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  • 1
    Keywords: Life sciences ; Pediatrics ; Cytology ; Life sciences ; Oxidative Stress ; Pediatrics ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Oxygen in health and disease -- Reactive oxygen species and nitric oxide in vascular function -- Nitrite pathway: Another important nitric oxide production system -- Nitric oxide and beyond: New insights and therapies for endothelial targeting -- Multifunctional roles of nitric oxide in neurons -- Oxidative stress biomarkers: Future perspectives -- Urinary clinical biomarkers in critical care -- Rapid diagnostic tests for oxidative stress status -- Analytical procedures for nitrative/nitrosative stress -- Animal models of enhanced oxidative stress -- Antioxidant supplementation and therapies -- Edaravone therapy -- Melatonin therapy -- Thioredoxin therapy -- Allergic and immunological disorders -- Cardiac disorders -- Environmental pollution and health consequences -- Gastrointestinal disorders -- Genetic disorders -- Growth, puberty and nutritional disturbances -- Hematologic disorders -- Infectious and inflammatory disorders -- Metabolic disorders -- Neurological disorders -- Renal disorders -- Respiratory disorders -- Trauma -- Vascular disorders
    Abstract: This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generating these species, clinically useful biomarkers for evaluating oxidative stress status in humans, and the pathophysiology, clinical course and management of a variety of pediatric disorders, among others. The book also describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders.℗ It explores emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents. Written by an international team of experts in both pediatrics and℗ free radical and antioxidant research, Studies on Pediatric Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series
    Pages: XII, 494 p. 115 illus., 53 illus. in color. : online resource.
    ISBN: 9781493906796
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  • 2
    Keywords: Life sciences ; Cytology ; Life sciences ; Oxidative Stress ; Cell Biology ; Springer eBooks
    Description / Table of Contents: 1. Oxidative nitrative and chlorinative stress: biomarkers -- Part 1. Clinical aspects -- 2. Oxidative stress in schizophrenia -- 3. Oxidative stress in bipolar disorders -- 4. Contribution of oxidative stress to the pathophysiology of autism spectrum disorders: Impact of genetic and environmental factors -- 5. Oxidative stress and anxiety disorder -- 6. The relationship between oxidative stress and obsessive- compulsive disorder -- 7. A relationship between oxidative status and attention deficit hyperactivity disorder -- 8. The role of oxidative stress in neurodegenerative diseases -- Part 2. Pathophysiological aspects -- 9. Magnetic resonance spectroscopy studies in Bipolar Disorder patients: Focus on the potential role of oxidative stress -- 10. The impact of oxidative stress on dopaminergic neurotransmission -- 11. The reciprocal effects of oxidative stress and glutamate neurotransmission -- 12. Mitochondrial dysfunction in psychiatric disorders -- 13. The kynurenine pathway at the interface between neuroinflammation, oxidative stress and neurochemical disturbances: Emphasis in schizophrenia -- 14. Dysregulation of glutathione synthesis in psychiatric disorders -- 15. Role of nitrative stress in brain of schizophrenic patients -- 16. Blood platelet as a peripheral cell in oxidative stress in psychiatric diseases -- 17. Mitochondrial dysfunction in autism -- 18. Ultrasound and Autism: How Disrupted Redox Homeostasis and Transient Membrane Porosity Confer Risk -- 19. Animal Model of Autistic Regression: Link to Toxicant-Induced Oxidative Stress -- 20. Genetic Polymorphism Related to Oxidative Stress in Autism -- 21. Telomere length in major psychiatric disorders. Is there any relationship between telomere length and oxidative stress? -- 22. The impact of oxidative stress on GAD67 levels and parvalbumin - positive neurons -- 23. The possible role of iron in neurodegeneration -- 24. Oxidation stress and polyunsaturated lipid peroxidation products in the CNS: focus on DHA-derived fragment -- Part 3. Therapeutic aspects -- 25. Antioxidant interventions in neuropsychiatric disorders -- 26. Antioxidant plant polyphenols and cognitive disorders -- 27. Hyperbaric oxygen treatment in autism spectrum disorders -- 28. Effects of lithium on oxidative stress -- 29. Cryostimulation as adjunct treatment in psychiatric disorders -- Index
    Abstract: This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories. Written by leading researchers in their fields,℗ Studies on Psychiatric Disorders℗ explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants€”ín particular polyphenols, Ϝ-3 fatty acids or combination of both́€”could be effective for long-term treatment of some neuropsychiatric disorders
    Pages: XX, 596 p. 31 illus., 17 illus. in color. : online resource.
