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  • 1
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Biomedicine ; Neurosciences ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Optogenetic Stimulation of Neurons in the Brainstem of Freely Behaving Rats and Mice -- Stimulating Peripheral Afferents to Evoke Cardiorespiratory Reflex responses in the In Situ Arterially-Perfused Preparation -- Excitatory Responses to Microinjection of Glutamate Depend on Dose not Volume: A Meta-Analysis of Studies in Rat RVLM -- Acute Activation and Inhibition of the Sympathetic Baroreceptor Reflex -- Pharmacological Dissection of G Protein-Mediated Second Messenger Cascades in Neurons -- In Vivo Manipulation of Intracellular Signalling Pathways -- Identification of Spinally Projecting Neurons in the Rostral Ventrolateral Medulla In Vivo -- Microionotophoretic Study of Individual Neurons During Intracellular Recording -- Neurobiotin Electroporation for Combined Structural and Functional Analysis of Neurons in Developing Mouse Brain Slices -- Juxtacellular Neuronal Labelling, Physiological Characterization, and Phenotypic Identification of Single Neurons In Vivo -- Analysis of Sympathetic Nerve Activity Analysis of Sympathetic Nerve Activity -- Insight into Autonomic Nervous System Control of Heart Rate in the Rat Using Analysis of Heart Rate Variability and Baroreflex Sensitivity -- Neurophysiological Recording of the Compound Muscle Action Potential for Motor Unit Number Estimation in Mice -- Animal Models of Neuropathic Pain Due to Nerve Injury -- Detection of Sensitized Nerve Responses: Dorsal Root Reflexes, Live Cell Calcium, and ROS Imaging -- Visual Evoked Potential Recording in Rodents -- The Visual Evoked Potential in Humans -- Improving Motor Activation Patterns after Stroke with Wii-Based Movement Therapy
    Abstract: Activation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools.℗ In Stimulation and Inhibition of Neurons, experts in the field provide an overview of modern methods for generating lesions as well as for stimulating and inhibiting neural pathways.℗ Many new techniques such as optogenetics and the use of the in situ perfused preparation are examined, while, in other sections, the use and validity of more well-known approaches are reassessed. Written for the Neuromethods series, chapters examine their respective topics thoroughly and include the kind of detail and implementation advice that ensures successful results in the laboratory. ℗ Authoritative and cutting-edge, Stimulation and Inhibition of Neurons serves as an ideal guide for researchers seeking to gain further knowledge of the complex functions of the brain
    Pages: XII, 319 p. 73 illus., 15 illus. in color. : digital.
    ISBN: 9781627032339
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Cerebral Microdialysis: Research Technique or Clinical Tool? -- In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration -- Application of Reverse Microdialysis in Neuropharmacological Studies -- Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools -- In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain -- Quantitative In Vivo Microdialysis in Pharmacokinetic Studies -- Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry -- Application of Spinal Microdialysis in Freely Moving Rats -- Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach -- Intracerebral Human Microdialysis in Parkinson’s Disease -- Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach -- Measurement of Neuropeptides in Dialysate by LC-MS -- Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis -- Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples -- Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography -- Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats
    Abstract: Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. Microdialysis Techniques in Neuroscience focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The booḱ€™s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the Neuromethods series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice. ℗ Detailed and authoritative, Microdialysis Techniques in Neuroscience will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications
    Pages: XVII, 341 p. 113 illus., 10 illus. in color. : digital.
    ISBN: 9781627031738
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  • 3
    Keywords: Medicine ; Neurosciences ; Neurochemistry ; Biomedicine ; Neurosciences ; Neurochemistry ; Springer eBooks
    Description / Table of Contents: Microelectrode Designs for Oxidase-Based Biosensors -- Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection -- The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue -- Hexacyanoferrates as Mediators for Microelectrode Biosensors -- Enzyme Immobilization on Microelectrode Biosensors -- Characterization of Polymer€“Énzyme Composite Biosensors for Brain Monitoring In Vivo -- Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors -- Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays -- Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors -- Measurement of Purine Release with Microelectrode Biosensors -- Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle -- Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors -- Carbon Nanotubes-Based Microelectrode (Bio)sensors -- Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy -- Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins -- Electrochemiluminescent Biosensors: Neuroscience Applications -- Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing
    Abstract: For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences.℗ The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results. ℗ Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit
    Pages: XV, 387 p. 111 illus., 45 illus. in color. : digital.
