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  • 1
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Proteomics ; Systems Biology ; Bacteriology ; Life sciences ; Systems Biology ; Proteomics ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Protein–Protein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides
    Abstract: This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data
    Pages: IX, 319 p. 58 illus., 55 illus. in color. : online resource.
    ISBN: 9783319236032
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  • 2
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    Cham : Springer International Publishing
    Keywords: Medicine ; Radiology ; Medicine & Public Health ; Ultrasound ; Springer eBooks
    Description / Table of Contents: Part I – High Intensity Focused Ultrasound Ablation of Pathological Tissue -- Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar -- Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouvière, S. Crouzet, A. Gelet -- Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries -- Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer -- F.M. Knuttel, M.A.A.J. van den Bosch -- Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer -- T.D. Khokhlova, J.H. Hwang -- Chapter 6. MR-guided Transcranial Focused Ultrasound -- J.F. Aubry, M. Tanter -- Chapter 7. Focused Ultrasound & Lithotripsy -- T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto -- Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu -- Part II – Drug and Gene Delivery using Bubble-assisted Ultrasound -- Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis -- Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikov -- Chapter 11. Design of Microbubbles for Gene/Drug Delivery T. Bettinger, F. Tranquart -- Chapter 12. Co-administration of Microbubbles and Drugs in Ultrasound-assisted Drug Delivery: Comparison with Drug-carrying Particles R. Suzuki, A.L. Klibanov -- Chapter 13. Drug-loaded Perfluorocarbon Nanodroplets for Ultrasound-mediated Drug delivery N. Rapoport -- Chapter 14. Bubble-assisted Ultrasound: Application in Immunotherapy and Vaccination J.M. Escoffre, R. Deckers, C. Bos, C. Moonen -- Chapter 15. Sonoporation: Application for Cancer Therapy -- J. Qin, T.Y. Wang, J.K. Willmann -- Chapter 16. Microbubble-assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System A. Burgess, K. Hynynen -- Chapter 17. Microbubbles & Ultrasoun: Therapeutic Applications in Diabetic Nephropathy W.J. Cao, P.N. Matkar, H.H. Chen, A. Mofid, H. Leong-Poi -- Chapter 18. Drug and Gene Delivery using Sonoporation for Cardiovascular Disease J. Castle, S.B. Feinstein -- Chapter 19. Sonothrombolysis K.B. Bader, G. Bouchoux, C.K. Holland -- Part III- Other Ultrasound Therapy -- Chapter 20. Ultrasound-mediated Polymeric Micelle Drug Delivery H. Xia, Y. Zhao, R. Tong -- Chapter 21. Stimulation of Bone Repair with Ultrasound -- F. Padilla, R. Puts, L. Vico, A. Guignadon, K. Raum -- Chapter 22. Sonodynamic Therapy: Concept, Mechanism & Application to Cancer Treatment A.P. McHale, J.F. Callan, N. Nomikou, C. Fowley, B. Callen
    Abstract: This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology
    Pages: VIII, 465 p. 114 illus., 76 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319225364
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  • 3
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Medical parasitology ; Biomedicine ; Parasitology ; Immunology ; Medical Microbiology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Form and Function in the Digenea -- The Systematics of the Trematoda -- Schistosomiasis -- Fascioliasis -- Paragonimiasis -- Liver Flukes -- Intestinal Trematode Infections -- Epidemiology of Trematode Infections -- Diagnosis of Human Trematode Infections -- Schistosomatidae and Diplostomidea -- Amphistomes -- Dicrocoeliidae Family -- Selected Wildlife Trematodiasis
    Abstract: Digenetic trematodes constitute a major helminth group that parasitize humans and animals, and are a major cause of morbidity and mortality. The diseases caused by trematodes have been neglected for years, especially as compared with other parasitic diseases. However, the geographical limits and the populations at risk are currently expanding and changing in relation to factors such as growing international markets, improved transportation systems, and demographic changes. This has led to a growing international interest in trematode infections, although factors such as the difficulties entailed in the diagnosis, the complexity of human and agricultural practices, the lack of assessments of the economic costs, or the limited number of effective drugs are preventing the development of control measures of these diseases in humans and livestock. In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. The main goal of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite interactions and to show applications of new techniques and concepts for the studies on digenetic trematodes. This is an ideal book for parasitologists, microbiologists, zoologists, immunologists, professional of public health workers, clinicians, and graduate and post-graduate students
    Pages: XI, 474 p. 45 illus., 41 illus. in color. : online resource.
