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  • 1
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research -- Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery -- Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction -- Physicochemical Properties and Structural Alerts -- Quantitative Structure-Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans -- An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury -- Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities -- Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury -- Evaluation of Drug-induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches -- Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing -- Engineered Human Liver Co-Cultures for Investigating Drug-Induced Liver Injury -- Status and Future of 3D Cell Culture in Toxicity Testing -- Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design -- In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury -- Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches -- High Content Screening for Prediction of Human Drug-Induced Liver Injury -- Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge -- Perspectives on the Regulatory and Clinical Science of Drug-Induced Liver Injury (DILI) -- Regulatory Toxicological Studies: Identifying Drug-Induced Liver Injury Using Nonclinical Studies -- Hy’s Law and eDISH for Clinical Studies -- Variability in Baseline Liver Test Values in Clinical Trials: Challenges in Enhancing Drug-Induced Liver Injury Assessment in Subjects with Liver Disease -- Postmarketing Surveillance of Drug-Induced Liver Injury -- Host Risk Modifiers in Idiosyncratic Drug-Induced Liver Injury (DILI) and Its Interplay with Drug Properties -- Human Leukocyte Antigen (HLA) and Other Genetic Risk Factors in Drug-Induced Liver Injury (DILI) -- Immune Mechanisms in Drug-Induced Liver Injury -- Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury -- Causality Assessment Methods in Drug-Induced Liver Injury -- Circulating MicroRNAs as Novel Biomarkers of Drug-Induced Liver Injury in Humans -- Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI) -- Non-Invasive Pre-Clinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury
    Abstract: This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com
    Pages: XX, 667 p. 119 illus., 70 illus. in color. : online resource.
    ISBN: 9781493976775
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  • 2
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides -- Fabrication of cRGD Conjugated Dual Responsive Micelles to Target ÎłvÎø5℗ Integrin Overexpressed Cancer.-℗ Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy.-℗ Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides -- Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins.-℗ 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer -- Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures -- Integrin ÎłvÎø3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide -- Integrin Targeting Using RGD-Based Peptide Amphiphiles -- Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting -- Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors.-℗ NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780 -- Synergistic Active Targeting to B16F10 Tumors by ÎłvÎø3/CD44-Targeted Nanoparticles Loaded with Docetaxel
    Abstract: This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.℗ Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research
    Pages: XI, 226 p. 68 illus. : online resource.
    ISBN: 9781493974450
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  • 3
    Keywords: Medicine ; Toxicology ; Oncology ; Biomedicine ; Pharmacology/Toxicology ; Oncology ; Springer eBooks
    Description / Table of Contents: Combining Computational and Experimental Methods for Identifying Molecular Targets of Phytochemicals -- Common Methods Used for the Discovery of Natural Anticancer Compounds -- Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals -- Methods to Analyze Chemopreventive Effect of Silibinin on Prostate Cancer Biomarkers Protein Expression -- An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer -- The Use of Mouse Models for Lung Cancer Chemoprevention Studies -- The Azoxymethane Plus Dextran Sulfate Sodium-Induced Mouse Colon Cancer Model for the Study of Dietary Chemoprevention of Inflammation-Associated Carcinogenesis -- The Use of Seahorse Extracellular Flux Analyzer in Mechanistic Studies of Naturally-Occurring Cancer Chemopreventive Agents -- Utilizing RNA-Seq to Define Phytochemical-Induced Alterations in Insulin and IGF Regulated Transcriptomes -- The Ex Vivo Use of Keratinocytes from Adult Mice to Define Stem Cell Activities in Cancer Research -- Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Alcohol Consumption -- Imaging Tools in Discovery and Development of Phytochemical Chemopreventive Agents -- Designing the Chemoprevention Trials of Tomorrow: Applying Lessons Learned from Past Definitive Trials
    Abstract: Focused on the discovery of precise molecular targets for the development of the cancer preventive agents, Cancer Prevention: Dietary Factors and Pharmacology provides researchers and non-researchers with practical methodologies for developing and validating small molecule and phytochemical-derived drug discovery and mechanisms by which these compounds can modulate distinct target proteins involved in oncogenic signaling. While this volume is primarily focused toward cancer prevention research, the range of techniques demonstrated in the book also provides an introduction of cancer prevention research methods to researchers outside the field. Chapters deal with a critical discussion of both laboratory and clinical topics, with each chapter containing both a discursive section along with a detailed methods section. As part of the Methods in Pharmacology and Toxicology series, this meticulous volume includes the kind of key implementation advice that seeks to ensure successful results in the lab. Practical and authoritative, Cancer Prevention: Dietary Factors and Pharmacology aims to guide research toward identifying molecular targets and conducting human studies with phytochemicals which would, ideally, provide an enhanced approach to the goal of personalized cancer prevention
    Pages: XV, 288 p. 48 illus., 32 illus. in color. : online resource.
