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  • 1
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Simultaneous Functional Magnetic Resonance and Two Dimensional Optical Imaging Spectroscopy -- Neurovascular Coupling Investigated by Simultaneous Optical Coherence Tomography and Electrophysiology -- Studying Adenosine and Cerebral Blood Flow (CBF) Using Pharmacological Methods -- Imaging Vasodynamics in the Awake Mouse Brain with Two-Photon Microscopy -- Neurovascular Coupling in the Deep Brain Using Confocal Fiber-Optic Endomicroscopy -- Non-Invasive Neural Imaging and Tissue Oxygenation in the Visual System -- High-Resolution Wide-Field Optical Imaging of Micro-Vascular Characteristics: From the Neocortex to the Eye -- Optical Intrinsic Signal Imaging for Elucidating Functional Structures in Higher Visual Area -- Closed Cranial Window Applications in the Rat: Studies on Neurovascular Coupling Involving Pial Arterioles and the Glia Limitans -- Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry and Light Scattering -- Physiological Basis of BOLD fMRI Decreases -- Simultaneous Multi-Wavelength Optical Imaging of Neuronal and Hemodynamic Activity -- Non-Invasive Laser-Induced Photoacoustic Tomography for Functional Imaging -- Neurovascular Coupling in Relation to Cortical Spreading Depression -- Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging -- Cerebral Monitoring and Surveillance Using High Resolution Functional Optical Imaging
    Abstract: Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques, or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy, and cerebrovascular diseases, such as ischemia, hemorrhage, and spreading depression.℗ As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab. ℗ Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans
    Pages: XIX, 332 p. 120 illus., 99 illus. in color. : online resource.
    ISBN: 9781493907243
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  • 2
    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Springer eBooks
    Description / Table of Contents: The Transcranial Magnetic Stimulation (TMS) Device and Foundational Techniques -- Transcranial Magnetic Stimulation (TMS) Safety Considerations and Recommendations -- Neuronavigation for Transcranial Magnetic Stimulation -- Reaching Deep Brain Structures: The H-Coils -- Single-Pulse Transcranial Magnetic Stimulation (TMS) Protocols and Outcome Measures -- Paired-Pulse Transcranial Magnetic Stimulation (TMS) Protocols -- Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols -- Off-Line and On-Line “Virtual Lesion” Protocols -- State-Dependent Transcranial Magnetic Stimulation (TMS) Protocols -- Combination of Transcranial Magnetic Stimulation (TMS) with Functional Magnetic Resonance Imaging -- Electroencephalography During Transcranial Magnetic Stimulation: Current Modus Operandi -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Therapeutics -- Transcranial Magnetic Stimulation (TMS) Clinical Applications: Diagnostics -- A Review of Current Clinical Practice in the Treatment of Major Depression -- Protocol for Depression Treatment Utilizing H-Coil Deep Brain Stimulation -- Navigated Transcranial Magnetic Stimulation: Principles and Protocol for Mapping the Motor Cortex -- Speech Mapping with Transcranial Magnetic Stimulation
    Abstract: Transcranial Magnetic Stimulation seeks to enable new and existing practitioners to learn and follow established TMS protocols. The individual chapters in this detailed volume describe methods for single and multiple pulse TMS as well as methods for TMS coupled with associated techniques, from electromyography to neuroimaging. The collection promises to facilitate growth and exploration of clinical and experimental TMS. As a volume in the popular Neuromethods series, chapters include the kind of expert implementation advice that encourages successful and reproducible results. ℗ Authoritative and practical, Transcranial Magnetic Stimulation will serve not only as a good methodological introduction for those new to this growing field, but also as a source of continual reference for experienced practitioners when re-visiting older, exploring novel, or developing new concepts
    Pages: XI, 386 p. 79 illus., 60 illus. in color. : online resource.
