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  • 1
    Keywords: Life sciences ; Medical genetics ; Nucleic Acids ; Plant breeding ; Animal genetics ; Life sciences ; Animal Genetics and Genomics ; Plant Genetics & Genomics ; Gene Function ; Nucleic Acid Chemistry ; Springer eBooks
    Description / Table of Contents: Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion
    Abstract: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution
    Pages: VIII, 56 p. : digital.
    ISBN: 9783034806794
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  • 2
    Keywords: Medicine ; Spectroscopy ; Biotechnology ; Chemistry, Organic ; Chemistry, Physical organic ; Biochemistry ; Biomedicine ; Biomedicine general ; Spectroscopy/Spectrometry ; Biotechnology ; Physical Chemistry ; Organic Chemistry ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: The basis of Nuclear Magnetic Resonance Spectroscopy -- Spectroscopic parameters in Nuclear Magnetic Resonance -- Basic NMR experiments -- Biomolecular NMR
    Abstract: This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the development experienced by NMR in recent times. Many of the books currently available on NMR deal with the theoretical basis and some of its main applications, but they generally demand a strong background in Physics and Mathematics for a full understanding. This book is aimed to a wide scientific audience, trying to introduce NMR by making all possible effort to remove, without losing any formality and rigor, most of the theoretical jargon that is present in other NMR books. Furthermore, illustrations are provided that show all the basic concepts using a naive vector formalism, or using a simplified approach to the particular NMR-technique described. The intention has been to show simply the foundations and main concepts of NMR, rather than seeking thorough mathematical expressions
    Pages: XII, 115 p. 36 ill. : digital.
    ISBN: 9789400769762
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  • 3
    Keywords: Medicine ; Genetic Engineering ; Computer Simulation ; Microbial genetics ; Entomology ; Biomedicine ; Biomedicine general ; Microbial Genetics and Genomics ; Genetic Engineering ; Entomology ; Simulation and Modeling ; Springer eBooks
    Description / Table of Contents: Foreword by Michel Morange -- Preface -- 1 What is synthetic biology? -- 2 What was synthetic biology? -- 3 What is life? -- 4 Strategies for making life -- 5 Synthetic biology in action -- 6 The iGEM competition -- 7 Are we doing synthetic biology? Postface by Ricard Solé -- Onomastic index -- Subject index
    Abstract: Synthetic Biology (SB) is a revolutionary discipline with a vast range of practical applications, but is SB research really based on engineering principles? Does it contributing to the artificial synthesis of life or does it utilise approaches sufficiently advanced to fall outside the scope of biotechnology or metabolic engineering? This volume reviews the development of SB and includes the major milestones of the discipline, the ́€˜top-dowń€™ and ́€˜bottom-uṕ€™ approaches towards the construction of an artificial cell and the development of the €œíGEḾ€ competition. We conclude that SB is an emerging field with extraordinary technological potential, but that most research projects actually are an extension of metabolic engineering since the complexity of living organisms, their tight dependence on evolution and our limited knowledge of the interactions between the molecules, actually make life difficult to engineer
    Pages: XII, 77 p. 24 illus., 21 illus. in color. : online resource.
    ISBN: 9789401793827
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  • 4
    Keywords: Medicine ; Medical genetics ; Genetic Engineering ; Biology / Philosophy ; Evolution (Biology) ; Biomedicine ; Gene Function ; Evolutionary Biology ; Philosophy of Biology ; Genetic Engineering ; Springer eBooks
    Description / Table of Contents: Introduction: Some facts about our Universe -- Problems of logical typing: The "one" and the "unity" -- Logical typing and the notion of time in biology -- Organisation of the genetic system: Proteins as vehicles of distinction -- Harnessing energy and information: Time-irreversibility of thermodynamics -- Social communications and logical typing in the social system
    Abstract: This book explores the double coding property of DNA, which is manifested in the digital and analog information types as two interdependent codes. This double coding principle can be applied to all living systems, from the level of the individual cell to entire social systems, seen as systems of communication. Further topics discussed include the ubiquitous problem of logical typing, which reflects our inherent incapacity to simultaneously perceive the distinction between discontinuity and continuity, the problem of time, and the peculiarities of autopoietic living systems. It is shown that the scientific “truths” that appear to be coherent constructions connecting the scientifically verified observations by the rules of logic are in fact always relative and never absolute
    Pages: VIII, 92 p. 24 illus., 10 illus. in color. : online resource.
    ISBN: 9783319174259
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  • 5
    Keywords: Life sciences ; Neurosciences ; Neurochemistry ; Biochemistry ; Animal genetics ; Neurobiology ; Life sciences ; Protein Science ; Neurosciences ; Neurochemistry ; Animal Genetics and Genomics ; Biochemistry, general ; Neurobiology ; Springer eBooks
    Description / Table of Contents: 1. Introduction -- 2. Historical and Topological Perspective of Connexins -- 3. Molecular Components and Nomenclature of Gap Junctions -- 4. General Cell Biology of Connexins -- 5. Genomic Organization of Connexins -- 6. Transcriptional Regulation of the Connexin Gene -- 7. Epigenetic Regulation of Connexins -- 8. Translation Regulation of Connexins -- 9. Interaction Partners of Connexin Proteins -- 10. Tissue Distribution of Connexins -- 11. Connexin Functions -- 12. Connexin Mutations and Disease -- 13. Suggested Reading
    Abstract: Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins.℗ The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins
    Pages: XV, 93 p. 4 illus. in color. : online resource.