    ISBN: 9781461492276
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  • 4
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Congenital Malformations -- Pharmacovigilance and the Eye -- Pharmacovigilance of Herbal and Traditional Medicines -- Pediatric Pharmacovigilance: Current Practice and Future Perspectives -- Detecting Safety Issues in Clinical Trials -- Developments and Future Directions of Prescription-Based Observational Cohort Pharmacovigilance -- Electronic Health Record, Transactional Insurance Claims, and Distributed Databases in Pharmacovigilance -- Patient Registries for Safetyness -- Patient-Reported Outcomes in Pharmacovigilance -- Evidence-Based Pharmacovigilance for Medicines Used in Public Health Programs in Africa -- Pharmacoepidemiological Approaches for Population-Based Hypothesis Testing -- Risk Management and Minimization -- Benefit-Risk Assessment in Pharmacovigilance -- Concluding Thoughts
    Abstract: This book examines insights into the latest thinking and core concepts in areas of key methodological endeavor in Pharmacovigilance (PV), which strives to ever more effectively protect patients from harm caused by the medicines they need. Each book chapter tends to have a clear quantitative or clinical slant and an aim to provide an overview of methodological insights within a specific topic, while also providing a perspective on how the area is anticipated to develop in the future. Quantitative chapters focus more on statistical and epidemiological strategies and the thinking that underpins core developments in Pharmacovigilance, whereas clinical chapters focus on clinical methods for detecting hypotheses for and determining side effects of medicinal products as well as misdiagnosis pitfalls. Examples of areas of importance include signal detection, risk management, and risk benefit assessment. Vital and authoritative, Evidence-Based Pharmacovigilance: Clinical and Quantitative Aspects aims to provide readers with a sense of the advances that have occurred in pharmacovigilance methods and approaches, as well as inspiration and motivation to advance the field of pharmacovigilance with a strong sense that there is much more work to be done in ensuring the safe use of medications by patients
    Pages: XV, 275 p. 36 illus., 27 illus. in color. : online resource.
    ISBN: 9781493988181
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  • 5
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors -- Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies -- Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells -- Histamine H2 Receptor Biased Signaling Methods -- Ligand-Binding Kinetics on Histamine Receptors -- Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor -- Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst -- Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils -- Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis -- Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy -- Histamine and the Kidney: In Vivo Animal Models -- Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer -- Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels -- Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis -- In Vivo Diagnostic Procedures for IgE-Mediated Allergic Disorders -- Dermatological Indications of Antihistamines -- Histamine Quantification in Human Blood Samples
    Abstract: This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area
    Pages: XVI, 517 p. 138 illus., 93 illus. in color. : online resource.
