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  • 1
    Keywords: Medicine ; Oncology ; Human Genetics ; Neurosciences ; Biomedicine ; Human Genetics ; Cancer Research ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Preface -- Epigenetic programming of the brain -- Epigenetics and maternal brain evolution -- Social environment and DNA methylation:℗ A mechanism for linking nurture and nature -- Sex differences in epigenetic programming of brain differentiation: Implications for mental health and disease -- Epigenetics and neurological disorders -- Phenotypic plasticity, pleiotropy, and the growth-first theory of imprinting -- The imprinted brain: How genes set the balance between autism and psychosis -- Epigenetics at the interface of genetics and environmental factors in autism -- Epigenomic and non-coding℗ RNA regulation in addictive processes -- Epigenetic therapies in neurological diseases -- Epigenetics, nutrition, diabetes, and obesity -- Nutrition, histone epigenetic marks, and disease -- Chromatin switching and gene dynamics associated with type 2 diabetes -- Developmental epigenetic programming in diabetes and obesity -- Epigenetics and cancer -- Developmental reprogramming by environmental estrogens: How early life exposures affect cancer risk in adulthood.-℗ Human cancer epigenetics -- Epigenetics and the law -- Legal and ethical implications of epigenetics -- Subject index.℗
    Abstract: The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming
    Pages: : digital.
    ISBN: 9783642368271
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  • 2
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Endocrinology ; Biomedicine ; Neurosciences ; Human Genetics ; Endocrinology ; Springer eBooks
    Description / Table of Contents: Foreword by Dietmar Spengler & Elisabeth Binder -- Part I, Epigenetics And The Stress System -- I.1 From vulnerability to neurotoxicity: A developmental approach to the effects of stress on brain and behavior -- I.2 Dynamic regulation of chromatin modification and transcription by GR and the steroid receptors -- I.3 NR receptor coactivators -- I.4 Glucocorticoid-dependent epigenetic regulation of Fkbp5 -- I.5 Epigenetic programming of the HPA axis by early-life adversity -- I.6 Epigenetic programming of hypothalamic Pomc regulates feeding and obesity -- I.7 Effects of maternal care in monkeys -- I.8 Stress, transposons and the brain epigenome -- Part II; Epigenetics And Sexual Differentiation -- II.1 Neuroepigenetics of sexual differentiation of brain and behavior -- II.2 Differential regulation of androgen receptor and DNA methylation in songbirds -- II.3 chapter title "GnRH gene/Kiss gene, sexual dimorphism, puberty
    Abstract: The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders
    Pages: XXIII, 264 p. 36 illus., 30 illus. in color. : online resource.
    ISBN: 9783319244938
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  • 3
    Keywords: Medicine ; Oncology ; Human Genetics ; Medical genetics ; Biomedicine ; Human Genetics ; Cancer Research ; Gene Function ; Springer eBooks
    Abstract: Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming
    Pages: : digital.
