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  • 1
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Simultaneous Functional Magnetic Resonance and Two Dimensional Optical Imaging Spectroscopy -- Neurovascular Coupling Investigated by Simultaneous Optical Coherence Tomography and Electrophysiology -- Studying Adenosine and Cerebral Blood Flow (CBF) Using Pharmacological Methods -- Imaging Vasodynamics in the Awake Mouse Brain with Two-Photon Microscopy -- Neurovascular Coupling in the Deep Brain Using Confocal Fiber-Optic Endomicroscopy -- Non-Invasive Neural Imaging and Tissue Oxygenation in the Visual System -- High-Resolution Wide-Field Optical Imaging of Micro-Vascular Characteristics: From the Neocortex to the Eye -- Optical Intrinsic Signal Imaging for Elucidating Functional Structures in Higher Visual Area -- Closed Cranial Window Applications in the Rat: Studies on Neurovascular Coupling Involving Pial Arterioles and the Glia Limitans -- Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry and Light Scattering -- Physiological Basis of BOLD fMRI Decreases -- Simultaneous Multi-Wavelength Optical Imaging of Neuronal and Hemodynamic Activity -- Non-Invasive Laser-Induced Photoacoustic Tomography for Functional Imaging -- Neurovascular Coupling in Relation to Cortical Spreading Depression -- Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging -- Cerebral Monitoring and Surveillance Using High Resolution Functional Optical Imaging
    Abstract: Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques, or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy, and cerebrovascular diseases, such as ischemia, hemorrhage, and spreading depression.℗ As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab. ℗ Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans
    Pages: XIX, 332 p. 120 illus., 99 illus. in color. : online resource.
    ISBN: 9781493907243
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Springer eBooks
    Description / Table of Contents: The Transcranial Magnetic Stimulation (TMS) Device and Foundational Techniques -- Transcranial Magnetic Stimulation (TMS) Safety Considerations and Recommendations -- Neuronavigation for Transcranial Magnetic Stimulation -- Reaching Deep Brain Structures: The H-Coils -- Single-Pulse Transcranial Magnetic Stimulation (TMS) Protocols and Outcome Measures -- Paired-Pulse Transcranial Magnetic Stimulation (TMS) Protocols -- Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols -- Off-Line and On-Line “Virtual Lesion” Protocols -- State-Dependent Transcranial Magnetic Stimulation (TMS) Protocols -- Combination of Transcranial Magnetic Stimulation (TMS) with Functional Magnetic Resonance Imaging -- Electroencephalography During Transcranial Magnetic Stimulation: Current Modus Operandi -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Therapeutics -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Diagnostics -- A Review of Current Clinical Practice in the Treatment of Major Depression -- Protocol for Depression Treatment Utilizing H-Coil Deep Brain Stimulation -- Navigated Transcranial Magnetic Stimulation: Principles and Protocol for Mapping the Motor Cortex -- Speech Mapping with Transcranial Magnetic Stimulation
    Abstract: Transcranial Magnetic Stimulation seeks to enable new and existing practitioners to learn and follow established TMS protocols. The individual chapters in this detailed volume describe methods for single and multiple pulse TMS as well as methods for TMS coupled with associated techniques, from electromyography to neuroimaging. The collection promises to facilitate growth and exploration of clinical and experimental TMS. As a volume in the popular Neuromethods series, chapters include the kind of expert implementation advice that encourages successful and reproducible results. ℗ Authoritative and practical, Transcranial Magnetic Stimulation will serve not only as a good methodological introduction for those new to this growing field, but also as a source of continual reference for experienced practitioners when re-visiting older, exploring novel, or developing new concepts
    Pages: XI, 386 p. 79 illus., 60 illus. in color. : online resource.
    ISBN: 9781493908790
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  • 3
    Call number: W410:1
    Keywords: Xenopus / embryology ; Animals, Genetically Modified / embryology ; Neurobiology / methods
    Pages: xviii, 198 p. : ill.
