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  • 1
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    Berlin, Heidelberg : Springer
    Keywords: Medicine ; Neurosciences ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Neurosciences ; Springer eBooks
    Abstract: 〈p〉Botulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications.〈/p〉〈p〉This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies.〈/p〉
    ISBN: 9783642335709
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  • 2
    Keywords: Medicine ; Immunology ; Cytokines ; Biomedicine ; Immunology ; Cytokines and Growth Factors ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies and IL-10 polymorphisms -- Control of intestinal inflammation by interleukin-10 -- Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications -- Interleukin-10-producing B cells and the regulation of immunity -- Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?- IL-10: achieving balance during persistent viral infection -- The role of microRNAs in the control and mechanism of action of IL-10 -- The regulation of IL-10 expression -- The Molecular Basis of IL-10 Function:℗ From Receptor Structure to the Onset of Signaling -- Role of IL-22 in microbial host defense
    Abstract: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date
    Pages: VIII, 238 p. 16 illus. in color. : online resource.
    ISBN: 9783662434925
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  • 3
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Public Health ; Bacteriology ; Biomedicine ; Medical Microbiology ; Immunology ; Vaccine ; Molecular Medicine ; Public Health ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Group A Streptococcal Diseases and Their Global Burden -- Molecular Markers for the Study of Streptococcal Epidemiology -- Epidemiology and Pathogenicity of Zoonotic Streptococci -- Adherence and Invasion of Streptococci to Eukaryotic Cells and Their Role in Disease Pathogenesis -- Common Regulators of Virulence in Streptococci -- Host-Pathogen Interactions in Streptococcal Immune Sequelae -- Immunopathogenesis of Streptococcal Deep Tissue Infections -- Modulation of the Coagulation System During Severe Streptococcal Disease -- Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine -- Clinical Management of the Most Common Group A β-Hemolytic Streptococcal Infections
    Abstract: Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases
    Pages: : digital.
    ISBN: 9783642363405
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  • 4
    Call number: ATV-MIB:1/243
    Keywords: Molecular Conformation ; Biochemistry ; Immunity ; Protein Engineering
    Pages: vi, 189 p. : ill.
    ISBN: 3-540-65704-5
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    ATV-MIB:1/243 departmental collection or stack – please contact the library
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  • 5
    Keywords: Medicine ; Immunology ; Drug Interactions ; Medical virology ; Clinical Medicine ; Biomedicine ; Virology ; Immunology ; Drug Resistance ; Hepatology ; Springer eBooks
    Description / Table of Contents: The Origin of Hepatitis C Virus -- Cell Culture Systems for Hepatitis C Virus -- Animal Models for Hepatitis C -- Hepatitis C Virus Entry -- Hepatitis C Virus Proteins: From Structure to Function -- Hepatitis C Virus RNA Translation -- Hepatitis C Virus RNA Replication -- Virion Assembly and Release -- Innate Immune Responses to Hepatitis C Virus -- Adaptive Immune Responses in Hepatitis C Virus Infection -- Liver Injury and Disease Pathogenesis in Chronic Hepatitis C -- Hepatitis C Virus-Specific Directly Acting Antiviral Drugs -- Treatment of Chronic Hepatitis C: Current and Future
    Abstract: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted
    Pages: : digital.
    ISBN: 9783642273407
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  • 6
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Biomedicine ; Medical Microbiology ; Immunology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Between Commensalism and Pathogenicity:Bacterial and Host Aspects -- E. coli as an all-rounder: The thin line between commensalism and pathogenicity.-℗ What distinguishes non-pathogenic, from medium and highly pathogenic staphylococci? -- Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung.-℗ Lactobacillus: Host-Microbe Relationships -- Bacterial Moonlighting Proteins and Bacterial Virulence.-℗ Symbionts and pathogens - what is the difference? -- Host-microbe Interaction in the Intestinal Tract -- Ecology and physiology of the intestinal tract -- The gut microflora and its variety of roles in℗ health and disease -- Mammalian intestinal host-microbe relationships -- Contribution of the intestinal microbiota to human health - from birth to 100 years of age.-℗ Subject index.℗
    Abstract: Microbes colonize nearly every biotic and abiotic niche on our planet. This also includes our human body, which is densely populated with microbes, the majority of which interact with us in a commensal, sometimes even mutualistic, relationship. Only a minority of our microbiota are pathogenic organisms with the ability to cause infection.This book covers various aspects of the interplay between commensal and pathogenic bacteria with their hosts. The chapters summarize recent findings on the geno- and phenotypic traits of opportunistic bacterial pathogens, such as Escherichia coli, staphylococci or Pseudomonas aeruginosa, as well as the impact of commensal and probiotic bacteria on intestinal physiology and health. The differential interaction of pathogenic, commensal and probiotic bacteria with their host is reviewed from both the bacterial and the host’s perspective to round out this compilation of articles on the differences and similarities of pathogenic and commensal microorganisms
    Pages: : digital.
    ISBN: 9783642365607
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  • 7
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    Berlin : Springer-Verlag
    Associated volumes
    Call number: ATV-MIB:1/190
    Keywords: Borna Disease / virology ; Borna Disease / epidemiology ; Borna Disease Virus / pathogenicity ; Central Nervous System Diseases / etiology
    Pages: vi, 134 p. : ill.
    ISBN: 3540573887
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    ATV-MIB:1/190 departmental collection or stack – please contact the library
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  • 8
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    Cham : Springer International Publishing
    Keywords: Medicine ; Medical Microbiology ; Pharmacology ; Infectious Diseases ; Biomedicine ; Medical Microbiology ; Pharmacology/Toxicology ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Two feet on the membrane: uptake of clostridial neurotoxins -- Receptors and binding structures for Clostridium difficile Toxins A and B -- Cell entry of C3 exoenzyme from Clostridium botulinum.-℗ Receptor-binding and up-take of binary actin-ADP-ribosylating toxins -- Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal ́€œCoup de Grac逝 -- Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins -- Multivalent Inhibitors of Channel-Forming Bacterial Toxins -- Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules
    Abstract: This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists
    Pages: VII, 256 p. : online resource.
    ISBN: 9783319588933
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  • 9
    Call number: ATV-MIB:1/264,1
    Keywords: Pathogenic micro-biology ; Microbial genetics ; Plasmids ; Mobile genetic elements
    Notes: Includes index
    Pages: IX,231 p. : ill. (some col.)
    ISBN: 3-540-42681-7
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    ATV-MIB:1/264,1 departmental collection or stack – please contact the library
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  • 10
    Call number: ATV-MIB:1/264,2
    Keywords: Pathogenic micro-organisms ; Microbial genetics ; Plasmids ; Mobile genetic elements
    Notes: Includes index
    Pages: IX,208 p. : ill. (some col.)
    ISBN: 3-540-42682-5
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    ATV-MIB:1/264,2 departmental collection or stack – please contact the library
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