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  • 1
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides -- Fabrication of cRGD Conjugated Dual Responsive Micelles to Target ÎłvÎø5℗ Integrin Overexpressed Cancer.-℗ Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy.-℗ Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides -- Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins.-℗ 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer -- Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures -- Integrin ÎłvÎø3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide -- Integrin Targeting Using RGD-Based Peptide Amphiphiles -- Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting -- Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors.-℗ NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780 -- Synergistic Active Targeting to B16F10 Tumors by ÎłvÎø3/CD44-Targeted Nanoparticles Loaded with Docetaxel
    Abstract: This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.℗ Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research
    Pages: XI, 226 p. 68 illus. : online resource.
    ISBN: 9781493974450
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  • 2
    Keywords: Medicine ; Pharmacology ; Cell Cycle ; Apoptosis ; Biomedicine ; Pharmacology/Toxicology ; Cell Cycle Analysis ; Apoptosis ; Springer eBooks
    Description / Table of Contents: An Overview of Apoptosis Methods in Toxicological Research: Recent Updates -- Detection of Apoptosis: From Bench Side to Clinical Practice -- Determining the Extent of Toxicant-Induced Apoptosis Using Concurrent Phased Apoptosis Assays -- Measurement of Apoptosis by Multiparametric Flow Cytometry -- Detecting Apoptosis, Autophagy, and Necrosis -- A Low-Cost Method for Tracking the Induction of Apoptosis Using FRET-Based Activity Sensors in Suspension Cells -- FRET-Based Measurement of Apoptotic Caspase Activities by High-Throughput Screening Flow Cytometry -- Automated Ratio Imaging Using Nuclear-Targeted Fret Probe-Expressing Cells for Apoptosis Detection -- Antibody-Based Proteomic Analysis of Apoptosis Signaling -- Novel Electrochemical Biosensor for Apoptosis Evaluation -- Microplate-Based Whole Zebrafish Caspase 3/7 Assay for Screening Small Molecule Compounds -- Targeting Cancer Cell Death with Small-Molecule Agents for Potential Therapeutics -- Liposomes in Apoptosis Induction and Cancer Therapy
    Abstract: This detailed volume provides a single, valuable reference source for methods that definitively identify and accurately quantify apoptosis. The book begins with common methods utilized to detect and quantitate apoptosis, as well as apoptosis signaling pathways in toxicological and other related research. It continues with multi-parametric and phased apoptosis assays for detecting early and late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughput assays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancer therapeutics targeting apoptosis. Written for the Methods in Pharmacology and Toxicology series, chapters feature step-by-step descriptions of the methodologies, as well as expert tips and implementation advice. Vital and authoritative, Apoptosis Methods in Toxicology serves novice scientists as well as experts, utilizing a range of instruments from common laboratory equipment to high-end expensive and automated machinery capable of performing real time apoptotic measurements
    Pages: X, 244 p. 46 illus., 35 illus. in color. : online resource.
