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  • 1
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Identification of Glutamatergic Neurons -- Single Nanoparticle Tracking: A Method for Investigating the Surface Dynamics of Glutamate Receptors -- Positron Emission Tomography of Metabotropic Glutamate Receptors -- NMR Spectroscopy of Brain Glutamate Function -- Imaging Glutamate with Genetically Encoded Fluorescent Sensors -- Measurement of Astrocytic Glutamate Release using Genetically-Encoded Probe Combined with TIRF Microscopy -- Drugs to Alter Extracellular Concentration of Glutamate: Modulators of Glutamate Uptake Systems -- Drugs to Tune Up Glutamatergic Systems: Modulators of Glutamate Metabotropic Receptors -- Glutamatergic Synthesis, Recycling, and Receptor Pharmacology at Drosophila and Crustacean Neuromuscular Junctions -- Optical Control of Glutamate Receptors of the NMDA-Kind in Mammalian Neurons, with the use of Photoswitchable Ligands -- In Vivo Electrochemical Studies of Optogenetic-Control of Glutamate Signaling Measured Using Enzyme-Based Ceramic Microelectrode Arrays -- Separation-Based Sensors using Microchip Electrophoresis with Microdialysis for Monitoring Glutamate and Other Bioactive Amines -- Brain Glutamate Monitoring by Microdialysis and Separation Methods with a Special Focus on Capillary Electrophoresis with Laser-Induced Fluorescence Detection -- In Vivo Determination of Glutamate Uptake by Brain Microdialysis -- Enzymes of Glutamate System -- The Glutamatergic System as Potential Clinical Biomarkers for Blood and Cerebrospinal Fluid Monitoring -- Clinical CNS Microdialysis of Glutamate with a Special Methodological Focus on Human Spinal Cord
    Abstract: This volume presents techniques and recent developments in biochemical approaches to study glutamatergic neurotransmission. This book contains detailed discussions on tracing neuronal pathways, functional or spectroscopic imaging, optogenetic or pharmacological tools, and extracellular neurochemistry in experimental clinical models. The chapters cover topics such as: identification of glutamatergic neurons in a discrete brain area, tools to study dynamics of single ionotropic receptors, in vivo extracellular glutamate monitoring in preclinical research using biosensors, capillary electrophoresis and liquid chromatography, and potential brain glutamatergic clinical biomarkers in biofluids and tissues. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Biochemical Approaches for Glutamatergic Neurotransmission is a valuable resource for researchers studying glutamate neurochemistry
    Pages: XXII, 565 p. 136 illus., 101 illus. in color. : online resource.
    ISBN: 9781493972289
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  • 2
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections ℗ focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques needed to quantify experiments that use nanoparticles in the nervous system
    Pages: XVI, 296 p. 98 illus., 66 illus. in color. : online resource.
    ISBN: 9781493975846
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  • 3
    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Springer eBooks
    Description / Table of Contents: Operational Architectonics Methodology for EEG Analysis: Theory and Results -- Clinical Electroencephalography in the Diagnosis and Management of Epilepsy -- Effective Brain Connectivity from Intracranial EEG recordings: Identification of Epileptogenic Zone in Human Focal Epilepsies -- On the Effect of Volume Conduction on Graph Theoretic Measures of Brain Networks in Epilepsy -- Methods for Seizure Detection and Prediction: An Overview -- Graph-Theoretic Indices of Evaluating Brain Network Synchronization: Application in an Alcoholism Paradigm -- Time-Varying Effective Connectivity for Investigating the Neurophysiological Basis of Cognitive Processes -- Assessment of Sensory Gating Deficit in Schizophrenia Using a Wavelet Transform Methodology on Auditory Paired-Click Evoked Potentials -- Schizophrenia Assessment Using Single Trial Analysis of Brain Activity -- Phase Variants of the Common Spatial Patterns Method -- Estimation of Regional Activation Maps and Interdependencies from Minimum Norm Estimates of Magnetoencephalography (MEG) Data -- Blind Signal Separation Methods in Computational Neuroscience -- Current Trends in ERP Analysis Using EEG and EEG/ fMRI Synergistic Methods -- Computer-Based Assessment of Alzheimer’s Disease Employing fMRI and/or EEG: A Comprehensive Review
    Abstract: Modern Electroencephalographic Assessment Techniques: Theory and Applications presents numerous signal processing and connectivity analysis methodologies addressing a wide variety of clinical applications including epilepsy, schizophrenia, Alzheimer's disease, and even alcoholism. Among the different topics addressed, the neurophysiological basis of cognitive processes is also investigated. The goal is to provide a comprehensive overview of the most modern and widely established approaches mainly applied in, but not limited to, decomposing high resolution multichannel Electroencephalography (EEG) and Magnetoencephalography (MEG) signals into functional interconnected brain regions. Synergistic approaches linking both EEG/ MEG and functional Magnetic Resonance Imaging (fMRI) techniques are also discussed. In line with the popular Neuromethods series, chapters present the theoretical basis of each method along with prosperous application domains, in the form of a balanced mixture of theoretical tutorials, comprehensive reviews, and original research. Emphasis is given to the underlying assumptions, to technical matters that greatly affect the outcome of each proposed method, to the ambitions, and to the domain of application of each method. Furthermore, links to graph theory and visualization of connectivity motifs is also addressed in an attempt to better describe the functional characteristics of brain networks. ℗ Authoritative and practical, Modern Electroencephalographic Assessment Techniques: Theory and Applications touches upon both the biomedical and computational aspects of this exciting and rapidly evolving field, and will allow for a more in-depth, vital understanding of the braiń€™s complex underlying mechanisms
    Pages: XIX, 386 p. 72 illus., 67 illus. in color. : online resource.