    ISBN: 9781627033701
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  • 4
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design. Different background topics like molecular etiologies of Alzheimer’s disease, targets for new drug development, and different cheminformatic modeling strategies are covered for completeness. Special topics like multi-target drug development, natural products, protein misfolding, and nanomaterials are also included in connection with computational modeling of anti-Alzheimer drug development. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Computational Modeling of Drugs Against Alzheimer’s Disease is a valuable resource for learning about the latest computational techniques used to study this disease
    Pages: XVII, 645 p. 222 illus., 158 illus. in color. : online resource.
    ISBN: 9781493974047
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  • 5
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Identification of Glutamatergic Neurons -- Single Nanoparticle Tracking: A Method for Investigating the Surface Dynamics of Glutamate Receptors -- Positron Emission Tomography of Metabotropic Glutamate Receptors -- NMR Spectroscopy of Brain Glutamate Function -- Imaging Glutamate with Genetically Encoded Fluorescent Sensors -- Measurement of Astrocytic Glutamate Release using Genetically-Encoded Probe Combined with TIRF Microscopy -- Drugs to Alter Extracellular Concentration of Glutamate: Modulators of Glutamate Uptake Systems -- Drugs to Tune Up Glutamatergic Systems: Modulators of Glutamate Metabotropic Receptors -- Glutamatergic Synthesis, Recycling, and Receptor Pharmacology at Drosophila and Crustacean Neuromuscular Junctions -- Optical Control of Glutamate Receptors of the NMDA-Kind in Mammalian Neurons, with the use of Photoswitchable Ligands -- In Vivo Electrochemical Studies of Optogenetic-Control of Glutamate Signaling Measured Using Enzyme-Based Ceramic Microelectrode Arrays -- Separation-Based Sensors using Microchip Electrophoresis with Microdialysis for Monitoring Glutamate and Other Bioactive Amines -- Brain Glutamate Monitoring by Microdialysis and Separation Methods with a Special Focus on Capillary Electrophoresis with Laser-Induced Fluorescence Detection -- In Vivo Determination of Glutamate Uptake by Brain Microdialysis -- Enzymes of Glutamate System -- The Glutamatergic System as Potential Clinical Biomarkers for Blood and Cerebrospinal Fluid Monitoring -- Clinical CNS Microdialysis of Glutamate with a Special Methodological Focus on Human Spinal Cord
    Abstract: This volume presents techniques and recent developments in biochemical approaches to study glutamatergic neurotransmission. This book contains detailed discussions on tracing neuronal pathways, functional or spectroscopic imaging, optogenetic or pharmacological tools, and extracellular neurochemistry in experimental clinical models. The chapters cover topics such as: identification of glutamatergic neurons in a discrete brain area, tools to study dynamics of single ionotropic receptors, in vivo extracellular glutamate monitoring in preclinical research using biosensors, capillary electrophoresis and liquid chromatography, and potential brain glutamatergic clinical biomarkers in biofluids and tissues. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Biochemical Approaches for Glutamatergic Neurotransmission is a valuable resource for researchers studying glutamate neurochemistry
    Pages: XXII, 565 p. 136 illus., 101 illus. in color. : online resource.
    ISBN: 9781493972289
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  • 6
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume focuses on the optogenetics workflow, and covers topics on viral vectors, targeting strategies, choice on opsins, animal models and readouts, and applications in systems neuroscience. This book shows readers how to identify the critical aspects of each methodological step, and how to determine the necessary level of complexity to address the particular research question. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Optogenetics: A Roadmap is a valuable guide for both the optogenetics novices and the experts.℗
    Pages: XII, 302 p. 66 illus., 63 illus. in color. : online resource.
    ISBN: 9781493974177
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  • 7
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections ℗ focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques needed to quantify experiments that use nanoparticles in the nervous system
    Pages: XVI, 296 p. 98 illus., 66 illus. in color. : online resource.
