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  • 1
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Proteomics ; Systems Biology ; Bacteriology ; Life sciences ; Systems Biology ; Proteomics ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Protein–Protein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides
    Abstract: This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data
    Pages: IX, 319 p. 58 illus., 55 illus. in color. : online resource.
    ISBN: 9783319236032
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  • 2
    Keywords: Chemistry ; Biochemistry ; Nanochemistry ; Emerging infectious diseases ; Chemistry ; Medicinal Chemistry ; Nanochemistry ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Bacterial Resistance to Quaternary Ammonium Compounds (QAC) Disinfectants -- Immunological Markers that Correlate with Protection Immunity against Tularemia Infection -- Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants -- Microbial Pathogenicity: A New Approach to Drug Development -- Current Trend on Syphilis Diagnosis: Issues and Challenges -- Rapid Spreading and Immune Evasion by Vaccinia Virus -- Nanonization Increases the Antileishmanial Efficacy of Amphotericin B: An Ex-vivo Approach
    Abstract: The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a second volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal. The book focuses mainly on the topics: emerging infectious diseases; antimicrobial agents, vaccines and immunity; drug design, drug delivery and tissue engineering; and nanomaterials and biomedical materials
    Pages: XIV, 99 p. 29 illus. : online resource.
    ISBN: 9788132217749
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  • 3
    Keywords: Dentistry ; Life sciences ; Systems Biology ; Regenerative Medicine ; Tissue Engineering ; Life sciences ; Systems Biology ; Regenerative Medicine/Tissue Engineering ; Dentistry ; Springer eBooks
    Description / Table of Contents: 3D printing and biofabrication for load bearing tissue engineering -- Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues -- Electrospinning of bioinspired polymer scaffolds -- Bone tissue engineering challenges in oral & maxillofacial surgery -- Engineering Pre-vascularized Scaffolds for Bone Regeneration -- Morphogenic Peptides in Regeneration of Load Bearing Tissues -- Osseointegration of Plateau Root Form Implants: Unique Healing Pathway leading to Haversian-Like Long-Term Morphology -- Dentin matrix proteins in bone tissue engineering -- Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration -- Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments -- Hard-soft tissue interface engineering -- Cementum and periodontal ligament regeneration -- Amelogenin in enamel tissue engineering -- Whole tooth regeneration as a future dental treatment
    Abstract: This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues
    Pages: X, 276 p. 60 illus., 54 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319223452
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  • 4
    Keywords: Medicine ; Human Physiology ; Immunology ; Pneumology ; Biomedicine ; Human Physiology ; Immunology ; Pneumology/Respiratory System ; Springer eBooks
    Description / Table of Contents: Mitochondrial Genetic Abnormalities after Radiation Exposure -- Crediting Six Discoverers of Oxygen -- Hypoxia in Tumors: Pathogenesis-related Classification, Characterization of Hypoxia subtypes, and Associated Biological and Clinical Implications -- Heterogeneity in Tissue Oxygenation: From Physiological Variability in Normal Tissues to Pathophysiological Chaos in Malignant Tumours -- Oxygen Diffusion: An Enzyme-controlled Variable Parameter -- Role of Microvascular Shunts in the Loss of Cerebral Blood Flow Autoregulation -- Impact of Hypoxia-related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs in vitro and in vivo -- The Founding of ISOTT: The Shamattawa of Engineering Science and Medical Science -- A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism -- Advances in Probes and Methods for Clinical EPR