    ISBN: 9781493912988
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  • 4
    New York, NY : Springer
    Keywords: Medicine ; Neurosciences ; Neurochemistry ; Biomedicine ; Neurosciences ; Neurochemistry ; Springer eBooks
    Description / Table of Contents: Genetic and Epigenetic Methods for Analysis of the Dopamine D2 Receptor Gene -- Characterization of D1 Dopamine Receptor Post-Transcriptional Regulation -- Computational Approaches in the Structure-Function Studies of Dopamine Receptors -- Cell-Free Protein Synthesis and Purification of the Dopamine D2 Receptor -- Wnt Ligand Binding to and Regulation of Dopamine D2 Receptors -- Regulation of Pre- and Postsynaptic Protein Phosphorylation by Dopamine D2 Receptors -- Study of Dopamine D1 Receptor Regulation by G Protein-Coupled Receptor Kinases Using Whole-Cell Phosphorylation and Cross-Linking Methods -- Ubiquitination of Dopamine Receptor Studied by Sequential Double Immunoprecipitation -- Dopamine Receptors in the Subthalamic Nucleus: Identification and Localization of D5 Receptors -- MALDI Mass Spectrometry Imaging of Dopamine and PET D1 and D2 Receptor Ligands in Rodent Brain Tissues -- Positron Emission Tomography Imaging of Dopaminergic Receptors in Rats -- Transactivation of Receptor Tyrosine Kinases by Dopamine Receptors -- Dopamine Receptors in Human Embryonic Stem Cell Differentiation -- Calcium and PLC Signaling Through Dopamine Receptors -- Intracellular Trafficking Assays for Dopamine D2-Like Receptors -- Study of Crosstalk Between Dopamine Receptors and Ion Channels -- Study of Dopamine Receptor and Dopamine Transporter Networks in Mice -- Optogenetic Regulation of Dopamine Receptor-Expressing Neurons -- Characterization of D3 Dopamine Receptor Agonist-Dependent Tolerance Property -- Dopamine D1 and D2 Receptors in Chronic Mild Stress: Analysis of Dynamic Receptor Changes in an Animal Model of Depression Using In Situ Hybridization and Autoradiography
    Abstract: To foster a better understanding of dopamine receptor functionality, this detailed volume creates an interface between updated classical methods and new emerging technologies heretofore not available to new or seasoned researchers. Divided in five sections dedicated to experimental approaches investigating different facets of dopaminergic signal transduction, Dopamine Receptor Technologies covers epigenetic and post-transcriptional analysis, computational and biochemical techniques, visualization and imaging methods, molecular and cell biological tools, as well as behavioral assessment. The book, as a part of the popular Neuromethods series, provides insightful step-by-step protocols and methodological reviews that readers will find useful. Practical and versatile, Dopamine Receptor Technologies seeks to aid researchers in developing new pharmacological tools to improve our knowledge of in vivo roles played by each receptor subtype and the synthesis of prospective lead compounds for drug discovery
    Pages: XIV, 379 p. 63 illus., 26 illus. in color. : online resource.
