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  • 1
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    London : Henry Stewart Talks
    Keywords: Brain / Diseases ; Neuronal Plasticity ; Protein-protein interactions ; Synapses / physiology ; Synaptic Transmission / physiology ; Brain Diseases / physiopathology ; Nerve Tissue Proteins / metabolism ; Neuronal Plasticity / physiology ; Synapses / physiology ; Synaptic Transmission / physiology
    Description / Table of Contents: Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (48 min.) : color, sound).
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  • 2
    Keywords: Adenosine triphosphate ; Muscles / Innervation ; Myoneural junction ; Neural transmission ; Neurotransmitter receptors ; Purines / Receptors ; Neuromuscular Junction ; Receptors, Neurotransmitter / physiology ; Receptors, Purinergic P2X2 ; Receptors, Purinergic P2Y2 ; Receptors, Purinergic / physiology ; Signal Transduction ; Synaptic Transmission / physiology
    Description / Table of Contents: Contents: Purinergic transmission and the role of ATP as a neurotransmitter -- Neuromuscular junctions and neuromodulation -- Synaptic transmission in peripheral and central nervous systems -- NANC excitatory and inhibitory nerves -- Sympathetic nerve stimulation and co-transmission -- Purinergic pathologies -- Sensory-motor nerves -- P1 and P2 purinergic receptors -- Fast and slow excitatory synaptic pathways -- Expression of P2X and P2Y receptor subtypes and their properties
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (48 min.) : color, sound).
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  • 3
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    London : Henry Stewart Talks
    Keywords: Drug Discovery ; Drug targeting ; Protein-protein interactions ; Proteins / Inhibitors ; Drug Design ; Protein Binding / drug effects ; Protein Interaction Mapping ; Proteins / antagonists & inhibitors ; Proteins / metabolism ; Small Molecule Libraries / pharmacology
    Description / Table of Contents: Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (35 min.) : color, sound).
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  • 4
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    London : Henry Stewart Talks
    Keywords: Central nervous system / Diseases ; Central Nervous System / physiology ; Ion Channels ; Neurotransmitter receptors ; Synapses / physiology ; Central Nervous System Diseases / metabolism ; Central Nervous System / metabolism ; Ion Channel Gating / physiology ; Neurotransmitter Agents ; Receptors, GABA-A ; Receptors, Neurotransmitter / physiology ; Synapses / physiology
    Description / Table of Contents: Contents: The structure & molecular properties the GABA/A receptor -- GABA/A receptor subunit families and subtype abundance & diversity -- GABA receptor activation -- GABA/A receptor role in physiology & disease -- The inhibitory synapse & domain specific inhibition -- Ion channel (selectivity, channel gate and associated drugs) -- Phosphorylation of GABA/A receptors -- GABA/A receptor binding epitopes
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 5
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    London : Henry Stewart Talks
    Keywords: Cancer cells ; Chromatin ; Genetic regulation ; Leukemia / Genetic aspects ; Cell Transformation, Neoplastic ; Chromatin / genetics ; Gene Expression Regulation ; Histone-Lysine N-Methyltransferase ; Leukemia / genetics ; Myeloid-Lymphoid Leukemia Protein ; Neoplasms / genetics ; Transcriptional Elongation Factors / metabolism
    Description / Table of Contents: Contents: MLL genes and their pathogenic translocations -- Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis -- Proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation -- What is the function of MLL? -- Why do translocations of MLL with so many different partners result in leukemogenesis? -- The AFF4 complex and Hox genes -- COMPASS family of H3K4 methylases and their mutations in cancer -- Chromatin Bivalency -- The ELL family of Pol II elongation factors -- Drosophila Trr -- Enhancer/promoter interactions, malfunctions and their outcomes
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 6
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    London : Henry Stewart Talks
    Keywords: Calcium / Physiological effect ; Neural transmission ; Neuroprotective agents ; Neurotransmitter receptors ; Calcium Signaling ; Mitochondria / metabolism ; Neuroprotective Agents / metabolism ; Neurotoxins / toxicity ; Receptors, Neurotransmitter / physiology ; Receptors, N-Methyl-D-Aspartate / metabolism
    Description / Table of Contents: Contents: Excitotoxicity -- Historical background, implication of NMDA receptors and role in acute and chronic disorders -- Pro-survival signaling to gene expression from the NMDA receptor -- Mechanisms of excitotoxicity and role of receptor location and subunit composition -- Signaling to mitochondria in excitotoxicity
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (44 min.) : color, sound).