    ISBN: 9781493909155
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  • 4
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Biomedicine ; Biomedicine general ; Human Physiology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: 〈p〉The Role of Hypoxia-Inducible Factors in Oxygen Sensing by the Carotid Body ́€“ Invited Article -- Neuronal Mechanisms of Oxygen Chemoreception: An Invertebrate Perspective ́€“ Invited Article -- 〈b〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers℗ Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway ́€“ Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia ́€“ Invited Article -- The Retrotrapezoid Nucleus and Breathing ́€“ Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of℗ Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats ́€“ Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings -- Human Carotid Body HIF and NGB℗ Expression During Human℗ Development and Aging -- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia -- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains -- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia -- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat -- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia -- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia -- 〈p〉℗ 〈/p〉Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats -- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance -- Some Reflections on Intermittent Hypoxia. Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers? -- Role of Central / Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea ́€“ Invited Article -- Physiologic Basis for Intermittent Hypoxic Episodes In Preterm Infants -- Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats -- Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia -- Antioxidation and the Hypoxic Ventilatory Response -- Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia -- Heart Failure and Carotid Body Chemoreception.〈/p〉〈/b〉〈/p〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers℗ Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway ́€“ Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia ́€“ Invited Article -- The Retrotrapezoid Nucleus and Breathing ́€“ Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of℗ Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats ́€“ Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings
    Abstract: 〈p〉Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid.℗ Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis.℗ ℗ Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body.℗ Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases.℗ Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments.〈/p〉〈p〉This book is a required text for any researcher in the field of arterial chemoreception for years to come.℗ It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension. ℗ ℗ 〈/p〉〈p〉℗ 〈/p〉
    Pages: XXIV, 406 p. 62 illus., 30 illus. in color. : digital.
    ISBN: 9789400745841
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  • 5
    Keywords: Life sciences ; Human Physiology ; Endocrinology ; Microbiology ; Life sciences ; Microbiology ; Endocrinology ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Part I: Basic Concepts Underlying the Microbiota-Gut-Brain Axis -- Microbial Endocrinology and the Microbiota-Gut-Brain Axis -- Utilizing €œómicś€ Tools to Study the Complex Gut Ecosystem -- The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control -- Intestinal Barrier Function and the Brain-Gut Axis -- Vagal Pathways for Microbiome-Brain-Gut Axis Communication -- The Brain-Gut Axis in Health and Disease -- Part II: Mechanistic Factors Influencing the Microbiota-Gut-Brain Axis -- Gastrointestinal Hormones and Their Targets -- Microbiome, HPA Axis and Production of Endocrine Hormones in the Gut -- Neuropeptides and the MicrobiotထGut́€‘Brain Axis -- Bacterial Neuroactive Compounds Produced by Psychobiotics -- Multidirectional Chemical Signalling Between Mammalian Hosts, Resident Microbiota, and Invasive Pathogens:℗ Neuroendocrine Hormone-Induced Changes in Bacterial Gene Expression -- Influence of Stressor-Induced Nervous System Activation on the Intestinal Microbiota and the Importance for Immunomodulation -- Part III: The Microbiota-Gut-Brain Axis in Health and Disease -- The Effects of Inflammation, Infection and Antibiotics on the Microbiota-Gut-Brain Axis -- Microbiota, Inflammation and Obesity -- Microbiota, Immunoregulatory Old Friends and Psychiatric Disorders -- Microbiota-Gut-Brain Axis and Cognitive Function -- The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential -- Neuroimaging the Microbiome-Gut́€“Brain Axis -- The Future of Probiotics for Disorders of the Brain-Gut Axis -- Index
    Abstract: The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (€œúś€).℗ This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books℗ dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease
    Pages: XVIII, 436 p. 48 illus., 19 illus. in color. : online resource.