    ISBN: 9781493935888
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  • 3
    Keywords: Medicine ; Toxicology ; Oncology ; Biomedicine ; Pharmacology/Toxicology ; Oncology ; Springer eBooks
    Description / Table of Contents: Combining Computational and Experimental Methods for Identifying Molecular Targets of Phytochemicals -- Common Methods Used for the Discovery of Natural Anticancer Compounds -- Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals -- Methods to Analyze Chemopreventive Effect of Silibinin on Prostate Cancer Biomarkers Protein Expression -- An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer -- The Use of Mouse Models for Lung Cancer Chemoprevention Studies -- The Azoxymethane Plus Dextran Sulfate Sodium-Induced Mouse Colon Cancer Model for the Study of Dietary Chemoprevention of Inflammation-Associated Carcinogenesis -- The Use of Seahorse Extracellular Flux Analyzer in Mechanistic Studies of Naturally-Occurring Cancer Chemopreventive Agents -- Utilizing RNA-Seq to Define Phytochemical-Induced Alterations in Insulin and IGF Regulated Transcriptomes -- The Ex Vivo Use of Keratinocytes from Adult Mice to Define Stem Cell Activities in Cancer Research -- Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Alcohol Consumption -- Imaging Tools in Discovery and Development of Phytochemical Chemopreventive Agents -- Designing the Chemoprevention Trials of Tomorrow: Applying Lessons Learned from Past Definitive Trials
    Abstract: Focused on the discovery of precise molecular targets for the development of the cancer preventive agents, Cancer Prevention: Dietary Factors and Pharmacology provides researchers and non-researchers with practical methodologies for developing and validating small molecule and phytochemical-derived drug discovery and mechanisms by which these compounds can modulate distinct target proteins involved in oncogenic signaling. While this volume is primarily focused toward cancer prevention research, the range of techniques demonstrated in the book also provides an introduction of cancer prevention research methods to researchers outside the field. Chapters deal with a critical discussion of both laboratory and clinical topics, with each chapter containing both a discursive section along with a detailed methods section. As part of the Methods in Pharmacology and Toxicology series, this meticulous volume includes the kind of key implementation advice that seeks to ensure successful results in the lab. Practical and authoritative, Cancer Prevention: Dietary Factors and Pharmacology aims to guide research toward identifying molecular targets and conducting human studies with phytochemicals which would, ideally, provide an enhanced approach to the goal of personalized cancer prevention
    Pages: XV, 288 p. 48 illus., 32 illus. in color. : online resource.
    ISBN: 9781461492276
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  • 4
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Characterization of Formulations for Freeze Drying -- Formulation and Process Development for Lyophilized Biological Reference Materials -- Controlled Ice Nucleation Using ControLyo® Pressurization-Depressurization Method -- Alternative Methods of Controlling Nucleation in Freeze Drying -- Tunable Diode Laser Absorption Spectroscopy in Lyophilization -- Containment Options for the Freeze-Drying of Biological Entities and Potent Materials -- Freeze Drying Systems: Freeze Dryer Design Requirements & Automatic Loading and Unloading Systems (ALUS™) -- Regulatory Aspects of Freeze Drying -- Container and Reconstitution Systems for Lyophilized Drug Products -- Scale-Up of Freeze-Drying Cycles, the Use of Process Analytical Technology (PAT) and Statistical Analysis -- Through Vial Impedance Spectroscopy (TVIS): A Novel Approach to Process Understanding for Freeze-Drying Cycle Development -- Lyophilization of High-Concentration Protein Formulations -- Mechanical Behavior and Structure of Freeze Dried Cakes -- High Resolution Mass Spectrometric Methods for Proteins in Lyophilized Solids
    Abstract: This detailed volume brings together leading practitioners in the freeze-drying community to address recent progress, not only in new analytical tools and applications of the data derived in cycle design but also in the manufacturing of lyophilized products in the healthcare sector – whether these be therapeutics, vaccines or diagnostic products - and indeed the equipment to deliver this scale of freeze-drying. Areas of focus include analytical and formulation issues, process monitoring and control, as well as post-lyophilization analysis. Written for the Methods in Pharmacology and Toxicology series, chapters include the type of expert advice that leads to superior results in the lab. Authoritative and practical, Lyophilization of Pharmaceuticals and Biologicals: New Technologies and Approaches serves as an ideal guide for researchers working in or just seeking an update on this rapidly changing field
    Pages: XIV, 382 p. 188 illus., 148 illus. in color. : online resource.