Oximetry -- Real-Time, In Vivo Determination of Dynamic Changes in Lung and Heart Tissue Oxygenation using EPR Oximetry -- Modulation of Hypoxia by Magnetic Nanoparticle Hyperthermia to Augment Therapeutic Index -- Skeletal Muscle and Glioma Oxygenation by Carbogen Inhalation in Rats: A Longitudinal Study by EPR Oximetry using Single-Probe Implantable Oxygen Sensors -- Recurrent Low-dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors -- How in vivo EPR Measures and Images Oxygen -- What We Learn From In Vivo EPR Oxygen Images -- EPR Image Based Oxygen Movies for Transient Hypoxia -- Repetitive Measurements of Intrarenal Oxygenation in vivo using L band Electron Paramagnetic Resonance -- Quantitative Hypoxia Imaging for Treatment Planning of Radiotherapy -- A New Flavonoid Regulates Angiogenesis and Reactive Oxygen Species Production -- Angiotensin II Reduces Transport-Dependent Oxygen Consumption but Increases Transport-Independent Oxygen Consumption in Immortalized Mouse Proximal Tubular Cells -- Investigation of Cerebral Autoregulation in the Newborn Piglet during Anaesthesia and Surgery -- Influence of the Maternal use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS -- Development of a Near Infrared Multi-Wavelength, Multi-channel, Time-Resolved Spectrometer for Measuring Brain Tissue Haemodynamics and Metabolism -- Simulating NIRS and MRS measurements during cerebral hypoxia-ischaemia in piglets using a computational model -- Analysis of Slow Wave Oscillations in Cerebral Haemodynamics and Metabolism Following Subarachnoid Haemorrhage -- Effects of Enriched Environment on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Global Ischemia -- Automated Image Analysis for Diameters and Branching Points of Cerebral Penetrating Arteries and Veins Captured with Two-Photon Microscopy -- Cerebral Hemodynamic Changes and Metabolic Alteration in Severe Hemorrhagic Shock -- Physiological Mechanism of Increase in Deoxy-hemoglobin Concentration during Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model -- Effect of Blood in the Cerebrospinal Fluid on the Accuracy of Cerebral Oxygenation Measured by Near Infrared Spectroscopy -- Vessel Specific Imaging of Glucose Transfer with Fluorescent Glucose Analogue in Anesthetized Mouse Cortex -- Ischemic Pretreatment Delays Ischemic Brain Vasospasm Injury in Gerbils -- Changes in Cerebral Blood Oxygenation Induced by Active Standing Test in Children with POTS and NMS -- Optical Imaging of Brain Activation in Gambian Infants -- Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome -- Changes of Cerebral Tissue Oxygen Saturation at Sleep Transitions in Adolescents -- Influence of Subjective Happiness on the Prefrontal Brain Activity: An fNIRS Study -- Ginkobiloba Extract Improves Working Memory Performance in Middle-aged women; Role of Asymmetry of Prefrontal Cortex Activity during a Working Memory Task -- Bayesian Prediction of Anxiety Level in Aged People at Rest using 2-Channel NIRS Data from Prefrontal Cortex -- Short-term Hypoxic Preconditioning Improved Survival following Cardiac Arrest and Resuscitation in rats -- Venular Valves and Retrograde Perfusion -- Monitoring of Filter Patency during Carotid Artery Stenting using Near-Infrared Spectroscopy with High Time-Resolution -- Use of NIRS to Assess Effect of Training on Peripheral Muscle Oxygenation Changes in Elite Rugby Players Performing Repeated Supramaximal Cycling Tests -- Skeletal Muscle Deoxygenation Responses during Treadmill Exercise in Children -- Development of a Hybrid Microwave-Optical Thermoregulation Monitor for the Muscle -- Evaluation of a Textile-Based Near Infrared Spectroscopy System in Calf Muscle Oxygenation Measurements -- Skin Temperature in Lower Hind Limb Subjected to Distal Vein Arterialization in Rats -- Index
    Abstract: This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme “the wisdom of ISOTT” in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integrated overviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer
    Pages: XXX, 372 p. 152 illus., 60 illus. in color. : online resource.