    ISBN: 9783642233807
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  • 4
    Keywords: Medicine ; Human Genetics ; Molecular Biology ; Cell Biology ; Biomedicine ; Human Genetics ; Cell Biology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Preface -- Formation of Bacterial Lineages in Salmonella enterica by Epigenetic Mechanisms -- Non-coding RNAs and Chromatin Modifications in the Developmental Control of Imprinted Genes -- Lymphocyte Identity and Genomic Switches -- Epigenetic Imprinting of Immunological Memory -- Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity -- Epigenetic Alterations of Viral and Cellular Genomes in EBV Infected Cells -- Epigenetic Destabilization by Inserting Foreign DNA Into Mammalian Genomes: Oncogenesis and Evolution -- What Mechanisms Induce Methylation of FMR1 Gene Full Mutation? A Still Unanswered Question -- Silencing of Human Cytomegalovirus Gene Expression Mediated by Components of PML Nuclear Bodies -- Azanucleoside DNA Methyltransferase Inhibitor Drugs: Update on Clinical Applications in Myelodysplastic Syndromes and Acute Myeloid Leukemia -- Oxidative Stress and Cancer Epigenomics -- Glossary
    Abstract: This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics. The last part of the book highlights proteins and peptides as epigenetic modulators
    Pages: XVI, 254 p. 41 illus., 9 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319271866
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  • 5
    Keywords: Medicine ; Human Genetics ; Neurosciences ; Endocrinology ; Biomedicine ; Neurosciences ; Human Genetics ; Endocrinology ; Springer eBooks
    Description / Table of Contents: PART III; EPIALLELES AND NEUROENDOCRINOLOGY -- III.1 Fkbp5 epiallels -- III.2 Genomic regulation of the PACAP receptor, PAC1, and implications for psychiatric disease -- III.3 Prodynorphin epialleles -- PART IV;TRANSGENERATIONAL REGULATION OF THE NEUROENDOCRINE SYSTEM -- IV.1 Epigenetic Risk Factors for Diseases: A Transgenerational Perspective -- IV.2 Epigenetic alteration to NR3C1 and HSD11B2 and the developmental origins of mental disease risk -- IV.3 Intergenerational effects of PTSD on offspring glucocorticoid receptor methylation -- PART V; EPIGENETIC BIOMARKERS AND NEUROENDOCRINOLOGY -- V.1 Epigenetic biomarkers for early life adversity -- V.2 Epigenetic biomarkers of maternal stress -- V.3 Epigenetic modifications in borderline personality disorder -- V.4 Oxytocin receptors and neurobehavior -- V.5 Psychosocial stress and DNA methylation
    Abstract: The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders
    Pages: XXIII, 261 p. 25 illus., 3 illus. in color. : online resource.
    ISBN: 9783319299013
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  • 6
    Keywords: Medicine ; Human Genetics ; Nucleic Acids ; Biological models ; Cytology ; Biomedicine ; Human Genetics ; Cell Biology ; Systems Biology ; Nucleic Acid Chemistry ; Springer eBooks
    Abstract: The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field
    Pages: XVIII, 230 p. 20 illus., 19 illus. in color. : online resource.
    ISBN: 9783642319747
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  • 7
    Keywords: Medicine ; Human Genetics ; Psychiatry ; Biomedicine ; Human Genetics ; Psychiatry ; Springer eBooks
    Pages: : digital
    ISBN: 9783642174261
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  • 8
    Keywords: Medicine ; Cancer Research ; Human Genetics ; Medical Microbiology ; Parasitology ; Virology ; Biomedicine ; Human Genetics ; Virology ; Cancer Research ; Parasitology ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: DNA Methylation of Human Papillomavirus (HPV) Genomes During Infection and Cancer Progression -- Epigenetic regulation of gammaherpesviruses: A focus on Kaposi’s Sarcoma-associated Herpesvirus (KSHV/HHV-8) -- Discoveries in molecular genetics with the Adenovirus 12 system: Integration of viral DNA and epigenetic consequences -- Epigenetic consequences of Epstein-Barr virus infection -- Epigenetic Programming by Microbial Pathogens and Impacts on Acute and Chronic Disease -- Crosstalk between bacteria and the host epigenetic machinery -- Epigenetic phase variation in bacterial pathogens -- Epigenetic switching in the human fungal pathogen Candida albicans -- Modification of the host epigenome by parasitic protists -- Epigenetic regulation in T. brucei: Changing coats is a chance to survive -- Epigenetics of malaria parasites
    Abstract: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health
    Pages: VIII, 277 p. 22 illus., 14 illus. in color. : online resource.
    ISBN: 9783319550213
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  • 9
    Keywords: Medicine ; Oncology ; Human Genetics ; Biomedicine ; Human Genetics ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function -- Subject index
    Abstract: In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders
    Pages: XIII, 416 p. 49 illus. in color. : online resource.
    ISBN: 9783642451980
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  • 10
    Keywords: Medicine ; Human Genetics ; Reproductive Medicine ; Biomedicine ; Human Genetics ; Reproductive Medicine ; Springer eBooks
    Pages: : digital
    ISBN: 9783642147739
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