Critical Care Toxicology : Diagnosis and Management of the Critically Poisoned Patient (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Pharmacology ; Emergency Medicine ; Critical care medicine ; Biomedicine ; Pharmacology/Toxicology ; Emergency Medicine ; Intensive / Critical Care Medicine ; Springer eBooks
Description / Table of Contents: 4-Dimethylaminophenol -- Acetaminophen (Paracetamol) -- Beta Receptor Antagonists -- Cardiac Conduction and Rate Disturbances -- Digitalis Glycosides -- Extracorporeal Membrane Oxygenation and Cardiopulmonary Bypass in the Poisoned Patient -- Fumigants -- Gyromitra Mushrooms -- Hydrocarbons and Halogenated Hydrocarbons -- Irritant and Toxic Respiratory Injuries -- Lipid Resuscitation Therapy -- Marine Vertebrates, Cnidarians and Mollusks -- Nerve Agents -- Organophosphorus and Carbamate Insecticides -- Phosphine and Metal Phosphide -- Rifampin, Dapsone, and Vancomycin -- Salicylates -- Thallium -- Unithiol (DMPS) -- Valproic Acid -- Widow and Related Lactrodectus Spiders
Abstract: Building on the previous edition with contributions from internationally renowned experts this book provides a fully comprehensive resource for managing the post emergency/treatment stage of acute poisoning. Chapters incorporate evidence-based paradigms with up-to-date citations from the original medical literature. Topic areas covered include: diagnosis and management of the critically poisoned patient, including pediatric patients and poisoning in pregnancy; toxic syndromes including hepatotoxic and pulmonary syndromes as well as poisonings from medications, drugs of abuse, chemical and biological agents. This book is an essential resource for Clinical Toxicologists, Intensivists and Emergency Medicine specialists in training and in practice
Pages: 675 illus., 294 illus. in color. eReference. : online resource.
Edition: 2nd ed. 2017.
ISBN: 9783319179001
Cell Division Machinery and Disease (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Cell Cycle ; Cell Physiology ; Life sciences ; Cell Cycle Analysis ; Cell Physiology ; Cancer Research ; Springer eBooks
Description / Table of Contents: 1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization
Abstract: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases
Pages: XIV, 235 p. 33 illus., 32 illus. in color. : online resource.
ISBN: 9783319571270
Drug and Gene Delivery to the Central Nervous System for Neuroprotection : Nanotechnological Advances (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedical Engineering ; Biomedicine ; Neurosciences ; Biomedical Engineering ; Neurobiology ; Springer eBooks
Description / Table of Contents: Chapter 1 Renewable Biomaterials as Nanocarriers for Drug and Gene Delivery -- Chapter 2 Nanocarriers as CNS Drug Delivery Systems for Enhanced Neuroprotection -- Chapter 3 Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment -- Chapter 4 Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases -- Chapter 5 Sleep Deprivation Induced Blood-Brain Barrier Breakdown and Brain Pathology. Neuroprotective Effects of Tio2-Nanowired Delivery of Cerebrolysin and Ondansetron -- Chapter 6 Glyco-Functionalised Biomaterials in Neuroregeneration -- Chapter 7 Targeting Nanoparticles to Brain: Impact of N-Methyl D-Aspartate Receptors
Abstract: This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease
Pages: XIII, 228 p. 47 illus., 38 illus. in color. : online resource.
ISBN: 9783319576961
Perioperative Inflammation as Triggering Origin of Metastasis Development (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: The Natural History of Breast Cancer -- Perioperative Inflammation as Triggering Origin of Metastasis Development -- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients -- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation -- Circulating tumor cells as predictive marker in metastatic disease -- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints -- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs -- The impact of wound inflammation on cancer progression; Studies in fish and patients -- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives -- Cancer: Nurture and Nature -- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer
Abstract: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities
Pages: XXIII, 236 p. 49 illus., 39 illus. in color. : online resource.