    ISBN: 9781493989287
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  • 5
    Keywords: Toxicology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Cheminformatics Approaches to Study Drug Polypharmacology -- Computational Predictions for Multi-Target Drug Design -- Computational Multi-Target Drug Design -- Multi-Target Drug Design for Neurodegenerative Diseases -- Molecular Docking Studies in Multi-Target Antitubercular Drug Discovery -- Advanced Chemometric Modeling Approaches for the Design of Multi-Target Drugs against Neurodegenerative Diseases -- Computational Studies on Natural Products for the Development of Multi-Target Drugs -- Computational Design of Multi-Target Drugs against Alzheimer’s Disease -- Design of Multi-Target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease -- Virtual Screening for Dual Hsp90/B-Raf Inhibitors -- Strategies for Multi-Target Directed Ligands: Application in Alzheimer's Disease (AD) Therapeutics -- Computational Design of Multi-Target Kinase Inhibitors -- Proteochemometrics for the Prediction of Peptide Binding to Multiple HLA Class II Proteins -- Linked Open Data: Ligand-Transporter Interaction Profiling and Beyond -- Design of Novel Dual Target Hits against Malaria and Tuberculosis Using Computational Docking -- Computational Design of Multi-Target Drugs against Breast Cancer -- Computational Methods for Multi-Target Drug Designing against Mycobacterium tuberculosis -- Development of a Web-Server for Identification of Common Lead Molecules for Multiple Protein Targets -- Computational Method for Prediction of Targets for Breast Cancer Using siRNAs Approach -- Historeceptomics: Integrating a Drug's Multiple Targets (Polypharmacology) with Their Expression Pattern in Human Tissues -- Networking of Smart Drugs: A Chem-Bioinformatic Approach to Cancer Treatment
    Abstract: This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design are also featured in this collection. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of key implementation advice that will aid researchers greatly in their laboratory pursuits. Authoritative and practical, Multi-Target Drug Design Using Chem-Bioinformatic Approaches seeks to aid all scientists working in the field of drug discovery research
    Pages: XVI, 563 p. 100 illus., 90 illus. in color. : online resource.
    ISBN: 9781493987337
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  • 6
    Keywords: Medicine ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Label-Free Technologies: Which Technique to Use and What to Watch Out For! -- Label-Free Cell Phenotypic Profiling and Screening: Techniques, Experimental Design, and Data Assessment -- Surface Plasmon Resonance for Therapeutic Antibody Characterization -- Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysis -- Kinetics Characterization of Ligand-Receptor Interactions Using Oblique-Incidence Reflectivity Difference Method -- Label-Free Inhibition in Solution Assays for Fragment Screening -- Silicon Photonic Micro-Ring Resonators for Drug Screening and Kinetic Analysis -- Optical Waveguide Light-Mode Spectroscopy for Ion Channel Profiling -- Label-Free Profiling of Endogenous Receptor Responses in Primary Isolated Cardiac Cells -- Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells -- Triple-Addition Label-Free Assays for High Throughput Screening of Muscarinic M1 Receptor Agonists, Antagonists, and Allosteric Modulators -- Multiplexing Label-Free and Florescence-Based Methods for Pharmacological Characterization of GPCR Ligands -- Label-Free Cell Phenotypic Identification of Active Compounds in Traditional Chinese Medicines -- Use of the Quartz Crystal Microbalance with Dissipation Monitoring for Pharmacological Evaluation of Cell Signaling Pathways Mediated by Epidermal Growth Factor Receptors -- Profiling Sodium-Dependent Phosphate Transporter NaPi-IIb with Resonant Waveguide Grating Biosensor -- Label-Free Impedance Measurements for Profiling Drug-Induced Cardiotoxicity -- Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening -- Label-Free Profiling of Cell Adhesion: Determination of the Dissociation Constant for Native Cell Membrane Adhesion Receptor-Ligand Interaction -- Label-Free Impedance-Based Monitoring of Cell Migration and Invasion -- Infrared Surface Plasmon Spectroscopy Decodes Early Processes in Epithelial Host Cells Upon Enteropathogenic Escherichia coli Infection -- Surface Plasmon Resonance for Clinical Diagnosis of Type I Allergy
    Abstract: This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field
    Pages: XI, 390 p. 114 illus., 93 illus. in color. : online resource.
