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  • 1
    Call number: QH506:60/485(2)
    Keywords: HIV (Viruses) / Research ; HIV (Viruses)
    Pages: xiv, 457 p. : ill.
    Edition: 2nd ed.
    ISBN: 9781588298591
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  • 2
    Call number: QH506:60/488(2)
    Keywords: RNA-Binding Proteins / analysis ; Ribonucleoproteins / analysis ; RNA / chemistry
    Notes: Previous ed.: 1999.
    Pages: xv, 416 p. : ill.
    Edition: 2nd ed.
    ISBN: 9781588294197
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    QH506:60/488(2) available
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  • 3
    Keywords: Life sciences ; Microbiology ; Bacteriology ; Life sciences ; Microbiology ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Methods for Dynamic Investigations of Surface Attached in vitro Bacterial and Fungal Biofilms -- Aqueous Two-Phase System Technology for Patterning Bacterial Communities and Biofilms -- Quorum Sensing in Gram-Positive Bacteria: Assay Protocols for Staphylococcal agr and enterococcal fsr Systems -- Advanced Techniques for in situ Analysis of the Biofilm Matrix (Structure, Composition, Dynamics) by Means of Laser Scanning Microscopy -- Multiplex Fluorescence in situ Hybridization (M-FISH) and Confocal Laser Scanning Microscopy (CLSM) to Analyse Multispecies Oral Biofilms -- Field Emission Scanning Electron Microscopy of Biofilm-Growing Bacteria Involved in Nosocomial Infections -- Experimental Approaches to Investigating the Vaginal Biofilm Microbiome -- Imaging Bacteria and Biofilms on Hardware and Periprosthetic Tissue in Orthopaedic Infections -- Animal Models to Evaluate Bacterial Biofilm Development -- Animal Models to Investigate Fungal Biofilm Formation -- Non-Mammalian Model Systems to Investigate Fungal Biofilms -- Microbiological Methods for Target-Oriented Screening of Biofilm Inhibitors -- In vitro Screening of Antifungal Compounds Able to Counteract Biofilm Development -- Biofilm Matrix-Degrading Enzymes -- Efficacy Evaluation of℗ Antimicrobial Drug-Releasing Polymer Matrices -- Antibiotic Polymeric Nanoparticles for Biofilm-Associated Infection Therapy -- Pharmacokinetics and Pharmacodynamics of Antibiotics in Biofilm Infections of Pseudomonas aeruginosa in vitro and in vivo -- Contribution of Confocal Laser Scanning Microscopy in Deciphering Biofilm Tridimensional Structure and Reactivity -- Chip-Calorimetry for Evaluation of Biofilm Treatment with Biocides, Antibiotics and Biological Agents -- Bacteriophage Attack as an Anti-Biofilm Strategy -- Photodynamic Therapy as a Novel Antimicrobial Strategy Against Biofilm-Based Nosocomial Infections: Study Protocols -- Capturing Air-Water Interface Biofilms for Microscopy and Molecular Analysis -- Biofilm-Growing Bacteria Involved in the Corrosion of Concrete Wastewater Pipes: Protocols for Comparative Metagenomic Analyses -- Culture-Independent Methods to Study Subaerial Biofilm Growing on Biodeteriorated Surfaces of Cultural Heritage Stone Materials and Frescoes -- Biofilms of Thermophilic Bacilli Isolated from Dairy Processing Plants and Efficacy of Sanitizers
    Abstract: The discovery that most of the chronic infections in humans, including the oral, lung, vaginal and foreign body-associated infections, are biofilm-based, has prompted the need to design new and properly focused preventive and therapeutic strategies for these diseases. Microbial Biofilms: Methods and Protocols provides a detailed description of the currently available methods and protocols to investigate bacterial and fungal biofilms, exhaustively illustrated and critically annotated in 25 chapters written by authors well known for their experience in the respective fields. The book has joined together microbiologists and specialists in infectious diseases, hygiene and public health involved in exploring different aspects of microbial biofilms as well as in designing new methods and/or developing innovative laboratory protocols. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ℗ Authoritative and easily accessible, Microbial Biofilms: Methods and Protocols presents readers with the most established and validated experimental procedures to investigate microbial biofilms
    Pages: XIII, 380 p. 100 illus., 62 illus. in color. : online resource.
