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  • 1
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Simultaneous Functional Magnetic Resonance and Two Dimensional Optical Imaging Spectroscopy -- Neurovascular Coupling Investigated by Simultaneous Optical Coherence Tomography and Electrophysiology -- Studying Adenosine and Cerebral Blood Flow (CBF) Using Pharmacological Methods -- Imaging Vasodynamics in the Awake Mouse Brain with Two-Photon Microscopy -- Neurovascular Coupling in the Deep Brain Using Confocal Fiber-Optic Endomicroscopy -- Non-Invasive Neural Imaging and Tissue Oxygenation in the Visual System -- High-Resolution Wide-Field Optical Imaging of Micro-Vascular Characteristics: From the Neocortex to the Eye -- Optical Intrinsic Signal Imaging for Elucidating Functional Structures in Higher Visual Area -- Closed Cranial Window Applications in the Rat: Studies on Neurovascular Coupling Involving Pial Arterioles and the Glia Limitans -- Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry and Light Scattering -- Physiological Basis of BOLD fMRI Decreases -- Simultaneous Multi-Wavelength Optical Imaging of Neuronal and Hemodynamic Activity -- Non-Invasive Laser-Induced Photoacoustic Tomography for Functional Imaging -- Neurovascular Coupling in Relation to Cortical Spreading Depression -- Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging -- Cerebral Monitoring and Surveillance Using High Resolution Functional Optical Imaging
    Abstract: Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques, or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy, and cerebrovascular diseases, such as ischemia, hemorrhage, and spreading depression.℗ As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab. ℗ Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans
    Pages: XIX, 332 p. 120 illus., 99 illus. in color. : online resource.
    ISBN: 9781493907243
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Springer eBooks
    Description / Table of Contents: The Transcranial Magnetic Stimulation (TMS) Device and Foundational Techniques -- Transcranial Magnetic Stimulation (TMS) Safety Considerations and Recommendations -- Neuronavigation for Transcranial Magnetic Stimulation -- Reaching Deep Brain Structures: The H-Coils -- Single-Pulse Transcranial Magnetic Stimulation (TMS) Protocols and Outcome Measures -- Paired-Pulse Transcranial Magnetic Stimulation (TMS) Protocols -- Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols -- Off-Line and On-Line “Virtual Lesion” Protocols -- State-Dependent Transcranial Magnetic Stimulation (TMS) Protocols -- Combination of Transcranial Magnetic Stimulation (TMS) with Functional Magnetic Resonance Imaging -- Electroencephalography During Transcranial Magnetic Stimulation: Current Modus Operandi -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Therapeutics -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Diagnostics -- A Review of Current Clinical Practice in the Treatment of Major Depression -- Protocol for Depression Treatment Utilizing H-Coil Deep Brain Stimulation -- Navigated Transcranial Magnetic Stimulation: Principles and Protocol for Mapping the Motor Cortex -- Speech Mapping with Transcranial Magnetic Stimulation
    Abstract: Transcranial Magnetic Stimulation seeks to enable new and existing practitioners to learn and follow established TMS protocols. The individual chapters in this detailed volume describe methods for single and multiple pulse TMS as well as methods for TMS coupled with associated techniques, from electromyography to neuroimaging. The collection promises to facilitate growth and exploration of clinical and experimental TMS. As a volume in the popular Neuromethods series, chapters include the kind of expert implementation advice that encourages successful and reproducible results. ℗ Authoritative and practical, Transcranial Magnetic Stimulation will serve not only as a good methodological introduction for those new to this growing field, but also as a source of continual reference for experienced practitioners when re-visiting older, exploring novel, or developing new concepts
    Pages: XI, 386 p. 79 illus., 60 illus. in color. : online resource.
    ISBN: 9781493908790
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  • 3
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Cerebral Microdialysis: Research Technique or Clinical Tool? -- In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration -- Application of Reverse Microdialysis in Neuropharmacological Studies -- Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools -- In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain -- Quantitative In Vivo Microdialysis in Pharmacokinetic Studies -- Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry -- Application of Spinal Microdialysis in Freely Moving Rats -- Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach -- Intracerebral Human Microdialysis in Parkinson’s Disease -- Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach -- Measurement of Neuropeptides in Dialysate by LC-MS -- Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis -- Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples -- Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography -- Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats
    Abstract: Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. Microdialysis Techniques in Neuroscience focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The booḱ€™s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the Neuromethods series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice. ℗ Detailed and authoritative, Microdialysis Techniques in Neuroscience will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications
    Pages: XVII, 341 p. 113 illus., 10 illus. in color. : digital.
