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1.
PAPER CURRENT
Aptamer-Based Dual-Functional Probe for Rapid and Specific Counting and Imaging of MCF-7 Cells (2018)
American Chemical Society (ACS)
Publication Date: 2018-01-21
Description: Analytical Chemistry DOI: 10.1021/acs.analchem.7b04927
Print ISSN: 0003-2700
Electronic ISSN: 1520-6882
Topics: Chemistry and Pharmacology
2.
PAPER CURRENT
3D Network and 2D Paper of Reduced Graphene Oxide/Cu2O Composite for Electrochemical Sensing of Hydrogen Peroxide (2018)
American Chemical Society (ACS)
Publication Date: 2018-01-21
Description: Analytical Chemistry DOI: 10.1021/acs.analchem.7b04070
Print ISSN: 0003-2700
Electronic ISSN: 1520-6882
Topics: Chemistry and Pharmacology
3.
PAPER CURRENT
Identification of Individual Bacterial Cells through the Intermolecular Interactions with Peptide-Functionalized Solid-State Pores (2018)
American Chemical Society (ACS)
Publication Date: 2018-01-21
Description: Analytical Chemistry DOI: 10.1021/acs.analchem.7b04950
Print ISSN: 0003-2700
Electronic ISSN: 1520-6882
Topics: Chemistry and Pharmacology
4.
PAPER CURRENT
Use of Cysteine Aminoethylation To Identify the Hypervariable Peptides of an Antibody (2018)
American Chemical Society (ACS)
Publication Date: 2018-01-21
Description: Analytical Chemistry DOI: 10.1021/acs.analchem.7b02732
Print ISSN: 0003-2700
Electronic ISSN: 1520-6882
Topics: Chemistry and Pharmacology
5.
PAPER CURRENT
BMP4 signaling in NPCs upregulates Bcl-xL to promote their survival in the presence of FGF-2 (2018)
Elsevier
Publication Date: 2018-01-21
Description: Publication date: Available online 19 January 2018 Source: Biochemical and Biophysical Research Communications Author(s): Hanako Yamamoto, Masashi Kurachi, Masae Naruse, Koji Shibasaki, Yasuki Ishizaki We previously reported that BMP4 does not promote proliferation or differentiation of CD44-positive astrocyte precursor cells (APCs) but greatly promotes their survival in the presence of fibroblast growth factor-2 (FGF-2). In this study, we examined if BMP4 acts as a survival factor also for neural stem/progenitor cells (NPCs) isolated from ganglionic eminence of neonatal mouse brain. We found BMP4 promotes survival but not proliferation or differentiation of these cells, just as in the case for CD44-positive APCs. Microarray analysis revealed some candidate molecules in the signaling pathway downstream of BMP4. Among them, we focused on Id1 (inhibitor of DNA-binding 1) and Bcl-xL in this study. Expression of both genes was promoted in the presence of BMP4, and this promotion was reduced by dorsomorphin, an inhibitor of BMP4 signaling. Furthermore, cytochrome c release from mitochondria was significantly reduced in the presence of BMP4, suggesting up-regulation of Bcl-xL activity by BMP4. Id1 siRNA reduced the expression of Bcl-xL, and negated survival promoting effect of BMP4. These data suggest that BMP4 promotes survival of NPCs by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling.
Print ISSN: 0006-291X
Electronic ISSN: 1090-2104
Topics: Biology , Chemistry and Pharmacology , Physics
Published by Elsevier
6.
PAPER CURRENT
Negative regulation of BRCA1 by transforming acidic coiled-coil protein 3 (TACC3) (2018)
Elsevier
Publication Date: 2018-01-21
Description: Publication date: Available online 19 January 2018 Source: Biochemical and Biophysical Research Communications Author(s): Jung-Lye Kim, Geun-Hyoung Ha, Loredana Campo, Eun-Kyoung Breuer In spite of the push to identify modifiers of BRCAness, it still remains unclear how tumor suppressor BRCA1 is lost in breast cancers in the absence of genetic or epigenetic aberrations. Mounting evidence indicates that the transforming acidic coiled-coil 3 (TACC3) plays an important role in the centrosome-microtubule network during mitosis and gene expression, and that deregulation of TACC3 is associated with breast cancer. However, the molecular mechanisms by which TACC3 contributes to breast cancer development have yet to be elucidated. Herein, we found that high levels of TACC3 in human mammary epithelial cells can cause genomic instability possibly in part through destabilizing BRCA1. We also found that high levels of TACC3 inhibited the interaction between BRCA1 and BARD1, thus subsequently allowing the BARD1-uncoupled BRCA1 to be destabilized by ubiquitin-mediated proteosomal pathway. Moreover, there is an inverse correlation between TACC3 and BRCA1 expression in breast cancer tissues. Overall, our findings provide a new insight into the role of TACC3 in genomic instability and breast tumorigenesis.