    ISBN: 9781493908790
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  • 3
    Unknown
    Totowa, NJ : Humana Press
    Keywords: Medicine ; Neurosciences ; Psychiatry ; Laboratory animals ; Biomedicine ; Neurosciences ; Psychiatry ; Animal Models ; Springer eBooks
    Description / Table of Contents: Introduction: Binge Eating, Bulimia Nervosa, and Hedonic Overeating -- Binge-Prone vs. Binge-Resistant Rats and Their Concomitant Behavioral Profiles -- Binge Eating in Female Rats Induced by Yo-Yo Dieting and Stress -- Binge-Type Eating Induced by Limited Access to Optional Foods -- Assessment of Stress-Independent Binge-Like Eating Behavior in Mice -- Predicting and Classifying Rats Prone to Overeating Fat -- Modeling Binge Eating in Non-Human Primates -- Psychosocial Stress and Diet History Promote Emotional Feeding in Female Rhesus Monkeys -- Stressful Experiences in Early Life and Subsequent Food Intake -- Sham Feeding in Rats Translates Into Modified Sham Feeding in Women with Bulimia Nervosa and Purging -- Animal Models of Binge Eating Palatable Foods: Emergence of Addiction-Like Behaviors and Brain Changes in the Rat -- Deep Brain Stimulation for the Treatment of Binge Eating: Mechanisms and Preclinical Models -- Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse -- Food Seeking in Spite of Harmful Consequences -- Introduction: Anorexia and Undereating -- Food Restriction and Reward in Rats -- Activity-Based Anorexia in the Rat -- Food-Anticipatory Activity: Rat Models and Underlying Mechanisms -- Anorexia and Drugs of Abuse Abnormally Suppress Appetite, the Result of a Shared Molecular Signal Foul-Up -- The Anorectic Phenotype of the Anx/anx Mouse is Related to Hypothalamic Dysfunction -- Functional Magnetic Resonance Imaging in Awake Rats: Studies Relevant to Addiction and the Reward Circuitry
    Abstract: The growth of the field of eating disorder research has led to a vast array of empirical articles, and the development of new animal models that can be used to study these disorders continues to stimulate new research.℗ Animal Models of Eating Disorders serves as a collection of detailed techniques contributed by experts in the field who are well-versed in the development and implementation of these models. Since eating disorders are complex and likely due to a combination of environmental, genetic, and social causes, the detailed chapters of this volume have been designed to highlight different contributing factors. Collectively, these chapters give a comprehensive and representative overview of both recently developed and classic methodologies used in the study of eating disorders.℗ Written for the popular Neuromethods series, this work contains the kind of thorough description and implementation advice that promises successful results. ℗ Authoritative and practical, Animal Models of Eating Disorders aims to aid researchers in the use of animal models to assist in their investigation and characterization of the behaviors and neurochemical alterations associated with these devastating disorders
    Pages: XVI, 379 p. 76 illus., 10 illus. in color. : digital.