ISBN: 9783319579436
Current Proteomic Approaches Applied to Brain Function (2017)
New York, NY : Springer New York
(Neuromethods, 127)  
Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
Description / Table of Contents: Brain Proteomics: Decoding Neuroproteomes using Mass-Spectrometry -- Applications of Amine-Reactive Tandem Mass Tags (TMT) in Human Neuroproteomics -- Application of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to Monitor Olfactory Proteomes during Alzheimer´s Disease Progression -- Protein Microarrays in Neurodegenerative Diseases -- Comprehensive Shotgun Proteomic Analyses of Oligodendrocytes using Ion Mobility and Data Independent Acquisition -- Non-Targeted Brain Lipidomics Profiling Performed by UPLC-ESI-qTOF-MS/MS -- Methods for Human Olfactory Bulb-Tissue Studies using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) -- Neuroproteomics using Short GeLC-SWATH: From the Evaluation of Proteome Changes to the Clarification of Protein Function -- Analysis of Brain Phosphoproteome using Titanium Dioxide Enrichment and High Resolution LC-MS/MS -- N-Glycomics and N-Glycoproteomics of Human Cerebrospinal Fluid -- In Vivo Strategies to Isolate and Characterize the Neuronal Ubiquitinated Proteome -- Characterization of the Phosphoproteome and Sialoproteome in Brain Tissues by Mass Spectrometry -- Proteomic Analysis of SUMOylation in the Post-Ischemic Brain -- S-Nitrosylation in Alzheimer´s Disease using Oxidized Cysteine-Selective cPILOT -- Proteomic Analysis of Extracellular Vesicles in Neurological Diseases -- Quantitative In-Depth Profiling of the Postsynaptic Density Proteome to Understand the Molecular Mechanisms Governing Synaptic Physiology and Pathology -- Nuclear Proteomics for Exploring MK-801 Treated Oligodendrocytes to Better Understand Schizophrenia -- Localized Proteomics of Individual Neurons Isolated from Formalin-Fixed, Paraffin Embedded Tissue Sections using Laser Capture Microdissection -- Creation of Reusable Bioinformatics Workflows for Reproducible Analysis of LC-MS Proteomics Data -- Integration of Transcriptomic and Proteomic Data for Disease Insights
Abstract: This volume focuses on protein analysis covering a wide spectrum of the utility of mass spectrometry within neurobiological disciplines. The chapters in this book discuss label (iTRAQ, TMT, protein arrays) and label-free workflows (SWATH, MALDI Imaging, and label-free quantitation). Other chapters look at experimental strategies targeted to the identification and quantitation of specific lipids and post-translational modifications, as well as proteomic workflows that focus on characterization of subcellular proteomes. The last few chapters in the book describe various bioinformatics pipelines used to analyze the molecular data derived from high-throughput transcriptomic and proteomic experiments on brain tissue. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Thorough and comprehensive, Current Proteomic Approaches Applied to Brain Function is a valuable resource for graduate students and postdoctoral fellows interested in neuroproteomics, as well as researchers looking for further insight into the growing field of mass spectrometry in neuroscience
Pages: XVI, 360 p. 91 illus., 61 illus. in color. : online resource.
ISBN: 9781493971190
Natural Antibodies : Methods and Protocols (2017)
New York, NY : Springer New York
Keywords: Medicine ; Immunology ; Biomedicine ; Immunology ; Springer eBooks
Description / Table of Contents: Natural Antibodies: Next Steps towards Translational Investigation -- Isolation of Natural Anti-FceRIa Autoantibodies from Healthy Donors -- Isolation of Antibodies from Human Plasma, Saliva, Breast Milk, and Gastrointestinal Fluid -- Purification of Natural Antibodies against Tau Protein by Affinity Chromatography -- Unbiased RACE-Based Massive Parallel Surveys of Human IgA Antibody Repertoires -- Analysis of Signaling Events in B-1a Cells -- Exploring the Role of Microbiota in the Limiting of B1 and MZ B-Cell Numbers by Naturally-Secreted Immunoglobulins -- Assessment of Anti-Tumor Cytotoxic Activity of Naturally Occurring Antibodies in Human Serum or Plasma -- Hydrolysis and Dissolution of Amyloids by Catabodies -- Methods for Post-Translational Induction of Polyreactivity of Antibodies -- Characterization of Natural IgM Antibodies Recognizing Oxidation-Specific Epitopes on Circulating Microvesicles -- Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans -- Detection of Natural Antibodies and Serological Diagnosis of Pneumococcal Pneumonia using a Bead-Based High-Throughput Assay -- Detection of Naturally Occurring Human Antibodies against Gangliosides by ELISA -- Evaluating the Impact of Natural IgM on Adenovirus Type 5 Gene Therapy Vectors
Abstract: This volume looks at the role of natural antibodies in pathogen elimination, cell survival, inflammation, cancer, and autoimmunity. The chapters in this book cover numerous topics, such as isolation of natural antibodies; methods for separating natural antibodies from human plasma, saliva, breast milk, and gastrointestinal fluids; functional properties of natural antibodies such as anti-tumor cytocoxic activity, and hydrolysis and dissolution of their target antigens; their utility in serological diagnosis of microbial antigens; and the role of natural antibodies in inhibiting viral vectors in the absence of prior exposure to the virus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Natural Antibodies: Methods and Protocols is a valuable resource for researchers and experts who are interested in further studies of natural antibodies
Pages: XI, 199 p. 22 illus., 11 illus. in color. : online resource.
