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  • 1
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Fluorescence Proteins and Time-Lapse Imaging of the Cytoskeleton -- Visualizing In Vitro Trafficking -- Interaction of the Glycocalyx with the Actin Cytoskeleton -- Cytoskeleton Dynamics and Binding Factors -- Principles of Proteomic Approaches to the Cytoskeleton -- Analyzing the Cytoskeletal Transcriptome: Sex Differences in Rat Hypothalamus -- Proteomic Approaches for the Study of Electrical Synapses and Associated Protein-Interaction Complexes -- The Cytoskeleton as a Pharmacological Target in Neurodegenerative Diseases -- Neurofilaments: Properties, Functions, and Regulation -- From an Axon into a Growth Cone after Axotomy: A Model for Cytoskeletal Dynamics -- Isolation of the Postsynaptic Density: A Specialization of the Subsynaptic Cytoskeleton -- Cell-to-Cell Communication in Astroglia and the Cytoskeletal Impact -- Reactive Astrocytes, Astrocyte Intermediate Filament Proteins, and Their Role in the Disease Pathogenesis -- Microtubules and Associated Proteins in Oligodendrocytes, the Myelin Forming Cells of the Central Nervous System -- Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton
    Abstract: The cerebral cytoskeleton, considered to be the working horse in brain tissues, becomes particularly important when degenerative diseases of the nervous system are considered.℗ The Cytoskeleton: Imaging, Isolation, and Interaction assembles chapters on general aspects of the cytoskeleton, which are helpful for polishing knowledge of the cytoskeleton in a brief and informative way, and these pieces are flanked by a collection of detailed protocols on diverse emerging techniques including in vivo and in vitro imaging of the cytoskeleton at work as well as proteomics methodologies addressing preparative strategies for the isolation of cytoskeletal components of the central nervous system.℗ Written for the popular Neuromethods series, this work contains the kind of meticulous descriptions and implementation advice to guarantee successful results. ℗ Authoritative and cutting-edge, The Cytoskeleton: Imaging, Isolation, and Interaction provides a compilation of papers written by a team of experts which aims to strengthen our efforts at overcoming at least some of the fatal outcomes of the diseased brain cytoskeleton
    Pages: XIV, 359 p. 52 illus., 31 illus. in color. : digital.
    ISBN: 9781627032667
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurology ; Laboratory animals ; Biomedicine ; Neurosciences ; Neurology ; Animal Models ; Springer eBooks
    Description / Table of Contents: Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix? -- Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints -- The VM Mouse Model of Glioblastoma Multiforme -- Oligodendroglioma Models -- Medulloblastoma Model -- Learning about Retinoblastoma from Mouse Models that Missed -- Ependymoma Models -- Meningioma Models -- Pituitary Models -- Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors -- Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children -- EGFR and Tumor–Suppressor Function in Brain Cancer Development -- Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts -- Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models -- Assessing Mechanisms of Glioblastoma Invasion -- Positron Emission Tomography (PET)-Based Molecular Imaging -- In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)- Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research
    Abstract: Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis.℗ Animal Models of Brain Tumors brings together developments and discoveries in €œín vivó€ experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, ℗ therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism.℗ Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. ℗ Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments
    Pages: XIII, 391 p. 66 illus., 43 illus. in color. : digital.
    ISBN: 9781627032094
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  • 3
    Keywords: Medicine ; Neurosciences ; Neurochemistry ; Biomedicine ; Neurosciences ; Neurochemistry ; Springer eBooks
    Description / Table of Contents: Microelectrode Designs for Oxidase-Based Biosensors -- Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection -- The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue -- Hexacyanoferrates as Mediators for Microelectrode Biosensors -- Enzyme Immobilization on Microelectrode Biosensors -- Characterization of Polymer€“Énzyme Composite Biosensors for Brain Monitoring In Vivo -- Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors -- Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays -- Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors -- Measurement of Purine Release with Microelectrode Biosensors -- Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle -- Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors -- Carbon Nanotubes-Based Microelectrode (Bio)sensors -- Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy -- Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins -- Electrochemiluminescent Biosensors: Neuroscience Applications -- Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing
    Abstract: For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences.℗ The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results. ℗ Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit
    Pages: XV, 387 p. 111 illus., 45 illus. in color. : digital.
    ISBN: 9781627033701
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  • 4
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons
    Pages: XVI, 382 p. 90 illus., 67 illus. in color. : online resource.