    ISBN: 9781493906208
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  • 5
    Keywords: Medicine ; Oncology ; Immunology ; Biomedicine ; Cancer Research ; Immunology ; Oncology ; Springer eBooks
    Description / Table of Contents: Inflammation and Lung Cancer -- Inflammation and Colon Cancer -- Inflammation and Breast Cancer -- Inflammation and Brain Cancer -- Inflammation and Head & Neck Cancer -- Inflammation and Pancreatic Cancer -- Inflammation and Prostate Cancer -- Inflammation and Bladder Cancer -- Inflammation and Renal Cancer -- Inflammation and Gastric Cancer -- Inflammation and Sarcoma -- Inflammation and Lymphoma -- Inflammation and Leukemia -- Inflammation and Multiple myeloma -- Inflammation and Cervical Cancer -- Inflammation and Liver Cancer -- Inflammation and Skin Cancer
    Abstract: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation, and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix, and skin as well as gastric cancer, sarcoma, lymphoma, leukemia, and multiple myeloma
    Pages: XII, 490 p. 24 illus., 19 illus. in color. : online resource.
    ISBN: 9783034808378
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  • 6
    Keywords: Medicine ; Oncology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    ISBN: 9789400745841
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  • 7
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Biomedicine ; Biomedicine general ; Human Physiology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: 〈p〉The Role of Hypoxia-Inducible Factors in Oxygen Sensing by the Carotid Body ́€“ Invited Article -- Neuronal Mechanisms of Oxygen Chemoreception: An Invertebrate Perspective ́€“ Invited Article -- 〈b〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers℗ Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway ́€“ Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia ́€“ Invited Article -- The Retrotrapezoid Nucleus and Breathing ́€“ Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of℗ Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats ́€“ Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings -- Human Carotid Body HIF and NGB℗ Expression During Human℗ Development and Aging -- Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia -- ATP Release from the Carotid Bodies (CB) of DBA/2J and A/J Inbred Mouse Strains -- Effect of Oxygen on Phosphodiesterases (PDE) 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia -- Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat -- Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor Expression in the Rat Carotid Body in Chronic and Intermittent Hypoxia -- Rabbit Ventilatory Responses to Peripheral Chemoexcitators: Effects of Chronic Hypoxia -- 〈p〉℗ 〈/p〉Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats -- Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs. Clinical Significance -- Some Reflections on Intermittent Hypoxia. Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers? -- Role of Central / Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea ́€“ Invited Article -- Physiologic Basis for Intermittent Hypoxic Episodes In Preterm Infants -- Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats -- Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia -- Antioxidation and the Hypoxic Ventilatory Response -- Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia -- Heart Failure and Carotid Body Chemoreception.〈/p〉〈/b〉〈/p〉〈p〉Peripheral Chemoreceptors in Air- versus Water- Breathers℗ Invited Article -- Sex-specific Effects of Daily Gavage With a Mixed Progesterone and Glucorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats -- Age-Dependent Changes in Breathing Stability in Rats -- Dose Dependant Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats -- Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization -- Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway ́€“ Invited Article -- Time-course of Ventilation, Arterial and Pulmonary CO〈sub〉2〈/sub〉 Tension During CO〈sub〉2〈/sub〉 Increase in Humans -- Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex -- Ion channel regulation by the Lkb1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. - Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices -- Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells -- Acute Hypoxia Does Not Influence Intracellular ph in Isolated Rat Carotid Body Type I Cells -- Hydrogen Sulphide (H〈sub〉2〈/sub〉S): A Physiologic Mediator Of Carotid Body Response To Hypoxia ́€“ Invited Article -- The Retrotrapezoid Nucleus and Breathing ́€“ Invited Article -- The Interaction Between Low Glucose and Hypoxia in the 〈i〉in vitro,〈/i〉 Rat Carotid Body -- Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans? -- Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation -- CO〈sub〉2〈/sub〉 Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca〈sup〉2+〈/sup〉 and pH -- Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of℗ Prolyl Hydroxylase -1(PHD-1) Deficient Mice -- Precision-cut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal Mice -- Oxygen Sensitivity of Gill Neuroepithelial Cells in the Anoxia-tolerant Goldfish -- Interaction of Hypoxia and Core Temperature: potential role of TRPV1 -- Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats -- LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats are Suppressed by Bilateral Carotid Chemodenervation -- Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells: Potential Role of the K〈sub〉ATP〈/sub〉 Channel -- Contribution of Inflammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia -- Spexin is Expressed in the Carotid Body and is Upregulated by Postnatal Hyperoxia Exposure -- Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction between Hypoxia and Hypercapnia in the Carotid Body.225 -- Interactions between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respiratory Function -- Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis after Carotid Chemoreceptor Stimulation in Rats -- Hydrogen Sulfide Acting at the Carotid Body and Elsewhere in the Organism -- Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats ́€“ Invited Article -- Serotonin Dynamics and Actions in the Rat Carotid Body: Preliminary Findings
    Abstract: 〈p〉Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid.℗ Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis.℗ ℗ Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body.℗ Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases.℗ Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments.〈/p〉〈p〉This book is a required text for any researcher in the field of arterial chemoreception for years to come.℗ It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension. ℗ ℗ 〈/p〉〈p〉℗ 〈/p〉
    Pages: XXIV, 406 p. 62 illus., 30 illus. in color. : digital.