    ISBN: 9781493904679
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  • 4
    Keywords: Medicine ; Oncology ; Vaccines ; Biomedicine ; Cancer Research ; Oncology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules -- Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine -- Pulsing Dendritic Cells with Whole Tumor Cell Lysates -- Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy -- Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens -- Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma -- Dendritic Cells Primed with Protein-Protein Fusion Adjuvant -- Antigen-Specific mRNA Transfection of Autologous Dendritic Cells -- Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material -- Dendritic Cells Transfected with Adenoviral Vectors as Vaccines -- Genetic Modification of Dendritic Cells with RNAi -- Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy -- Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation -- Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines -- Modification of T Lymphocytes to Express Tumor Antigens -- Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor -- Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors -- Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients -- Cytokine Activation of Natural Killer Cells -- Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation -- Autologous Tumor Cells Engineered to Express Bacterial Antigens -- Tumor Cell Transformation Using Antisense Oligonucleotide -- The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy -- Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine -- Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography -- Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu -- TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens -- Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens -- Preparation of Polypeptides Comprising Multiple TAA Peptides -- Idiotype Vaccine Production Using Hybridoma Technology -- Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens -- Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule -- Bacterial Vectors for the Delivery of Tumor Antigens -- Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides -- Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells -- Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection -- The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy -- Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines -- Challenges Facing the Development of Cancer Vaccines -- Future of Cancer Vaccines
    Abstract: Cancer Vaccines: Methods and Protocols explores the manipulation and modification of immune cells, the manipulation and modification of tumor cells, as well as the manipulation of immune/tumor interactions and various delivery mechanisms, with the overall end goal of evoking a tumor-specific response and overcoming the immuno-evasive mechanisms employed by the tumor cells.℗ This detailed volume also covers the subject of cancer vaccines in a more global sense with its section on the advances, challenges, and future of cancer vaccines.℗ Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ℗ Comprehensive and authoritative, Cancer Vaccines: Methods and Protocols aims to help guide researchers toward developing further generations of cancer vaccines that are both safe and efficacious, with the hope that cancer vaccines will be the standard of care in the very near future
    Pages: XVIII, 569 p. 80 illus., 42 illus. in color. : online resource.
    ISBN: 9781493903450
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  • 5
    Call number: QH506:60/463
    Keywords: Cell nuclei
    Pages: xviii,323 p. : ill. (some col.)
    ISBN: 9781588299772
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  • 6
    Call number: QH506:60/420
    Keywords: Drosophila melanogaster ; Molecular Biology / methods ; Models, Animal
    Pages: xi, 437 p. : ill.
    ISBN: 9781588298171
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  • 7
    Keywords: Life sciences ; Bioinformatics ; Biological models ; Biology / Data processing ; Life sciences ; Bioinformatics ; Systems Biology ; Computer Appl. in Life Sciences ; Springer eBooks
    Description / Table of Contents: Introduction to Biomedical literature text mining: Context and Objectives -- Accessing Biomedical Literature in the Current Information Landscape -- Mapping of Biomedical Text to Concepts of Lexicons, Terminologies and Ontologies -- Drug Interaction Text Mining -- Biological Information Extraction and Co-occurence Analysis: State of the Art and Perspectives -- Roles of Text Mining in Protein Function Prediction -- Functional Molecular Units for Guiding Biomarker Panel Design -- Mining Biological Networks from Full-text Articles -- Scientific Collaboration Networks using Biomedical Text -- Predicting future discoveries from current scientific literature -- Mining Emerging Biomedical Literature for Understanding Disease Associations in Drug Discovery -- Integrating Literature and Data Mining to Rank Disease Candidate Genes -- Role of Text Mining in Early Identification of Potential Drug Safety Issues -- Systematic Drug Repositioning using Text Mining -- Mining℗ the Electronic Health Record for Disease-Specific Knowledge
    Abstract: Biomedical Literature Mining,℗ discusses the multiple facets of modern biomedical literature mining and its many applications in genomics and systems biology. The volume is divided into three sections focusing on information retrieval, integrated text-mining approaches, and domain-specific mining methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Biomedical Literature Mining℗ is℗ designed as a useful bioinformatics resource in biomedical literature text mining for both those long experienced in, or entirely new to, the field
    Pages: XII, 288 p. 51 illus., 36 illus. in color. : online resource.