    ISBN: 9788132219194
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  • 6
    Keywords: Medicine ; Biochemistry ; Biomedicine ; Biomedicine general ; Biochemistry, general ; Protein Science ; Springer eBooks
    Description / Table of Contents: Overview and book plan -- Chaperones: General characteristics and classifications -- The chaperonopathies: classification, mechanisms, structural features -- Structural and hereditary chaperonopathies: mutation -- Other genetic chaperonopathies -- Acquired chaperonopathies -- Other types of chaperonopathies -- Impact of chaperonopathies in protein homeostasis and beyond -- Extracellular chaperones
    Abstract: Memory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer
    Pages: : digital.
    ISBN: 9789400746671
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  • 7
    Keywords: Life sciences ; Chemistry / Mathematics ; Biochemistry ; Bioinformatics ; Life sciences ; Protein Structure ; Bioinformatics ; Math. Applications in Chemistry ; Protein Science ; Springer eBooks
    Description / Table of Contents: Studying protein exterior with fractal dimension -- Characterization of protein-protein interfaces, considering surface-roughness and local shape -- Adhesion on protein (and other rough biomolecular) surfaces
    Abstract: The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Exterior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Although these ideas are entirely mathematical, mathematical expositions have been avoided, unless the use of some expressions becomes absolutely obligatory. A first chapter introduce into fractal dimensions, protein exteriors and to methods to study the roughness of surfaces. The main topics covered in the following chapters include: protein-protein interaction interfaces; protein surface-roughness and local shape as well as adhesion on protein and other rough biomolecular surfaces
    Pages: : digital.
    ISBN: 9783034806541
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  • 8
    Keywords: Medicine ; Neurochemistry ; Biochemistry ; Animal models in research ; Biomedicine ; Neurochemistry ; Biochemistry, general ; Animal Models ; Springer eBooks
    Description / Table of Contents: Overview of Mechanosensory Transduction -- ́€œGating-Sprinǵ€ Model for Mechanotransduction -- Mechanoreceptors in Drosophila melanogaster.-℗ Mechanotransduction in Drosophila mechanoreceptors -- Drosophila℗ Mechanotransduction Channels
    Abstract: This book offers an essential introduction for all graduate students and researchers who are working on or interested in mechanotransduction using fruit flies as their model organisms. Designed for accessibility, it follows a simple five-chapter structure, beginning with a general introduction to mechanotransduction in physiology (Chapter 1) and some basic considerations on the principles behind mechanotransduction processes (Chapter 2).℗ In turn, Chapters 3, 4 and 5 focus on mechanoreceptors in℗ Drosophila melanogaster. Chapter 3 explains how the flý€™s mechanosensitive cells (i.e. mechanoreceptors) contribute to its daily life, while Chapter 4 explores the ultrastructural and mechanical basis for the working mechanisms of various fly mechanoreceptors. Lastly, Chapter 5 elaborates on the structure, function and physiology of mechanosensitive molecules in fly mechanoreceptors. Accordingly, the book provides an overall framework, helping readers understand mechanosensory transduction, from the physiological level to the molecular level
    Pages: IX, 82 p. 30 illus., 26 illus. in color. : online resource.
    ISBN: 9789811065262
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  • 9
    Keywords: Life sciences ; Microbiology ; Proteomics ; Proteins ; Life sciences ; Protein Science ; Protein Structure ; Proteomics ; Protein-Ligand Interactions ; Applied Microbiology ; Springer eBooks
    Description / Table of Contents: Protein folding -- Molten Globule -- Uniqueness of toxin structure and function -- Molten globule conformational implication on toxicity
    Abstract: This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein toxicity. This concise and yet thorough text also discusses using toxin structure as a model for studying structural and functional aspects of protein chemistry. Protein Toxins in Modeling Biochemistry, a SpringerBrief, is essential reading for advanced researchers, scientists and advanced graduate students interested in protein chemistry and related areas of biochemistry and molecular science
    Pages: XIX, 145 p. 249 illus., 205 illus. in color. : online resource.
    ISBN: 9783319435404
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  • 10
    Keywords: Life sciences ; Toxicology ; Nucleic Acids ; Cytology ; Life sciences ; Nucleic Acid Chemistry ; Cell Biology ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: DNA replication -- Disturbances of the DNA replication system -- Fate of DNA replisome upon encountering DNA damage -- External Causes for DNA Damage -- Effect of environmental carcinogens on cellular physiology -- Protocols for studies of bypass of DNA damage by DNA polymerase
    Abstract: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health
    Pages: XI, 43 p. 4 illus., 1 illus. in color. : online resource.
    ISBN: 9789401772129
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