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  • 1
    Keywords: Life sciences ; Chemistry / Mathematics ; Biochemistry ; Bioinformatics ; Life sciences ; Protein Structure ; Bioinformatics ; Math. Applications in Chemistry ; Protein Science ; Springer eBooks
    Description / Table of Contents: Studying protein exterior with fractal dimension -- Characterization of protein-protein interfaces, considering surface-roughness and local shape -- Adhesion on protein (and other rough biomolecular) surfaces
    Abstract: The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Exterior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Although these ideas are entirely mathematical, mathematical expositions have been avoided, unless the use of some expressions becomes absolutely obligatory. A first chapter introduce into fractal dimensions, protein exteriors and to methods to study the roughness of surfaces. The main topics covered in the following chapters include: protein-protein interaction interfaces; protein surface-roughness and local shape as well as adhesion on protein and other rough biomolecular surfaces
    Pages: : digital.
    ISBN: 9783034806541
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  • 2
    Keywords: Medicine ; Human Genetics ; Molecular Biology ; Medical Biochemistry ; Biomedicine ; Molecular Medicine ; Human Genetics ; Medical Biochemistry ; Springer eBooks
    Description / Table of Contents: 1) The NF-kB signaling pathways: players and Functions -- 2) Genetic Diseases Affecting the Canonical Pathway of NF-kB Activation -- 3) Genetic Diseases Affecting hte Non-Camonical Pathway of NF-kB Activation -- 4) Genetic Diseases Affecting Ubiquitination Processes in NF-kB Signaling -- 5)Lessons Learned from Studying NF-kB Related Genetic Diseases
    Abstract: This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes
    Pages: XII, 70 p. 17 illus. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319258508
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  • 3
    Keywords: Medicine ; Genetic Engineering ; Computer Simulation ; Microbial genetics ; Entomology ; Biomedicine ; Biomedicine general ; Microbial Genetics and Genomics ; Genetic Engineering ; Entomology ; Simulation and Modeling ; Springer eBooks
    Description / Table of Contents: Foreword by Michel Morange -- Preface -- 1 What is synthetic biology? -- 2 What was synthetic biology? -- 3 What is life? -- 4 Strategies for making life -- 5 Synthetic biology in action -- 6 The iGEM competition -- 7 Are we doing synthetic biology? Postface by Ricard Solé -- Onomastic index -- Subject index
    Abstract: Synthetic Biology (SB) is a revolutionary discipline with a vast range of practical applications, but is SB research really based on engineering principles? Does it contributing to the artificial synthesis of life or does it utilise approaches sufficiently advanced to fall outside the scope of biotechnology or metabolic engineering? This volume reviews the development of SB and includes the major milestones of the discipline, the ́€˜top-dowń€™ and ́€˜bottom-uṕ€™ approaches towards the construction of an artificial cell and the development of the €œíGEḾ€ competition. We conclude that SB is an emerging field with extraordinary technological potential, but that most research projects actually are an extension of metabolic engineering since the complexity of living organisms, their tight dependence on evolution and our limited knowledge of the interactions between the molecules, actually make life difficult to engineer
    Pages: XII, 77 p. 24 illus., 21 illus. in color. : online resource.
    ISBN: 9789401793827
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  • 4
    Keywords: Life sciences ; Medicine ; Biochemistry ; Biomaterials ; Life sciences ; Protein Science ; Biomedicine general ; Biomaterials ; Springer eBooks
    Description / Table of Contents: 1. Protein Based Fibres -- 2. Biomedical Applications of Heat Shock Proteins -- 3. Biomedical applications of silkworm pupae proteins -- 4. Studies on Indian Eri Silk Electrospun Fibroin Scaffold for Biomedical Applications -- 5. Self assembled Nanoparticles prepared from Tasar Antherea mylitta Silk Sericin -- 6. Bioactive Proteins: source, synthesis and applications -- 7. Role of protein interleukin 8 (IL-8) in human life -- 8. Importance of Natural proteins in infectious diseases -- 9. Adverse Effect in Human beings Associated with Excess Dietary Protein Intake -- 10. Gelatin Nanocomposites (GNCs): An Efficient Drug Delivery System.℗ ℗
    Abstract: This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives. The book is divided into ten chapters, each of which explains different natural proteins and their established biomedical applications. The first chapter extensively deals with protein based natural fibers and provides an overview of all protein based fibers currently available.℗ In turn, chapter two mainly focuses on the biomedical applications of a special class of proteins called Heat Shock Proteins; the biomedical applications of silkworm pupae proteins are dealt in chapter three. Chapter four examines an interesting use of Eri silk fibroin as a biomaterial for Tissue Engineering, while chapter five discusses the key experimental details involved in converting Tasar silk sericin into self-assembled nanoparticles. Chapter six offers brief descriptions of bioactive proteins with respect to their sources, synthesis and applications. Chapter seven is dedicated to Interleukine-8 and its role in human life, while chapter eight addresses the importance of natural proteins in infectious diseases. Chapter nine explores the issue of excess intake of dietary proteins and its adverse effects, and finally, chapter ten discusses the efficiency of drug delivery systems made up of gelatin nanocomposites. The book is above all intended as a valuable resource for students and researchers alike, sparking their curiosity with regard to the applications of natural proteins and motivating them to focus their own energies on the discovery or identification of additional natural proteins for diverse biomedical uses
    Pages: XV, 148 p. 37 illus., 23 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9788132224914
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  • 5
    Keywords: Medicine ; Gene Therapy ; Immunology ; Vaccines ; Medical virology ; Biomedicine ; Gene Therapy ; Virology ; Immunology ; Vaccine ; Springer eBooks
    Description / Table of Contents: Principles of Gene Therapy -- Injection of Naked DNA -- Non-Viral Gene Transfer (Transfection) Methods -- Viral gene transfer (transduction) methods -- Retroviruses -- Other viruses.-℗ History of Gene Therapy.-℗ Principles of HIV Gene Therapy.-℗ Gene Therapy Vectors.-℗ Lentiviral vectors.-℗ Other modifications and additions.-℗ Anti-HIV genes.-℗ RNA-strategies.-℗ Vector production.-℗ Stem Cells for HIV Gene Therapy.-℗ Pluripotent stem cells.-℗ Animal Models Used in HIV Gene Therapy -- Murine models.-℗ HIV infections in humanized mice.-℗ Non-human primates.-℗ Manufacturing of a GMP grade product for HIV gene therapy.-℗ Clinical applications of HIV gene therapy.-℗ Clinical trials of T cell gene therapy.-℗ Stem cell gene therapy clinical trials for HIV.-℗ Is A Cure for HIV Possible?
