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  • 1
    Keywords: Medicine ; Medical Microbiology ; Bacteriology ; Biomedicine ; Medical Microbiology ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Chapter 1: The concept of biofilm-related implant malfunction and “low-grade infection” -- Chapter 2: Mechanisms of bacterial colonization of implants and host response -- Chapter 3: Animal models of implant-related low grade infections -- Chapter 4: Microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- Chapter 5: The role of the new biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma -- Chapter 6: Fast resorbable antibacterial hydrogel coating of implants to prevent bacterial colonization and implant malfunction: what is the evidence ? -- Chapter 7: Prophylaxis and therapy in Orthopaedic implant infection: where are we? -- Chapter 8: Antibacterial bioglass for chronic bone infection -- Chapter 9: Prosthetic Joint Infections and cost analysis
    Abstract: This book discusses Prosthetic Joint Infection (PJI), which remains one of the most common problems necessitating revision arthroplasty. It pursues a multidisciplinary approach, bringing together opinions from the leading experts in the field. The book identifies the potential causes of these infections, provides sound diagnostic criteria guidelines, and explains how these prosthetic infections are managed from orthopedic surgery, clinical and diagnostic perspectives. PJI can lead to multiple revision surgeries and significant patient morbidity. Periprosthetic infection rates remain around 1–2% after primary total hip and knee arthroplasty and account for approximately 7–12% of all revision cases. Orthopedic hardware infections are much-feared and costly complications that can occur when these devices are implemented both in traumatic cases as well as in joint replacement surgery. Because these infections can lead to higher morbidity, it is important to understand their pathophysiology and the principles behind their diagnosis and initial treatment. The pathogenesis of these kinds of infections is intimately connected to the biofilm-producing trait characteristic of many microorganisms, which can have a critical effect on the likely success of treatments. The book offers a unique guide for all scientists working in arthroplasty who are seeking an update on the field, and for newcomers alike
    Pages: VI, 119 p. 20 illus. in color. : online resource.
    ISBN: 9783319522746
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  • 2
    Keywords: Life sciences ; Proteins ; Bioinformatics ; Cell Biology ; Life sciences ; Bioinformatics ; Protein Science ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins -- Structure and Dynamics of Intrinsically Disordered Proteins -- NMR methods for the study of IDP structure, dynamics and interactions: general overview and practical guidelines -- Ensemble Calculation for IDPs Using NMR Parameters -- NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins -- Recombinant IDPs for NMR: Tips and Tricks -- Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an €œÉlephant and Blind Meń€ Situation -- Application of SAXS for the Structural Characterization of IDPs -- Bioinformatics Approaches for Predicting Disordered Protein Motifs -- Towards Understanding Protein Disorder In-Cell -- The Protein Ensemble Database -- Order and Disorder in the Replicative Complex of Paramyxoviruses -- Druggability of Intrinsically Disordered Proteins -- Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease
    Abstract: This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research. Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas
    Pages: XIII, 421 p. 111 illus., 98 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319201641
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  • 3
    Keywords: Laboratory Medicine ; Animal models in research ; Molecular Biology ; Laboratory Medicine ; Animal Models ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Chapter 1: Using forward and reverse genetics in mouse to study birth defects -- Chapter 2: Using animals to study neural tube defects -- Chapter 3: Using animals to study ciliopathies -- Chapter 4: Using animals to model human skeletal defects -- Chapter 5: Understanding eye defects using animal models -- Chapter 6: Modelling kidney and urinary tract defects in animals -- Chapter 7: Pancreas development and type I diabetes -- Chapter 8: Using animals to study human birth defects affecting the functions of the digestive system -- Chapter 9: Modelling human birth defects with zebrafish -- Chapter 10: Modelling diseases with C. elegans -- Chapter 11: Infectious disease and birth defects
    Abstract: This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects
    Pages: VII, 244 p. 54 illus., 43 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811523892
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  • 4
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Medical parasitology ; Biomedicine ; Parasitology ; Immunology ; Medical Microbiology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Form and Function in the Digenea -- The Systematics of the Trematoda -- Schistosomiasis -- Fascioliasis -- Paragonimiasis -- Liver Flukes -- Intestinal Trematode Infections -- Epidemiology of Trematode Infections -- Diagnosis of Human Trematode Infections -- Schistosomatidae and Diplostomidea -- Amphistomes -- Dicrocoeliidae Family -- Selected Wildlife Trematodiasis
    Abstract: Digenetic trematodes constitute a major helminth group that parasitize humans and animals, and are a major cause of morbidity and mortality. The diseases caused by trematodes have been neglected for years, especially as compared with other parasitic diseases. However, the geographical limits and the populations at risk are currently expanding and changing in relation to factors such as growing international markets, improved transportation systems, and demographic changes. This has led to a growing international interest in trematode infections, although factors such as the difficulties entailed in the diagnosis, the complexity of human and agricultural practices, the lack of assessments of the economic costs, or the limited number of effective drugs are preventing the development of control measures of these diseases in humans and livestock. In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. The main goal of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite interactions and to show applications of new techniques and concepts for the studies on digenetic trematodes. This is an ideal book for parasitologists, microbiologists, zoologists, immunologists, professional of public health workers, clinicians, and graduate and post-graduate students
    Pages: XI, 474 p. 45 illus., 41 illus. in color. : online resource.