    ISBN: 9781493975846
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  • 8
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: A Survey of Current Neuroanatomical Tracing Techniques.-℗ Wheat-Germ Agglutinin (WGA) Tracing: A Classic Approach for Unraveling Neural Circuitry -- Retrograde Tract-Tracing ́€˜Pluś€™: Adding Extra Value to Retrogradely-Traced Neurons -- Simultaneous Collection of In Vivo Functional and Anatomical Data from Individual Neurons in Awake Mice -- Single-Cell Electroporation for In Vivo Imaging of Neuronal Morphology and Growth Dynamics -- Practical Methods for In Vivo Cortical Physiology with 2-Photon Microscopy and Bulk Loading of Fluorescent Calcium Indicator Dyes -- Optogenetic Dissection of Neural Circuit Function in Behaving Animals -- Remote Control of Neural Activity Using Chemical Genetics -- Generation of BAC Transgenic Mice for Functional Analysis of Neural Circuits -- Engineered Rabies Virus for Transsynaptic Circuit Tracing -- Genetic Labeling of Synapses -- Genetic Pathways to Circuit Understanding in Drosophila
    Abstract: This volume seeks to familiarize readers with a diverse range of technologies and approaches for probing neuron and circuit architecture, and, when possible, to attach detailed protocols to help guide readers toward practical application. From classical lipophilic dye and conjugated lectin tracing techniques, to electrophysiological, in vivo imaging, viral tract tracing, and emerging genetic methods to mark, manipulate, and monitor neural circuits, Neural Tracing Methods: Tracing Neurons and Their Connections includes reference to an arsenal of tools and technologies currently being implemented in model systems ranging from flies to mice. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Essential and authoritative, Neural Tracing Methods: Tracing Neurons and Their Connections collects a comprehensive compilation of chapters authored by inventors and expert users, that describes state-of-the-art neuronal tracing and functional analysis methods in order to aid researchers in continuing this vital pathway of study
    Pages: XII, 278 p. 52 illus., 47 illus. in color. : online resource.
    ISBN: 9781493919635
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  • 9
    Unknown
    New York, NY : Springer
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Human Genetics ; Neurology ; Springer eBooks
    Description / Table of Contents: An Overview of Methods Used in Neurogenomics and Their Applications -- Gene Expression-Based Approaches to Understanding Huntington’s Disease and New Tools for the Interpretation of Expression Datasets -- Location Analysis and Expression Profiling Using Next Generation Sequencing for Research in Neurodegenerative Diseases -- RNA Sequencing from Laser Capture Microdissected Brain Tissue to Study Normal Aging and Alzheimer’s Disease -- Targeted Re-Sequencing in Psychiatric Disorders -- Role of Neurogenomics in the Development of Personalized Neurology
    Abstract: This detailed volume reflects the considerable new developments that have taken place in the area of applied neurogenomics, particularly with the rapid progress in next generation sequencing. Beginning with an introduction to the technologies relevant to neurogenomics with an emphasis on next generation sequencing, the book also covers detailed methods relevant to the genomics of neurodegenerative diseases, particularly Alzheimer's disease and Huntington’s disease, targeted sequencing of psychiatric disorders, as well as the role of genomics in the development of personalized neurology. Written in the popular Neuromethods series format, chapters provide the kind of practical description and implementation advice necessary to consistently produce successful results in the lab. Timely and convenient, Applied Neurogenomics serves as an invaluable reference for researchers working in this expanding, dynamic field
    Pages: XII, 158 p. 17 illus., 6 illus. in color. : online resource.
    ISBN: 9781493922475
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  • 10
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Human Genetics ; Neurology ; Springer eBooks
    Description / Table of Contents: Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Lentiviral Vectors for Gene Delivery to the Nervous System -- Gene Therapy for Parkinson’s Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF) -- Gene Delivery and Gene Therapy for Alzheimer’s Disease -- Gene Therapy for Huntington’s Disease -- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury -- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors -- Targeted Gene Therapy for Ischemic Stroke -- Adeno-Associated Viral Gene Therapy for Retinal Disorders -- Gene Therapy for Epilepsies -- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement -- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice -- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain? -- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
    Abstract: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for℗ the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authorś€™ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimeŕ€™s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.℗ Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders
    Pages: XIV, 359 p. 65 illus., 51 illus. in color. : online resource.
    ISBN: 9781493923069
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