    ISBN: 9781493908974
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  • 6
    Keywords: Medicine ; Biomedicine ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Oxidation and inflammation, a molecular link between non-communicable diseases.-℗ Oxidative stress and DNA damage in obesity-related tumorigenesis -- High density lipoproteins and ischemia reperfusion injury: The therapeutic potential of HDL to modulate cell survival pathways.-℗ The DING family of phosphate binding proteins in inflammatory diseases -- Inflammation, infection, cancer and all that́€ŒThe role of paraoxonases -- Autophagy is an inflammation-related defensive mechanism against disease -- Delta-5 and Delta-6 Desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease -- Systemic inflammation, intestine and paraoxonase-1.-℗ Serotonin modulation of macrophage polarization: inflammation and beyond -- Energy metabolism and metabolic sensors in stem cells: The metabostem crossroads of aging and cancer -- Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties -- Postprandial Inflammation: Targeting glucose and lipids -- Dynamic interplay between metabolic syndrome and immunity -- The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease -- The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration
    Abstract: Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation, and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and℗ Inflammation in Non-communicable Diseases: Molecular Mechanisms and℗ Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field, and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine, and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine
    Pages: VI, 223 p. 50 illus., 34 illus. in color. : online resource.
    ISBN: 9783319073200
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  • 7
    Call number: E020:19
    Keywords: Oxygen / Physiological transport ; Oxygen / Physiological transport ; Tissue respiration
    Notes: Based on the 29th annual meeting of the International Society on Oxygen Transport to Tissue held in historic Philadelphia, USA, from August 11 to 15, 2001.
    Pages: xviii, 421 p. : ill.
    ISBN: 0306473941
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  • 8
    Call number: B065:27
    Keywords: Biomedicine ; Cancer Research ; Medical Microbiology ; Protein Science ; Membrane Biology ; Biomedicine general
    Pages: xiii, 609 p.
    ISBN: 9781489980311
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  • 9
    Keywords: Life sciences ; Gene Expression ; Biochemistry ; Biological models ; Life sciences ; Systems Biology ; Protein Science ; Gene Expression ; Springer eBooks
    Description / Table of Contents: Encyclopedia of RNA binding protein expression and domain annotations -- RNA localization and RNA binding proteins that control localization -- Genome-wide approaches to studying alternative polyadenylation events and the RBPs that control them -- RNA binding proteins, PRC complex and long ncRNAs -- Gene and genome regulation by piwi proteins -- Engineering Artificial RBP interactions -- Querying functional polymorphisms by high throughput binding and functional assays -- RNA binding protein networks in EMT/MET -- Therapies against diseases associated with RNA processing defects and RNA binding proteins -- Repeat-disorders and the RNA binding proteins implicated in them -- RNA binding proteins in heart development -- Identification of miRNAs and their targets in C elegans -- Splicing code -- Index
    Abstract: After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA. This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases
    Pages: X, 468 p. 54 illus., 52 illus. in color. : online resource.
    ISBN: 9781493912216
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  • 10
    Keywords: Medicine ; Human Physiology ; Biochemistry ; Biomedicine ; Human Physiology ; Medicine/Public Health, general ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: A20€”Á Bipartite Ubiquitin Editing Enzyme with Immunoregulatory Potential -- The Biology of A20-Binding Inhibitors of NF- ÎðB Activation (Abins) -- The Biology of A20-Like Molecules -- Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20 -- A20 Expressing Tumors and Anticancer Drug Resistance -- Translational Studies of A20 in Atherosclerosis and Cardiovascular Disease -- A Biomarker of Allograft Outcome: A Showcase in Kidney Transplantation -- A20€”Án Omnipotent Protein in the Liver: Prometheus Myth Resolved? -- Emerging Roles for A20 in Islet Biology and Pathology -- Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases
    Abstract: This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target
    Pages: XXI, 188 p. : online resource.
    ISBN: 9781493903986
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