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  • 1
    Keywords: Dentistry ; Life sciences ; Systems Biology ; Regenerative Medicine ; Tissue Engineering ; Life sciences ; Systems Biology ; Regenerative Medicine/Tissue Engineering ; Dentistry ; Springer eBooks
    Description / Table of Contents: 3D printing and biofabrication for load bearing tissue engineering -- Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues -- Electrospinning of bioinspired polymer scaffolds -- Bone tissue engineering challenges in oral & maxillofacial surgery -- Engineering Pre-vascularized Scaffolds for Bone Regeneration -- Morphogenic Peptides in Regeneration of Load Bearing Tissues -- Osseointegration of Plateau Root Form Implants: Unique Healing Pathway leading to Haversian-Like Long-Term Morphology -- Dentin matrix proteins in bone tissue engineering -- Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration -- Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments -- Hard-soft tissue interface engineering -- Cementum and periodontal ligament regeneration -- Amelogenin in enamel tissue engineering -- Whole tooth regeneration as a future dental treatment
    Abstract: This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues
    Pages: X, 276 p. 60 illus., 54 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319223452
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  • 2
    Keywords: Medicine ; Cytology ; Engineering ; Surfaces (Physics) ; Biomedicine ; Biomedicine general ; Medicine/Public Health, general ; Cell Biology ; Nanotechnology and Microengineering ; Characterization and Evaluation of Materials ; Springer eBooks
    Description / Table of Contents: 1 Presence in, and release of, nanomaterials from consumer products -- 2 Nanoparticle aggregation -- 3 Influences of nanomaterials on the barrier function of epithelial cells -- 4 Engineered nanoparticles induced brush border disruption in a human model of the intestinal epithelium -- 5 Nanoparticles: Cellular uptake and cytotoxicity. -6 Atomic force microscopy study of the interaction of DNA and nanoparticles -- 7 Intracellular signal modulation by nanomaterials -- 8 Nanomaterials: Impacts on cells and cell organelles -- 9 Design, synthesis, and functionalization of nanoparticles for therapeutic drug delivery -- 10 Preparation of nanoscale pulmonary drug delivery formulations by spray drying -- 11 Nanomedicine: The Promise and Challenges in Cancer Chemotherapy -- 12 Transgenerational effects of NMs -- 13 Stem cells and nanomaterials -- Index
    Abstract: The rapidly developing field of nanomaterials has expanded in many commercial areas.℗ More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, include research into stem cells.℗ Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues.℗ ℗ While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function.℗ ℗ ℗ In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer, and an increasing number of new applications.℗ ℗ This book investigates these areas and also includes new methods for assessment in cell biology and medicine
    Pages: XI, 278 p. 70 illus., 42 illus. in color. : online resource.
    ISBN: 9789401787390
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  • 3
    Keywords: Chemistry ; Biochemistry ; Nanochemistry ; Emerging infectious diseases ; Chemistry ; Medicinal Chemistry ; Nanochemistry ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Auger-architectomics: Introducing a New Nanotechnology to Infectious Disease -- Rational Design of Antigens to Improve the Sero-diagnosis of Tick-borne Borreliosis in Central Regions of Russia -- Ayurvedic Bhasmas: Overview on Nanomaterialistic Aspects, Applications and Perspectives -- Nanobiosensors: Role in Cancer Detection and Diagnosis -- Cell Compatible Arginine Containing Cationic Polymer: One-pot Synthesis and Preliminary Biological Assessment -- Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in Humans -- Bacteriophages as Potential Treatment Option for Antibiotic Resistant Bacteria
    Abstract: The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a℗ first volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal. The book focuses mainly on the topics: emerging infectious diseases; antimicrobial agents, vaccines and immunity; drug design, drug delivery and tissue engineering; and nanomaterials and biomedical materials
    Pages: XIII, 119 p. 25 illus. : online resource.