    ISBN: 9781627031738
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  • 4
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Identification of Glutamatergic Neurons -- Single Nanoparticle Tracking: A Method for Investigating the Surface Dynamics of Glutamate Receptors -- Positron Emission Tomography of Metabotropic Glutamate Receptors -- NMR Spectroscopy of Brain Glutamate Function -- Imaging Glutamate with Genetically Encoded Fluorescent Sensors -- Measurement of Astrocytic Glutamate Release using Genetically-Encoded Probe Combined with TIRF Microscopy -- Drugs to Alter Extracellular Concentration of Glutamate: Modulators of Glutamate Uptake Systems -- Drugs to Tune Up Glutamatergic Systems: Modulators of Glutamate Metabotropic Receptors -- Glutamatergic Synthesis, Recycling, and Receptor Pharmacology at Drosophila and Crustacean Neuromuscular Junctions -- Optical Control of Glutamate Receptors of the NMDA-Kind in Mammalian Neurons, with the use of Photoswitchable Ligands -- In Vivo Electrochemical Studies of Optogenetic-Control of Glutamate Signaling Measured Using Enzyme-Based Ceramic Microelectrode Arrays -- Separation-Based Sensors using Microchip Electrophoresis with Microdialysis for Monitoring Glutamate and Other Bioactive Amines -- Brain Glutamate Monitoring by Microdialysis and Separation Methods with a Special Focus on Capillary Electrophoresis with Laser-Induced Fluorescence Detection -- In Vivo Determination of Glutamate Uptake by Brain Microdialysis -- Enzymes of Glutamate System -- The Glutamatergic System as Potential Clinical Biomarkers for Blood and Cerebrospinal Fluid Monitoring -- Clinical CNS Microdialysis of Glutamate with a Special Methodological Focus on Human Spinal Cord
    Abstract: This volume presents techniques and recent developments in biochemical approaches to study glutamatergic neurotransmission. This book contains detailed discussions on tracing neuronal pathways, functional or spectroscopic imaging, optogenetic or pharmacological tools, and extracellular neurochemistry in experimental clinical models. The chapters cover topics such as: identification of glutamatergic neurons in a discrete brain area, tools to study dynamics of single ionotropic receptors, in vivo extracellular glutamate monitoring in preclinical research using biosensors, capillary electrophoresis and liquid chromatography, and potential brain glutamatergic clinical biomarkers in biofluids and tissues. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Biochemical Approaches for Glutamatergic Neurotransmission is a valuable resource for researchers studying glutamate neurochemistry
    Pages: XXII, 565 p. 136 illus., 101 illus. in color. : online resource.
    ISBN: 9781493972289
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  • 5
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume focuses on the optogenetics workflow, and covers topics on viral vectors, targeting strategies, choice on opsins, animal models and readouts, and applications in systems neuroscience. This book shows readers how to identify the critical aspects of each methodological step, and how to determine the necessary level of complexity to address the particular research question. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Optogenetics: A Roadmap is a valuable guide for both the optogenetics novices and the experts.℗
    Pages: XII, 302 p. 66 illus., 63 illus. in color. : online resource.
    ISBN: 9781493974177
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  • 6
    Unknown
    New York, NY : Springer
    Keywords: Neurosciences ; Proteomics ; Neurosciences ; Proteomics ; Springer eBooks
    Description / Table of Contents: Neuroproteomics: The Methods -- Dissection of Rodent Brain Regions: Guided Free-Hand Slicing and Dissection of Frozen Tissue -- Isolation of Synapse Sub-Domains by Subcellular Fractionation Using Sucrose Density Gradient Centrifugation: Purification of the Synaptosome, Synaptic Plasma Membrane, Postsynaptic Density, Synaptic Membrane Raft, and Postsynaptic Density Lattice -- Laser Microdissection for Spatial Proteomics of Post Mortem Brain Tissue -- High pH Reversed-Phase Pre-Fractionation for In-Depth Shotgun Proteomics -- Sample Preparation for Proteomics Analysis: Filter-Aided Sample Preparation (FASP) and Single-Pot Solid-Phase Sample Preparation (SP3) -- Enrichment of Low-Molecular-Weight Phosphorylated Biomolecules Using Phos-Tag Tip -- Integrated Immunoprecipitation: Blue Native Gel Electrophoresis - Mass Spectrometry for the Identification of Protein Sub-Complexes -- Analysis of Synaptic Protein-Protein Interaction by Crosslinking-Mass Spectrometry -- TMT-MS3 Enabled Proteomic Quantification of Human IPSC Derived Neurons -- Data Independent Acquisition (SWATH) Mass Spectrometry Analysis of Protein Content in Primary Neuronal Cultures -- Quantitative Analysis of Mass Spectrometry-Based Proteomics Data -- 2D-DIGE as a Tool in Neuroproteomics -- Neuropeptidomics of the Mammalian Brain -- MALDI Imaging Mass Spectrometry - Neurochemical Imaging of Proteins and Peptides -- A Combined Cellomics and Proteomics Approach to Uncover Neuronal Pathways to Psychiatric Disorder
    Abstract: This second edition volume expands on the previous edition with updates on the latest techniques used in the field of proteomics. Tissue and cellular proteins are now being analyzed at near proteome-wide levels and mass spectrometers are achieving higher sensitivity and speed, resolution, and accuracy. The chapters in this book cover various new methods used in proteomic workflows such as laser microdissection for spatial proteomics of post-mortem brain tissue, sample preparation in single vessel with FASP and SP3 protocols, the crosslinking mass spectrometry, TMT-MS3 based proteomic with synchronous precursor selection, mass spectrometric data dependent acquisition (DDA) and data independent acquisition (DIA, SWATH) methods, 2D-DIGE, and MALDI Imaging Mass Spectrometry. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neuroproteomics, Second Edition is a valuable guide that help researchers obtain the finest results from current proteomics platforms
    Pages: XIII, 218 p. 55 illus., 37 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493996629
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  • 7
    Keywords: Medicine ; Neurosciences ; Neurochemistry ; Biomedicine ; Neurosciences ; Neurochemistry ; Springer eBooks
    Description / Table of Contents: Novel Approaches to Serotonin Receptor Interaction Studies -- Techniques for the Study of GPCR Heteromerization in Living Cells and Animal Models -- Organotypic Slices and Biolistic Transfection for the Study of Serotonin Receptor Function in CNS Neurons -- Dissecting a Model of Depressive-Related Phenotype and Antidepressants Effects in 129S2/SvPas Mice -- The Murine Serotonin Syndrome and the 5-HT1A Receptor: Behavioral Effects and Hypothermia -- 5-HT4 Receptor Subtype, β-arrestin Level, and Rapid Onset Effects of Antidepressant Drugs -- Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved? -- Flow Cytometry to Determine Serotonin Transporter Function in Human Peripheral Blood Cells -- Functional Genomics of Serotonin Receptors in Helminth Parasites: Elucidation of Receptor Function through RNA Interference (RNAi) -- Visualization of the Serotonin System in Drosophila Brain: Immunofluorescence and Confocal Microscopy -- Serotonin Modulates Adult Neurogenesis in an Invertebrate Model: Approaches to Receptor Localization and Function -- Immunolocalization of Serotonergic Neurons in Arthropod Developmental and Phylogenetic Neuroanatomy
    Abstract: Reflecting a vast amount of new information concerning the functional characteristics of the various 5-HT receptor subtypes and the Na+-dependent serotonin transporter (SERT), this volume provides state of the art methodologies currently applied in serotonin research from leading experts in the field. Serotonin Receptor Technologies describes approaches that vary from molecular biological and biochemical techniques (e.g., regarding receptor dimerization), fluorescence microscopy and imaging applications, flow cytometry, the use of organotypic slice and cell cultures to the generation of genetically modified animal models and the development of sophisticated behavioral tests, thus covering a wide spectrum of techniques to study serotonergic signaling in detail. Written for the popular Neuromethods series, chapters include the kind of detail and practical advice that ensures successful results in the lab. Authoritative and convenient, Serotonin Receptor Technologies serves to foster both basic and translational research aiming to further deepen our understanding of the various facets of aminergic systems, as well as to aid research on similar problems with related GPCRs and neurotransmitter transporters
    Pages: XII, 245 p. 51 illus., 35 illus. in color. : online resource.