    ISBN: 9781493926176
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  • 7
    Keywords: Medicine ; Human Genetics ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use -- The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test -- Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticles -- The Control of Hydrophobic Compound Exposure in In Vitro Tests for Genotoxicity -- The In Vitro Micronucleus Assay and FISH Analysis -- The In Vivo Rodent Micronucleus Test -- Chromosomal Aberration Test Utilities In Vitro and In Vivo -- Chromosome Painting of Mouse Peripheral Blood and Spleen Tissues -- T-Cell Receptor Mutation Assay for Monitoring Human Genotoxic Exposure -- The Human RBC PIG-A Gene Mutation Assay -- The Applicable Use of the HPRT Gene Mutation Assay as a Practical Tool in Mutagenesis and DNA Repair Studies -- The Comet Assay: High Throughput Use of FPG -- The Comet Assay In Vivo in Humans -- Analysis of Nanoparticle-Induced DNA Damage by the Comet Assay -- The Comet Assay in Drosophila: Neuroblast and Haemocyte Cells -- The SMART Assays of Drosophila: Wings and Eyes as Target Tissues -- Testing the Genotoxic Potential of Nanomaterials Using Drosophila -- Transgenic Rodent Gene Mutation Assay in Somatic Tissues -- The Mouse Lymphoma Assay -- Bhas 42 Cell Transformation Assay for Genotoxic and Non-Genotoxic Carcinogens -- Methods for Measuring DNA Repair: Introduction and Cellular Repair -- A Standardized Protocol for the In Vitro Comet-Based DNA Repair Assay -- Use of the Comet Assay to Study DNA Repair in Drosophila melanogaster -- Use of RNA Interference to Study DNA Repair -- The LacZ Plasmid-Based Transgenic Mouse Model: An Integrative Approach to Study the Genotoxicity of Nanomaterials
    Abstract: Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the €œÓECD guidelines for the testing of chemicalś€, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. ℗ Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study
    Pages: XII, 483 p. 70 illus., 42 illus. in color. : online resource.
    ISBN: 9781493910687
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  • 8
    Keywords: Medicine ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology -- Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models -- Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues -- Chemistry, Manufacturing, and Control of Ophthalmic Formulations -- ADME and Ocular Therapeutics: Retina -- Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs -- Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development -- The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings -- Study Design and Methodologies for Evaluation of Anti-Glaucoma Drugs -- Study Design and Methodologies for Study of Ocular Medical Devices -- Methodologies for Microscopic Characterization of Ocular Toxicity -- Nanoparticles for Drug and Gene Delivery in Treating Diseases of the Eye
    Abstract: Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies.℗ Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs.℗ As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results. ℗ Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures
    Pages: X, 323 p. 90 illus., 54 illus. in color. : online resource.
    ISBN: 9781627037457
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  • 9
    Keywords: Medicine ; Toxicology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Small Molecule Formulation Screening Strategies in Drug Discovery -- Assessment of Drug Plasma Protein Binding in Drug Discovery -- Drug Partition in Red Blood Cells -- Permeability Assessment Using 5-Day Cultured Caco-2 Cell Monolayers -- In Situ Single Pass Perfused Rat Intestinal Model -- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes -- Metabolic Assessment in Alamethicin-Activated Liver Microsomes: Co-Activating CYPs and UGTs -- Phenotyping UDP-Glucuronosyltransferases (UGTs) Involved in Human Drug Metabolism: An Update -- In Vitro CYP/FMO Reaction Phenotyping -- Human Pregnane X Receptor (hPXR) Activation Assay in Stable Cell Lines -- Characterization of Constitutive Androstane Receptor (CAR) Activation -- DNA Binding (Gel Retardation Assay) Analysis for Identification of Aryl Hydrocarbon (Ah) Receptor Agonists and Antagonists -- Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators -- In Vitro CYP Induction Using Human Hepatocytes -- Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes -- Evaluation of Time-Dependent CYP3A4 Inhibition Using Human Hepatocytes -- Rapidly Distinguishing Reversible and Time-Dependent CYP450 Inhibition Using Human Liver Microsomes, Co-Incubation, and Continuous Fluorometric Kinetic Analyses -- Identification of Time-Dependent CYP Inhibitors Using Human Liver Microsomes (HLM) -- CYP Time-Dependent Inhibition (TDI) Using an IC50 Shift Assay with Stable Isotopic Labeled Substrate Probes to Facilitate Liquid Chromatography/Mass Spectrometry Analyses -- Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors -- In Vitro Characterization of Intestinal Transporter, Breast Cancer Resistance Protein (BCRP) -- In Vitro Characterization of Intestinal and Hepatic Transporters: MRP2 -- In Vitro Characterization of Hepatic Transporters OATP1B1 and OATP1B3 -- In Vitro Characterization of Renal Transporters OAT1, OAT3, and OCT2 -- General Guidelines for Setting Up an In Vitro LC/MS/MS Assay -- Metabolite Identification in Drug Discovery -- Drug, Lipid, and Acylcarnitine Profiling Using Dried Blood Spot (DBS) Technology in Drug Discovery -- In Vitro Trapping and Screening of Reactive Metabolites Using Liquid Chromatography-Mass Spectrometry -- Quantitative Assessment of Reactive Metabolites -- In Vitro Assessment of the Reactivity of Acyl Glucuronides -- In Vitro COMET Assay for Testing Genotoxicity of Chemicals -- Assessing DNA Damage Using a Reporter Gene System -- Improved AMES Test for Genotoxicity Assessment of Drugs: Preincubation Assay Using a Low Concentration of Dimethyl Sulfoxide -- Methods for Using the Mouse Lymphoma Assay to Screen for Chemical Mutagenicity and Photo-Mutagenicity
    Abstract: Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve ́€œdrug-lik逝 characteristics in addition to efficacy properties and good safety profiles of drug candidates. ℗ Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development
    Pages: XVII, 597 p. 113 illus., 49 illus. in color. : online resource.
    Edition: 2nd ed. 2014.
    ISBN: 9781627037426
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  • 10
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Regulatory Guidelines on Stability Testing and Trending of Requirements -- The Stability Dossier: Common Deficiencies and Ways to Improve -- In Silico Drug Degradation Prediction -- Forced Degradation and Long-Term Stability Testing for Oral Drug Products: A Practical Approach -- A Model Approach for Developing Stability-Indicating Analytical Methods -- Protocols for Characterization of Degradation Products with Special Emphasis on Mutagenic Degradation Impurities -- Stability Studies: Facility and Systems -- User Requirements & Implementation of a Risk-Based, Compliant Stability Management System Based on the FDA New Guidance on DATA Integrity -- Stability Considerations in the Life Cycle of Generic Products -- Predictive Stability Testing Utilizing Accelerated Stability Assessment Program (ASAP) Studies -- Statistical Methods and Approaches to Avoid Stability Failures of Drug Product During Shelf-Life -- Estimation of Stability Based on Monitoring of Shipment and Storage -- Stability Testing Parameters and Issues for Nanotechnology-Based Drug Products -- Stability Testing Issues and Test Parameters for Herbal Medicinal Products -- Stability Testing Considerations for Biologicals and Biotechnology Products
    Abstract: This detailed volume collects numerous methods and protocols related to different aspects of stability programs that are followed in pharmaceutical development laboratories. Implementation of a successful stability program, vital in preventing product failures and recalls, requires critical and logical thinking that goes beyond the regular documented protocols and methods, so the experiences of the booḱ€™s internationally-based expert contributors fill the chapters with practical guidance. As a volume in the Methods in Pharmacology and Toxicology series, this book presents the kind of real-world advice that is essential for advancing laboratory research.℗ Authoritative and thorough, Methods for Stability Testing of Pharmaceuticals serves as a valuable addition to the existing armamentarium of resources available to stability testing personnel in research and industry
    Pages: XIV, 358 p. 93 illus., 42 illus. in color. : online resource.
    ISBN: 9781493976867
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