    ISBN: 9781493909155
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  • 5
    Call number: E020:19
    Keywords: Oxygen / Physiological transport ; Oxygen / Physiological transport ; Tissue respiration
    Notes: Based on the 29th annual meeting of the International Society on Oxygen Transport to Tissue held in historic Philadelphia, USA, from August 11 to 15, 2001.
    Pages: xviii, 421 p. : ill.
    ISBN: 0306473941
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    E020:19 departmental collection or stack – please contact the library
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  • 6
    Keywords: Life sciences ; Gene Expression ; Biochemistry ; Biological models ; Life sciences ; Systems Biology ; Protein Science ; Gene Expression ; Springer eBooks
    Description / Table of Contents: Encyclopedia of RNA binding protein expression and domain annotations -- RNA localization and RNA binding proteins that control localization -- Genome-wide approaches to studying alternative polyadenylation events and the RBPs that control them -- RNA binding proteins, PRC complex and long ncRNAs -- Gene and genome regulation by piwi proteins -- Engineering Artificial RBP interactions -- Querying functional polymorphisms by high throughput binding and functional assays -- RNA binding protein networks in EMT/MET -- Therapies against diseases associated with RNA processing defects and RNA binding proteins -- Repeat-disorders and the RNA binding proteins implicated in them -- RNA binding proteins in heart development -- Identification of miRNAs and their targets in C elegans -- Splicing code -- Index
    Abstract: After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA. This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases
    Pages: X, 468 p. 54 illus., 52 illus. in color. : online resource.
    ISBN: 9781493912216
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  • 7
    Keywords: Life sciences ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry ; Life sciences ; Protein Science ; Medical Biochemistry ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: There is a Taurine-Linked Disease Known As Melas -- Taurine And Hearty Topics -- Taurine Regulation Of Peripheral Hemodynamics -- Regulation Of Taurine Release By Neurotransmitter Receptors -- Neuropsychopharmacological Actions Of Taurine -- Neuro-Protective Mechanism Of Taurine ́€“ Role Of Endoplasmic Reticulum -- Differential Regulation Of Taut By Vitamin D3 And Retinoic Acid Via Vdr/Rxr In Llc-Pk1 And Mcf-7 Cells -- Are Taurine Haloamines (Taucl And Taubr) Good Candidates For The Treatment Of Biofilm€“Ássociated Infections? -- Comparative Evaluation Of Taurine And Thiotaurine As Protectants Against Experimental Diabetes-Induced Nephropathy In A Rat Model -- The Mechanism of Taurine Protection against Endoplasmic Reticulum Stress in Stroke Related Conditions in Primary Neuronal Cell Culture -- Direct interaction of taurine with the NMDA glutamate receptor sub-type via multiple mechanisms -- Perinatal taurine exposure affects patterns of autonomic nerve activity in adult male rats -- Lethality of taurine and alcohol co-administration in 7-day-old, adult and old mice -- Metabotropic effect of taurine regulation of potassium channels via 5-HT2A serotonin receptors -- Changes in gene expression at inhibitory synapses in response to taurine treatment -- Effects of Acute vs. Chronic Taurine Treatment on Context Fear Aversive Conditioning in Mice -- Taurine exerts robust protection against hypoxia and glucose deprivation in human neuroblastoma cell culture -- Perinatal taurine supplementation affects neural control of arterial pressure via estrogen receptors in adult female rats -- Gender specific effects of taurine on cardiovascular function -- Taurine affects release of insulin and GABA in Hit-T15 Îø cell line via calcium flux -- Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long duration of diabetes -- Preventive Roles of Taurine in Alloxan-Induced Diabetes -- Renin-angiotensin system and estrogen attenuates glucose-insulin dysregulation in adult female rats that are perinatally depleted of taurine -- Mechanism underlying calcium-dependent contractile defect in taurine transporter knockout heart -- The role of taurine deficiency under stress in cardiac and skeletal muscles: A study in taurine transporter gene knockout mice -- Effect of taurine chloramine on differentiation of human preadipocytes into adipocytes, and expression of adipokines in differentiated adipocytes -- Taurine chloramine increases HO-1 expression and activity by promoting Nrf2 activation via oxidative modification of Keap1 -- Protection of cells from oxidative stress-induced cytotoxicity and resolution of inflammation by taurine chloramine -- Reduced placental taurine transporter (TauT) activity in pregnancies complicated by maternal obesity and pre-eclampsia -- The physiological role of taurine during fish development ́€“ relevant aspects for the aquaculture industry -- Taurine and fish nutrition: where do we stand on the use of this mythical molecule? -- Gestational taurine availability and fetal programming of metabolism in C57BL/6 mice -- Taurine and mitochondrial bioenergetics -- The ability of taurine as a marker for the identification of natural Calculus Bovis and its substitutes -- Effect of arsenic on the expressions of thyroid hormone receptor genes in mice brains and protection of taurine -- Effects of taurine on iNOS-dependent DNA damage in heavy exercise skeletal muscle by inhibiting NF-̐±B signaling pathway -- Knockdown of TauT expression impairs human embryonic kidney 293 cell development -- Effect of arsenic on the expressions of thyroid hormone receptor genes in mice brains and protection of taurine -- Perspective on taurine research -- Monoaminergic activity is increased following electroconvulsive therapy (ECT), but less is known about amino acids -- ToC, cont'd
    Abstract: Taurine 8 represents the combined efforts of investigators on the roles of the amino acid taurine on human health and disease. The chapters covered in this book are directly derived from presentations of the contributors at the 18th International Taurine Meeting held in Marrakech, Morocco in April 2012. The purpose of this book is to disseminate current findings on taurine's contribution in several organ systems. This book covers the following topics: Taurine in the Nervous System, Taurine in the Immune System, Taurine and Diabetes, and Taurine and the Cardiovascular System. Dr. Abdeslem El Idrissi, College of Staten Island and Dr. William L€™Ámoreaux, College of Staten Island, ℗ were co-chairs of the Organizing Committee for the meeting.℗ Data presented at this meeting provided compelling evidence that taurine is not only cytoprotective in cardiomyocytes, but also is a potent GABA agonist, whereby it can facilitate vasodilation of conducting arteries. Taurine conjugates, such as taurine chloramine, may protect cells from oxidative stress via increased HO-1 expression. In adult rodents, taurine has a potent effect on plasma glucose levels, likely through the release of insulin in pancreatic beta cells. As a potential neurotransmitter, taurine is known to work via the GABAergic system, but current research presented at this meeting suggest that taurine may interact with glutamate and serotonin receptors as well. Data are also presented to demonstrate the protective roles of taurine on neurons in neuroblastoma. Perhaps the most important and exciting presentation is the role of taurine and alcohol: the combination may be lethal. Data are also presented at this meeting of the potential role taurine may have as an adjuvant treatment with cisplatin in chemotherapy
    Pages: : digital.
