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  • 1
    Keywords: Medicine ; Virology ; Biomedicine ; Virology ; Springer eBooks
    Description / Table of Contents: Preface -- History -- Chap. 1 Why and How Epstein-Barr Virus was discovered 50 years ago - Anthony Epstein, University of Oxford, UK -- Chap. 2. Tumor associations of EBV ́€“ historical perspectives - George Klein, Karolinska Institutet, Stockholm, Sweden -- Chap. 3. EBV-specific immune response: early research and personal reminiscences ́€“ Denis J. Moss and Viviana P. Lutzky, Queensland Institute of Medical Research, Brisbane, Australia -- Virus genetics and epigenetics -- Chap. 4. Epstein Barr virus strain variation - Paul J. Farrell, Imperial College, London, UK -- Chap. 5. Chromatin Structure of Epstein-Barr Virus Latent Episomes ℗ ́€“ Paul M. Lieberman, University of Pennsylvania, Philadelphia, USA -- Chap. 6. The epigenetic life cycle of Epstein-Barr virus - Wolfgang Hammerschmidt, Helmholtz Center Munich, Germany. Chap. 7. Epstein-Barr virus: from the detection of sequence polymorphisms to the recognition of viral types - Regina Feederle, Olaf Klinke, Anton Kutikhin, Remy Poirey, Ming-Han Tsai and Henri-Jacques Delecluse, German Cancer Research Center, Heidelberg, Germany -- Viral infection and associated diseases -- Chap. 8. EBV persistence ́€“ introducing the virus ́€“ David A. Thorley-Lawson, Tufts University, Boston, USA -- Chap. 9. Infectious mononucleosis ́€“ Samantha K. Dunmire, Kristin A. Hogquist and Henry H. Balfour, Jr., University of Minnesota, Minneapolis, USA -- Chap. 10. Primary immunodeficiencies associated with EBV disease - Jeffrey I. Cohen, National Institutes of Health, Bethesda, USA -- Chap. 11. Burkitt́€™s lymphoma ́€“ Rosemary Rochford℗ and Ann M. Moormann, University of Massachusetts, Worcester, and Upstate University of New York, Syracuse, USA -- Chap. 12. Contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin lymphoma ́€“ Paul Murray and Andrew Bell, University of Birmingham, UK -- Chap. 13. The role of EBV in the pathogenesis of diffuse large B cell lymphoma ́€“ Jane A. Healy and Sandeep S. Dave, Duke University, Raleigh, USA -- Chap. 14. Nasopharyngeal carcinoma:℗ an evolving role for the Epstein Barr virus ́€“ Nancy Raab-Traub, University of North Carolina, Chapel Hill, USA.-Chap. 15. EBV and autoimmunity ́€“ Alberto Ascherio and Kassandra Munger, Harvard University, Boston, USA -- Index
    Abstract: Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago.℗ Since its discovery in Burkitt́€™s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future
    Pages: VIII, 391 p. 50 illus., 38 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319228228
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  • 2
    Keywords: Medicine ; Immunology ; Medical virology ; Emerging infectious diseases ; Biomedicine ; Immunology ; Virology ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: The organization of the sphingosine-1-phosphate signaling system -- Structural biology of the S1P1 receptor -- Chemical and genetic tools to explore S1P biology -- S1P control of endothelial integrity -- Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen -- Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule -- Sphingosine-1-phosphate and central nervous system -- RORs in autoimmune disease
    Abstract: This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of℗ signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis.℗ One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses
    Pages: VII, 184 p. 27 illus., 22 illus. in color. : online resource.
    ISBN: 9783319058795
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  • 3
    Keywords: Medicine ; Immunology ; Cytokines ; Biomedicine ; Immunology ; Cytokines and Growth Factors ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies and IL-10 polymorphisms -- Control of intestinal inflammation by interleukin-10 -- Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications -- Interleukin-10-producing B cells and the regulation of immunity -- Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?- IL-10: achieving balance during persistent viral infection -- The role of microRNAs in the control and mechanism of action of IL-10 -- The regulation of IL-10 expression -- The Molecular Basis of IL-10 Function:℗ From Receptor Structure to the Onset of Signaling -- Role of IL-22 in microbial host defense
    Abstract: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date
    Pages: VIII, 238 p. 16 illus. in color. : online resource.