    ISBN: 9789400745841
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  • 8
    Keywords: Medicine ; Human Physiology ; Reproductive Medicine ; Embryology ; Biomedicine ; Human Physiology ; Reproductive Medicine ; Embryology ; Springer eBooks
    Description / Table of Contents: ́€œSurprised by Joý€ ́€“ Four Decades of Contributions to Developmental Physiology -- sGC-cGMP Signaling:℗ Target for Anticancer Therapy -- Lawrence D. Longo. From Chronic Fetal Hypoxia to Proteomic Predictors of Fetal Distress Syndrome: A life devoted to research and mentoring based on virtue-ethics -- Pregnancy Programming and Preeclampsia: Identifying a Human Endothelial Model to Study Pregnancy-Adapted Endothelial Function and Endothelial Adaptive Failure in Preeclamptic Subjects -- Regulation of Amniotic Fluid Volume: Evolving Concepts -- Gestational Diabetes, Preeclampsia and Cytokine Release: Similarities and Differences in Endothelial Cell Function -- Heart Disease Link to Fetal Hypoxia and Oxidative Stress -- Fetal Breathing Movements and Changes at Birth -- From Fetal Physiology to Gene Therapy ́€“ It All Started in Loma Linda -- 30+ Years of Exercise in Pregnancy -- Gap Junction Regulation of Vascular Tone: Implications of Modulatory Intercellular Communication during Gestation -- Effect of Preeclampsia on Placental Function: Influence of Sexual Dimorphism, microRNÁ€™s and Mitochondria -- Altitude, Attitude and Adaptation -- The Separation of Sexual Activity and Reproduction in Human Social Evolution -- The Influence of Growth Hormone on Bone and Adipose Programming -- The Fetal Cerebral Circulation: Three Decades of Exploration by the LLU Center for Perinatal Biology -- Placental Vascular Defects in Compromised Pregnancies: Effects of Assisted Reproductive Technologies and Other Maternal Stressors -- How to Build a Healthy Heart from Scratch -- Estrogen in the Fetus -- Calcitonin Gene Related Family Peptides: Importance in Normal Placental and Fetal Development
    Abstract: To celebrate the Center for Perinatal Biology’s 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease
    Pages: XX, 245 p. 61 illus., 15 illus. in color. : online resource.