    ISBN: 9788132217770
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  • 4
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Medical parasitology ; Biomedicine ; Parasitology ; Immunology ; Medical Microbiology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Form and Function in the Digenea -- The Systematics of the Trematoda -- Schistosomiasis -- Fascioliasis -- Paragonimiasis -- Liver Flukes -- Intestinal Trematode Infections -- Epidemiology of Trematode Infections -- Diagnosis of Human Trematode Infections -- Schistosomatidae and Diplostomidea -- Amphistomes -- Dicrocoeliidae Family -- Selected Wildlife Trematodiasis
    Abstract: Digenetic trematodes constitute a major helminth group that parasitize humans and animals, and are a major cause of morbidity and mortality. The diseases caused by trematodes have been neglected for years, especially as compared with other parasitic diseases. However, the geographical limits and the populations at risk are currently expanding and changing in relation to factors such as growing international markets, improved transportation systems, and demographic changes. This has led to a growing international interest in trematode infections, although factors such as the difficulties entailed in the diagnosis, the complexity of human and agricultural practices, the lack of assessments of the economic costs, or the limited number of effective drugs are preventing the development of control measures of these diseases in humans and livestock. In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. The main goal of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite interactions and to show applications of new techniques and concepts for the studies on digenetic trematodes. This is an ideal book for parasitologists, microbiologists, zoologists, immunologists, professional of public health workers, clinicians, and graduate and post-graduate students
    Pages: XI, 474 p. 45 illus., 41 illus. in color. : online resource.
    ISBN: 9781493909155
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  • 5
    Keywords: Medicine ; Oncology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    ISBN: 9789400745841
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  • 6
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Biomedicine ; Biomedicine general ; Human Physiology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: 〈p〉The Role of Hypoxia-Inducible Factors in Oxygen Sensing by the Carotid Body – Invited Article -- Neuronal Mechanisms of Oxygen Chemoreception: An Invertebrate Perspective – Invited Article -- 〈b〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers  Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway – Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia – Invited Article -- The Retrotrapezoid Nucleus and Breathing – Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of  Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats – Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings -- Human Carotid Body HIF and NGB  Expression During Human  Development and Aging -- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia -- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains -- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia -- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat -- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia -- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia -- 〈p〉 〈/p〉Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats -- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance -- Some Reflections on Intermittent Hypoxia. Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers? -- Role of Central / Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea – Invited Article -- Physiologic Basis for Intermittent Hypoxic Episodes In Preterm Infants -- Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats -- Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia -- Antioxidation and the Hypoxic Ventilatory Response -- Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia -- Heart Failure and Carotid Body Chemoreception.〈/p〉〈/b〉〈/p〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers  Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway – Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia – Invited Article -- The Retrotrapezoid Nucleus and Breathing – Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of  Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats – Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings -- Human Carotid Body HIF and NGB  Expression During Human  Development and Aging -- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia -- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains -- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia -- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat -- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia -- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia -- 〈p〉 〈/p〉Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats -- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance --
    Abstract: 〈p〉Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid.  Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis.  Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body.  Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases.  Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments.〈/p〉〈p〉This book is a required text for any researcher in the field of arterial chemoreception for years to come.  It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.   〈/p〉〈p〉 〈/p〉
    Pages: XXIV, 406 p. 62 illus., 30 illus. in color. : digital.
    ISBN: 9789400745841
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  • 7
    Keywords: Medicine ; Medical genetics ; Biochemistry ; Life sciences ; Biomedicine ; Biomedicine general ; Life Sciences, general ; Gene Function ; Medical Biochemistry ; Springer eBooks
    Description / Table of Contents: Preface -- 1 Evolution of integrin I domains -- 2 Integrin a1b1 -- 3 Integrin a2b1 -- 4 Integrin a10b1- a collagen receptor critical in skeletal development -- 5 Integrin a11b1 – a major collagen receptor on fibroblastic cells -- 6 Regulation of integrin activity by phosphorylation -- 7 Integrin aEb7:molecular features and functional significance in the immune system -- 8 Structural aspects of integrins -- 9 Integrin recognition motifs in the human collagens -- 10 Cellular signalling by collagen-binding integrins -- 11 The therapeutic potential of I-domain integrins -- Index
    Abstract: The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins
    Pages: XIV, 179 p. 50 illus., 32 illus. in color. : online resource.
