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1.
PAPER CURRENT
Prevention of dementia by targeting risk factors – Authors' reply (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: 21–27 April 2018 Source: The Lancet, Volume 391, Issue 10130 Author(s): Gill Livingston, Andrew Sommerlad, Lon Schneider, Naaheed Mukadam, Sergi Costafreda
Print ISSN: 0140-6736
Electronic ISSN: 1474-547X
Topics: Medicine
Published by Elsevier
2.
PAPER CURRENT
Department of Error (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: 21–27 April 2018 Source: The Lancet, Volume 391, Issue 10130
Print ISSN: 0140-6736
Electronic ISSN: 1474-547X
Topics: Medicine
Published by Elsevier
3.
PAPER CURRENT
Department of Error (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: 21–27 April 2018 Source: The Lancet, Volume 391, Issue 10130
Print ISSN: 0140-6736
Electronic ISSN: 1474-547X
Topics: Medicine
Published by Elsevier
4.
PAPER CURRENT
Department of Error (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: 21–27 April 2018 Source: The Lancet, Volume 391, Issue 10130
Print ISSN: 0140-6736
Electronic ISSN: 1474-547X
Topics: Medicine
Published by Elsevier
5.
PAPER CURRENT
Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used (2018)
Nature Publishing Group (NPG)
Publication Date: 2018-04-21
Description: Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used, Published online: 20 April 2018; doi:10.1038/s41375-018-0041-0 Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used
Print ISSN: 0887-6924
Electronic ISSN: 1476-5551
Topics: Medicine
6.
PAPER CURRENT
Late Miocene climate cooling and intensification of southeast Asian winter monsoon (2018)
Nature Publishing Group (NPG)
Publication Date: 2018-04-21
Description: Late Miocene climate cooling and intensification of southeast Asian winter monsoon Late Miocene climate cooling and intensification of southeast Asian winter monsoon, Published online: 20 April 2018; doi:10.1038/s41467-018-03950-1 The late Miocene period allows investigation of climate-carbon cycle dynamics on a warmer-than-modern Earth. Here, the authors show that changes in the global carbon cycle drove climate cooling, culminating in ephemeral Northern Hemisphere glaciations and intensification of the Asian winter monsoon from 7 to 5.5 Ma.
Electronic ISSN: 2041-1723
Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
7.
PAPER CURRENT
Author Correction: Quantum Landauer erasure with a molecular nanomagnet (2018)
Springer Nature
Publication Date: 2018-04-21
Description: Author Correction: Quantum Landauer erasure with a molecular nanomagnet Author Correction: Quantum Landauer erasure with a molecular nanomagnet, Published online: 20 April 2018; doi:10.1038/s41567-018-0140-x Author Correction: Quantum Landauer erasure with a molecular nanomagnet
Print ISSN: 1745-2473
Electronic ISSN: 1745-2481
Topics: Physics
Published by Springer Nature
8.
PAPER CURRENT
A Task-Optimized Neural Network Replicates Human Auditory Behavior, Predicts Brain Responses, and Reveals a Cortical Processing Hierarchy (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: Available online 19 April 2018 Source: Neuron Author(s): Alexander J.E. Kell, Daniel L.K. Yamins, Erica N. Shook, Sam V. Norman-Haignere, Josh H. McDermott A core goal of auditory neuroscience is to build quantitative models that predict cortical responses to natural sounds. Reasoning that a complete model of auditory cortex must solve ecologically relevant tasks, we optimized hierarchical neural networks for speech and music recognition. The best-performing network contained separate music and speech pathways following early shared processing, potentially replicating human cortical organization. The network performed both tasks as well as humans and exhibited human-like errors despite not being optimized to do so, suggesting common constraints on network and human performance. The network predicted fMRI voxel responses substantially better than traditional spectrotemporal filter models throughout auditory cortex. It also provided a quantitative signature of cortical representational hierarchy—primary and non-primary responses were best predicted by intermediate and late network layers, respectively. The results suggest that task optimization provides a powerful set of tools for modeling sensory systems. Teaser Kell et al. show that a deep neural network optimized to recognize speech and music replicated human auditory behavior and predicted cortical fMRI responses. Different network layers best predict primary and non-primary voxels, revealing hierarchical organization in human auditory cortex.
Print ISSN: 0896-6273
Electronic ISSN: 1097-4199
Topics: Biology , Medicine
Published by Elsevier on behalf of Cell Press.
9.
PAPER CURRENT
Different Neuronal Activity Patterns Induce Different Gene Expression Programs (2018)
Elsevier
Publication Date: 2018-04-21
Description: Publication date: Available online 19 April 2018 Source: Neuron Author(s): Kelsey M. Tyssowski, Nicholas R. DeStefino, Jin-Hyung Cho, Carissa J. Dunn, Robert G. Poston, Crista E. Carty, Richard D. Jones, Sarah M. Chang, Palmyra Romeo, Mary K. Wurzelmann, James M. Ward, Mark L. Andermann, Ramendra N. Saha, Serena M. Dudek, Jesse M. Gray A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron’s activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because it requires MAPK/ERK signaling but does not require de novo translation. Thus, the same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations. Graphical abstract Teaser Tyssowski et al. report that different durations of neuronal activity induce different gene expression profiles, enabling inference of past neuronal activity from gene expression data. Furthermore, they show that MAPK/ERK signaling partially establishes this activity-pattern-to-gene-induction coupling.
Print ISSN: 0896-6273
Electronic ISSN: 1097-4199
Topics: Biology , Medicine
Published by Elsevier on behalf of Cell Press.
10.
PAPER CURRENT
[ASAP] [3 + 2]-Cycloaddition of Azaoxyallyl Cations with Hexahydro-1,3,5-triazines: Access to 4-Imidazolidinones (2018)
American Chemical Society (ACS)
Publication Date: 2018-04-21
Description: Organic Letters DOI: 10.1021/acs.orglett.8b00951
Print ISSN: 1523-7060
Electronic ISSN: 1523-7052
Topics: Chemistry and Pharmacology