Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

5,380,397 hits in 0.117 seconds
Refine your search
Collection
Years
Select All   Deselect All   Toggle Selection   Add To Mindlist   Mail Export   File Export
1.
PAPER CURRENT
Crystal structures of dimethyl 5-iodoisophthalate and dimethyl 5-ethynylisophthalate (2018)
International Union of Crystallography (IUC)
Publication Date: 2018-07-14
Description: In dimethyl 5-iodoisophthalate, C10H9IO4, (I), the planes through the methyl carboxylate moieties are tilted with respect to the benzene ring, whereas the molecular framework of dimethyl 5-ethynylisophthalate, C12H10O4, (II), is perfectly planar. The crystal structure of (I) is stabilized by a three-dimensional supramolecular network comprising C—H...O=C hydrogen bonds, as well as I...O=C interactions. In the crystal of (II), the molecules are connected via C—Hethynyl...O=C hydrogen bonds to infinite strands. Moreover, π–π arene stacking interactions connect the molecular chains into two-dimensional supramolecular aggregates.
Keywords: crystal structure5-substituted dimethyl isophthalatesI...O=C interactionC—H...O and C—H...I hydrogen bondingπ–π stacking
Electronic ISSN: 1600-5368
Topics: Chemistry and Pharmacology , Geosciences
2.
PAPER CURRENT
Crystal structure of a dinuclear ruthenium(II) complex with a bent CO22− bridge (2018)
International Union of Crystallography (IUC)
Publication Date: 2018-07-14
Description: The molecular and crystal structures of a CO22−-bridged dinuclear ruthenium complex is reported, namely, μ-carbonito-κ2C:O-bis[bis(2,2′-bipyridine-κ2N,N′)carbonylruthenium(II)] bis(hexafluoridophosphate)–acetonitrile–diethyl ether (1/1/0.5), [Ru2(CO)2(C10H8N2)4(μ:κ2-C:O-CO2)](PF6)2·CH3CN·0.5C4H10O. The complex cation in the title compound consists of two {Ru(CO)(bpy)2}2+ units (bpy = 2,2′-bipyridine) singly bridged by a μ:κ2-C:O carbonite anion, resulting in an unsymmetrical dinuclear structure. Some of the interatomic C...O distances involving the carbonyl ligands are shorter than the sum of the van der Waals radii. There are intramolecular C—H...O and aromatic π–π contacts in the cationic complex. In the crystal, the cations are linked by pairs of C—H...F hydrogen bonds in addition to weak C—H...F interactions between the solvent molecules and PF6− counter-anions. The equatorial F atoms of one of the PF6− anions are disordered over two sets of sites with an occupancy ratio of 0.908 (7):0.092 (7) while the central O atom of the diethyl ether solvent molecule is disordered over an inversion centre.
Keywords: crystal structuredinuclear ruthenium(II) complexcarbon dioxidecarbonite ligand: bipyridyl ligand
Electronic ISSN: 1600-5368
Topics: Chemistry and Pharmacology , Geosciences
3.
PAPER CURRENT
Challenge Trump on women’s health during UK visit, doctors urge May (2018)
BMJ Publishing Group
Publication Date: 2018-07-14
Description: Doctors have urged the prime minister to discuss access to sexual and reproductive healthcare with the US president during his visit to the UK.Donald Trump arrived in the UK on 12 July ahead of talks...
Keywords: Obstetrics and gynaecology
Topics: Medicine
Published by BMJ Publishing Group
4.
PAPER CURRENT
Doctors and vets working together for antibiotic stewardship (2018)
BMJ Publishing Group
Publication Date: 2018-07-14
Description: In July 2014, David Cameron, then prime minister, commissioned economist Jim O’Neill to analyse the global problem of rising antimicrobial resistance and recommend how to tackle it. O’Neill...
Topics: Medicine
Published by BMJ Publishing Group
5.
PAPER CURRENT
Healthcare outcomes and quality in the NHS: how do we compare and how might the NHS improve? (2018)
BMJ Publishing Group
Publication Date: 2018-07-14
Description: Health outcomes in the United Kingdom have improved substantially since the NHS was established in 1948.1 For example, average life expectancy has increased by around 12 years from 68 to 80 years;...