    ISBN: 9789401791533
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  • 8
    Keywords: Life sciences ; Medicine ; Reproductive Medicine ; Wildlife management ; Life sciences ; Fish & Wildlife Biology & Management ; Reproductive Medicine ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Introduction: Reproductive science as an essential component of conservation biology -- Mayday Mayday Mayday, the millennium ark is sinking! -- Climate change, extinction risks, and reproduction of terrestrial vertebrates -- Impacts of endocrine disrupting chemicals on reproduction in wildlife -- The role of genomics in conservation and reproductive sciences -- The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction -- The Black-footed Ferret: On the Brink of Recovery? -- Comparative reproductive biology of elephants -- The koala (Phascolarctos cinereus): A case study in the development of reproductive technology in a marsupial -- Reproduction and Advances in Reproductive Studies in Carnivores -- Methods to examine reproductive biology in free-ranging, fully-marine mammals -- Amphibian declines in the 21st century: Why we need assisted reproductive technologies -- The reality, use and potential for cryopreservation of coral reefs -- Recent advances and prospects in germplasm preservation of rare and endangered species -- Sperm DNA fragmentation and its role in wildlife conservation -- Somatic Cells, Stem Cells, and Induced Pluripotent Stem Cells: How do they now contribute to conservation? -- Biosafety in embryos and semen cryopreservation, storage, management and transport -- Fertility Control in wildlife: review of current status, including novel and future technologies -- Cloning the mammoth: a complicated task or just a dream? -- Conclusions: environmental change, wildlife conservation and reproduction
    Abstract: Reproductive biology is more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species, technical developments have to be backed up by thorough biological understanding of the background behind the problems. This book is therefore threefold; (1) it provides a snapshot of the state of the art in terms of species-specific reproductive technologies, whether for individual animals or whole taxonomic groups; (2) it sets the reproductive problems in context and emphasizes the links between animal-based problems and the wider world, e.g. reproductive fitness and (3) it looks forward and presents realistic assessments of how effective some of the more recently developed techniques in reproductive technology might be at combating extinctions. This is a wide-ranging book that will be relevant to anyone involved in reproductive biology or in species conservation and provides provide them some useful perspectives about the real utility of current and emerging technologies. It has contributions from experts in reproduction and related fields
    Pages: XV, 533 p. 49 illus., 34 illus. in color. : online resource.
    ISBN: 9781493908202
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  • 9
    Keywords: Life sciences ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry ; Life sciences ; Protein Science ; Medical Biochemistry ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: There is a Taurine-Linked Disease Known As Melas -- Taurine And Hearty Topics -- Taurine Regulation Of Peripheral Hemodynamics -- Regulation Of Taurine Release By Neurotransmitter Receptors -- Neuropsychopharmacological Actions Of Taurine -- Neuro-Protective Mechanism Of Taurine ́€“ Role Of Endoplasmic Reticulum -- Differential Regulation Of Taut By Vitamin D3 And Retinoic Acid Via Vdr/Rxr In Llc-Pk1 And Mcf-7 Cells -- Are Taurine Haloamines (Taucl And Taubr) Good Candidates For The Treatment Of Biofilm€“Ássociated Infections? -- Comparative Evaluation Of Taurine And Thiotaurine As Protectants Against Experimental Diabetes-Induced Nephropathy In A Rat Model -- The Mechanism of Taurine Protection against Endoplasmic Reticulum Stress in Stroke Related Conditions in Primary Neuronal Cell Culture -- Direct interaction of taurine with the NMDA glutamate receptor sub-type via multiple mechanisms -- Perinatal taurine exposure affects patterns of autonomic nerve activity in adult male rats -- Lethality of taurine and alcohol co-administration in 7-day-old, adult and old mice -- Metabotropic effect of taurine regulation of potassium channels via 5-HT2A serotonin receptors -- Changes in gene expression at inhibitory synapses in response to taurine treatment -- Effects of Acute vs. Chronic Taurine Treatment on Context Fear Aversive Conditioning in Mice -- Taurine exerts robust protection against hypoxia and glucose deprivation in human neuroblastoma cell culture -- Perinatal taurine supplementation affects neural control of arterial pressure via estrogen receptors in adult female rats -- Gender specific effects of taurine on cardiovascular function -- Taurine affects release of insulin and GABA in Hit-T15 Îø cell line via calcium flux -- Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long duration of diabetes -- Preventive Roles of Taurine in Alloxan-Induced Diabetes -- Renin-angiotensin system and estrogen attenuates glucose-insulin dysregulation in adult female rats that are