    ISBN: 9781493910311
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  • 9
    Keywords: Medicine ; Proteomics ; Environmental protection ; Biomedicine ; Biomedicine general ; Proteomics ; Effects of Radiation/Radiation Protection ; Springer eBooks
    Description / Table of Contents: Mass spectrometry-based proteomics: Basic principles and emerging technologies and directions -- Ionizing radiation effects on cells, organelles and tissues on proteome level -- Radiation treatment effects on the proteome of the tumour microenvironment -- Serum and plasma proteomics and its possible use as detector and predictor of radiation diseases -- The Urine Proteome as a Radiation Biodosimeter -- Effects of radiofrequency-modulated electromagnetic fields on proteome -- Global protein expression in response to extremely low frequency magnetic fields -- Ultraviolet radiation effects on the proteome of skin cells -- Effects of ultraviolet radiation on skin cell proteome
    Abstract: Proteomics is widely used in search of biomarkers, pharmacology, clinical research and toxicology. With the help of proteomics large amount of information about the physiology of living cells can be obtained in a single experiment. Combining this information with data from genomics and other high-throughput screening techniques like transcriptomics and metabolomics allows gaining new insights into physiology of life and diseases.The area of research that is still waiting for the proteomics “boom” is the search for the biological effects of radiation. It is relatively much known about the effects of high doses of radiation, both ionizing and non-ionizing. However, much less is known about the effects of low or very low doses of radiation, to which people are often exposed in their every day life. The effects of the low doses of ionizing radiation (e.g. bystander effect) or low doses of non-ionizing radiation (e.g. effect of radiation emitted by wireless communication devices) are not yet reliably established. Often these effects are small and difficult to discover and to replicate. One of the limiting factors in the research of low dose radiation effects is often the lack of the knowledge of the cellular target molecules.Proteomics, the high-throughput screening of expression and activity of proteins is very well suited for the research aiming at discovery of molecular targets of low dose radiation. Proteomics approach seems to be particularly well suited for studying biological effects of low dose radiation because it might reveal effects that are not possible to predict based on the presently available knowledge concerning the effects of the high doses of radiation. Search through the published scientific literature shows that to date was published only a very limited number of proteomics studies examining effects of radiation. This book, Radiation Proteomics, presents the current status the research of radiation effects using proteomics approach. The book begins with the review of current status and the future direction in the development of proteomics methods. This is followed by chapters dealing with the effects of ionizing and non-ionizing radiation on cells, tissues and body fluids.The editor of the book, Research Professor Dariusz Leszczynski, is known for studies that introduced, some 10 years ago, the high-throughput screening techniques of proteomics and transcriptomics into the main stream of the research on the biological effects of the non-ionizing radiation emitted by the wireless communication devices. In recent years he has also done studies examining effects of low-dose ionizing radiation on cellular proteome
    Pages: : digital.
    ISBN: 9789400758964
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    Keywords: Life sciences ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry ; Life sciences ; Protein Science ; Medical Biochemistry ; Human Physiology ; Nutrition ; Cardiology ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Taurine, Glutathione And Bioenergetics -- Molybdenum Cofactor Deficiency: Metabolic Link Between Taurine And S-Sulfocysteine -- Taurine And Chinese Traditional Medicine Accelerate Alcohol Metabolism In Mice -- Taurine And Chinese Traditional Medicine Accelerate Alcohol Metabolism In Mice -- The Effect Of Long-Term Taurine Supplementation And Fructose Feeding On Glucose And Lipid Homeostasis In Wistar Rats -- Effect Of Taurine Feeding On Bone Mineral Density And Bone Markers In Rats -- The Effects Of Bisphosphonates On Taurine Transport In Retinal Capillary Endothelial Cells Under High Glucose Conditions -- Perinatal Taurine Imbalance Alters The Interplay Of Renin-Angiotensin