    ISBN: 9780896034570
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    W410:1 departmental collection or stack – please contact the library
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  • 4
    Unknown
    Totowa, NJ : Humana Press
    Keywords: Medicine ; Neurosciences ; Psychiatry ; Laboratory animals ; Biomedicine ; Neurosciences ; Psychiatry ; Animal Models ; Springer eBooks
    Description / Table of Contents: Introduction: Binge Eating, Bulimia Nervosa, and Hedonic Overeating -- Binge-Prone vs. Binge-Resistant Rats and Their Concomitant Behavioral Profiles -- Binge Eating in Female Rats Induced by Yo-Yo Dieting and Stress -- Binge-Type Eating Induced by Limited Access to Optional Foods -- Assessment of Stress-Independent Binge-Like Eating Behavior in Mice -- Predicting and Classifying Rats Prone to Overeating Fat -- Modeling Binge Eating in Non-Human Primates -- Psychosocial Stress and Diet History Promote Emotional Feeding in Female Rhesus Monkeys -- Stressful Experiences in Early Life and Subsequent Food Intake -- Sham Feeding in Rats Translates Into Modified Sham Feeding in Women with Bulimia Nervosa and Purging -- Animal Models of Binge Eating Palatable Foods: Emergence of Addiction-Like Behaviors and Brain Changes in the Rat -- Deep Brain Stimulation for the Treatment of Binge Eating: Mechanisms and Preclinical Models -- Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse -- Food Seeking in Spite of Harmful Consequences -- Introduction: Anorexia and Undereating -- Food Restriction and Reward in Rats -- Activity-Based Anorexia in the Rat -- Food-Anticipatory Activity: Rat Models and Underlying Mechanisms -- Anorexia and Drugs of Abuse Abnormally Suppress Appetite, the Result of a Shared Molecular Signal Foul-Up -- The Anorectic Phenotype of the Anx/anx Mouse is Related to Hypothalamic Dysfunction -- Functional Magnetic Resonance Imaging in Awake Rats: Studies Relevant to Addiction and the Reward Circuitry
    Abstract: The growth of the field of eating disorder research has led to a vast array of empirical articles, and the development of new animal models that can be used to study these disorders continues to stimulate new research.℗ Animal Models of Eating Disorders serves as a collection of detailed techniques contributed by experts in the field who are well-versed in the development and implementation of these models. Since eating disorders are complex and likely due to a combination of environmental, genetic, and social causes, the detailed chapters of this volume have been designed to highlight different contributing factors. Collectively, these chapters give a comprehensive and representative overview of both recently developed and classic methodologies used in the study of eating disorders.℗ Written for the popular Neuromethods series, this work contains the kind of thorough description and implementation advice that promises successful results. ℗ Authoritative and practical, Animal Models of Eating Disorders aims to aid researchers in the use of animal models to assist in their investigation and characterization of the behaviors and neurochemical alterations associated with these devastating disorders
    Pages: XVI, 379 p. 76 illus., 10 illus. in color. : digital.
    ISBN: 9781627031042
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  • 5
    Keywords: Medicine ; Neurosciences ; Neurology ; Laboratory animals ; Biomedicine ; Neurosciences ; Neurology ; Animal Models ; Springer eBooks
    Description / Table of Contents: The Spinal Cord: Functional Organization, Diseases, and Dysfunctions -- The Pathological Findings in Traumatic Injury to the Human Spinal Cord -- Acute Spinal Cord Injury In Vitro: Insight Into Basic Mechanisms -- Spinal Cord Injury: The Lamprey Model -- Dorsal Root Injury for the Study of Spinal Cord Injury Repair -- No-Laminectomy Spinal Cord-Transected Murine Model -- Spinal Cord Injury: The Rabbit Model -- The Cat Model of Spinal Cord Injury -- Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options -- Primate Models of Spinal Repair -- Animal Models of Spinal Cord Ischemia -- Magnetic Resonance Imaging of Experimental Spinal Cord Injury -- Spinal Cord Injuries: Principles and Methods for Outcome Assessment -- Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science
    Abstract: The development of treatment strategies that can help patients with spinal cord injury to regain lost functions and an improved quality of life is a major medical challenge, and experimental spinal cord research has to meet these challenges by resolving fundamental problems, establishing a basis for possible novel treatment strategies of spinal cord injury, and motivating their clinical translation.℗ In Animal Models of Spinal Cord Repair, expert researchers examine a broad range of experimental models for research on spinal cord injury, how they have contributed to our current state of knowledge, and what their advantages are in the further advancement of spinal cord repair.℗ With models from simple lamprey to non-human primates, the information presented is intended to guide the implementation of animal models for spinal cord repair as well as to raise the awareness of the relevance of experimental models which may not be in the current mainstream of this research.℗ As a part of the Neuromethods series, this work contains the kind of detailed description and implementation advice to guarantee successful results in the laboratory. ℗ Comprehensive and cutting-edge, ℗ Animal Models of Spinal Cord Repair presents the background information and hands-on methods descriptions, as well as the basic and clinical issues, needed to stimulate and guide researchers with different backgrounds towards the development of improved strategies for functionally relevant repair of the injured human spinal cord
    Pages: XII, 336 p. 49 illus., 36 illus. in color. : digital.
    ISBN: 9781627031974
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  • 6
    Keywords: Medicine ; Neurosciences ; Neurochemistry ; Biomedicine ; Neurosciences ; Neurochemistry ; Springer eBooks
    Description / Table of Contents: Microelectrode Designs for Oxidase-Based Biosensors -- Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detection -- The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue -- Hexacyanoferrates as Mediators for Microelectrode Biosensors -- Enzyme Immobilization on Microelectrode Biosensors -- Characterization of Polymer€“Énzyme Composite Biosensors for Brain Monitoring In Vivo -- Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors -- Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays -- Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors -- Measurement of Purine Release with Microelectrode Biosensors -- Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle -- Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors -- Carbon Nanotubes-Based Microelectrode (Bio)sensors -- Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy -- Aptamer-Based Electrochemical Biosensors for the Detection of Small Molecules and Plasma Proteins -- Electrochemiluminescent Biosensors: Neuroscience Applications -- Molecularly Imprinted Polymers: Promising Advanced Materials for In Vivo Sensing
    Abstract: For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences.℗ The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results. ℗ Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit
    Pages: XV, 387 p. 111 illus., 45 illus. in color. : digital.