    ISBN: 9781627031042
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  • 4
    Keywords: Neurosciences ; Cell Culture ; Neurosciences ; Cell Culture ; Springer eBooks
    Description / Table of Contents: In Vitro Blood-Brain Barrier Functional Assays in a Human iPSC-Based Model -- In Vitro Techniques for Assessing Neurotoxicity using Human iPSC-Derived Neuronal 1 Models -- Oxidative Stress Signatures in Human Stem Cell Derived Neurons -- Glial Reactivity in Response to Neurotoxins: Relevance and Methods -- Neuron-Glia Interaction Studied with In Vitro Co-Culture -- Assessment of Mitochondrial Stress in Neurons: Proximity Ligation Assays to Detect Recruitment of Stress-Responsive Proteins to Mitochondria -- Epigenetic Changes in Cultured Neurons and Astrocytes -- The Neurosphere Assay as an In Vitro Method for Developmental Neurotoxicity (DNT) Evaluation -- Zebrafish as a Tool to Assess Developmental Neurotoxicity -- Rat Brain Slices: An Optimum Biological Preparation for acute Neurotoxicological Studies -- Electrophysiological Neuromethodologies -- A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies -- Transporter Studies: Brain Punching Technique -- MicroRNA as a Marker for In Vitro Neurotoxicity Testing and Related Neurological Disorders -- Application of Non-Animal Methods to More Effective Neurotoxicity Testing for Regulatory Purposes
    Abstract: This volume discusses the requirements, advantages, and limitations of studying cell culture. The chapters in this book cover topics such as in vitro blood-brain barrier functional assays in human iPSC-based models; neuron-glia interactions examines with in vitro co-culture; epigenetic changes in cultures neurons and astrocytes; rat brain slices; brain punching technique; and using microRNA for in vitro neurotoxicity testing and related disorders. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Cell Culture Techniques, Second Edition is a valuable resource for students and experiences researchers who are interested in learning more and making risk decisions in this evolving field
    Pages: XIII, 302 p. 57 illus., 47 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493992287
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  • 5
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Abstract: This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons
    Pages: XVI, 382 p. 90 illus., 67 illus. in color. : online resource.
    ISBN: 9781493972807
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  • 6
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biology / Technique ; Biomedicine ; Neurosciences ; Neurobiology ; Biological Techniques ; Springer eBooks
    Description / Table of Contents: Preface -- Production of high-quality antibodies for the study of receptors and ion channels in brain -- Co-immunoprecipitation from brain -- Sub-synaptic membrane fractionation -- Investigation of ℗ neurotransmitter receptors in brain slices using cell surface biotinylation -- Single nanoparticle tracking of surface ion channels and receptors in brain cells -- Radioligand binding detection of receptors in brain membranes -- Recombinant Alphavirus-Mediated Expression of Ion Channels and Receptors in the Brain -- Fluorescent ligands and TR-FRET to study receptor-receptor interactions in the brain -- In situ Proximity Ligation Assay to study and understand the distribution and balance of GPCR homo- and heteroreceptor complexes in the brain -- Fluorescent in situ hybridization for sensitive and specific labeling -- Autoradiographic visualization of G protein-coupled receptors in brain -- Analysis of the expression profile and regional distribution of neurotransmitter receptors and ion channels in the central nervous system using histoblots -- Immunohistochemistry for ion channels and their interacting molecules: Tips for improving antibody accessibility -- Localization of GFP-tagged proteins at the electron microscope -- Pre-embedding methods in the localization of receptors and ion channels -- Post-embedding immunohistochemistry in the localization of receptors and ion channels -- High-Resolution localization of membrane proteins by SDS-digested freeze-fracture replica labelling (SDS-FRL) -- Application of virus vectors for anterograde tract-tracing and single-neuron labeling studies -- Analysis of synaptic connections using viral vectors at the electron microscopic level -- Morphological and neurochemical characterization of electrophysiologically identified cells -- Using electrophysiology to study synaptic and extrasynaptic ionotropic receptors in hippocampal neurons -- Biophysical methods to analyze direct G-protein regulation of neuronal voltage-gated calcium channels -- Electrophysiological recordings in behaving animals -- Voltammetry in behaving animals -- In vivo brain microdialysis of monoamines -- Calcium transients in single dendrites and spines of pyramidal neurons in vitro -- Dynamic recording of membrane potential from hippocampal neurons by using a FRET-based voltage biosensor -- Determination of GPCR-mediated cAMP accumulation in rat striatal synaptosomes -- GPCR-mediated MAPK/ERK cascade activation in brain slices -- Index
    Abstract: Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques
    Pages: XVIII, 475 p. 84 illus., 57 illus. in color. : online resource.