    Abstract: This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices
    Pages: VIII, 72 p. 3 illus. in color. : online resource.
    ISBN: 9781493904341
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  • 6
    Keywords: Medicine ; Cancer Research ; Immunology ; Pharmacology ; Biophysics ; Biological physics ; Biomedicine ; Immunology ; Biophysics and Biological Physics ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Summary -- Introduction.-℗ The measurement protocols of cell biophysical characteristics -- Biophysical characteristics of dendritic cells at different differentiation stages -- Biophysical characteristics of dendritic cells in tumor microenvironment -- Effects of Chinese traditional herbs on dendritic cells -- Future perspectives
    Abstract: In this book, the authors discuss the biophysical characteristics of Dendritic cells (DCs) at various differentiation stages and in tumor microenvironments in detail. A type of Chinese traditional herb, which can improve the biophysical and microrheological properties of DCs, is also introduced. DCs are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The biophysical and microrheological characteristics of DCs are important for their motility and normal immune function. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown. This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency of℗ anti-tumor therapy based on DCs. ℗ ℗ ℗
    Pages: VII, 66 p. 40 illus., 28 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9789401774055
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  • 7
    Keywords: Life sciences ; Neurosciences ; Neurochemistry ; Biochemistry ; Animal genetics ; Neurobiology ; Life sciences ; Protein Science ; Neurosciences ; Neurochemistry ; Animal Genetics and Genomics ; Biochemistry, general ; Neurobiology ; Springer eBooks
    Description / Table of Contents: 1. Introduction -- 2. Historical and Topological Perspective of Connexins -- 3. Molecular Components and Nomenclature of Gap Junctions -- 4. General Cell Biology of Connexins -- 5. Genomic Organization of Connexins -- 6. Transcriptional Regulation of the Connexin Gene -- 7. Epigenetic Regulation of Connexins -- 8. Translation Regulation of Connexins -- 9. Interaction Partners of Connexin Proteins -- 10. Tissue Distribution of Connexins -- 11. Connexin Functions -- 12. Connexin Mutations and Disease -- 13. Suggested Reading
    Abstract: Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins.℗ The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins
    Pages: XV, 93 p. 4 illus. in color. : online resource.
    ISBN: 9788132219194
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  • 8
    Keywords: Medicine ; Biochemistry ; Biomedicine ; Biomedicine general ; Biochemistry, general ; Protein Science ; Springer eBooks
    Description / Table of Contents: Overview and book plan -- Chaperones: General characteristics and classifications -- The chaperonopathies: classification, mechanisms, structural features -- Structural and hereditary chaperonopathies: mutation -- Other genetic chaperonopathies -- Acquired chaperonopathies -- Other types of chaperonopathies -- Impact of chaperonopathies in protein homeostasis and beyond -- Extracellular chaperones
    Abstract: Memory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer
    Pages: : digital.
    ISBN: 9789400746671
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  • 9
    Keywords: Life sciences ; Medical genetics ; Nucleic Acids ; Plant breeding ; Animal genetics ; Life sciences ; Animal Genetics and Genomics ; Plant Genetics & Genomics ; Gene Function ; Nucleic Acid Chemistry ; Springer eBooks
    Description / Table of Contents: Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion
    Abstract: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution
    Pages: VIII, 56 p. : digital.
    ISBN: 9783034806794
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  • 10
    Keywords: Medicine ; Spectroscopy ; Biotechnology ; Chemistry, Organic ; Chemistry, Physical organic ; Biochemistry ; Biomedicine ; Biomedicine general ; Spectroscopy/Spectrometry ; Biotechnology ; Physical Chemistry ; Organic Chemistry ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: The basis of Nuclear Magnetic Resonance Spectroscopy -- Spectroscopic parameters in Nuclear Magnetic Resonance -- Basic NMR experiments -- Biomolecular NMR
    Abstract: This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the development experienced by NMR in recent times. Many of the books currently available on NMR deal with the theoretical basis and some of its main applications, but they generally demand a strong background in Physics and Mathematics for a full understanding. This book is aimed to a wide scientific audience, trying to introduce NMR by making all possible effort to remove, without losing any formality and rigor, most of the theoretical jargon that is present in other NMR books. Furthermore, illustrations are provided that show all the basic concepts using a naive vector formalism, or using a simplified approach to the particular NMR-technique described. The intention has been to show simply the foundations and main concepts of NMR, rather than seeking thorough mathematical expressions
    Pages: XII, 115 p. 36 ill. : digital.
    ISBN: 9789400769762
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