    ISBN: 9781627033701
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  • 7
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume presents techniques and recently developments in extracellular recording. The chapters in this book explore topics such as mouse, rat and zebrafish models; extracellular recordings on human cognition; single-unit recordings and multi-electrode arrays; and recordings in perinatal and early developing mice. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Extracellular Recording Approaches is a valuable resource that provides readers with up-to-date applications and methods to study brain regions involved in sensory, motor, and cognitive functions
    Pages: XIII, 298 p. 74 illus., 62 illus. in color. : online resource.
    ISBN: 9781493975495
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  • 8
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer’s disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer’s Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry
    Pages: XIII, 272 p. 39 illus., 33 illus. in color. : online resource.
    ISBN: 9781493976744
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  • 9
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Preface -- Extracellular and intracellular recordings -- Theory of electrical transfer -- Amplifier -- Salt environment -- Micropipettes -- Spatiotemporal effects of synaptic input -- Perforated patch -- Isolation of synaptic current -- Fast and slow synaptic currents -- Measuring kinetics of synaptic current -- Measuring release probability -- Long-term measurements -- Measuring reversal potentials -- Amplitude -- Pre- and post-synaptic effect -- Run-up and run-down -- Kinetics of synaptic current -- Measurements of a single synapse -- Measurements of silent synapses -- Dendritic patch -- Electrophysiological tag -- In vivo electrophysiology
    Abstract: Electrophysiology is one of the finest approaches capable of detecting and analyzing electrical events in the brain. However, like all other experimental approaches, it has its limitations. This book was created to serve as a guide for those endeavoring to understand the function of electrophysiology and its underlying components: neurons, neural systems, and the brain. It introduces and highlights important topics in the field of electrophysiology, while also extending these topics to practical electrophysiological approaches through the perspective of the two authors. This book is ideal for graduate students or junior postdoctoral fellows interested in starting a journey in synaptic neuroscience
    Pages: XII, 263 p. 89 illus., 46 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9781493932740
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  • 10
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biology / Technique ; Biomedicine ; Neurosciences ; Neurobiology ; Biological Techniques ; Springer eBooks
    Description / Table of Contents: Preface -- Production of high-quality antibodies for the study of receptors and ion channels in brain -- Co-immunoprecipitation from brain -- Sub-synaptic membrane fractionation -- Investigation of ℗ neurotransmitter receptors in brain slices using cell surface biotinylation -- Single nanoparticle tracking of surface ion channels and receptors in brain cells -- Radioligand binding detection of receptors in brain membranes -- Recombinant Alphavirus-Mediated Expression of Ion Channels and Receptors in the Brain -- Fluorescent ligands and TR-FRET to study receptor-receptor interactions in the brain -- In situ Proximity Ligation Assay to study and understand the distribution and balance of GPCR homo- and heteroreceptor complexes in the brain -- Fluorescent in situ hybridization for sensitive and specific labeling -- Autoradiographic visualization of G protein-coupled receptors in brain -- Analysis of the expression profile and regional distribution of neurotransmitter receptors and ion channels in the central nervous system using histoblots -- Immunohistochemistry for ion channels and their interacting molecules: Tips for improving antibody accessibility -- Localization of GFP-tagged proteins at the electron microscope -- Pre-embedding methods in the localization of receptors and ion channels -- Post-embedding immunohistochemistry in the localization of receptors and ion channels -- High-Resolution localization of membrane proteins by SDS-digested freeze-fracture replica labelling (SDS-FRL) -- Application of virus vectors for anterograde tract-tracing and single-neuron labeling studies -- Analysis of synaptic connections using viral vectors at the electron microscopic level -- Morphological and neurochemical characterization of electrophysiologically identified cells -- Using electrophysiology to study synaptic and extrasynaptic ionotropic receptors in hippocampal neurons -- Biophysical methods to analyze direct G-protein regulation of neuronal voltage-gated calcium channels -- Electrophysiological recordings in behaving animals -- Voltammetry in behaving animals -- In vivo brain microdialysis of monoamines -- Calcium transients in single dendrites and spines of pyramidal neurons in vitro -- Dynamic recording of membrane potential from hippocampal neurons by using a FRET-based voltage biosensor -- Determination of GPCR-mediated cAMP accumulation in rat striatal synaptosomes -- GPCR-mediated MAPK/ERK cascade activation in brain slices -- Index
    Abstract: Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques
    Pages: XVIII, 475 p. 84 illus., 57 illus. in color. : online resource.
    ISBN: 9781493930647
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