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  • 1
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Applications of Modeling in Oral Solid Dosage Form Development and Manufacturing -- Population Balance Models for Pharmaceutical Processes -- A Quantitative Approach to Understand Raw Material Variability -- Discrete Element Modeling of Solid Dosage Manufacturing Processes -- A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products -- Advanced Process Decision Making Using Multivariate Latent Variable Methods -- Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes -- Mathematical Tools for the Quantitative Definition of a Design Space -- Optimization Methodologies for the Production of Pharmaceutical Products -- An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms
    Abstract: This thorough volume aims to provide pharmaceutical engineers with an introduction to the current state of the art in modeling and simulation of pharmaceutical processes and to summarize a number of practical applications of relevant methodologies in drug product development. Chapters include explorations of simulation and modeling methodologies, data collection and analysis, development of novel sensing techniques, development and integration of individual unit models, optimization approaches for data-based models, design space evaluation techniques, informatics-based methodologies, and emerging topics in pharmaceutical process development. As a part of the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and implementation advice that will make the transition into the laboratory as smooth as possible. ℗ Authoritative and cutting edge, Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture seeks to promote research into process systems methodologies and their application in pharmaceutical product and process development, which will undoubtedly become an increasingly important area in the future
    Pages: X, 393 p. 131 illus., 96 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9781493929962
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  • 2
    Keywords: Medicine ; Human Genetics ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use -- The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test -- Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticles -- The Control of Hydrophobic Compound Exposure in In Vitro Tests for Genotoxicity -- The In Vitro Micronucleus Assay and FISH Analysis -- The In Vivo Rodent Micronucleus Test -- Chromosomal Aberration Test Utilities In Vitro and In Vivo -- Chromosome Painting of Mouse Peripheral Blood and Spleen Tissues -- T-Cell Receptor Mutation Assay for Monitoring Human Genotoxic Exposure -- The Human RBC PIG-A Gene Mutation Assay -- The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair Studies -- The Comet Assay: High Throughput Use of FPG -- The Comet Assay In Vivo in Humans -- Analysis of Nanoparticle-Induced DNA Damage by the Comet Assay -- The Comet Assay in Drosophila: Neuroblast and Haemocyte Cells -- The SMART Assays of Drosophila: Wings and Eyes as Target Tissues -- Testing the Genotoxic Potential of Nanomaterials Using Drosophila -- Transgenic Rodent Gene Mutation Assay in Somatic Tissues -- The Mouse Lymphoma Assay -- Bhas 42 Cell Transformation Assay for Genotoxic and Non-Genotoxic Carcinogens -- Methods for Measuring DNA Repair: Introduction and Cellular Repair -- A Standardized Protocol for the In Vitro Comet-Based DNA Repair Assay -- Use of the Comet Assay to Study DNA Repair in Drosophila melanogaster -- Use of RNA Interference to Study DNA Repair -- The LacZ Plasmid-Based Transgenic Mouse Model: An Integrative Approach to Study the Genotoxicity of Nanomaterials
    Abstract: Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the €œÓECD guidelines for the testing of chemicalś€, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. ℗ Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study
    Pages: XII, 483 p. 70 illus., 42 illus. in color. : online resource.
    ISBN: 9781493910687
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  • 3
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Abstract: This volume presents a broad compendium of techniques used in biodegradation and toxicological research. Through both legacy and up-to-date approaches to practical methodologies with proven results, the book examines the role and applications of analytical biodegradation quantification as it applies to the environmental sciences, particularly in the range of byproducts that are usually linked to toxicology, and the test organisms most often used in toxicity testing. Topics include scientific and technical feasibility studies, contaminant impacts evaluation, study design and analytical techniques, key methodologies required to prepare the biodegradation and toxicology protocols, as well as the handling of microbial communities related to such processes. Written for the℗ Methods in Pharmacology and Toxicology℗ series, chapters deal with a critical discussion of laboratory scale experiments, as well as full scale in situ and ex situ apparatus, with each chapter containing both a discursive section along with a detailed methods section. Detailed and authoritative,℗ Toxicity and Biodegradation Testing℗ is primarily focused toward the environmental sciences researcher, while the range of techniques also provides an introduction to biodegradation and toxicology methods for researchers outside of the field
    Pages: XI, 397 p. 90 illus., 26 illus. in color. : online resource.