    ISBN: 9781493904402
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  • 3
    Keywords: Life sciences ; Ophthalmology ; Cytology ; Life sciences ; Oxidative Stress ; Ophthalmology ; Apoptosis ; Springer eBooks
    Description / Table of Contents: 1 Oxidative Stress in Cornea -- 2 Corneal Degenerations -- 3 Corneal Epithelial Nuclear Ferritin and its Transporter Ferritoid Afford Unique Protection to DNA from U.V. Light and Reactive Oxygen Species -- 4 Excitatory Amino Acid Transporters, Xc- Antiporter, Glutamyl Transpeptidase, Glutamine Synthetase Activity and Glutathione in Human Corneal Epithelial Cells -- 5 Transforming Growth Factor – β3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts -- 6 Corneal Stem Cells: a Source of Cell Renewal with Therapeutic Potential -- 7 New Agents for Treating Dry Eye Syndrome -- 8 Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells -- 9 Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis -- 10 The Human Lens: A living Biometric Indicator of Health Status and Successful Aging -- 11 Oxidative Stress in Lens -- 12 Protein Serine/Threonine Phosphatases-1 and –2A in Lens Development and Pathogenesis -- 13 Proteases in Lens and Cataract -- 14 Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System -- 15 p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation -- 16 Etiology and Prevention of Cataract -- 17 The Effects of Lutein in Preventing Cataract Progression -- 18 Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts -- 19 Updates and Advances in Corneal Surgery -- 20 Cataract and Diabetic Retinopathy -- 21 Traumatic Cataract-a Review -- 22 Cataract in Paediatric Age Group-a Review
    Abstract: This comprehensive volume presents℗ data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss℗ topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised of four chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group. Studies on the Cornea and Lens is an essential addition to the library or department of physicians and scientists who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. This book is an authoritative contribution to Springeŕ€™s Oxidative Stress in Applied Basic Research and Clinical Practice series
    Pages: XVI, 447 p. 124 illus., 81 illus. in color. : online resource.
    ISBN: 9781493919352
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  • 4
    Keywords: Life sciences ; Obstetrics ; Cytology ; Life sciences ; Oxidative Stress ; Obstetrics/Perinatology ; Cell Biology ; Springer eBooks
    Description / Table of Contents: 1. Impact of oxidative stress on development -- 2. Chorioamnionitis and oxidative stress: New ideas from experimental models -- 3. Oxidative stress in the pathophysiology of gestational diabetes mellitus -- 4. Tobacco smoking and oxidative stress in pregnancy -- 5. Preterm labor and oxidative stress -- 6. Developmental origins of disease: The role of oxidative stress -- 7. Down Syndrome as a special case of oxidatively induced developmental dysregulation -- 8. Retinopathy of prematurity and oxidative signaling -- 9. Necrotizing enterocolitis and oxidative stress -- 10. Oxidative stress and the perinatal circulation -- 11. Use of oxygen in the resuscitation of neonates -- 12. Antioxidant properties of commercial surfactants -- 13. Oxidative stress and Glutathione synthesis rates in postnatal life -- 14. Oxygen vulnerability of the immature brain -- 15. Hyperbilirubinemia and antioxidant defenses in the neonate -- 16. Neonatal pain and oxidative stress -- 17. Ontogeny of antioxidant systems -- 18. Antioxidant therapies in the neonates -- 19. Postnatal stress including nutrition -- 20. Oxidative stress in epilepsy -- 21. The oxidative stress in the fetus and newborn -- 22. New promising antioxidant drugs
    Abstract: This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series
    Pages: XIV, 435 p. 67 illus., 28 illus. in color. : online resource.