ISBN: 9781493971800
Genomes 4 (2017)
New York, NY : Garland Science
Call number: QH447:217(4)
Keywords: Genome
Description / Table of Contents: Genomes, transcriptomes and proteomes -- Studying DNA -- Mapping genomes -- Sequencing genomes -- Genome annotation -- Identifying gene functions -- Eukaryotic nuclear genomes -- Genomes of prokaryotes and eukaryotic organelles -- Virus genomes and mobile genetic elements -- Accessing the genome -- The role of DNA-binding proteins in genome expression -- Transcriptomes -- Proteomes -- Genome expression in the context of cell and organism -- Genome replication -- Mutations and DNA repair -- Recombination and transposition -- How genomes evolve
Notes: Preceded by: Genomes 3 / T. A. Brown. 3rd ed. New York : Garland Science, 2007.
Pages: xvii, 520 p. : ill.
Edition: 4th.
ISBN: 9780815345084
Keywords: Medicine ; Cancer Research ; Pharmacology ; Oncology ; Biomedicine ; Cancer Research ; Oncology ; Pharmacology/Toxicology ; Springer eBooks
Description / Table of Contents: Liver biomarkers and their applications to nutritional interventions in animal studies -- AST-to-platelet ratio index (APRI) as marker in liver disease.-Inflammatory biomarkers in ascites -- Biomarkers for hepatocellular carcinoma in East Asia -- Liver disease and acylcarnitines as mechanistic biomarkers.-Type VI Collagen: Biological Functions and its Neo-epitope as Hepatic Fibrosis Biomarker -- Fibrinogen α-chain as a serum marker of liver disease -- Monocyte chemotactic protein-1 (cytokine, receptors,and gene polymorphisms) in hepatitis -- Biomarkers for Recurrence of Hepatocellular Carcinoma.-Graft-derived cell-free DNA as a biomarker in liver transplantation -- Serum sialic acid as a biomarker in liver disease -- CD133 and EpCAM as Biomarkers in Liver Diseases -- Traditional markers in liver disease -- Biomarkers of extracellular matrix remodeling in liver diseases -- Squamous Cell Carcinoma Antigen- Immunoglobulin M (SCCA-IgM) as biomarker in liver disease: biological aspects and clinical applications -- microRNA-155 and microRNA-196b in hepatitis C virus infection -- Immunological biomarkers in liver transplantation -- Phosphatidylethanol and alcohol use in liver disease patients -- Interaction of sialyltransferases, sialidases and sialic acids in liver diseases and applications to biomarker discovery -- Biomarkers to monitor graft function following liver transplantation -- YKL-40 as a biomarker of liver diseases -- Peripheral venous, portal venous, hepatic venous, arterial and intrahepatic cytokine levels as biomarkers and functional correlations -- Histological Biomarkers of Non-Alcoholic Fatty Liver Disease -- Vascular cell adhesion molecule-1 (vcam-1) expression in liver disease -- Bilirubin as a biomarker in liver disease -- Hydroxyproline as a biomarker in liver disease -- Genetic biomarkers of paracetamol-induced acute liver failure -- PNPLA3 polymorphism and Nonalcoholic Fatty Liver Disease -- Hepascore and it's application to liver disease -- Model for End-Stage Liver Disease (MELD) Score as a Biomarker -- Biomarkers in focus: Alanine Aminotransferase -- PTX3 as a biomarker of liver disease
Abstract: There are numerous types of liver disease that may be due to toxic agents (such as alcohol or drugs), infectious agents including viruses, congenital conditions and even poor dietary patterns. It has been suggested that there are over 100 different types. As the consequences of liver failure can be devastating it is important that appropriate diagnosis and monitoring is carried out. Much of this characterisation entails the use of biological indicators, i.e biomarkers. Biomarkers in Liver Disease embraces a holistic approach by combining detailed information on different conditions that affect the liver and the use of biomarkers. Biomarkers are described in terms of conventional, new and emerging analytes, techniques, platforms and applications. It covers the latest knowledge, trends and innovations. New platforms are described which combine advances in biomedical sciences, physics, computing and chemistry
Pages: 162 illus., 110 illus. in color. eReference. : online resource.