    ISBN: 9781493974252
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  • 4
    Keywords: Medicine ; Pharmacology ; Cell Cycle ; Apoptosis ; Biomedicine ; Pharmacology/Toxicology ; Cell Cycle Analysis ; Apoptosis ; Springer eBooks
    Description / Table of Contents: An Overview of Apoptosis Methods in Toxicological Research: Recent Updates -- Detection of Apoptosis: From Bench Side to Clinical Practice -- Determining the Extent of Toxicant-Induced Apoptosis Using Concurrent Phased Apoptosis Assays -- Measurement of Apoptosis by Multiparametric Flow Cytometry -- Detecting Apoptosis, Autophagy, and Necrosis -- A Low-Cost Method for Tracking the Induction of Apoptosis Using FRET-Based Activity Sensors in Suspension Cells -- FRET-Based Measurement of Apoptotic Caspase Activities by High-Throughput Screening Flow Cytometry -- Automated Ratio Imaging Using Nuclear-Targeted Fret Probe-Expressing Cells for Apoptosis Detection -- Antibody-Based Proteomic Analysis of Apoptosis Signaling -- Novel Electrochemical Biosensor for Apoptosis Evaluation -- Microplate-Based Whole Zebrafish Caspase 3/7 Assay for Screening Small Molecule Compounds -- Targeting Cancer Cell Death with Small-Molecule Agents for Potential Therapeutics -- Liposomes in Apoptosis Induction and Cancer Therapy
    Abstract: This detailed volume provides a single, valuable reference source for methods that definitively identify and accurately quantify apoptosis. The book begins with common methods utilized to detect and quantitate apoptosis, as well as apoptosis signaling pathways in toxicological and other related research. It continues with multi-parametric and phased apoptosis assays for detecting early and late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughput assays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancer therapeutics targeting apoptosis. Written for the Methods in Pharmacology and Toxicology series, chapters feature step-by-step descriptions of the methodologies, as well as expert tips and implementation advice. Vital and authoritative, Apoptosis Methods in Toxicology serves novice scientists as well as experts, utilizing a range of instruments from common laboratory equipment to high-end expensive and automated machinery capable of performing real time apoptotic measurements
    Pages: X, 244 p. 46 illus., 35 illus. in color. : online resource.
    ISBN: 9781493935888
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  • 5
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Immunotherapy Against Amyloid-β in Alzheimer’s Disease: An Overview -- Active Immunization Against the Amyloid-β Peptide -- Immunotherapy Against N-Truncated Amyloid-β Oligomers -- Immunotherapy Against Amyloid-β Protofibrils: Opportunities and Challenges -- Immunotherapy Against α-Synuclein Pathology -- Extracellular α-Synuclein as a Target for Immunotherapy -- Immunotherapy of Parkinson’s Disease -- Tau Immunotherapy -- Active and Passive Immunotherapy Against Tau: Effects and Potential Mechanisms -- Immunotherapy on Experimental Models for Huntington’s Disease -- Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease -- Volumetric MRI as a Diagnostic Tool in Alzheimer's Disease -- PET Imaging as a Diagnostic Tool in Alzheimer´s Disease -- Αlpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Disease -- Imaging as a Diagnostic Tool in Parkinson’s Disease -- Mass Spectrometry-Based Proteomics in Biomarker Discovery for Neurodegenerative Diseases
    Abstract: This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer’s disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson’s disease and Huntington’s disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab. Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases
    Pages: X, 289 p. 40 illus., 32 illus. in color. : online resource.