    ISBN: 9781493914050
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  • 5
    Keywords: Life sciences ; Cancer Research ; Enzymology ; Oxidative Stress ; Life sciences ; Oxidative Stress ; Enzymology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Part 1. Pathophysiological Roles of Superoxide Dismutases (SOD) -- Superoxide and the Superoxide Dismutases: An Introduction by Irwin Fridovich -- The Discovery of Superoxide Dismutase and Its Role in Redox Biology -- Manganese Superoxide Dismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer -- Regulation of the Cellular Redox Environment by Superoxide Dismutases, Catalase and Glutathione Peroxidases During Tumor Metastasis -- Superoxide Dismutase Family of Enzymes in Brain Neurogenesis and Radioprotection -- Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment -- Part 2. Redox-Active Therapeutics – Design and Mechanisms of Action -- Mimicking SOD, Why and How: Bio-Inspired Manganese Complexes as SOD Mimics -- Mn Porphyrin-Based Redox-Active Therapeutics -- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mn porphyrins as Redox Modulators -- Nitrones as Potent Anticancer Therapeutics -- Salen Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through Modulation of Tissue Environment -- Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs -- Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism -- HNO/Thiol Biology as a Therapeutic Target -- Part 3. Redox-Active Therapeutics in Cancer -- Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents -- Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells -- Targeted Therapy for Malignant Brain Tumors -- Redox Therapeutics in Breast Cancer: Role of SOD Mimics -- Anticancer Action of Mn porphyrins in Head and Neck Cancers -- Redox-based Therapeutic Strategies in the Treatment of Skin Cancers -- Role of Oxidative Stress in Erectile Dysfunction after Prostate Cancer Therapy -- Theranostic Nanoconjugates of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy -- Part 4. Redox-Active Therapeutics in Other Diseases -- Quantum Dots in Photodynamic Therapy -- Metalloporphyrins in CNS injuries -- The Contribution of Nitroxidative Stress to Pathophysiological Pain and Opioid Analgesic Failure -- Amyotrophic Lateral Sclerosis – Present Understanding of the Role of SOD -- Redox Regulation and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral Sclerosis -- Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure -- Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes -- Redox-Active Metal Complexes in Trypanosomatids
    Abstract: This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springeŕ€™s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxom途the organism redox network€”ás an emerging frontier in drug design, redox biology and medicine
    Pages: XXX, 694 p. 162 illus., 124 illus. in color. : online resource.
    ISBN: 9783319307053
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  • 6
    Keywords: Life sciences ; Pharmacology ; Apoptosis ; Oxidative Stress ; Environmental Health ; Life sciences ; Oxidative Stress ; Pharmacology/Toxicology ; Apoptosis ; Environmental Health ; Springer eBooks
    Description / Table of Contents: Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress -- A historical perspective on oxidative stress and intracellular redox control -- An overview of free radicals as causes and consequences of toxicity -- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity -- Lipid oxidation -- Protein oxidation and toxicology -- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth? -- Glutathione and thiols -- Reactive oxygen species as initiators and mediators of cellular signaling processes -- Role of oxidative stress in the process of carcinogenesis -- Part II. Agents that produce toxicity – mechanisms and therapeutic interventions -- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents -- Oxidative stress and ethanol toxicity -- Pharmaceutical agents -- Insecticides and herbicides -- Health effects of indoor air pollution due to cooking with biomass fuel -- Outdoor pollutants -- Oxidative Stress and the Inorganic Carcinogens -- UV-induced signaling: Role of reactive oxygen species -- Nanomaterials -- Chemical warfare agents -- Part III. Special topics -- On the biochemistry of antioxidants — current aspects.-Prevention of age-related diseases — Effects of antioxidant supplements -- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity — a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging. -- Oxygen toxicity: From cough to convulsion -- Oxidative stress in reproductive toxicology -- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress -- Aquatic and marine biology
    Abstract: This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers
    Pages: XVI, 498 p. 96 illus., 53 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319190969
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  • 7
    Keywords: Life sciences ; Diabetes ; Cytology ; Life sciences ; Oxidative Stress ; Cell Biology ; Diabetes ; Springer eBooks
    Description / Table of Contents: 1. Oxidative Stress and Diabetes-induced Vascular Dysfunction: Role in Diabetic Neuropathy -- 2. Cerebrovascular Disease in Type 1 Diabetes: Role of Oxidative Stress -- 3. Complications in the Coronary Circulation Associated with Diabetes -- 4. Chronic Kidney Disease and Cardiovascular Risk -- 5. Mitochondria and Oxidative Stress in Diabetes -- 6. Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy -- 7. Oxidative Stress and Complications of the Diabetic Foot -- 8. Encephalopathies Accompanying Type 1 and Type 2 Diabetes -- 9. Oxidative Stress, Inflammation and Endothelial Dysfunction: The Link Between Obstructive Sleep Apnoea and Vascular Disease in Type 2 Diabetes -- 10. Taurine Treatment for Complications of Diabetes -- 11. Oxidative Stress and Cardiovascular Disease in Diabetes -- 12. Oxidative Stress in Diabetes Mellitus and Possible Interventions
    Abstract: Studies on Diabetes examines how increased oxidative and nitrosative stress ́€“ one of the leading causes of diabetes complications ́€“ pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease. Their contributions represent a wealth of knowledge on and research into how diabetes triggers metabolic abnormalities that lead to hyperactivation of cellular and mitochondrial pathways that ultimately result in oxidative and nitrosative stress that, left un-neutralized, results in tissue damage. Each chapter℗ provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease. Potential treatments for diabetes complications from animal models to the patient will also be discussed. This is essential reading for researchers and clinicians in endocrinology, diabetes, vascular disease and oxidative stress
    Pages: XIX, 265 p. 40 illus., 18 illus. in color. : online resource.