Keywords: Patient authored, NHS at 70
Topics: Medicine
Published by BMJ Publishing Group
6.
PAPER CURRENT
Communicating, consulting, and caring differently (2018)
BMJ Publishing Group
Publication Date: 2018-07-14
Description: Richards exhorts us, with passion, to work differently, for poorly served patients and overburdened staff.1 We need new approaches to healthcare interactions.We see such systems having several key...
Topics: Medicine
Published by BMJ Publishing Group
7.
PAPER CURRENT
Canadian government ordered to release unpublished Tamiflu data in landmark ruling (2018)
BMJ Publishing Group
Publication Date: 2018-07-14
Description: The Canadian government has been instructed to release unpublished clinical trial data relating to Tamiflu, Relenza, and three human papillomavirus vaccines immediately, in a landmark ruling hailed...
Topics: Medicine
Published by BMJ Publishing Group
8.
PAPER CURRENT
Referee acknowledgement for 2017 (2018)
Nature Publishing Group (NPG)
Publication Date: 2018-07-14
Description: Referee acknowledgement for 2017 Referee acknowledgement for 2017, Published online: 13 July 2018; doi:10.1038/s41416-018-0151-5 Referee acknowledgement for 2017
Print ISSN: 0007-0920
Electronic ISSN: 1532-1827
Topics: Medicine
9.
PAPER CURRENT
Publication Date: 2018-07-14
Description: Cancers, Vol. 10, Pages 233: Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability † Cancers doi: 10.3390/cancers10070233 Authors: Corina Cuceu Bruno Colicchio Eric Jeandidier Steffen Junker François Plassa Grace Shim Justyna Mika Monika Frenzel Mustafa AL Jawhari William M. Hempel Grainne O’Brien Aude Lenain Luc Morat Theodore Girinsky Alain Dieterlen Joanna Polanska Christophe Badie Patrice Carde Radhia M’Kacher Background: Microsatellite and chromosomal instability have been investigated in Hodgkin lymphoma (HL). Materials and Methods: We studied seven HL cell lines (five Nodular Sclerosis (NS) and two Mixed Cellularity (MC)) and patient peripheral blood lymphocytes (100 NS-HL and 23 MC-HL). Microsatellite instability (MSI) was assessed by PCR. Chromosomal instability and telomere dysfunction were investigated by FISH. DNA repair mechanisms were studied by transcriptomic and molecular approaches. Results: In the cell lines, we observed high MSI in L428 (4/5), KMH2, and HDLM2 (3/5), low MSI in L540, L591, and SUP-HD1, and none in L1236. NS-HL cell lines showed telomere shortening, associated with alterations of nuclear shape. Small cells were characterized by telomere loss and deletion, leading to chromosomal fusion, large nucleoplasmic bridges, and breakage/fusion/bridge (B/F/B) cycles, leading to chromosomal instability. The MC-HL cell lines showed substantial heterogeneity of telomere length. Intrachromosmal double strand breaks induced dicentric chromosome formation, high levels of micronucleus formation, and small nucleoplasmic bridges. B/F/B cycles induced complex chromosomal rearrangements. We observed a similar pattern in circulating lymphocytes of NS-HL and MC-HL patients. Transcriptome analysis confirmed the differences in the DNA repair pathways between the NS and MC cell lines. In addition, the NS-HL cell lines were radiosensitive and the MC-cell lines resistant to apoptosis after radiation exposure. Conclusions: In mononuclear NS-HL cells, loss of telomere integrity may present the first step in the ongoing process of chromosomal instability. Here, we identified, MSI as an additional mechanism for genomic instability in HL.
Electronic ISSN: 2072-6694
Topics: Medicine
10.
PAPER CURRENT
Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling (2018)
Nature Publishing Group (NPG)
Publication Date: 2018-07-14
Description: Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling, Published online: 13 July 2018; doi:10.1038/s41419-018-0807-3 Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling
Electronic ISSN: 2041-4889
Topics: Biology , Medicine