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  • 1
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    Berlin, Heidelberg : Springer
    Keywords: Medicine ; Immunology ; Medical virology ; Microbial genetics ; Plant Diseases ; Invertebrates ; Biomedicine ; Immunology ; Virology ; Microbial Genetics and Genomics ; Molecular Medicine ; Plant Pathology ; Invertebrates ; Springer eBooks
    Description / Table of Contents: The APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response
    Abstract: Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted. ℗
    Pages: : digital.
    ISBN: 9783642377655
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  • 2
    Call number: ATV-MIB:1/198
    Keywords: Apoptosis / immunology ; T-Lymphocytes / immunology
    Pages: viii, 224 p. : ill.
    ISBN: 354058725X
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    ATV-MIB:1/198 departmental collection or stack – please contact the library
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  • 3
    Call number: ATV-MIB:1/190
    Keywords: Borna Disease / virology ; Borna Disease / epidemiology ; Borna Disease Virus / pathogenicity ; Central Nervous System Diseases / etiology
    Pages: vi, 134 p. : ill.
    ISBN: 3540573887
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    ATV-MIB:1/190 departmental collection or stack – please contact the library
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  • 4
    Call number: ATV-MIB:1/264,1
    Keywords: Pathogenic micro-biology ; Microbial genetics ; Plasmids ; Mobile genetic elements
    Notes: Includes index
    Pages: IX,231 p. : ill. (some col.)
    ISBN: 3-540-42681-7
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    ATV-MIB:1/264,1 departmental collection or stack – please contact the library
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  • 5
    Keywords: Medicine ; Cancer Research ; Immunology ; Molecular Biology ; Biomedicine ; Immunology ; Molecular Medicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology
    Abstract: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases
    Pages: VIII, 231 p. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319261331
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  • 6
    Keywords: Medicine ; Immunology ; Biomedicine ; Immunology ; Springer eBooks
    Notes: Also print edition available.
    Pages: : digital
    ISBN: 9783642038587
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  • 7
    Call number: ATV-MIB:1/268
    Keywords: Ubiquitin ; Proteins / Degradation ; Proteins / metabolism ; Peptide Hydrolases / physiology ; Ubiquitins / physiology ; Protease Inhibitors
    Description / Table of Contents: Molecular evolution of proteasomes / C. Volker and A.N. Lupas -- The 20S proteasome / P. Zwickl -- Regulating the 26S proteasome / M.H. Glickman and V. Maytal -- The 11S regulators of 20S proteasome activity / C.P. Hill, E.I. Masters, and F.G. Whitby -- Immunological functions of the proteasome / G. Niedermann -- Natural substrates of the proteasome and their recognition by the ubiquitin system / H.D. Ulrich -- The intracellular localization of the proteasome / C. Gordon -- Proteasome inhibitors : complex tools for a complex enzyme / M. Bogyo and E.W. Wang
    Pages: 214 p. : ill.
    ISBN: 3-540-43096-2
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  • 8
    Keywords: Medicine ; Immunology ; Medical virology ; Biomedicine ; Virology ; Immunology ; Springer eBooks
    Pages: : digital
    ISBN: 9783642133329
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  • 9
    Keywords: Medicine ; Cancer Research ; Human Genetics ; Immunology ; Biomedicine ; Cancer Research ; Immunology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its Implications in Disease Conditions -- Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease -- Form and function of exosome associated long non-coding RNAs in cancer -- Long Non-coding RNAs in Lung Cancer -- Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease -- Functional long non-coding RNAs in vascular smooth muscle cells -- Long Non-coding RNAs as Targets and Regulators of Nuclear Hormone Receptors -- Non-coding transcriptional landscape in human aging -- LncRNAs in stress response -- Expression Specificity of Disease-Associated lncRNAs: towards Personalized Medicine
    Abstract: This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike
    Pages: VIII, 262 p. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319239071
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  • 10
    Keywords: Medicine ; Oncology ; Hematology ; Biomedicine ; Cancer Research ; Hematology ; Springer eBooks
    Notes: Also print edition available.
    Pages: : digital
    ISBN: 9783642126390
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