    ISBN: 9781489980359
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  • 8
    Keywords: Life sciences ; Pneumology ; Cytology ; Life sciences ; Oxidative Stress ; Cell Biology ; Pneumology/Respiratory System ; Springer eBooks
    Description / Table of Contents: Introduction to oxidative stress and anti-oxidant therapy -- Role of reactive oxygen and nitrogen species in respiratory diseases: general considerations -- Role of exhaled biomarkers volatiles and exhaled breath condensate -- Pulmonary infections and oxidative injury -- Role of reactive oxygen species in causing acute lung injury -- Free radicals in pulmonary tuberculosis -- Oxidative injury caused by smoking and air-pollution -- Oxidative stress in chronic obstructive pulmonary disease -- Oxidative stress in asthma and allergic disease -- Oxygen free radicals in pulmonary hypertension -- Pulmonary fibrosis and oxidative stress -- Oxidant injury in sarcoidosis and other granulomatous disorders -- Oxidative stress in lung cancer -- Pulmonary toxicity from drugs, heavy metals and other poisonings – oxidant injury and role of anti-oxidants -- Oxidative stress and respiratory muscle dysfunction -- The critical role of Nrf2 -- Development of novel antioxidants -- Asbestosis
    Abstract: Studies on Respiratory Disorders considers the whole panorama of oxidative damage in different respiratory disorders for the review of clinician and laboratory investigators and makes diverse information available in a single volume.℗ This volume provides a comprehensive review of numerous studies on the role of oxygen and nitrogen species in lung diseases; it also discusses the potential role of anti-oxidants in their treatment.℗ The contents are organized into three sections along fairly broad classifications: I.℗ General introductory chapters on oxidant stress; general considerations related to reactive oxygen and nitrogen species; the role of exhaled breath condensate and other volatile compounds as exhaled biomarkers of inflammation;℗ II. Oxidative stress in different groups of respiratory disorders such as pulmonary infections (viral, bacterial and tuberculosis); ℗ airway diseases such as chronic obstructive pulmonary diseases, air pollution, allergies and asthma; miscellaneous lung diseases (e.g., interstitial diseases, sarcoidosis, asbestosis, respiratory muscle dysfunction, pulmonary hypertension and cancer); and III., Anti-oxidant drugs. These final chapters on anti-oxidant drugs including the mimics (such as traditional herbs) provide a critical review of the available information on their success and failure.℗ Studies on Respiratory Disorders is an important addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and is essential reading℗ for those treating or researching treatment for respiratory disorders
    Pages: XII, 394 p. 26 illus., 19 illus. in color. : online resource.