    ISBN: 9781493921966
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  • 5
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: The Evolution of Immunocytochemistry in the Dissection of Neural Complexity.-n Immunofluorescence℗ and Genetic Fluorescent Labeling℗ Techniques in the Drosophila℗ Nervous System -- Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris -- Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish℗ Brain -- Immunocytochemical℗ Phenotype℗ of Differentiating℗ Neurons.-Immunocytochemical Identification of Mammalian Differentiating Neurons℗ in the Process of Adult℗ Neurogenesis℗ in the Hippocampal Dentate Gyrus -- Identification of Proliferating and Migrating Cells by BrdU℗ and Other Thymidine Analogues. Benefits and Limitations -- Flow Cytometry-Based Quantification of Neurogenesis in the Central Nervous System -- In Vivo and In Vitro Immunohistochemical Visualization of Neural Cell Apoptosis℗ and Autophagy -- Immunocytochemical Detection of Intraneuronal AÎø℗ Peptides in Mouse Models of Alzheimer's Disease -- Purification℗ and Characterization of Mouse Olfactory Ensheathing Cells and their Potential Use for Therapy in Amyotrophic Lateral Sclerosis (ALS) -- Immunocytochemistry of Microglial Cells -- Immunocytochemical Assessment of Blood-Brain Barrier Structure, Function, and Damage -- Quantification of Immunocytochemical Colocalization in Neurons -- Immunogold℗ Electron Microscopic℗ Quantification℗ of Small Molecular℗ Compounds and Proteins℗ at Synapses and Other Neural Profiles -- Combined Immunocytochemistry℗ and Tracing℗ of Neural Connections -- Neuronal Circuitry Dissected by Immunocytochemistry Combined with Retrograde Tracing -- Transfection Techniques and Combined Immunocytochemistry in Cell Cultures and Organotypic Slices -- Combined Immunochemistry and Live-Imaging of Fluorescent Protein Expressing Neurons in Mouse℗ Brain -- Array Tomography: A Novel High-Resolution Immunofluorescence Technique -- Single Molecule Localization Microscopy℗ to Study Neuronal℗ Microtubule Organization -- Studying Membrane Dynamics℗ of Proteins℗ Using Quantum Dots -- Optical℗ Protein℗ Patterning
    Abstract: This volume presents a collection of protocols for immunocytochemical analysis of neurons and neural networks. Chapters focus on immunocytochemical localization at light and electronic levels, biochemical characterization, and functional analysis in vivo or ex vivo by novel types of microscopy, as well as protocols for development and production of genetic probes. Written for the popular Neuromethods℗ series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.℗ Essential and authoritative, Immunocytochemistry and Related Techniques is intended for a large audience of scientists, including histologists, biochemists, cellular and molecular biologists, electrophysiologists that are currently active in the field or are willing to enter the exciting area of neuroscience research
    Pages: XIII, 473 p. 95 illus., 77 illus. in color. : online resource.
    ISBN: 9781493923137
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  • 6
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: In utero Electroporation of the Mouse Embryo -- Exo utero Electroporation of the Mouse Embryo -- In Vivo Electroporation of the Postnatal Rodent Forebrain -- Electroporation in the Rodent Retina in vivo and in vitro -- Electroporation in the Developing Mouse Olfactory Bulb -- Cell Migration Analysis of Cortical Interneurons after Electroporation -- Characterization of Newborn Interneurons In The Mouse Olfactory Bulb Using Postnatal Electroporation -- Genetic Manipulation Of Gyrencephalic Carnivores using in utero electroporation -- Electroporation for the Chick Embryonic CNS -- Targeting the Zebrafish Nervous System using In Vivo Electroporation -- Gene Transfer into Cultured Mammalian Embryos by Electroporation -- Electroporation Method for Mammalian CNS Neurons in Organotypic Slice Cultures -- Electroporation of Dissociated Hippocampal Neurons -- Tol2-Mediated Transgenesis And Its Application To Electroporation -- Control of Gene Expression In Neurons by the use of in vivo Electroporation and the Tetracycline System
    Abstract: This volume describes the methods of both in vivo and in vitro electroporation using ferrets, rats, mice, chickens, and zebrafish.℗ Recent advances of experiments using the tetracycline-regulated gene expression and Tol2 transposon systems are also included. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. ℗ Practical and authoritative, Electroporation Methods in Neuroscience serves to aid scientists in the further study into this crucially important way to study cells
    Pages: XII, 199 p. 71 illus., 58 illus. in color. : online resource.