    ISBN: 9781493968435
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  • 6
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Characterization of Formulations for Freeze Drying -- Formulation and Process Development for Lyophilized Biological Reference Materials -- Controlled Ice Nucleation Using ControLyo® Pressurization-Depressurization Method -- Alternative Methods of Controlling Nucleation in Freeze Drying -- Tunable Diode Laser Absorption Spectroscopy in Lyophilization -- Containment Options for the Freeze-Drying of Biological Entities and Potent Materials -- Freeze Drying Systems: Freeze Dryer Design Requirements & Automatic Loading and Unloading Systems (ALUS™) -- Regulatory Aspects of Freeze Drying -- Container and Reconstitution Systems for Lyophilized Drug Products -- Scale-Up of Freeze-Drying Cycles, the Use of Process Analytical Technology (PAT) and Statistical Analysis -- Through Vial Impedance Spectroscopy (TVIS): A Novel Approach to Process Understanding for Freeze-Drying Cycle Development -- Lyophilization of High-Concentration Protein Formulations -- Mechanical Behavior and Structure of Freeze Dried Cakes -- High Resolution Mass Spectrometric Methods for Proteins in Lyophilized Solids
    Abstract: This detailed volume brings together leading practitioners in the freeze-drying community to address recent progress, not only in new analytical tools and applications of the data derived in cycle design but also in the manufacturing of lyophilized products in the healthcare sector – whether these be therapeutics, vaccines or diagnostic products - and indeed the equipment to deliver this scale of freeze-drying. Areas of focus include analytical and formulation issues, process monitoring and control, as well as post-lyophilization analysis. Written for the Methods in Pharmacology and Toxicology series, chapters include the type of expert advice that leads to superior results in the lab. Authoritative and practical, Lyophilization of Pharmaceuticals and Biologicals: New Technologies and Approaches serves as an ideal guide for researchers working in or just seeking an update on this rapidly changing field
    Pages: XIV, 382 p. 188 illus., 148 illus. in color. : online resource.
    ISBN: 9781493989287
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  • 7
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Cheminformatics Approaches to Study Drug Polypharmacology -- Computational Predictions for Multi-Target Drug Design -- Computational Multi-Target Drug Design -- Multi-Target Drug Design for Neurodegenerative Diseases -- Molecular Docking Studies in Multi-Target Antitubercular Drug Discovery -- Advanced Chemometric Modeling Approaches for the Design of Multi-Target Drugs against Neurodegenerative Diseases -- Computational Studies on Natural Products for the Development of Multi-Target Drugs -- Computational Design of Multi-Target Drugs against Alzheimer’s Disease -- Design of Multi-Target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease -- Virtual Screening for Dual Hsp90/B-Raf Inhibitors -- Strategies for Multi-Target Directed Ligands: Application in Alzheimer's Disease (AD) Therapeutics -- Computational Design of Multi-Target Kinase Inhibitors -- Proteochemometrics for the Prediction of Peptide Binding to Multiple HLA Class II Proteins -- Linked Open Data: Ligand-Transporter Interaction Profiling and Beyond -- Design of Novel Dual Target Hits against Malaria and Tuberculosis Using Computational Docking -- Computational Design of Multi-Target Drugs against Breast Cancer -- Computational Methods for Multi-Target Drug Designing against Mycobacterium tuberculosis -- Development of a Web-Server for Identification of Common Lead Molecules for Multiple Protein Targets -- Computational Method for Prediction of Targets for Breast Cancer Using siRNAs Approach -- Historeceptomics: Integrating a Drug's Multiple Targets (Polypharmacology) with Their Expression Pattern in Human Tissues -- Networking of Smart Drugs: A Chem-Bioinformatic Approach to Cancer Treatment
    Abstract: This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design are also featured in this collection. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of key implementation advice that will aid researchers greatly in their laboratory pursuits. Authoritative and practical, Multi-Target Drug Design Using Chem-Bioinformatic Approaches seeks to aid all scientists working in the field of drug discovery research
    Pages: XVI, 563 p. 100 illus., 90 illus. in color. : online resource.
    ISBN: 9781493987337
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  • 8
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: High-Throughput Techniques for DNA Methylation Profiling -- Reduced Representation Bisulfite Sequencing (RRBS) and Cell Sorting Prior to DNA Methylation Analysis in Psychiatric Disorders -- Targeted DNA Methylation Analysis Methods -- Analyzing Targeted Nucleosome Position and Occupancy in Cancer, Obesity, and Diabetes -- Synthesis and Application of Cell-Permeable Metabolites for Modulating Chromatin Modifications Regulated by a-Ketoglutarate-Dependent Enzymes -- High-Throughput Screening of Small Molecule Transcriptional Regulators in Embryonic Stem Cells Using qRT-PCR -- Methods for MicroRNA Profiling in Cancer -- Microbiota and Epigenetic Regulation of Inflammatory Mediators -- Optical Microscopy and Spectroscopy for Epigenetic Modifications in Single Living Cells -- MicroRNAs in Therapy and Toxicity -- Genetics and Epigenetics of Multiple Sclerosis
    Abstract: This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicologyseries, the book includes the kind of detail and implementation advice to encourage success in the lab. Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics
    Pages: XII, 197 p. 38 illus., 22 illus. in color. : online resource.