    ISBN: 9781493907090
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  • 8
    Keywords: Medicine ; Immunology ; Vaccines ; Genetic Engineering ; Biomedicine ; Immunology ; Genetic Engineering ; Vaccine ; Springer eBooks
    Description / Table of Contents: A Blueprint for DNA Vaccines Design -- Enhancement of Plasmid-Mediated Transgene Expression -- Strategies for Improving DNA Vaccines Performance -- Enhancement of DNA Vaccine Efficacy by Intracellular Targeting Strategies -- Progresses in DNA-Based Heterologous Prime-Boost Immunization Strategies -- Development of Antibiotic-Free Selection System for Safer DNA Vaccination -- Electroporation-Based DNA Delivery Technology: Methods for Gene Electrotransfer to Skin -- DNA Vaccination in Skin Enhanced by Electroporation -- Intradermal Vaccination by DNA Tattooing -- Microneedle Applications for DNA Vaccine Delivery to the Skin -- Multivalent DNA-Based Vectors for DNA Vaccines Delivery -- Superparamagnetic Nanoparticles Delivery of DNA Vaccine -- Plasmid Fermentation Process for DNA Immunization Applications -- Pharmaceutical Grade℗ Large Scale℗ Plasmid DNA Manufacturing Process -- Protective and Therapeutic DNA Vaccination Against Allergic Diseases -- Immunotherapy for Alzheimeŕ€™s Disease: DNA- and Protein-Based Epitope Vaccines -- Tetravalent DNA Vaccine Product as a Vaccine Candidate Against Dengue -- DNA Vaccination as a Treatment for Chronic Kidney Disease
    Abstract: DNA Vaccines: Methods and Protocols, Third Edition explores innovative approaches and technologies used to design, deliver, and enhance the efficacy of DNA vaccines.℗ Featuring applications which should be of great value in moving vaccines from research to clinic, this detailed volume includes sections on DNA vaccine design and enhancement, delivery systems, production, purification, and quality, as well as chapters on new vaccine applications.℗ Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, DNA Vaccines: Methods and Protocols, Third Edition serves the important role of further documenting the potential of the DNA vaccination as a platform technology for treatment and prevention of human disease
    Pages: XI, 308 p. 43 illus., 32 illus. in color. : online resource.
    Edition: 3rd ed. 2014.
    ISBN: 9781493904105
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  • 9
    Keywords: Medicine ; Orthopedics ; Rheumatology ; Biomedicine ; Molecular Medicine ; Orthopedics ; Rheumatology ; Springer eBooks
    Description / Table of Contents: Intravital Multiphoton Microscopy for Dissecting Cellular Dynamics in Arthritic Inflammation and Bone Destruction -- Monitoring Multifunctionality of Immune-Exhausted CD8 T in Cancer Patients -- Characterization of Innate Immune Signalings Stimulated by Ligands for Pattern Recognition Receptors -- Principled for the Use of in vivo Transgene Techniques: Overview and an Introductory Practical Guide for the Selection of Tetracycline-Controlled Transgenic Mice -- Unraveling Autoimmunity with the Adoptive Transfer of T Cells from TCR-Transgenic Mice -- In Vivo Cell Transfer Assay to Detect Autoreactive T Cell Subsets -- Characterization of microRNAs and Their Targets -- Studies on the T Cell Receptor (TCR) Revision of Autoantibody-Inducing CD4T (aiCD4 T) Cell -- Basic Techniques for Studies of iNKT Cells and MAIT Cells -- Induction of de novo Autoimmune Disease in Normal Mice Upon Repeated Immunization with Antigen -- Mouse Models of Experimental Dermal Fibrosis: The Bleomycin-Induced Dermal Fibrosis -- Screening for Novel Serum Biomarker for Monitoring Disease Activity in Rheumatoid Arthritis Using iTRAQ Technology Based Quantitative Proteomic Approach -- Genome-Wide Genetic Study in Autoimmune Disease Prone Mice -- Bayesian Systems-Based Genetic Association Analysis with Effect Strength Estimation and Omic Wide Interpretation: A Case Study in Rheumatoid Arthritis -- Sample Processing, Protocol and Statistical Analysis of the Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) of Protein, Cell and Tissue Samples -- Label-Free Imaging of Adipogenesis by Coherent Anti-Stokes Raman Scattering Microscopy