    ISBN: 9781493924592
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  • 7
    Totowa, NJ : Humana Press
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Solution Single-Vesicle Fusion Assay by Single-Molecule Alternating Laser Excitation -- Imaging the Stages of Exocytosis in Epithelial Type II Pneumocytes -- Carbon-Fibre Amperometry in the Study of Exocytosis -- Imaging of Insulin Exocytosis from Pancreatic Beta Cells -- Functional, Quantitative, and Super-Resolution Imaging and Spectroscopic Approaches for Studying Exocytosis -- Electrophysiologic Measurements of Membrane Capacitance in Hormone-Secreting Cells -- Measuring Exocytosis in Endocrine Tissue Slices -- Intravital Microscopy and Its Application to Study Regulated Exocytosis in the Exocrine Glands of Live Rodents -- Rapid Analysis of Synaptic Vesicle Endocytosis in Synaptosomes -- Isolated Neurohypophysial Terminals: Model for Depolarization-Secretion Coupling -- The Sea Urchin Egg and Cortical Vesicles as Model Systems to Dissect the Fast, Ca2+-Triggered Steps of Regulated Exocytosis
    Abstract: Bringing together techniques and methods currently being applied to the study of exocytosis, Exocytosis Methods collects chapters from experts in the field, examining this fundamental process essential to functions ranging from protein secretion to hormone release and neurotransmission.℗ The book begins with a section covering a range of techniques being applied to the study of single-vesicle fusion events, which are key in order to gain insight into the final steps of vesicle fusion.℗ The volume continues with several model systems that are being employed to unravel the complexities of exocytosis.℗ Written for the Neuromethods series, chapters included in this work present the kind of detail and vital implementation advice that leads to successful results. ℗ Practical and authoritative, Exocytosis Methods seeks to promote the advent of new methods in microscopy and the development of new preparations, which would doubtlessly lead to many new and exciting discoveries in this field
    Pages: XIII, 248 p. 70 illus., 36 illus. in color. : online resource.
    ISBN: 9781627036764
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  • 8
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Biomedicine ; Neurosciences ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Lentiviral Vectors as Research Tools in Neurobiology: Design and Production -- Recombinant Adenovirus in Neurobiology -- Adeno-Associated Virus-Based Vectors -- Herpes Simplex Virus 1 (HSV-1)-Based Vectors -- Alphavirus-Based Vectors -- Viral Vectors to Study Synaptic Function -- Using Viral Vectors to Study the Memory Trace in Mice -- Development of Cell-Type Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction -- Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior -- Gene Therapy for Parkinson’s Disease -- Lentiviral Vectors in Huntington’s Disease Research and Therapy -- Application of Viral Vectors to Motor Neuron Disorders -- In Vivo Gene Silencing by Virally Delivered MicroRNA -- Viral Manipulation of Neural Stem/Precursor Cells -- Viral Vector-Based Techniques for Optogenetic Modulation In Vivo -- Viral Vectors for Optogenetics of Hypothalamic Neuropeptides -- Viral Vectors in Primate Research: Examples from Parkinson's Disease Research
    Abstract: Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders.℗ The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics.℗ Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results. ℗ Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications
    Pages: XIII, 347 p. 51 illus., 34 illus. in color. : online resource.
    ISBN: 9781627036108
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  • 9
    Keywords: Neurology ; Neurobiology ; Neurology ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Integrative Biomarkers in Stroke -- Vascular-Related Biomarkers of Ischemic Stroke -- Generation and Applicability of Genetic Risk Scores (GRS) in Stroke -- Neuroplasticity Biomarkers in Experimental Stroke Recovery -- Methods of Mitochondrial and Redox Measurements in Ischemic Stroke -- Blood Biomarkers for Stroke Differentiation -- Laser-Capture Micro-Dissection for Measurement of Angiogenesis after Stroke -- Blood-Borne Biomarkers of Hypertension Predicting Hemorrhagic and Ischemic Stroke -- RNA Gene Expression to Identify the Etiology of Acute Ischemic Stroke: The Biomarkers of Acute Stroke Etiology (BASE) Study -- Neurotoxicity Biomarkers Assays Development -- Glutamate Receptor Peptides as Potential Neurovascular Biomarkers of Acute Stroke -- Antibodies to NMDA Receptors in Cerebral and Spinal Cord Infarctions -- Impaired Retinal Vasoreactivity as an Early Marker of Stroke Risk in Diabetes -- Imaging Biomarkers: Keys to Decision Making in Stroke -- Neuroimaging Methods for Acute Stroke Diagnosis and Treatment -- Ultrasound Assessments of Risk for TIA and Stroke in Vascular Surgery -- Preoperative and Intraoperative Markers of Cerebral Ischemia -- Time is Brain: the Prehospital Phase and the Mobile Stroke Unit -- Acute Clinical Intervention and Chronic Management of Cerebral Vascular Accident -- Trends in Biomarkers Development for Stroke
    Abstract: This volume presents the latest data on recent achievements in new and emerging technologies for stroke biomarkers and innovations in stroke assessment. The topics discussed in this book explore the role of upcoming biomarkers in different types of stroke, and explores techniques that will allow researchers to be more effective when approaching clinical management and patient care. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to ensure successful results in the laboratory. Cutting-edge and comprehensive, Stroke Biomarkers is a valuable resource for both experimental and clinical scientists interested in expanding their knowledge in the field of stroke research
    Pages: XVII, 425 p. 80 illus., 58 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781493996827
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  • 10
    New York : Humana Press
    Call number: QZ380:202
    Keywords: Veterinary Medicine ; Veterinary oncology ; Disease Models, Animal ; Brain Neoplasms
    Pages: xiii, 391 p.
    ISBN: 9781627032087
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