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1.
PAPER CURRENT
Reviews and syntheses: parameter identification in marine planktonic ecosystem modelling (2017)
Copernicus
Publication Date: 2017-03-30
Description: Reviews and syntheses: parameter identification in marine planktonic ecosystem modelling Markus Schartau, Philip Wallhead, John Hemmings, Ulrike Löptien, Iris Kriest, Shubham Krishna, Ben A. Ward, Thomas Slawig, and Andreas Oschlies Biogeosciences, 14, 1647-1701, doi:10.5194/bg-14-1647-2017, 2017 Plankton models have become an integral part in marine ecosystem and biogeochemical research. These models differ in complexity and in their number of parameters. How values are assigned to parameters is essential. An overview of major methodologies of parameter estimation is provided. Aspects of parameter identification in the literature are diverse. Individual findings could be better synthesized if notation and expertise of the different scientific communities would be reasonably merged.
Print ISSN: 1810-6277
Electronic ISSN: 1810-6285
Topics: Biology , Geosciences
2.
PAPER CURRENT
Effects of low oxygen concentrations on aerobic methane oxidation in seasonally hypoxic coastal waters (2017)
Copernicus
Publication Date: 2017-03-30
Description: Effects of low oxygen concentrations on aerobic methane oxidation in seasonally hypoxic coastal waters Lea Steinle, Johanna Maltby, Tina Treude, Annette Kock, Hermann W. Bange, Nadine Engbersen, Jakob Zopfi, Moritz F. Lehmann, and Helge Niemann Biogeosciences, 14, 1631-1645, doi:10.5194/bg-14-1631-2017, 2017 Large amounts of methane are produced in anoxic, coastal sediments, from which it can seep into the overlying water column. Aerobic oxidation of methane (MOx) mediated by methanotrophic bacteria is an important sink for methane before its evasion to the atmosphere. In a 2-year seasonal study, we investigated the spatio-temporal variability of MOx in a seasonally hypoxic coastal inlet using radiotracer-based methods. In experiments, we assessed the effect of variable oxygen concentrations on MOx.
Print ISSN: 1810-6277
Electronic ISSN: 1810-6285
Topics: Biology , Geosciences
3.
PAPER CURRENT
Changes in the partial pressure of carbon dioxide in the Mauritanian-Cape Verde upwelling region between 2005 and 2012 (2017)
Copernicus
Publication Date: 2017-03-30
Description: Changes in the partial pressure of carbon dioxide in the Mauritanian-Cape Verde upwelling region between 2005 and 2012 Melchor González-Dávila, J. Magdalena Santana Casiano, and Francisco Machín Biogeosciences Discuss., doi:10.5194/bg-2017-83,2017 Manuscript under review for BG (discussion: open, 0 comments) The Mauritanian-Cape Verde upwelling is shown to be sensitive to climate change forcing on upwelling processes, which strongly affects the CO 2 surface distribution, ocean acidification rates and air-sea CO 2 exchange. They confirmed an upwelling intensification, an increase in the CO 2 outgassing and an important decrease in the pH of the surface waters. Upwelling areas are poorly studied and VOS lines are shown as one of the most significative contributors to the knowledge of the ocean response.
Print ISSN: 1810-6277
Electronic ISSN: 1810-6285
Topics: Biology , Geosciences
4.
PAPER CURRENT
Midwife-led maternity care in Ireland – a retrospective cohort study (2017)
BioMed Central
Publication Date: 2017-03-30
Description: Midwife-led maternity care is shown to be safe for women with low-risk during pregnancy. In Ireland, two midwife-led units (MLUs) were introduced in 2004 when a randomised controlled trial (the MidU study) was...
Electronic ISSN: 1471-2393
Topics: Medicine
Published by BioMed Central
5.
PAPER CURRENT
Why do women choose an unregulated birth worker to birth at home in Australia: a qualitative study (2017)
BioMed Central
Publication Date: 2017-03-30
Description: In Australia the choice to birth at home is not well supported and only 0.4% of women give birth at home with a registered midwife. Recent changes to regulatory requirements for midwives have become more restr...
Electronic ISSN: 1471-2393
Topics: Medicine
Published by BioMed Central
6.
PAPER CURRENT
Working memory training in children with neuropsychiatric disorders and mild to borderline intellectual functioning, the role of coaching; a double-blind randomized controlled trial (2017)
BioMed Central
Publication Date: 2017-03-30
Description: Working memory training (WMT) has been shown to offer therapeutic benefits to both patients with Attention-Deficit Hyperactivity Disorder (ADHD) and patients with mild to borderline Intellectual Disabilities (...
Electronic ISSN: 1471-244X
Topics: Medicine
Published by BioMed Central
7.
PAPER CURRENT
Evaluation and treatment for ovotesticular disorder of sex development (OT-DSD) - experience based on a Chinese series (2017)
BioMed Central
Publication Date: 2017-03-30
Description: The aim of this study is to review and present the clinical features and process of evaluation and treatment for OT-DSD in a single center in recent years in China.