    Abstract: Arthritis Research: Methods and Protocols, Second Edition expands upon the first edition to present new and current techniques for the research of arthritis and related conditions. A compendium of leaders in the field contribute chapters that cover practical research methods such as the intravital multiphoton microscopy technique, techniques for evaluating exhausted CD8 T cell and for studying nucleic acid sensors and their effects, methods for in vivo tetracycline-controlled transgenic mice and T cell receptor transgenic mice, protocols to detect V(D)J recombination products and microRNA, and the technique to make bleomycin-induced dermal fibrosis. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. ℗ Authoritative and easily accessible, Arthritis Research: Methods and Protocols, Second Edition will serve both professionals and novices with state-of-the-art techniques pertaining to this fascinating research field
    Pages: X, 204 p. 65 illus., 31 illus. in color. : online resource.
    Edition: 2nd ed. 2014.
    ISBN: 9781493904044
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  • 10
    Keywords: Life sciences ; Agriculture ; Botany ; Life sciences ; Plant Sciences ; Agriculture ; Springer eBooks
    Description / Table of Contents: Measuring Freezing Tolerance: Survival and Regrowth Assays -- Measuring Freezing Tolerance: Electrolyte Leakage and Chlorophyll Fluorescence Assays -- Conducting Field Trials for Freezing Tolerance Breeding in Cereals -- A Whole Plant Screening Test to Identify Genotypes with Superior Freezing Tolerance -- Mapping of Quantitative Trait Loci (QTL) Associated with Plant Freezing Tolerance and Cold Acclimation -- Common Garden Experiments to Characterize Cold Acclimation Responses in Plants from Different Climatic Regions -- Identification of Arabidopsis Mutants with Altered Freezing Tolerance -- Infrared Thermal Analysis of Plant Freezing Processes -- Cryo-Scanning Electron Microscopy to Study the Freezing Behavior of Plant Tissues -- Three-Dimensional Reconstruction of Frozen and Thawed Plant Tissues from Microscopic Images -- Proteomic Approaches to Identify Cold Regulated Soluble Proteins -- Proteomic Approaches to Identify Cold Regulated Plasma Membrane Proteins -- Profiling Methods to Identify Cold Regulated Primary Metabolites Using Gas Chromatography Coupled to Mass Spectrometry -- A Lipidomic Approach to Identify Cold-Induced Changes in Arabidopsis Membrane Lipid Composition -- Quantification of Superoxide and Hydrogen Peroxide in Leaves -- Estimating Ice Encasement Tolerance of Herbage Plants -- Characterization of Ice Binding Proteins from Sea Ice Algae -- Isolation and Characterization of Ice Binding Proteins from Higher Plants.℗
    Abstract: Plant Cold Acclimation: Methods and Protocols details many of the methods and protocols commonly used to study plant cold acclimation and freezing tolerance, breeding, genetics, physiology or molecular biology, or any combination of these specialties.℗ Chapters focus on interdisciplinary approaches, experimental methods, and concepts from different areas of science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Plant Cold Acclimation: Methods and Protocols seeks to help not only new researchers starting in this field, but also those already working in a particular area of cold acclimation and freezing tolerance research who are looking to expand their range of experimental approaches
    Pages: XI, 282 p. 75 illus., 49 illus. in color. : online resource.
    ISBN: 9781493908448
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