    ISBN: 9781493972807
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  • 5
    Keywords: Neurosciences ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Brain Derived Neurotrophic Factor and the €œÁttivit© plastic dei neuron퀝, the Neuronal Plasticity as Defined by Ernesto Lugaro (1870-1940) -- Usage of Bacterial Artificial Chromosomes for Studying BDNF Gene Regulation in Primary Cultures of Cortical Neurons and Astrocytes -- Detecting Single and Multiple BDNF Transcripts In Situ in Neuronal Cultures and Brain Sections -- Studying BDNF/TrkB Signaling: Transcriptome Analysis from a Limited Number of Purified Adult or Aged Murine Brain Neurons -- Studying BDNF/TrkB Signaling: High-Throughput Microfluidic Gene Expression Analysis from rare of Limited Samples of Adult and Aged Central Neurons -- Detecting BDNF Protein Forms by ELISA, Western Blot, and Immunofluorescence -- Methodology for Detecting and Tracking brain-Derived Neurotrophic Factor Complexes in Neurons using Single Quantum Dots -- Recording Activity-Dependent Release of BDNF from Hippocampal Neurons -- Ultrastructural Localization of BDNF and trkB Receptors -- Analysis of TrkB Receptor Activity using FRET Sensors -- BDNF-Induced Intracellular Signaling -- A Microfluidic Culture Platform for Neurotrophin Signaling Studies -- BDNF-Induced Local Protein Synthesis in Synaptoneurosomes Assessed with Click-iT L-azidohomoalanine -- Proteomic Tools to Study the Effect of BDNF on de novo Protein Synthesis -- BDNF Function in Long-Term Synaptic Plasticity in the Dentate Gyrus in Vivo: Methods for Local Drug Delivery and Biochemical Analysis of Translation
    Abstract: This volume discusses the latest techniques and methodologies used in the neurotrophin field to study the physiology of the Brain-Derived Neurotrophic Factor (BDNF). The book provides the tools essential to any researcher that intends to explore the peculiar regulation of this neurotrophin from gene expression to its release and the signaling by TrkB receptors, as well as to study the neuronal responses to BDNF or the role of neurotrophin in various neurological diseases. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting edge and comprehensive, Brain-Derived Neurotrophic Factor(BDNF) is a valuable resource for researchers who want to further study the diversity of physiological roles of this important growth factor
    Pages: XII, 258 p. 35 illus., 31 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9781493989706
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  • 6
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume presents techniques and recently developments in extracellular recording. The chapters in this book explore topics such as mouse, rat and zebrafish models; extracellular recordings on human cognition; single-unit recordings and multi-electrode arrays; and recordings in perinatal and early developing mice. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Extracellular Recording Approaches is a valuable resource that provides readers with up-to-date applications and methods to study brain regions involved in sensory, motor, and cognitive functions
    Pages: XIII, 298 p. 74 illus., 62 illus. in color. : online resource.
    ISBN: 9781493975495
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  • 7
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer’s disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer’s Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry
    Pages: XIII, 272 p. 39 illus., 33 illus. in color. : online resource.
    ISBN: 9781493976744
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  • 8
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: In Vivo Whole-Cell Recordings -- Juxtasomal Loose-Patch Recordings in Awake, Head-Fixed Rats to Study the Link between Structure and Function of Individual Neurons -- Studying Sodium Channel Gating In Heterologous Expression Systems -- Elucidating the Link between Structure and Function of Ion Channels and Transporters with Voltage-Clamp and Patch-Clamp Fluorometry -- Dendrites: Recording from Fine Neuronal Structures Using Patch-Clamp and Imaging Techniques -- Patch-clamp Recording from Myelinated Central Axons -- Analysis of Transsynaptic Attentional Neuronal℗ Circuits with Octuple Patch-Clamp Recordings -- Optogenetic Dissection of the Striatal Microcircuitry -- Paired Recordings from Synaptically Coupled Neurones in Acute Neocortical Slices -- Extracting Quantal Properties of Transmission at Central Synapses -- Acousto-optical Scanning-Based High Speed 3D Two-Photon Imaging In Vivo -- Intracellular Voltage-Sensitive Dyes for Studying Dendritic Excitability and Synaptic Integration -- Modeling the Kinetic Mechanisms of Voltage-Gated Ion Channels -- Recording and Hodgkin-Huxley Kinetic Analysis of Voltage-Gated Ion Channels in Nucleated Patches -- Creating and Constraining Compartmental Models of Neurons Using Experimental Data
    Abstract: This volume presents current adaptations of the patch-clamp technique to neuroscience. Chapters focus on in-vivo recordings, voltage-gated channel recording and analysis, dendritic and axonal recordings, synaptic current recording and analysis, advanced fluorescent techniques, optogenetics and voltage-sensitive dye imaging, and finally channel and neuronal modeling. Written for the popular Neuromethods℗ series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical,℗ Advanced℗ Patch-Clamp Analysis for Neuroscientists aims℗ to ensure successful results in the further study of this vital field