    ISBN: 9781493935604
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  • 6
    Keywords: Pharmaceutical technology ; Cancer Research ; Immunology ; Pharmaceutical Sciences/Technology ; Cancer Research ; Immunology ; Springer eBooks
    Description / Table of Contents: An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies -- High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry -- In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis -- Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays -- Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates -- Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay -- 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment -- Considerations in Developing Reporter Gene Bioassays for Biologics -- Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies -- Precision Medicine: The Function of Receptor Occupancy in Drug Development -- In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics -- The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era
    Abstract: This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics
    Pages: X, 262 p. 91 illus., 83 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071601716
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  • 7
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery -- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7 -- Visual G Protein-Coupled Receptor Kinases -- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily -- “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs -- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications -- Differential Regulation of IGF-1 and Insulin Signaling by GRKs -- Differential Control of Potassium Channel Activity by GRK2 -- Critical Role of GRK2 in the Prevention of Chronic Pain -- Roles of GRK Dysfunction in Alzheimer’s Pathogenesis -- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases -- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation -- GRK Roles in C. elegans -- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway
    Abstract: This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies
    Pages: XI, 329 p. 36 illus., 33 illus. in color. : online resource.
    ISBN: 9781493937981
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  • 8
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors -- Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies -- Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells -- Histamine H2 Receptor Biased Signaling Methods -- Ligand-Binding Kinetics on Histamine Receptors -- Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor -- Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst -- Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils -- Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis -- Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy -- Histamine and the Kidney: In Vivo Animal Models -- Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer -- Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels -- Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis -- In Vivo Diagnostic Procedures for IgE-Mediated Allergic Disorders -- Dermatological Indications of Antihistamines -- Histamine Quantification in Human Blood Samples
    Abstract: This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area
    Pages: XVI, 517 p. 138 illus., 93 illus. in color. : online resource.
    ISBN: 9781493968435
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  • 9
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Cheminformatics Approaches to Study Drug Polypharmacology -- Computational Predictions for Multi-Target Drug Design -- Computational Multi-Target Drug Design -- Multi-Target Drug Design for Neurodegenerative Diseases -- Molecular Docking Studies in Multi-Target Antitubercular Drug Discovery -- Advanced Chemometric Modeling Approaches for the Design of Multi-Target Drugs against Neurodegenerative Diseases -- Computational Studies on Natural Products for the Development of Multi-Target Drugs -- Computational Design of Multi-Target Drugs against Alzheimer’s Disease -- Design of Multi-Target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease -- Virtual Screening for Dual Hsp90/B-Raf Inhibitors -- Strategies for Multi-Target Directed Ligands: Application in Alzheimer's Disease (AD) Therapeutics -- Computational Design of Multi-Target Kinase Inhibitors -- Proteochemometrics for the Prediction of Peptide Binding to Multiple HLA Class II Proteins -- Linked Open Data: Ligand-Transporter Interaction Profiling and Beyond -- Design of Novel Dual Target Hits against Malaria and Tuberculosis Using Computational Docking -- Computational Design of Multi-Target Drugs against Breast Cancer -- Computational Methods for Multi-Target Drug Designing against Mycobacterium tuberculosis -- Development of a Web-Server for Identification of Common Lead Molecules for Multiple Protein Targets -- Computational Method for Prediction of Targets for Breast Cancer Using siRNAs Approach -- Historeceptomics: Integrating a Drug's Multiple Targets (Polypharmacology) with Their Expression Pattern in Human Tissues -- Networking of Smart Drugs: A Chem-Bioinformatic Approach to Cancer Treatment
    Abstract: This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design are also featured in this collection. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of key implementation advice that will aid researchers greatly in their laboratory pursuits. Authoritative and practical, Multi-Target Drug Design Using Chem-Bioinformatic Approaches seeks to aid all scientists working in the field of drug discovery research
    Pages: XVI, 563 p. 100 illus., 90 illus. in color. : online resource.
    ISBN: 9781493987337
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  • 10
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space” -- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk -- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology -- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes -- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential -- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions -- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems -- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes -- Decoding Ca2+ Signals as a Non-Electrophysiological Method for Assessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes -- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes -- Edge Detection for Contractility Measurements with Cardiac Spheroids -- Contractile Force Readout of hESC-Cardiomyocytes -- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models -- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes -- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA) -- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies
    Abstract: This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design
    Pages: XII, 341 p. 124 illus., 108 illus. in color. : online resource.
    ISBN: 9781493966615
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