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  • 7
    Keywords: Central nervous system / Diseases ; Drug development ; Ion Channels ; Neuropharmacology ; Neurotransmitter receptors ; Synapses / Effect of drugs on ; alpha7 Nicotinic Acetylcholine Receptor ; Central Nervous System Diseases / drug therapy ; Drug Discovery ; Ion Channels / physiology ; Neuropharmacology ; Receptors, Neurotransmitter / physiology ; Synapses / drug effects ; Synapses / metabolism ; Synapses / pathology ; Synaptic Transmission
    Description / Table of Contents: Contents: Drug-target selection -- Synaptic targets for CNS treatments: Receptors/ion-channels -- Drug binding at receptors -- Drug discovery process -- Discovery of selective ligands of nicotinic a7 receptors -- Current developments in drug discovery
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (33 min.) : color, sound).
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  • 8
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    London : Henry Stewart Talks
    Keywords: Calcium / Physiological effect ; Neural transmission ; Neuroplasticity ; Synapses / physiology ; Calcium / physiology ; Neuronal Plasticity / physiology ; Neurons / physiology ; Synapses / physiology ; Synaptic Transmission
    Description / Table of Contents: Contents: What is short-term synaptic plasticity? -- Use of quantal analysis to show that plasticity arises presynaptically -- Synaptic depression and the "Depletion Model" -- Relationship of depletion model parameters to binomial statistical parameters -- Refinements to the depletion hypothesis -- Origin of slow phases of depression -- Role of multiple vesicle pools -- Role of vesicle endocytosis -- Role for calcium in recovery -- Why depression is sometimes absent -- Other forms of depression -- Phases of synaptic enhancement: facilitation, augmentation, and potentiation -- Presynaptic electrical events in synaptic enhancement -- Calcium and the nonlinear summation single site hypothesis -- Kinetic components of calcium removal -- Multiple sites of calcium action -- Problems with identifying molecular mediators -- Candidate molecular mediators -- A comprehensive model of presynaptic plasticity -- Other forms of synaptic enhancement -- Computational roles of short-term synaptic plasticity -- Physiological roles of short-term synaptic plasticity
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (54 min.) : color, sound).
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  • 9
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    London : Henry Stewart Talks
    Keywords: Drug development ; Drug targeting ; Protein-protein interactions ; Proteins / Inhibitors ; Drug Design ; Protein Binding / drug effects ; Protein Interaction Mapping ; Proteins / antagonists & inhibitors ; Proteins / metabolism ; Small Molecule Libraries / pharmacology
    Description / Table of Contents: Contents: The druggable proteome -- Objectives -- Five propositions about the druggability of PPI targets -- Classification of PPI targets -- Why are small molecule inhibitors of PPI hard to obtain? -- PPI topology can vary widely -- Classification of PPI interfaces -- Druggability -- Fragment-based lead identification -- Empirical measures of druggability -- Factors affecting druggability -- Computational assessment of PPI druggability with FTMAP -- Evaluating PPI using FTMAP -- Nature of druggable sites in PPI
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (41 min.) : color, sound).
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  • 10
    Keywords: Drug development ; Drugs / Design ; Drugs / Research ; Pharmaceutical chemistry ; Chemistry, Pharmaceutical / methods ; Computational Biology / methods ; Drug Discovery / methods ; Drug Evaluation, Preclinical
    Description / Table of Contents: Contents: Academic targets and the translational gap -- Chemistry & attrition (Reductionism, genomics and high throughput screening) -- Screening diverse compounds (advantages and disadvantages) -- Medicinal chemistry (A pattern recognition discipline) -- Biology and chemistry networks analysis -- Ligand efficiency and selectivity
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 online resource (1 streaming video file (78 min.) : color, sound).
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