Electronic ISSN: 1471-2490
Topics: Medicine
Published by BioMed Central
8.
PAPER CURRENT
A Revised Fibrinogen Cutoff Value in the Chinese Disseminated Intravascular Coagulation Scoring System May Provide a Better Prognostic Value for Hematological Malignancies (2017)
Karger
Publication Date: 2017-03-30
Description: To retrospectively validate the prognostic value of the latest Chinese disseminated intravascular coagulation (DIC) scoring system (CDSS) in hematological malignancies, 260 patients with confirmed hematological malignancies and suspected DIC in West China Hospital between 2011 and 2015 were included in this study. We evaluated via univariate and multivariate analyses the diagnostic biomarkers, and the cutoff levels used in the CDSS, except those for fibrinogen, were found to be valid. In subgroup analyses, the value of fibrinogen was found to be mainly unfit for the acute promyelocytic leukemia group. Forty-six patients (17.7%) had elevated fibrinogen levels (>4 g/L) and tended to have a poor prognosis, and thus we redetermined the cutoff value of fibrinogen ( 4 g/L was defined as abnormal). As a result, all of the markers used in the CDSS had prognostic value (including for the promyelocytic leukemia group); meanwhile, this modification also resulted in a larger area under the receiver operating characteristic curve compared to the CDSS and the International Society on Thrombosis and Haemostasis score. We believe that, with regard to prognosis prediction, this cutoff value modification for fibrinogen is preferable for DIC patients with a tendency toward severe hypofibrinogenemia. However, a multicenter, prospective study is needed to validate this possibility. Acta Haematol 2017;137:132-140
Print ISSN: 0001-5792
Electronic ISSN: 1421-9662
Topics: Medicine
Published by Karger
9.
PAPER CURRENT
Results from Two Consecutive Studies of Consolidation Therapy after Autologous Transplant for Multiple Myeloma: Thalidomide, Dexamethasone, and Clarithromycin or Lenalidomide, Dexamethasone, and Clarithromycin (2017)
Karger
Publication Date: 2017-03-30
Description: Background: In multiple myeloma (MM), relapse is a problem after autologous hematopoietic stem cell transplantation (ASCT). In the nontransplant setting, thalidomide/dexamethasone/clarithromycin (BLT-D) and lenalidomide/dexamethasone/clarithromycin (BiRd) achieve responses with acceptable toxicity. Both regimens are reasonable objects of study in the post-ASCT setting. Patients and Methods: We report on BLT-D and BiRd given post-ASCT. Studies were conducted consecutively. After recovery from ASCT, therapy was started. All 3 drugs were given for 1 year, and then immunomodulatory drugs alone were given as long as tolerated or until disease progression. Results: For BLT-D, the most common toxicity was peripheral neuropathy (PN). For BiRd, infection, PN, and neutropenia were the most common adverse events. BiRd was associated with a higher frequency of secondary cancers. The median follow-up for BLT-D was 10.2 years (range 8.6-10.7) and for BiRd it was 7.5 years (range 6.4-8.4). After BLT-D, 18 patients (67%) were alive and 10 (37%) were alive without disease progression, and after BiRd, 18 patients (58%) were alive and 10 (32%) were alive without disease progression. Conclusions: BLT-D and BiRd can be given post-ASCT with different toxicity profiles and comparable disease-free and overall survival rates. A randomized study comparing these regimens to single-agent lenalidomide is needed to determine which approach is superior. Key Message: Relapse of MM is a major problem after ASCT. Strategies are needed post-ASCT to improve outcomes. In the nontransplant setting, thalidomide or lenalidomide/dexamethasone/clarithromycin treat MM with acceptable toxicity. We, thus, studied both regimens post- ASCT. They can be given with different toxicity profiles and result in good disease control. Acta Haematol 2017;137:123-131
Print ISSN: 0001-5792
Electronic ISSN: 1421-9662
Topics: Medicine
Published by Karger
10.
PAPER CURRENT
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis (2017)
Springer
Publication Date: 2017-03-30
Description: Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease characterized by degeneration and premature death of motor neurons. The contribution of mutant TDP-43-mediated damage within motor neurons was evaluated using mice expressing a conditional allele of an ALS-causing TDP-43 mutant (Q331K) whose broad expression throughout the central nervous system mimics endogenous TDP-43. TDP-43 Q331K mice develop age- and mutant-dependent motor deficits from degeneration and death of motor neurons. Cre-recombinase-mediated excision of the TDP-43 Q331K gene from motor neurons is shown to delay onset of motor symptoms and appearance of TDP-43-mediated aberrant nuclear morphology, and abrogate subsequent death of motor neurons. However, reduction of mutant TDP-43 selectively in motor neurons did not prevent age-dependent degeneration of axons and neuromuscular junction loss, nor did it attenuate astrogliosis or microgliosis. Thus, disease mechanism is non-cell autonomous with mutant TDP-43 expressed in motor neurons determining disease onset but progression defined by mutant acting within other cell types.
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
Topics: Medicine
Published by Springer