ISBN: 9789400776753
on loan
Inside graduate admissions : merit, diversity, and faculty gatekeeping (2016)
Cambridge, Massachusetts : Harvard University Press
Call number: ALLG-BERUF-LB2371:8
Keywords: Universities and colleges / Graduate work / United States ; Discrimination in higher education / United States ; Minorities / Education (Higher) / United States ; Universities and colleges / Faculty / United States ; Teacher participation in administration / United States
Pages: 250 p.
ISBN: 9780674088696
Ärztliche Schweigepflicht und Schutz der Patientendaten : Wissenswertes vom Datenschutz über die Praxisdurchsuchung bis zum Zeugnisverweigerungsrecht des Arztes (2017)
Landsberg am Lech : ecomed Medizin
Call number: W32GG4:12
Pages: 411p.
ISBN: 9783609103556
Das Toxikologiebuch : Grundlagen, Verfahren, Bewertung (2017)
Weinheim : Wiley-VCH
Call number: QV600:83
Keywords: Toxicology
Pages: xlvii, 1013 p. : ill.
ISBN: 9783527339730
Genetik und Molekularbiologie (2017)
Berlin : Springer Spektrum
Call number: QH431:145
Pages: xvi, 320 p. : ill.
ISBN: 9783662502730
Keywords: Life sciences ; Biomedical Engineering ; Bioinformatics ; Life sciences ; Bioinformatics ; Biomedical Engineering/Biotechnology ; Computational Biology/Bioinformatics ; Springer eBooks
Description / Table of Contents: 1. Nucleotide sequence analysis -- 2. Protein sequence analysis -- 3. Protein structure analysis -- 4. Protein-ligand interactions -- 5. RNA analysis -- 6. DNA marker analysis
Abstract: This manual offers a stand-alone reading companion, unique in simplifying the practical components of Bioinformatics in a unique and user-friendly manner. It covers the practical component of syllabi used at most leading universities and discusses the most extensively used tools and methodologies in Bioinformatics. Research in the biological sciences has made tremendous strides in recent years due in part to the increased automation in data generation. At the same time, storing, managing and interpreting huge volumes of data has become one of the most challenging tasks for scientists. These two aspects have ultimately necessitated the application of computers, giving rise to a highly interdisciplinary discipline–Bioinformatics. Despite the richness of bioinformatics resources and methods, the exposure of life sciences undergraduates and postgraduates to bioinformatics is extremely limited. Though the internet offers various tools for free, and provides guides for using them, it fails to help users interpret the processed data. Moreover, most sites fail to update their help pages to accommodate software upgrades. Though the market is flooded with books discussing the theoretical concepts in Bioinformatics, a manual of this kind is rarely found. The content developed to meet the needs of readers from diverse background and to incorporate the syllabi of undergraduate and postgraduate courses at various universities
Pages: XV, 283 p. 333 illus. : online resource.