    ISBN: 9781461461302
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  • 8
    Keywords: Medicine ; Immunology ; Toxicology ; Medical virology ; Emerging infectious diseases ; Microbiology ; Biomedicine ; Immunology ; Microbiology ; Virology ; Infectious Diseases ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: €‹Ís Transcription the Dominant Force during Dynamic Changes in Gene Expression? -- MicroRNAs: Key Components of Immune Regulation -- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV -- Natural Killer cell Licensing during Viral Infection -- Bridging Innate NK cell Functions with Adaptive Immunity -- Control of Innate Immunity by Memory CD4 T cells -- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells -- Blimp1: Driving Terminal Differentiation to a T -- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis -- Impact of Differential Glycosylation on IgG Activity -- Murine Model of Chronic Respiratory Inflammation -- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1 -- Influenza Vaccines: What do we Want and How can we Get it?.́€&#x2039
    Abstract: This volume presents a collection of reviews derived from work presented at the Aegean Conference: ́€œ4th℗ Crossroads between innate and adaptive immunitý€.℗ This meeting was the fourth℗ in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference ́€œCrossroads between Innate and Adaptive Immunitý€ brought together leading international scientists and experts to address critical areas of Innate and Adaptive immunity something necessary for the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive immunity. The conference had limited participation and a scientific and social program that maximized scientific interchange through lecture presentations, poster sessions and informal discussions
    Pages: : digital.
    ISBN: 9781461462170
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  • 9
    Keywords: Medicine ; Neurosciences ; Endocrinology ; Reproductive Medicine ; Biomedicine ; Biomedicine general ; Endocrinology ; Reproductive Medicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Part One: Kisspeptin Signaling in vivo and in vitro -- Kisspeptin: Past, Present and Prologue -- Structure, Synthesis, and Phylogeny of Kisspeptin and its Receptor -- Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects -- The Effects of Kisspeptin on Gonadotropin Release in Non-Human Mammals -- Effects of Kisspeptin on Hormone Secretion in Humans -- Kisspeptin Excitation of GnRH Neurons -- Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations -- Kisspeptin Antagonists -- Kisspeptin and Clinical Disorders -- Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation -- Part Two: Development and Regulation of Kisspeptin Neurons -- The Development of Kisspeptin Circuits in the Mammalian Brain -- Kisspeptin and Puberty in Mammals -- Sex Steroid Regulation of Kisspeptin Circuits -- Kisspeptin and GnRH Pulse Generation -- Interactions between Kisspeptins and Neurokinin B -- Electrophysiology of Kisspeptin Neurons -- Metabolic Regulation of Kisspeptin -- Circadian Regulation of Kisspeptin in Female Reproductive Functioning -- Kisspeptin and Seasonality of Reproduction -- Stress Regulation of Kisspeptin in the Modulation of Reproductive Function -- Effects of Environmental Endocrine Disruptors and Phytoestrogens on the Kisspeptin System -- Model Systems for Studying Kisspeptin Signaling: Mice and Cells -- Index
    Abstract: Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.℗ This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.℗ The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.℗ Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis
    Pages: : digital.
    ISBN: 9781461461999
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  • 10
    Keywords: Oncology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Overview of Basic Immunology and Translational Relevance for Clinical Investigators -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: A New Age in cancer treatment -- Update on Immunotherapy in AML and MDS: Monoclonal Antibodies and Checkpoint Inhibitors Paving the Road for Clinical Practice -- Skin Reactions to Immune Checkpoint Inhibitors -- Immune-related Adverse Events: Pneumonitis -- Immune checkpoint inhibitors-induced colitis -- Immune checkpoint inhibitors-induced hepatitis -- Symptoms as patient-reported outcomes in cancer patients undergoing immunotherapies
    Abstract: The second edition of Immunotherapy is an updated overview of immuno-oncology in acute myleloid leukemia, non-small cell lung cancer and sarcomas, showcasing advances in the management of cancer broadly classified as hematological malignancies, solid tumors and tumors arising in the connective tissue. Scientists, oncologists and advanced students will be provided with knowledge of basic immunology in the context of tumor biology, providing a comprehensive overview of the cellular components of the immune system that interact with each other to provide a successful immune response. A number of new, scientific findings in his fast moving field have necessitated a thoroughly updated and revised edition including the use of immunotherapy for gastrointestinal and genitourinary cancers, as well as discussions on optimizing radiotherapy with immunotherapeutic approaches, biomarkers of response or resistance to immunotherapy, cancer imaging in immunotherapy, skin reactions to immune checkpoint inhibitors and more. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. The new edition will discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies and clinical implications. Additionally, the book will outline how new advances in medical imaging technology has the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Edited by two renowned experts in the field, the book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science
    Pages: VIII, 182 p. 12 illus., 8 illus. in color. : online resource.
    Edition: 2nd ed. 2018.
    ISBN: 9783030025052
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