System And Estrogen On Glucose-Insulin Regulation In Adult Female Rats -- Reduced Placental Taurine Transporter (Taut) Activity In Pregnancies Complicated By Pre-Eclampsia And Maternal Obesity -- Effects Of Taurine Supplementation Upon Food Intake And Central Insulin Signaling In Malnourished Mice Fed On A High Fat Diet -- Positive Correlation Between Serum Taurine And Adiponectin Levels In High-Fat-Induced Obesity Rats -- Relationship Among Serum Taurine, Serum Adipokines And Body Composition During 8-Week Human Body Weight Control Program -- Dietary Taurine And Nutrients Intake And Dietary Quality By Alcohol Consumption Level In Korean Male College Students -- Taurine Supplementation Restores Insulin Secretion And Reduces Er Stress Markers In Protein-Malnourished Mice -- Taurine As A Marker For The Identification Of Natural Calculus Bovis And Its Substitutes -- Taurine Deficiency And Melas Are Closely Related Syndromes -- Antioxidant And Dna Protection Effects Of Taurine By Electron Spin Resonance Spectroscopy -- Additional Effects Of Taurine On The Benefits Of Bcaa Intake For The Delayed-Onset-Muscle Soreness And Muscle Damage Induced By High-Intensity Eccentric Exercise -- Taurine Enhances Anticaner Activity Of Cisplatin In Human Cervical Cancer Cells -- Comparative Evaluation Of The Effects Of Taurine And Thiotaurine On Alterations Of The Cellular Redox Status And Activities Of Antioxidant And Glutathione-Related Enzymes By Acetaminophen In The Rat -- Effects Of Taurine On Myocardial Cgmp/Camp Ratio, Antioxidant Ability And Ultrastructure In Cardiac Hypertrophy Rats Induced By Isoproterenol -- Protective Effect Of Taurine On Tri-Ortho-Cresyl Phosphate (Tocp) Induced Cytotoxicity In C6 Glioma Cells -- The Mechanism Of Taurine Protection Against Endoplasmic Reticulum Stress In An Animal Stroke Model Of Cerebral Artery Occlusion And Stroke-Related Conditions In Primary Neuronal Cell Culture -- Relationship Among Self-Reported Fatigue, Dietary Taurine Intake And Dietary Habits In Korean College Students -- Simulative Evaluation Of Taurine Against Alopecia Caused By Stress In Caenorhabditis Elegans -- Protective Effect Of Taurine On The Decreased Biogenic Amine Neurotransmitter Levels In Brain Of Mice Exposed To Arsenic -- Differential Regulation Of Taut By Calcitriol And Retinoic Acid Via Vdr/Rxr In Llc-Pk1 And Mcf-7 Cells -- Knockdown Of Taut Expression Impairs Human Embryonic Kidney 293 Cell Development -- The Role Of Taurine On Skeletal Muscle Cell Differentiation -- Taurine And Fish Development: Insights For The Aquaculture Industry -- Effect Of Dietary Taurine And Arginine Supplementation On Bone Mineral Density In Growing Female Rats -- Taurine Enhances The Sexual Response And Mating Ability In Aged Male Rats
    Abstract: Taurine℗ 8 represents the combined efforts of investigators on the roles of the amino acid taurine on human health and disease. The chapters covered in this book are directly derived from presentations of the contributors at the 18th International Taurine Meeting held in Marrakech, Morocco in April 2012. The purpose of this book is to disseminate current findings on taurine's contribution in several organ systems. This book covers the following topics: Taurine in Nutrition and Metabolism, the Protective Role of Taurine, and the Role of Taurine in Reproduction, Development, and Differentiation. Dr. Abdeslem El Idrissi, College of Staten Island and Dr. William L€™Ámoreaux, College of Staten Island, ℗ were co-chairs of the Organizing Committee for the meeting.℗ Data presented at this meeting provided compelling evidence that taurine is not only cytoprotective in cardiomyocytes, but also is a potent GABA agonist, whereby it can facilitate vasodilation of conducting arteries. Taurine conjugates, such as taurine chloramine, may protect cells from oxidative stress via increased HO-1 expression. In adult rodents, taurine has a potent effect on plasma glucose levels, likely through the release of insulin in pancreatic beta cells. As a potential neurotransmitter, taurine is known to work via the GABAergic system, but current research presented at this meeting suggest that taurine may interact with glutamate and serotonin receptors as well. Data are also presented to demonstrate the protective roles of taurine on neurons in neuroblastoma. Perhaps the most important and exciting presentation is the role of taurine and alcohol: the combination may be lethal. Data are also presented at this meeting of the potential role taurine may have as an adjuvant treatment with cisplatin in chemotherapy
    Pages: : digital.
    ISBN: 9781461460930
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