    ISBN: 9781493904976
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  • 9
    Keywords: Life sciences ; Otorhinolaryngology ; Pathology ; Cytology ; Life sciences ; Oxidative Stress ; Otorhinolaryngology ; Pathology ; Springer eBooks
    Description / Table of Contents: 1. Introduction -- Section 1: Basic Science of Free Radical Biology in ENT -- 2. Free radicals and oxidative stress: Basic concepts and misconceptions -- 3. A Question of Balance:℗ Free Radicals and Cochlear Homeostasis -- 4. Antioxidants and their effect on stress-induced pathology in the inner ear -- Section 2: Epidemiology of Hearing Loss -- 5. Role of free radicals in hearing loss due to heavy metals -- 6. The role of nutrition in healthy hearing: human evidence -- Section 3: Oxidative Stress and Noise-Induced Hearing Loss -- 7. Basic mechanisms underlying noise-induced hearing loss -- 8. Oxidative stress in noise-induced hearing loss -- 9. Strategies for evaluating antioxidant efficacy in clinical trials assessing prevention of noise-induced hearing loss -- Section 4: Oxidative Stress and Drug-Induced Hearing Loss -- 10. Aminoglycoside-induced oxidative stress: pathways and protection -- 11. Hearing loss after cis-platin: oxidative stress pathways and potential for protection -- 12. Assessment of interventions to prevent drug-induced hearing loss (DIHL) -- Section 5: Oxidative Stress and Age-Related Hearing Loss -- 13. Age-related hearing loss: biochemical pathways and molecular targets -- 14. Genetics and age-related hearing loss -- 15. Mechanisms of age-related hearing loss -- 16. Interventions to prevent age-related hearing loss -- Section 6. Hereditary Hearing Loss -- 17. Genes and hearing loss: relationship to oxidative stress and free radical formation -- 18. Strategies for the treatment of hereditary hearing loss -- Section 7: Cochlear Implants, Radiation, Trauma and Other Stress Factors -- 19. Loss of Residual Hearing Initiated by Cochlear Implantation: Role of Inflammation-Initiated Cell -- 20. Role of oxidative stress in sudden hearing loss and Menier這s disease -- Section 8: Head and Neck -- 21. Role of free radicals in head and neck pathology -- 22. Free radicals and sleep apnea -- 23. Free radicals in nasal and paranasal disease -- 24. Conclusion
    Abstract: This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and ́€œwhite papeŕ€ that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently,℗ new interventions to medically treat ENT pathology
    Pages: XIV, 507 p. 43 illus., 32 illus. in color. : online resource.
    ISBN: 9783319134734
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  • 10
    Keywords: Life sciences ; Clinical Medicine ; Cytology ; Life sciences ; Oxidative Stress ; Hepatology ; Springer eBooks
    Description / Table of Contents: Part 1: Oxidative Stress: Basic Principles in the Liver Scenario -- Principles of Redox Signaling -- Oxidative Stress, Antioxidant Defenses and the Liver -- Oxidative Mechanisms in Liver Senescence and Regeneration -- Part 2: Oxidative Stress and Liver Pathophysiology: From Cell Damage and Death to Inflammatory and Fibrogenic Responses -- Oxidative Stress and Hepatocellular Injury -- Oxidative Stress and the Unfolded Protein Response in the Liver -- Oxidative Stress and Liver Inflammation -- Oxidative Stress and Liver Ischemia-Reperfusion Injury -- Oxidative Stress and Liver Fibrogenesis -- Part 3: Oxidative Stress in Specific Liver Disease Conditions -- Oxidative Stress in Acute Liver Failure -- Oxidative Stress in Alcoholic Liver Disease -- Oxidative Stress in Chronic Viral Hepatitis -- Oxidative Stress in Nonalcoholic Fatty Liver Disease -- Oxidative Stress in Non-autoimmune Biliary Diseases -- Oxidative Stress in Autoimmune Liver Diseases -- Oxidative Stress and Hepatic Iron Overload -- Oxidative Stress in the Central Nervous System Complications of Chronic Liver Failure -- Oxidative Stress and Liver Transplantation -- Antioxidant Approach to the Therapy of Chronic Liver Disease -- Part 4: Oxidative Stress and Liver Cancer -- Liver Cancer Classification -- Oxidative Stress Mechanisms in Hepatocarcinogenesis -- The Role of Oxidative Stress in Hepatocarcinogenesis
    Abstract: This volume examines the impact of free radical biology on hepatic disorders such as viral hepatitis, alcoholic disease, iron overload, and Wilson’s disease. It thoroughly explores the role of oxidative stress in acute and chronic disease, addressing factors such as redox biomarkers; antioxidant defense and protection; cell signaling; mutations; oxidative damage involving lipids, proteins, and nucleic acids; membrane trafficking; inflammation; mitochondrial dysfunction; alterations in immunological function; toxicology; and hypoxia. Its four sections, consisting of chapters by recognized field leaders, deal with basic principles of oxidation and hepatology, oxidative stress-related pathophysiology, oxidative stress and liver disease, and liver cancer. Intuitively structured and comprehensive, Studies on Hepatic Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and an essential resource for clinical hepatologists and researchers interested in the role of oxidative stress on liver function and disease
    Pages: XXII, 516 p. 49 illus., 31 illus. in color. : online resource.
    ISBN: 9783319155395
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