perinatally depleted of taurine -- Mechanism underlying calcium-dependent contractile defect in taurine transporter knockout heart -- The role of taurine deficiency under stress in cardiac and skeletal muscles: A study in taurine transporter gene knockout mice -- Effect of taurine chloramine on differentiation of human preadipocytes into adipocytes, and expression of adipokines in differentiated adipocytes -- Taurine chloramine increases HO-1 expression and activity by promoting Nrf2 activation via oxidative modification of Keap1 -- Protection of cells from oxidative stress-induced cytotoxicity and resolution of inflammation by taurine chloramine -- Reduced placental taurine transporter (TauT) activity in pregnancies complicated by maternal obesity and pre-eclampsia -- The physiological role of taurine during fish development ́€“ relevant aspects for the aquaculture industry -- Taurine and fish nutrition: where do we stand on the use of this mythical molecule? -- Gestational taurine availability and fetal programming of metabolism in C57BL/6 mice -- Taurine and mitochondrial bioenergetics -- The ability of taurine as a marker for the identification of natural Calculus Bovis and its substitutes -- Effect of arsenic on the expressions of thyroid hormone receptor genes in mice brains and protection of taurine -- Effects of taurine on iNOS-dependent DNA damage in heavy exercise skeletal muscle by inhibiting NF-̐±B signaling pathway -- Knockdown of TauT expression impairs human embryonic kidney 293 cell development -- Effect of arsenic on the expressions of thyroid hormone receptor genes in mice brains and protection of taurine -- Perspective on taurine research -- Monoaminergic activity is increased following electroconvulsive therapy (ECT), but less is known about amino acids -- ToC, cont'd
    Abstract: Taurine 8 represents the combined efforts of investigators on the roles of the amino acid taurine on human health and disease. The chapters covered in this book are directly derived from presentations of the contributors at the 18th International Taurine Meeting held in Marrakech, Morocco in April 2012. The purpose of this book is to disseminate current findings on taurine's contribution in several organ systems. This book covers the following topics: Taurine in the Nervous System, Taurine in the Immune System, Taurine and Diabetes, and Taurine and the Cardiovascular System. Dr. Abdeslem El Idrissi, College of Staten Island and Dr. William L€™Ámoreaux, College of Staten Island, ℗ were co-chairs of the Organizing Committee for the meeting.℗ Data presented at this meeting provided compelling evidence that taurine is not only cytoprotective in cardiomyocytes, but also is a potent GABA agonist, whereby it can facilitate vasodilation of conducting arteries. Taurine conjugates, such as taurine chloramine, may protect cells from oxidative stress via increased HO-1 expression. In adult rodents, taurine has a potent effect on plasma glucose levels, likely through the release of insulin in pancreatic beta cells. As a potential neurotransmitter, taurine is known to work via the GABAergic system, but current research presented at this meeting suggest that taurine may interact with glutamate and serotonin receptors as well. Data are also presented to demonstrate the protective roles of taurine on neurons in neuroblastoma. Perhaps the most important and exciting presentation is the role of taurine and alcohol: the combination may be lethal. Data are also presented at this meeting of the potential role taurine may have as an adjuvant treatment with cisplatin in chemotherapy
    Pages: : digital.
    ISBN: 9781461461302
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  • 10
    Keywords: Medicine ; Oncology ; Gene Expression ; Bioinformatics ; Biological models ; Biomedicine ; Cancer Research ; Bioinformatics ; Computational Biology/Bioinformatics ; Systems Biology ; Molecular Medicine ; Gene Expression ; Springer eBooks
    Description / Table of Contents: Preface -- 1 MicroRNAs in human cancer -- 2 Bioinformatics, non-coding RNAs and its possible application in personalized medicine -- 3 MicroRNA target prediction and validation -- 4 MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology -- 5 The p53/microRNA network in cancer: experimental and bioinformatics approaches.-6 MicroRNAs in melanoma biology -- 7 MicroRNA in the lung -- 8 The E2F1-miRNA cancer progression network -- 9 Modeling of microRNA-transcription factor networks in cancer -- 10 Coordinated networks of microRNAs and transcription factors with evolutionary perspectives -- 11 Mathematical modeling of microRNA-mediated mechanisms of translation repression -- 12 Web resources for microRNA research -- 13 Discovery of microRNA regulatory networks by integrating multidimensional high-throughput data -- 14 Discovering the functional microRNA-mRNA regulatory modules in heterogeneous data -- 15 Elucidating the role of microRNAs in cancer through data mining techniques -- 16 Working together: Combinatorial regulation by microRNAs. ℗
    Abstract: This book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology
    Pages: : digital.
    ISBN: 9789400755901
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