ISBN: 9789811018572
Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Human Genetics ; Biostatistics ; Microbial genetics ; Microbial genomics ; Life sciences ; Microbial Genetics and Genomics ; Human Genetics ; Biostatistics ; Springer eBooks
Description / Table of Contents: Part I: overview -- 1. NGS, The new gold standard of identification of defective genes -- 2. Principles of target gene enrichments, pros and cons -- 3. Criteria for clinical application: Full validation and performance characteristics -- 4. Clinical requirements: variant interpretation, confirmation, and turnaround time -- Part II: Experiences in various applications -- 5. The metabolic pathways: GSD, CDG, cobalamin metabolism, and others -- 6. The eye gene panels -- 7. The otogenes -- 8. The immunodeficiency disorders -- 9. The bone density and skeletal related disorders -- 10.The hereditary cancer genes -- 11.The molecular diagnosis of cancers and implications in treatment: Marilyn Li -- 12. Neuromuscular disorders -- 13. The cardiac panel: YuXin Fan, GeneDx or Harvard Partner -- 14. The mitochondrial genome -- 15. The Nuclear Mitomes
Abstract: Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application
Pages: VIII, 364 p. 23 illus., 17 illus. in color. : online resource.
ISBN: 9783319564180
Isolation and Molecular Characterization of Circulating Tumor Cells (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
Description / Table of Contents: Preface -- Circulating Tumor Cells as Cancer Biomarkers -- Strategies for Isolation and Molecular Profiling of Circulating Tumor Cells -- Aptamer-Based Methods for Detection of Circulating Tumor Cells and Their Potential for Personalized Diagnostics -- Development of a Protocol for Single-Cell Analysis of Circulating Tumor Cells in Patients with Solid Tumors -- Flow Cytometric Methods for Circulating Tumor Cell Isolation and Molecular Analysis -- Enrichment and Detection of Circulating Tumor Cells and Other Rare Cell Populations by Microfluidic Filtration -- Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype -- Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures -- Detection of Gene-Rearrangements in Circulating Tumor Cells: Examples of ALK-, ROS1-, RET-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer -- Enrichment, Isolation, and Molecular Characterization of EpCAM-Negative Circulating Tumor Cells -- Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells
Abstract: The past decade has seen remarkable progress in elucidating the clinical relevance of circulating tumor cells (CTCs). Evidence from numerous clinical studies has unequivocally demonstrated the importance of CTCs as harbingers of poor outcome. Despite these advances, the molecular nature of CTCs remains elusive. This is in part due to the difficulty in isolating pure CTCs away from blood cells. Recent advancements in rare-cell technology have provided solutions to the once daunting task of isolating extremely rare CTCs in the blood of cancer patients. This book presents different novel approaches for detection and purification of CTCs. In addition, the readers are introduced to new technologies for molecular profiling of CTCs, including techniques to overcome limitations posed by the paucity of cells and the biomolecules available for downstream molecular analysis. This book is particularly relevant to scientists and academicians who are interested in the field of CTC research. It provides an overview of the recent technological advances in CTC isolation and profiling. This work also includes discussions on pertinent issues regarding the biology of CTCs, and their potential utility as liquid biopsy for personalized medicine. We hope that this book stimulate further research and help advance our understanding of the molecular biology of CTCs
Pages: XVI, 301 p. 42 illus., 15 illus. in color. : online resource.