    Pages: XII, 350 p. 81 illus., 28 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9781493934119
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  • 9
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biology / Technique ; Biomedicine ; Neurosciences ; Neurobiology ; Biological Techniques ; Springer eBooks
    Description / Table of Contents: Preface -- Production of high-quality antibodies for the study of receptors and ion channels in brain -- Co-immunoprecipitation from brain -- Sub-synaptic membrane fractionation -- Investigation of ℗ neurotransmitter receptors in brain slices using cell surface biotinylation -- Single nanoparticle tracking of surface ion channels and receptors in brain cells -- Radioligand binding detection of receptors in brain membranes -- Recombinant Alphavirus-Mediated Expression of Ion Channels and Receptors in the Brain -- Fluorescent ligands and TR-FRET to study receptor-receptor interactions in the brain -- In situ Proximity Ligation Assay to study and understand the distribution and balance of GPCR homo- and heteroreceptor complexes in the brain -- Fluorescent in situ hybridization for sensitive and specific labeling -- Autoradiographic visualization of G protein-coupled receptors in brain -- Analysis of the expression profile and regional distribution of neurotransmitter receptors and ion channels in the central nervous system using histoblots -- Immunohistochemistry for ion channels and their interacting molecules: Tips for improving antibody accessibility -- Localization of GFP-tagged proteins at the electron microscope -- Pre-embedding methods in the localization of receptors and ion channels -- Post-embedding immunohistochemistry in the localization of receptors and ion channels -- High-Resolution localization of membrane proteins by SDS-digested freeze-fracture replica labelling (SDS-FRL) -- Application of virus vectors for anterograde tract-tracing and single-neuron labeling studies -- Analysis of synaptic connections using viral vectors at the electron microscopic level -- Morphological and neurochemical characterization of electrophysiologically identified cells -- Using electrophysiology to study synaptic and extrasynaptic ionotropic receptors in hippocampal neurons -- Biophysical methods to analyze direct G-protein regulation of neuronal voltage-gated calcium channels -- Electrophysiological recordings in behaving animals -- Voltammetry in behaving animals -- In vivo brain microdialysis of monoamines -- Calcium transients in single dendrites and spines of pyramidal neurons in vitro -- Dynamic recording of membrane potential from hippocampal neurons by using a FRET-based voltage biosensor -- Determination of GPCR-mediated cAMP accumulation in rat striatal synaptosomes -- GPCR-mediated MAPK/ERK cascade activation in brain slices -- Index
    Abstract: Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques
    Pages: XVIII, 475 p. 84 illus., 57 illus. in color. : online resource.
    ISBN: 9781493930647
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  • 10
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Neurosurgery ; Biomedicine ; Neurosciences ; Neurosurgery ; Springer eBooks
    Description / Table of Contents: Animal Models of Traumatic Brain Injury -- Experimental Radiosurgery in Animal Models -- Stereotactic Surgery in Rats -- Rat Middle Cerebral Artery (MCA) Occlusion Models Which Involve a Frontotemporal Craniectomy -- Inferior Colliculus Approach in a Rat -- Why Robots Entered Neurosurgery -- Impact Model of Spinal Cord Injury -- Acute Clip Contusion Compression Model of SCI -- Microsurgical Approach to Spinal Canal in Rats -- Stereotaxic Injection into the Rat Spinal Cord -- Surgical Access to Cisterna Magna Using Concorde-Like Position for Cell Transplantation in Mice and CNS Dissection within Intact Dura for Evaluation of Cell Distribution -- Animal Models for Experimental Neurosurgery of Peripheral and Cranial Nerves -- Surgery of the Brain and Spinal Cord in a Porcine Model -- Real-Time Convection Delivery of Therapeutics to the Primate Brain -- Focal Cerebral Ischemia by Permanent Middle Cerebral Artery Occlusion in Sheep – Surgical Technique, Clinical Imaging, and Histopathological Results -- A Non-Human Primate Model of Delayed Cerebral Vasospasm after Aneurismal Subarachnoid Hemorrhage
    Abstract: This volume provides a full explanation and technical details to perform surgical techniques properly on small and large animal models. The first six chapters of Experimental Neurosurgery in Animal Models focus primarily on the brain, while the next six chapters concern the spinal cord in rodents. The last four chapters provide a description of operative procedures in large animals. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Experimental Neurosurgery in Animal Models aims to ensure successful results in the further study of this vital field
    Pages: XIII, 255 p. 131 illus., 75 illus. in color. : online resource.
    ISBN: 9781493937301
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