    ISBN: 9781493930647
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  • 7
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Human Genetics ; Neurology ; Springer eBooks
    Description / Table of Contents: Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Lentiviral Vectors for Gene Delivery to the Nervous System -- Gene Therapy for Parkinson’s Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF) -- Gene Delivery and Gene Therapy for Alzheimer’s Disease -- Gene Therapy for Huntington’s Disease -- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury -- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors -- Targeted Gene Therapy for Ischemic Stroke -- Adeno-Associated Viral Gene Therapy for Retinal Disorders -- Gene Therapy for Epilepsies -- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement -- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice -- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain? -- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
    Abstract: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for℗ the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authorś€™ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimeŕ€™s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.℗ Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders
    Pages: XIV, 359 p. 65 illus., 51 illus. in color. : online resource.
    ISBN: 9781493923069
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  • 8
    Unknown
    Totowa, NJ : Humana Press
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Solution Single-Vesicle Fusion Assay by Single-Molecule Alternating Laser Excitation -- Imaging the Stages of Exocytosis in Epithelial Type II Pneumocytes -- Carbon-Fibre Amperometry in the Study of Exocytosis -- Imaging of Insulin Exocytosis from Pancreatic Beta Cells -- Functional, Quantitative, and Super-Resolution Imaging and Spectroscopic Approaches for Studying Exocytosis -- Electrophysiologic Measurements of Membrane Capacitance in Hormone-Secreting Cells -- Measuring Exocytosis in Endocrine Tissue Slices -- Intravital Microscopy and Its Application to Study Regulated Exocytosis in the Exocrine Glands of Live Rodents -- Rapid Analysis of Synaptic Vesicle Endocytosis in Synaptosomes -- Isolated Neurohypophysial Terminals: Model for Depolarization-Secretion Coupling -- The Sea Urchin Egg and Cortical Vesicles as Model Systems to Dissect the Fast, Ca2+-Triggered Steps of Regulated Exocytosis
    Abstract: Bringing together techniques and methods currently being applied to the study of exocytosis, Exocytosis Methods collects chapters from experts in the field, examining this fundamental process essential to functions ranging from protein secretion to hormone release and neurotransmission.℗ The book begins with a section covering a range of techniques being applied to the study of single-vesicle fusion events, which are key in order to gain insight into the final steps of vesicle fusion.℗ The volume continues with several model systems that are being employed to unravel the complexities of exocytosis.℗ Written for the Neuromethods series, chapters included in this work present the kind of detail and vital implementation advice that leads to successful results. ℗ Practical and authoritative, Exocytosis Methods seeks to promote the advent of new methods in microscopy and the development of new preparations, which would doubtlessly lead to many new and exciting discoveries in this field
    Pages: XIII, 248 p. 70 illus., 36 illus. in color. : online resource.
    ISBN: 9781627036764
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  • 9
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    Berlin : Springer.
    Notes: This is a series title, single volumes see link below.
    ISSN: 1940-6045
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  • 10
    Unknown
    New York, NY : Springer New York
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Introduction -- Stroke -- Disorders of Consciousness -- Traumatic Brain Injury -- Parkinson’s Diseae -- Dystonia -- Meningitis -- Multiple Sclerosis -- Alzheimer’s Disease -- Tumors of the Central Nervous System -- Spinal Cord Injury -- Peripheral Neuropathy -- Epilepsy -- Future of Clinical Trials in Neurology
    Abstract: This volume provides in-depth descriptions and discussion of clinical trial designs based on novel data analysis of high-quality trials for 11 different neurological conditions in order to ultimately improve the quality of care in neurology. Some of the conditions discussed in this book are stroke, traumatic brain injury, Alzheimer’s disease, epilepsy, and tumors of the central nervous system. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Clinical Trials in Neurology is a valuable guide for individuals in the research, education, and clinical practice fields, specifically in the fields of medicine, physical therapy, occupational therapy, nursing, and public health. This volume is also an important resource for clinicians aiming to improve their understanding in methodology of clinical trials
    Pages: XII, 616 p. 109 illus., 95 illus. in color. : online resource.
    ISBN: 9781493978809
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