    ISBN: 9783662434925
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  • 4
    Call number: ATV-MIB:1/243
    Keywords: Molecular Conformation ; Biochemistry ; Immunity ; Protein Engineering
    Pages: vi, 189 p. : ill.
    ISBN: 3-540-65704-5
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    ATV-MIB:1/243 departmental collection or stack – please contact the library
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  • 5
    Keywords: Medicine ; Immunology ; Microbiology ; Vaccines ; Public Health ; Bacteriology ; Biomedicine ; Medical Microbiology ; Immunology ; Vaccine ; Molecular Medicine ; Public Health ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Group A Streptococcal Diseases and Their Global Burden -- Molecular Markers for the Study of Streptococcal Epidemiology -- Epidemiology and Pathogenicity of Zoonotic Streptococci -- Adherence and Invasion of Streptococci to Eukaryotic Cells and Their Role in Disease Pathogenesis -- Common Regulators of Virulence in Streptococci -- Host-Pathogen Interactions in Streptococcal Immune Sequelae -- Immunopathogenesis of Streptococcal Deep Tissue Infections -- Modulation of the Coagulation System During Severe Streptococcal Disease -- Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine -- Clinical Management of the Most Common Group A β-Hemolytic Streptococcal Infections
    Abstract: Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases
    Pages: : digital.
    ISBN: 9783642363405
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  • 6
    Keywords: Medicine ; Human Genetics ; Human Physiology ; Neurosciences ; Developmental Biology ; Biomedicine ; Human Physiology ; Human Genetics ; Neurosciences ; Regenerative Medicine/Tissue Engineering ; Developmental Biology ; Springer eBooks
    Description / Table of Contents: Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis -- Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals -- Cellular Plasticity During Vertebrate Appendage Regeneration -- Cell Signaling Pathways in Vertebrate Lens Regeneration -- Regenerative Medicine: Challenges and Perspectives for Successful Therapies -- Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects -- Muscle Repair and Regeneration:℗ Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration -- Neural Regeneration -- Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System -- Epigenetics and Regeneration -- Cell Cycle Regulation and Regeneration.℗ ℗ ℗ ℗ ́€&#x2039
    Abstract: Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential℗ developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term ́€œregenerative medicin逝 was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general.℗ Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cell cycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerative℗ disease, are recurring themes throughout the book.We are all now part of the regeneration revolution
    Pages: : digital.
    ISBN: 9783642358104
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  • 7
    Keywords: Immunology ; Microbiology ; Medical virology ; Immunology ; Medical Microbiology ; Virology ; Springer eBooks
    Description / Table of Contents: Activity-based protein profiling – enabling multimodal functional studies of microbial communities -- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles -- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria -- Activity-Based Protein Profiling at the Host–Pathogen Interface -- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens -- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling -- ABPP and Host–Virus Interactions -- Activity-Based Protein Profiling for the Study of Parasite Biology -- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling -- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics -- Development of Activity-Based Proteomic Probes for Protein Citrullination -- Recent Advances in Activity-Based Protein Profiling of Proteases -- Opportunities for Lipid-Based Probes in the Field of Immunology -- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases -- Target Identification of Bioactive Covalently Acting Natural Products -- Applications of Reactive Cysteine Profiling
    Abstract: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions
    Pages: X, 417 p. 115 illus., 70 illus. in color. : online resource.
    ISBN: 9783030111434
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  • 8
    Keywords: Medicine ; Immunology ; Monoclonal antibodies ; Vaccines ; Biomedicine ; Vaccine ; Immunology ; Antibodies ; Springer eBooks
    ISBN: 9783642236938
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  • 9
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    Berlin : Springer-Verlag
    Associated volumes
    Call number: ATV-MIB:1/198
    Keywords: Apoptosis / immunology ; T-Lymphocytes / immunology
    Pages: viii, 224 p. : ill.
    ISBN: 354058725X
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    ATV-MIB:1/198 departmental collection or stack – please contact the library
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  • 10
    Call number: ATV-MIB:1/264,1
    Keywords: Pathogenic micro-biology ; Microbial genetics ; Plasmids ; Mobile genetic elements
    Notes: Includes index
    Pages: IX,231 p. : ill. (some col.)
    ISBN: 3-540-42681-7
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    ATV-MIB:1/264,1 departmental collection or stack – please contact the library
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