    ISBN: 9781493921874
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  • 8
    Unknown
    New York, NY : Springer
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Human Genetics ; Neurology ; Springer eBooks
    Description / Table of Contents: An Overview of Methods Used in Neurogenomics and Their Applications -- Gene Expression-Based Approaches to Understanding Huntington’s Disease and New Tools for the Interpretation of Expression Datasets -- Location Analysis and Expression Profiling Using Next Generation Sequencing for Research in Neurodegenerative Diseases -- RNA Sequencing from Laser Capture Microdissected Brain Tissue to Study Normal Aging and Alzheimer’s Disease -- Targeted Re-Sequencing in Psychiatric Disorders -- Role of Neurogenomics in the Development of Personalized Neurology
    Abstract: This detailed volume reflects the considerable new developments that have taken place in the area of applied neurogenomics, particularly with the rapid progress in next generation sequencing. Beginning with an introduction to the technologies relevant to neurogenomics with an emphasis on next generation sequencing, the book also covers detailed methods relevant to the genomics of neurodegenerative diseases, particularly Alzheimer's disease and Huntington’s disease, targeted sequencing of psychiatric disorders, as well as the role of genomics in the development of personalized neurology. Written in the popular Neuromethods series format, chapters provide the kind of practical description and implementation advice necessary to consistently produce successful results in the lab. Timely and convenient, Applied Neurogenomics serves as an invaluable reference for researchers working in this expanding, dynamic field
    Pages: XII, 158 p. 17 illus., 6 illus. in color. : online resource.
    ISBN: 9781493922475
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  • 9
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: The Evolution of Immunocytochemistry in the Dissection of Neural Complexity.-n Immunofluorescence℗ and Genetic Fluorescent Labeling℗ Techniques in the Drosophila℗ Nervous System -- Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris -- Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish℗ Brain -- Immunocytochemical℗ Phenotype℗ of Differentiating℗ Neurons.-Immunocytochemical Identification of Mammalian Differentiating Neurons℗ in the Process of Adult℗ Neurogenesis℗ in the Hippocampal Dentate Gyrus -- Identification of Proliferating and Migrating Cells by BrdU℗ and Other Thymidine Analogues. Benefits and Limitations -- Flow Cytometry-Based Quantification of Neurogenesis in the Central Nervous System -- In Vivo and In Vitro Immunohistochemical Visualization of Neural Cell Apoptosis℗ and Autophagy -- Immunocytochemical Detection of Intraneuronal AÎø℗ Peptides in Mouse Models of Alzheimer's Disease -- Purification℗ and Characterization of Mouse Olfactory Ensheathing Cells and their Potential Use for Therapy in Amyotrophic Lateral Sclerosis (ALS) -- Immunocytochemistry of Microglial Cells -- Immunocytochemical Assessment of Blood-Brain Barrier Structure, Function, and Damage -- Quantification of Immunocytochemical Colocalization in Neurons -- Immunogold℗ Electron Microscopic℗ Quantification℗ of Small Molecular℗ Compounds and Proteins℗ at Synapses and Other Neural Profiles -- Combined Immunocytochemistry℗ and Tracing℗ of Neural Connections -- Neuronal Circuitry Dissected by Immunocytochemistry Combined with Retrograde Tracing -- Transfection Techniques and Combined Immunocytochemistry in Cell Cultures and Organotypic Slices -- Combined Immunochemistry and Live-Imaging of Fluorescent Protein Expressing Neurons in Mouse℗ Brain -- Array Tomography: A Novel High-Resolution Immunofluorescence Technique -- Single Molecule Localization Microscopy℗ to Study Neuronal℗ Microtubule Organization -- Studying Membrane Dynamics℗ of Proteins℗ Using Quantum Dots -- Optical℗ Protein℗ Patterning
    Abstract: This volume presents a collection of protocols for immunocytochemical analysis of neurons and neural networks. Chapters focus on immunocytochemical localization at light and electronic levels, biochemical characterization, and functional analysis in vivo or ex vivo by novel types of microscopy, as well as protocols for development and production of genetic probes. Written for the popular Neuromethods℗ series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.℗ Essential and authoritative, Immunocytochemistry and Related Techniques is intended for a large audience of scientists, including histologists, biochemists, cellular and molecular biologists, electrophysiologists that are currently active in the field or are willing to enter the exciting area of neuroscience research
    Pages: XIII, 473 p. 95 illus., 77 illus. in color. : online resource.
    ISBN: 9781493923137
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  • 10
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Human Genetics ; Neurology ; Springer eBooks
    Description / Table of Contents: Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Lentiviral Vectors for Gene Delivery to the Nervous System -- Gene Therapy for Parkinson’s Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF) -- Gene Delivery and Gene Therapy for Alzheimer’s Disease -- Gene Therapy for Huntington’s Disease -- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury -- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors -- Targeted Gene Therapy for Ischemic Stroke -- Adeno-Associated Viral Gene Therapy for Retinal Disorders -- Gene Therapy for Epilepsies -- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement -- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice -- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain? -- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
    Abstract: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for℗ the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors's laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimeŕ€™s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.℗ Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders
    Pages: XIV, 359 p. 65 illus., 51 illus. in color. : online resource.
    ISBN: 9781493923069
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