Print ISSN: 0006-291X
Electronic ISSN: 1090-2104
Topics: Biology , Chemistry and Pharmacology , Physics
Published by Elsevier
7.
PAPER CURRENT
Cancers, Vol. 10, Pages 24: Contemporary Management of Localized Resectable Pancreatic Cancer (2018)
Molecular Diversity Preservation International (MPDI)
Publication Date: 2018-01-21
Description: Cancers, Vol. 10, Pages 24: Contemporary Management of Localized Resectable Pancreatic Cancer Cancers doi: 10.3390/cancers10010024 Authors: Anuhya Kommalapati Sri Tella Gaurav Goyal Wen Ma Amit Mahipal Pancreatic cancer is the third most common cause of cancer deaths in the United States. Surgical resection with negative margins still constitutes the cornerstone of potentially curative therapy, but is possible only in 15–20% of patients at the time of initial diagnosis. Accumulating evidence suggests that the neoadjuvant approach may improve R0 resection rate in localized resectable and borderline resectable diseases, and potentially downstage locally advanced disease to achieve surgical resection, though the impact on survival is to be determined. Despite advancements in the last decade in developing effective combinational chemo-radio therapeutic options, preoperative treatment strategies, and better peri-operative care, pancreatic cancer continues to carry a dismal prognosis in the majority. Prodigious efforts are currently being made in optimizing the neoadjuvant therapy with a better toxicity profile, developing novel agents, imaging techniques, and identification of biomarkers for the disease. Advancement in our understanding of the tumor microenvironment and molecular pathology is urgently needed to facilitate the development of novel targeted and immunotherapies for this setting. In this review, we detail the current literature on contemporary management of resectable, borderline resectable and locally advanced pancreatic cancer with a focus on future directions in the field.
Electronic ISSN: 2072-6694
Topics: Medicine
8.
PAPER CURRENT
Hepatitis B Virus Infection and Hepatitis C Virus Treatment in a Large Cohort of Hepatitis C–Infected Patients in the United States (2018)
Elsevier
Publication Date: 2018-01-21
Description: Publication date: Available online 19 January 2018 Source: Gastroenterology Author(s): Anne C. Moorman, Jian Xing, Loralee B. Rupp, Stuart C. Gordon, Philip R. Spradling, Joseph A. Boscarino, Mark A. Schmidt, Yihe G. Daida, Eyasu H. Teshale, Scott D. Holmberg
Print ISSN: 0016-5085
Electronic ISSN: 1528-0012
Topics: Medicine
Published by Elsevier
9.
PAPER CURRENT
IJERPH, Vol. 15, Pages 164: Fate of Fecal Indicators in Resource-Oriented Sanitation Systems Using Nitrifying Bio-Treatment (2018)
MDPI Publishing
Publication Date: 2018-01-21
Description: IJERPH, Vol. 15, Pages 164: Fate of Fecal Indicators in Resource-Oriented Sanitation Systems Using Nitrifying Bio-Treatment International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15010164 Authors: Shervin Hashemi Mooyoung Han Eun Namkung Hygienic fecal treatment in resource-oriented sanitation (ROS) systems is an important concern. Although the addition of nitrifying microorganisms is a sustainable fecal treatment method in ROS systems, it is essential to examine the cleanliness of this method. In this study, we investigated the fate of fecal indicators in source-separated fecal samples through tracking Escherichia coli and total coliforms. The effects of adding different amounts of Nitrosomonas europaea bio-seed, along with a constant amount of Nitrobacter winogradskyi bio-seed, were studied. In intact feces samples, the pathogen population underwent an initial increase, followed by a slight decrease, and eventually became constant. Although the addition of nitrifying microorganisms initially enhanced the pathogen growth rate, it caused the reduction process to become more efficient in the long-term. In addition to a constant concentration of 10,000 cells of N. winogradskyi per 1 g feces, a minimum amount of 3000 and 7000 cells of N. europaea per 1 g feces could completely remove E. coli and total coliforms, respectively, in less than 25 days. Increasing the amount of bio-seeds added can further reduce the time required for total pathogen removal.
Print ISSN: 1661-7827
Electronic ISSN: 1660-4601
Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
Published by MDPI Publishing
10.
PAPER CURRENT
Publication Date: 2018-01-21
Description: Publication date: Available online 17 January 2018 Source: Journal of Structural Biology
Print ISSN: 1047-8477
Electronic ISSN: 1095-8657
Topics: Biology
Published by Elsevier