    ISBN: 9781493967438
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  • 9
    Keywords: Medicine ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Histopathology: A Canvas and Landscape of Disease in Drug and Diagnostic Development -- A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise -- Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives -- Histopathology in Mouse Models of Rheumatoid Arthritis -- Markers Used for Visualization and Quantification of Blood Vessels and Lymphatic Vessels -- Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity -- Quantitative Histopathology and Alternative Approaches to Assessment of Fibrosis for Drug Development in Hepatitis C and Nonalcoholic Steatohepatitis -- Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms -- Image Analysis Tools for Quantification of Spinal Motor Neuron Subtype Identities -- Development of a Tissue Image Analysis Algorithm for Celiac Drug Development -- Quantitative Histopathology for Evaluation of In Vivo Biocompatibility Associated with Biomedical Implants -- Quantitative Histomorphometry and Quantitative Polymerase Chain Reaction (PCR) as Assessment Tools for Product Development -- Measuring the Messenger: RNA Histology in Formalin Fixed Tissues -- Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues -- Solid Tissue-Based DNA Analysis by FISH in Research and Molecular Diagnostics -- Preanalytic Considerations for Molecular Genomic Analyses of Tissue -- Next Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice -- The Impact of Pre-Analytic Variables on Tissue Quality from Clinical Samples Collected in a Routine Clinical Setting: Implications for Diagnostic Evaluation, Drug Discovery, and Translational Research -- Adapting HER2 Testing for a Different Organ:℗ New Wine in Old Wineskins -- Tissue-Based Companion Diagnostics:℗ Development of IHC Assays from an Industry Perspective -- Development of Tissue-Based Companion Diagnostics:℗ The Relationship Between the Pharmaceutical Company, Diagnostic Partner, and the Biomarker Laboratory -- Navigating Regulatory Approval for Tissue-Based Companion Diagnostics -- Implementing a Multi-Analyte Immunohistochemistry Panel into a Drug Development Program -- Cutpoint Analysis and Related Statistical Methods in Digital Pathology and Companion Diagnostics
    Abstract: Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development gathers diverse experts to present state of the art guidance and application of histopathology in drug development settings ranging from discovery research to human clinical trials. While many current applications of quantitative histology and molecular pathology in the biopharmaceutical industry are focused on oncology, this volume in addition explores non-oncologic disease areas including nonalcoholic steatohepatitis, arthritis, celiac disease, myeloproliferative disorders, neurology, and wound healing. The authors write from years of experience in diagnostic practice and pharmaceutical drug development, aiming to educate pharmaceutical and academic scientists how to best use tissue to diagnose disease and improve the process of drug development.℗ As part of the Methods in Pharmacology and Toxicology series, this volume is designed to provide wisdom and examples that others can follow and apply as part of drug development. ℗ Comprehensive and practical, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will inform and enlighten both tissue-focused and non-tissue-focused drug development professionals about better use and interpretation of the multidimensional data contained in a tissue biopsy
    Pages: XVIII, 375 p. 57 illus., 37 illus. in color. : online resource.
    ISBN: 9781493926817
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  • 10
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus -- Critical Periods of Development in Teratology -- Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies -- A Developmental and Reproductive Toxicology Program for Chemical Registration -- The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility -- Effects of Chemicals on Mammary Gland Development -- Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals -- Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies -- High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays
    Abstract: This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy℗ as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the℗ Methods in Pharmacology and Toxicology℗ series, this collection includes the kind of detailed implementation advice necessary for success in the lab.℗ Authoritative and practical,℗ Developmental and Reproductive Toxicology℗ is an ideal resourc e for researchers working in this vital field of study
    Pages: XII, 314 p. 24 illus., 17 illus. in color. : online resource.
    ISBN: 9781493972081
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