ISBN: 9783319559476
Biotechnology and Production of Anti-Cancer Compounds (2017)
Cham : Springer International Publishing
Keywords: Life sciences ; Cancer Research ; Pharmacology ; Cell Culture ; Plant breeding ; Natural resources ; Life sciences ; Plant Breeding/Biotechnology ; Cell Culture ; Natural resources ; Pharmacology/Toxicology ; Cancer Research ; Springer eBooks
Description / Table of Contents: Chapter 1 Medicinal Plants: Ethno-Uses to Biotechnology Era -- Chapter 2 How Plants Can Contribute to the Supply of Anti-Cancer Compounds -- Chapter 3 Cancer and Biotechnology: A Matchup that Should Never Slowdown -- Chapter 4 Plant Derived Compounds with Anti-Cancer Properties: From Folklore to Practice -- Chapter 5 Anticancer Drugs from Plants -- Chapter 6 Cambial Meristematic Cells: A Sustainable Platform for the Production of Plant-Derived Anti-Cancer Crugs -- Chapter 7 Family Fabaceae: A Boon for Cancer Therapy -- Chapter 8 Small Cells For Big Ideas: The Cytotoxic Podophyllotoxin And The Long Journey In Discovering Its Biosynthetic Pathway -- Chapter 9 Hairy Root Culture for the Production of Useful Secondary Metabolites -- Chapter 10 Edible Mushrooms and Their In Vitro Culture as a Source of Anticancer Compounds -- Chapter 11 Genomics and Artificial Intelligence Working Together in Drugs Discovery and Repositioning: The Advent of Adaptive Pharmacogenomics in Glioblastoma and Chronic Arterial Inflammation Therapies -- Chapter 12 A Multiscale Haemorheological Computer-based Model of Chronic Inflammation: an in-Depth Investigation of Erythrocytes-driven Flow Characteristics in Atheroma Development
Abstract: This book discusses cancers and the resurgence of public interest in plant-based and herbal drugs. It also describes ways of obtaining anti-cancer drugs from plants and improving their production using biotechnological techniques. It presents methods such as cell culture, shoot and root culture, hairy root culture, purification of plant raw materials, genetic engineering, optimization of culture conditions as well as metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. In addition, it describes the applications and limitations of large-scale production of anti-cancer compounds using biotechnological means. Lastly, it discusses future economical and eco-friendly strategies for obtaining anti-cancer compounds using biotechnology
Pages: XV, 328 p. 53 illus., 36 illus. in color. : online resource.
ISBN: 9783319538808
Mechanisms of Molecular Carcinogenesis : Volume 1 (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Gene Expression ; Molecular Biology ; Oncology ; Cytokines ; Growth factors ; Biomedicine ; Cancer Research ; Oncology ; Molecular Medicine ; Cytokines and Growth Factors ; Gene Expression ; Springer eBooks
Description / Table of Contents: Preface -- Modern technologies -- MACC1, a novel player in solid cancer carcinogenesis -- The endocannabinoid system in carcinogenesis -- Stem cells in carcinogenesis -- Insulin pathways and carcinogenesis -- Role of Triglyceride Lipases in Tumor Metabolism -- mTOR signalling in carcinogenesis -- Nuclear Factor Kappa B -- Gliomas -- Non-glial brain tumors -- Ocular neoplasms -- Thyroid carcinogenesis -- Head and Neck including Oral cavity, Larynx, Pharynx -- Oesophagus -- Lung Carcinogenesis -- Progression of lung cancer: role of hypoxia and the metabolic tumor microenvironment
Abstract: Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets. The book addresses basic scientists and medical researchers interested in translational cancer research
Pages: VIII, 299 p. 33 illus., 29 illus. in color. : online resource.
ISBN: 9783319536590
Epigenetics of Infectious Diseases (2017)
Cham : Springer International Publishing
Keywords: Medicine ; Cancer Research ; Human Genetics ; Medical Microbiology ; Parasitology ; Virology ; Biomedicine ; Human Genetics ; Virology ; Cancer Research ; Parasitology ; Medical Microbiology ; Springer eBooks
Description / Table of Contents: DNA Methylation of Human Papillomavirus (HPV) Genomes During Infection and Cancer Progression -- Epigenetic regulation of gammaherpesviruses: A focus on Kaposi’s Sarcoma-associated Herpesvirus (KSHV/HHV-8) -- Discoveries in molecular genetics with the Adenovirus 12 system: Integration of viral DNA and epigenetic consequences -- Epigenetic consequences of Epstein-Barr virus infection -- Epigenetic Programming by Microbial Pathogens and Impacts on Acute and Chronic Disease -- Crosstalk between bacteria and the host epigenetic machinery -- Epigenetic phase variation in bacterial pathogens -- Epigenetic switching in the human fungal pathogen Candida albicans -- Modification of the host epigenome by parasitic protists -- Epigenetic regulation in T. brucei: Changing coats is a chance to survive -- Epigenetics of malaria parasites
Abstract: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health
Pages: VIII, 277 p. 22 illus., 14 illus. in color. : online resource.
ISBN: 9783319550213